Journal of the Turkish German Gynecological Association最新文献

Mobilization and protection of the ureter during laparoscopic total hysterectomy for cervical fibroids. 腹腔镜宫颈肌瘤全子宫切除术中输尿管的动员与保护。

IF 1.4

Journal of the Turkish German Gynecological Association Pub Date : 2025-07-31 DOI: 10.4274/jtgga.galenos.2025.2024-11-1

Jiahui Cao, Aayale Chaimaa, Weiyue Zhang, Jiangnan Qiu, Chengyan Luo

{"title":"Mobilization and protection of the ureter during laparoscopic total hysterectomy for cervical fibroids.","authors":"Jiahui Cao, Aayale Chaimaa, Weiyue Zhang, Jiangnan Qiu, Chengyan Luo","doi":"10.4274/jtgga.galenos.2025.2024-11-1","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2025.2024-11-1","url":null,"abstract":"Cervical fibroids (CFs) grow in the narrowest part of the uterus, which is adjacent to the ureter, uterine vessels and their branches. The ureter is at risk of being divided, thermally injured, and/or misligated when handling the vessels during total laparoscopic hysterectomy (TLH) to treat CFs We present a series of videos to detail the methods and skills required to perform blunt ureterolysis and handle the uterine vessels during TLH for CFs. This video contains three cases of CFs that underwent TLH. In Case 1, the surgeon did not separate the ureter in advance and mistook the ureter for a vessel during coagulating the vessels with bipolar forceps, which resulted in thermal injury to the ureter. Therefore, a ureteral stent was placed under cystoscopy, which was removed three months after the operation. In both Cases 2, 3, the surgeon used a curved vascular clamp to bluntly separate and fully expose the pelvic part of the ureter and then coagulated and divided the vessels. The separation started when the ureter traced the base of the posterior lobe of the broad ligament until it entered below the uterine artery. The uterine artery dissection site differed in Cases 2 and 3, with Case 2 being at the origin of the internal iliac artery and Case 3 in an area close to the CF, depending on the space between the CF and uterine artery. After six months of follow-up, all three patients were free of pyelonephrosis and ureteral dilatation, and no ureterovaginal fistulae occurred. Blunt ureterolysis procedure can effectively avoid ureter injury in TLH for CFs.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective evaluation of transvaginal cervical cerclage cases in a tertiary reference center: comparison of indications and suture materials. 回顾性评价经阴道宫颈环扎术病例在三级参考中心：比较适应证和缝合材料。

IF 1.4

Journal of the Turkish German Gynecological Association Pub Date : 2025-07-31 DOI: 10.4274/jtgga.galenos.2025.2024-11-4

Umutcan Kayıkçı, Erdem Fadıloğlu, Ayşe Çiğdem Bayrak, İlgi Adalı, Edip Alptuğ Kır, Özgür Deren

{"title":"Retrospective evaluation of transvaginal cervical cerclage cases in a tertiary reference center: comparison of indications and suture materials.","authors":"Umutcan Kayıkçı, Erdem Fadıloğlu, Ayşe Çiğdem Bayrak, İlgi Adalı, Edip Alptuğ Kır, Özgür Deren","doi":"10.4274/jtgga.galenos.2025.2024-11-4","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2025.2024-11-4","url":null,"abstract":"Objective: To compare history-indicated cervical cerclage (HICC), ultrasound-indicated CC (UICC) and physical examination-indicated CC (PEICC) in terms of obstetric outcomes and to compare the outcomes related to braided and non-braided suture materials (Prolene suture vs. Mersilene tape).Material and methods: We retrospectively evaluated 173 transvaginal CC procedures performed in a single center. Cases were classified based on procedure indications and the type of suture material used.Results: Of the 173 cases reviewed, 103 (59.5%), 45 (26.0%) and 25 (14.4%) cases were in the HICC, UICC and PEICC groups, respectively. Patients in the PEICC group underwent cerclage at significantly later gestational weeks, had higher hospitalization rates, longer hospital stays following the procedure, a shorter interval between cerclage and delivery, and a higher rate of procedure-related pregnancy loss compared to the other groups (p<0.05 for all). Both the gestational age at delivery and the take-home baby rate were lower in this group compared to the other groups (p<0.05 for both). There were no significant differences identified in terms of suture materials used. Subgroup analyses revealed similar obstetric outcomes between different suture materials.Conclusion: PEICC had worse perinatal outcomes compared to HICC and UICC procedures. CC indication was the major determinant of perinatal outcome in this cohort while suture material had no significant effect on perinatal outcomes.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conservative management of idiopathic gross hematuria post-cesarean delivery. 剖宫产后特发性肉眼血尿的保守治疗。

IF 1.4

Journal of the Turkish German Gynecological Association Pub Date : 2025-07-30 DOI: 10.4274/jtgga.galenos.2025.2025-2-7

Sunayna Lashkari, Arun Kumar Dora, Avantika Gupta, Ketan Mehra

引用次数: 0

Transplacental cancer transmission: a comprehensive review focusing on mechanisms, challenges, and maternal-fetal outcomes. 胎盘癌传播：一项全面的综述，重点是机制、挑战和母胎结局。

IF 1.4

Journal of the Turkish German Gynecological Association Pub Date : 2025-07-30 DOI: 10.4274/jtgga.galenos.2025.2025-9-8

Mishu Mangla, Seetu Palo, Naina Kumar

{"title":"Transplacental cancer transmission: a comprehensive review focusing on mechanisms, challenges, and maternal-fetal outcomes.","authors":"Mishu Mangla, Seetu Palo, Naina Kumar","doi":"10.4274/jtgga.galenos.2025.2025-9-8","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2025.2025-9-8","url":null,"abstract":"The phenomenon of transplacental transmission of cancer, where cancer cells pass from a pregnant mother to her fetus is an extremely rare occurrence. This phenomenon has significant implications for maternal and fetal health, challenging our understanding of cancer biology and maternal-fetal interactions. The literature on transplacental cancer transmission is sparse, consisting mainly of case reports, small cohort studies, and reviews. Examples of cancers that have been transmitted in this way include melanoma, choriocarcinoma, leukaemia, and lymphoma. Understanding this phenomenon is important because it has direct clinical implications for managing pregnant women with cancer and the infant, raises questions about the placental barrier and immune interactions between mother and fetus, and offers insights that could influence cancer biology and treatment strategies. This review aims to evaluate existing data, identify and synthesize evidence on transplacental cancer transmission cases, evaluate cancer types involved, their transmission mechanisms, and clinical outcomes for both mothers and infants. A comprehensive electronic search of databases was conducted for relevant case reports and series, using specific keywords related to vertical and transplacental transmission of cancer. The review elucidates comprehensive information from the reports to understand how cancer transmission occurred and was confirmed as vertical transmission, aiming to enhance knowledge in this critical area of maternal-fetal medicine.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of research on vulvar intraepithelial neoplasia: towards precision diagnostics and risk stratification. 外阴上皮内瘤变研究的未来：走向精确诊断和风险分层。

IF 1.4

Journal of the Turkish German Gynecological Association Pub Date : 2025-07-29 DOI: 10.4274/jtgga.galenos.2025.2025-7-5

Mario Preti, Niccolò Gallio, Jacob Bornstein, Elmar Joura, Koray Görkem Saçıntı, Pedro Vieira Baptista

{"title":"The future of research on vulvar intraepithelial neoplasia: towards precision diagnostics and risk stratification.","authors":"Mario Preti, Niccolò Gallio, Jacob Bornstein, Elmar Joura, Koray Görkem Saçıntı, Pedro Vieira Baptista","doi":"10.4274/jtgga.galenos.2025.2025-7-5","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2025.2025-7-5","url":null,"abstract":"Vulvar intraepithelial neoplasia (VIN) represents a heterogeneous group of premalignant lesions arising through distinct human papillomavirus (HPV)-associated and HPV-independent pathways. Despite well-characterized differences in etiology, prognosis, and progression risk, current management remains largely uniform and predominantly surgical. This one-size-fits-all approach neglects opportunities for individualized care and exposes patients, particularly younger women and those with multifocal disease, to potentially avoidable psychosexual morbidity. Recent advances in molecular pathology, including immunohistochemistry, genomic profiling, DNA methylation analysis, and copy number alteration detection, offer promising avenues for refining diagnostic precision and enabling risk stratification. Integration of markers such as p16INK4a, p53, and emerging methylation panels into diagnostic workflows may improve differentiation between lesion subtypes, guide surveillance, and identify candidates for conservative therapy. Moreover, the unique pathogenesis of vulvar high-grade squamous intraepithelial neoplasia, which diverges from squamocolumnar junction (SCJ)-driven models seen in other HPV-associated cancers, highlights the need for focused research on host-virus interactions and early oncogenic events in non-SCJ epithelium. Future directions include non-invasive sampling methods, molecularly-guided surveillance protocols, therapeutic HPV vaccines, and combined immunomodulatory treatments to reduce the burden of excisional therapy. Establishing precision-based approaches for VIN could not only preserve vulvar integrity and function but also improve oncological outcomes through targeted prevention and early intervention strategies.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is your diagnosis? 你的诊断是什么？

IF 1.4

Journal of the Turkish German Gynecological Association Pub Date : 2025-07-29 DOI: 10.4274/jtgga.galenos.2025.2024-12-3

Mrudula Chandrupatla, Mishu Mangla, Ariyanachi Kaliappan, Seetu Palo, Aparna Setty, Geetha Sulochana Gopidas, Punnapa Raviteja, Deepa G

引用次数: 0

Determining the optimal follow-up protocol after primary surgery in patients with early-stage endometrial cancer. 确定早期子宫内膜癌患者初次手术后的最佳随访方案。

IF 1.2

Journal of the Turkish German Gynecological Association Pub Date : 2025-06-10 DOI: 10.4274/jtgga.galenos.2025.2025-2-4

Can Ozan Ulusoy, Bulut Varlı, Ali Gökçe, Duygu Altın, Şahin Kaan Baydemir, Uğur Fırat Ortaç, Salih Taşkın

{"title":"Determining the optimal follow-up protocol after primary surgery in patients with early-stage endometrial cancer.","authors":"Can Ozan Ulusoy, Bulut Varlı, Ali Gökçe, Duygu Altın, Şahin Kaan Baydemir, Uğur Fırat Ortaç, Salih Taşkın","doi":"10.4274/jtgga.galenos.2025.2025-2-4","DOIUrl":"10.4274/jtgga.galenos.2025.2025-2-4","url":null,"abstract":"Objective: The aim of this study was to investigate the timing of recurrence in patients with early-stage endometrial cancer and to determine the optimal postoperative follow-up protocol for the detection of recurrence.Material and methods: Patients with stage 1 and 2, grade 1-3 endometrioid type endometrial cancer who underwent follow-up for at least two years were included. The diagnostic method for recurrence was analyzed for each patient. Analysis of risk factors for recurrence were done using SPSS. Sensitivity analyzes were performed comparing the diagnostic methods.Results: A total of 303 patients were included and recurrence was diagnosed in 17 (5.61%). Cumulative risk of recurrence was 3.06% in the first 23 months, rising to 7.52% in the first 33 months. Sensitivity of physical examination (PE) was 50.00%, specificity 99.52%, positive predictive value 88.89%, negative predictive value 96.30% and accuracy rate 96.00% respectively. It was found that each step increase of grade increased recurrence odds by 2.549 times [95% confidence interval (CI): 1.078-6.027; p=0.033] while each step increase of stage increased recurrence odds by 2.943 times (95% CI: 1.270-6.820; p=0.012).Conclusion: It is notable that recurrence rate increased after 25 months and the risk of recurrence increased as the tumor stage and grade worsened. Symptoms in patients with high-grade and deep myometrial invasion, especially after the first two years, should be considered risky and patients should be informed about seeking medical care when symptoms occur. PE and symptoms of patients are key factors in detecting reccurence while other diagnostic methods can be used according to clinical findings.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"26 2","pages":"82-89"},"PeriodicalIF":1.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of COVID-19 (SARS-CoV-2) vaccines on vulvar condylomata. COVID-19 （SARS-CoV-2）疫苗对外阴尖锐湿疣的影响。

IF 1.2

Journal of the Turkish German Gynecological Association Pub Date : 2025-06-10 DOI: 10.4274/jtgga.galenos.2025.2025-4-8

Mustafa Şahin, Şeyma Banu Arslanca

{"title":"The effect of COVID-19 (SARS-CoV-2) vaccines on vulvar condylomata.","authors":"Mustafa Şahin, Şeyma Banu Arslanca","doi":"10.4274/jtgga.galenos.2025.2025-4-8","DOIUrl":"10.4274/jtgga.galenos.2025.2025-4-8","url":null,"abstract":"Objective: Current evidence concerning the possible clinical effects of coronavirus disease-2019 (COVID-19) vaccines on vulvar lesions is limited. The aim was to describe the effect of vaccines against COVID-19 on the progression of vulvar condylomas.Material and methods: The data of patients diagnosed with condylomata acuminate and treated with trichloroacetic acid (TCA) between January 2021 and January 2023 in the gynecological oncology surgery clinic were evaluated. The patients were divided into groups based on their vaccination status; vaccinated or unvaccinated. The number/area of condylomas and symptom degrees of the patients before and after TCA treatment were compared.Results: A total of 202 patients, 102 vaccinated and 100 unvaccinated, were included. There was no significant difference between the groups in terms of age, parity, smoking, oral contraceptive use, amount of condyloma and symptom degree (all p>0.05). There was no significant difference in the amount of condyloma between the groups after six months [p=0.589, 95% confidence interval (CI)=0.238-1.566]. Moreover, there was no difference in the degree of symptoms after six months between the groups (p=0.467, 95% CI=1.113-1.799).Conclusion: The systemic effects caused by COVID-19 vaccines are still not fully understood. Considering that this vaccine, like many vaccines, elicits a strong immunogenic reaction, the possible clinical impact of this non-specific systemic inflammatory response on vulvar condyloma is a matter of curiosity. This study showed there was no difference in the amount of condyloma and the degree of symptoms six months after TCA treatment in the unvaccinated and vaccinated group. The low number of patients is the biggest limitation of this study. Larger studies may provide more robust information.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"26 2","pages":"116-120"},"PeriodicalIF":1.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The histologic results in multiple-type HPV infections. 组织学结果为多型HPV感染。

IF 1.2

Journal of the Turkish German Gynecological Association Pub Date : 2025-06-10 DOI: 10.4274/jtgga.galenos.2025.2023-4-2

Sevgi Koç, Dilek Yüksel, Eylem Ünlübilgin, Tuğba Kınay, Fulya Kayıkçıoğlu

{"title":"The histologic results in multiple-type HPV infections.","authors":"Sevgi Koç, Dilek Yüksel, Eylem Ünlübilgin, Tuğba Kınay, Fulya Kayıkçıoğlu","doi":"10.4274/jtgga.galenos.2025.2023-4-2","DOIUrl":"10.4274/jtgga.galenos.2025.2023-4-2","url":null,"abstract":"Objective: To evaluate the rate, cytology and histopathological findings of multiple-type human papillomavirus (HPV) positive women referred to a tertiary colposcopy center. To compare the role of multiple- and single-type HPV infections in women with high-grade squamous intra epithelial lesion and cervical cancer (HSIL+).Material and methods: The cytological and histopathological results of 2070 HPV positive women were evaluated. Infection with more than one type was defined as multiple-type HPV infection. Patients were divided into single or multiple HPV groups and subgroups in terms of HPV types; and also examined in three age groups. Age-stratified HSIL and cervical cancer rates of the study groups were compared.Results: The women with multiple HPV subtypes accounted for 24.9% of the study population. Multiple-type HPV infection rates in normal cytology, atypical glandular cells, low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells, cannot exclude HSIL and HSIL were 28.2%, 26.8%, 19.3%, 22.6%, and 21.8%, respectively. Age stratified multiple-type HPV infection rates in under 30 years, 30-49 years and ≥50 years were 27.8%, 24.1%, and 27.3%, respectively. The multiple-type HPV infection rates in LSIL, HSIL, and cancer patients were 31.4%, 19%, and 12.5%, respectively.Conclusion: Multiple-type HPV infections were statistically less common in HSIL and cancer patients than single type HPV infection. However, multiple type infection rates were remarkable in older HSIL and cervical cancer patients.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"26 2","pages":"90-97"},"PeriodicalIF":1.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is your diagnosis? 你的诊断是什么？

IF 1.2

Journal of the Turkish German Gynecological Association Pub Date : 2025-06-10 DOI: 10.4274/jtgga.galenos.2025.2024-7-10

Avantika Gupta, Manpreet Kaur, Karanpreet Kaur Bakshi, Erukkambattu Jayashankar

引用次数: 0