Journal of the Turkish German Gynecological Association最新文献

{"title":"Effectiveness of first trimester maternal fat tissue measurement in prediction of gestational diabetes: a prospective cohort study","authors":"Cağdaş Nurettin Emeklioğlu, Hicran Acar Şirinoğlu, Miraç Özalp, Melike Eren, Elif Akkoç Demirel, Simten Genç, Veli Mihmanlı","doi":"10.4274/jtgga.galenos.2023.2023-4-6","DOIUrl":"10.4274/jtgga.galenos.2023.2023-4-6","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to find a cost-effective, more practical method to be used in the early gestational weeks as an alternative to the oral glucose tolerance test (OGTT) for predicting gestational diabetes mellitus (GDM). The method selected was adipose tissue measurements made in the first trimester.</p><p><strong>Material and methods: </strong>The study was designed as a prospective, cohort study. Ultrasound images were used to calculate abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) thicknesses of the first trimester pregnant women. Two groups were formed: those who were diagnosed with GDM and those who were not, based on the results of the OGTT performed in the same patients at 24^th-28^th weeks of gestation. Ultrasonographic records were examined and compared between these two groups using received operator characteristic curves and logistic regression analyses.</p><p><strong>Results: </strong>A total of 292 pregnant women were included, of whom 21.2% were diagnosed with GDM. In the group diagnosed with GDM, SAT, VAT and total adipose tissue (TAT) values were significantly higher than the women who did not have GDM. Threshold values for SAT, VAT and TAT were 18 mm, 55 mm and 55 mm.</p><p><strong>Conclusion: </strong>First trimester SAT, VAT and TAT measurements of pregnant women with GDM were significantly higher than those without GDM diagnosis. Although our results showed that adipose measurements cannot be an alternative to OGTT; they may be a powerful aid in identify at-risk pregnant women, suggesting to perform an early OGTT in the first trimester.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"224-230"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal serum luteinizing hormone, total testosterone, and free testosterone levels do not impact IVF outcomes in patients with polycystic ovary syndrome.","authors":"Nir Kugelman, Alyson Digby, Keren Rotshenker-Olshinka, Véronique Bellemare, Amrita Pooni, Weon-Young Son, Michael H Dahan","doi":"10.4274/jtgga.galenos.2024.2024-2-9","DOIUrl":"10.4274/jtgga.galenos.2024.2024-2-9","url":null,"abstract":"<p><strong>Objective: </strong>To assess the influence of basal serum levels of luteinizing hormone (LH), total testosterone (TT), and free testosterone (FT) on in vitro fertilization (IVF) success rates in patients with polycystic ovary syndrome (PCOS).</p><p><strong>Material and methods: </strong>A retrospective cohort analysis of PCOS patients who underwent freeze-all, gonadotropin releasing hormone (GnRH) antagonist IVF protocols from January 2013 to December 2019. Patients were grouped based on median basal serum levels of LH, TT, and FT to compare their IVF outcomes.</p><p><strong>Results: </strong>A total of 76 women with PCOS diagnosed as per the 2003 Rotterdam criteria were included. When analyzed by LH levels, groups had similar baseline characteristics except for higher mean ± standard deviation TT (1.4±0.9 vs. 1.9±0.9 nmol/L, p=0.02) and FT (0.6±0.5 vs. 0.9±0.5 nmol/L, p=0.03) in the elevated LH group. However, clinical pregnancy rates (CPR) (34.2% vs. 44.7%, p=0.35) and live birth rates (LBR) (21.0% vs. 31.6%, p=0.29) were not different. The group with lower TT had more previous pregnancies (0.9±1.2 vs. 0.3±0.7, p=0.02) and shorter infertility duration (2.3±2.0 vs. 3.7±2.7 years, p=0.04), but again CPR (46.8% vs. 42.8%, p=0.90) and LBR (37.5% vs. 25.7%, p=0.33) were similar. FT analysis revealed no significant differences in CPR (48.2% vs. 36.7%, p=0.36) and LBR (23.2% vs. 37.9%, p=0.22) despite higher TT (1.1±0.4 vs. 2.2±1.1 nmol/L, p<0.001) and LH (6.1±3.8 vs. 11.2±7.2 IU/L, p<0.001) in the high FT group.</p><p><strong>Conclusion: </strong>Basal serum levels of LH, TT, and FT did not significantly affect IVF outcomes in patients with PCOS using GnRH antagonist, freeze-all protocols.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"192-199"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is your diagnosis?","authors":"Anupama Bahadur, Rajlaxmi Mundhra, Ayush Heda, Shalinee Rao, Gupchee Singh, Shriram Rundla, Sakshi Heda","doi":"10.4274/jtgga.galenos.2024.2024-4-3","DOIUrl":"10.4274/jtgga.galenos.2024.2024-4-3","url":null,"abstract":"","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"266-269"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new technique for stress urinary incontinence without using vaginal mesh.","authors":"Emin Erhan Dönmez, Mustafa Oğuzhan Kılıç, Fisun Vural","doi":"10.4274/jtgga.galenos.2023.2022-12-17","DOIUrl":"10.4274/jtgga.galenos.2023.2022-12-17","url":null,"abstract":"<p><p>Stress urinary incontinence (SUI) is a fairly common disease among women. Synthetic meshes are frequently used in midurethral sling procedures due to the high long-term success rates. Because of the publications about vaginal mesh complications in recent years, urogynecologists are turning to techniques without mesh. The purpose of this video is to show that SUI can be treated without mesh complications by utilizing the meshless urethropexy technique. A 50-year-old woman applied to our urogynecology department with complaints of incontinence. Physical examination, stress test, Q-tip test, urine test and transperineal ultrasound performed. Post-void residual urine measured. The patient completed incontinence questionnaires: urogenital distress inventory-6, incontinence impact questionnaire-7. After discussing results SUI was diagnosed. Treatment options were offered to the patient. Due to mesh complications concern the patient preferred this approach and underwent urethropexy. The steps of meshless urethropexy technique was demonstrated in this video. SUI can be treated with this approach without worrying about mesh complications, but long-term results are needed.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"277-279"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second-trimester spontaneous uterine rupture: a rare case of diagnostic nuances and multidisciplinary management","authors":"Celine Sooknarine, Esra Çetin, David H Pyatt Ii, Koray Görkem Saçıntı, Atinuke L Akinpeloye","doi":"10.4274/jtgga.galenos.2024.2024-10-3","DOIUrl":"10.4274/jtgga.galenos.2024.2024-10-3","url":null,"abstract":"","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"273-276"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialist and general emergency room: from \"A to Z\" case series of possible misdiagnosis due to the influence of gender.","authors":"Paola Algeri, Maria Donata Spazzini, Nina Pinna","doi":"10.4274/jtgga.galenos.2024.2024-12-6","DOIUrl":"10.4274/jtgga.galenos.2024.2024-12-6","url":null,"abstract":"","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"270-272"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biological and psychological impact of the Coronavirus disease-19 pandemic on the characteristics of the menstrual cycle.","authors":"Tiago Almeida Costa, Marina de Pádua Nogueira Menezes","doi":"10.4274/jtgga.galenos.2024.2023-6-9","DOIUrl":"10.4274/jtgga.galenos.2024.2023-6-9","url":null,"abstract":"<p><p>The Coronavirus disease-19 (COVID-19) pandemic was declared in March 2020 by the World Health Organization. The severe acute respiratory syndrome-coronavirus-2 virus enters host cells through angiotensin-converting enzyme 2 receptors and transmembrane serine protease type II that are expressed in pulmonary alveoli, as well as in hepatocytes, endothelium, ovaries, uterus, vagina, thyroid, and other tissues. In addition to viral injury, the COVID-19 pandemic, through protective measures such as social isolation and lockdown, has promoted a scenario of psychosocial stress, especially in women. In this context of isolation, anxiety, fear, and mental distress, there is dysregulation of the hypothalamic-pituitary-adrenal axis and subsequent gonadal side effects. Furthermore, studies report an association between COVID-19 and temporary menstrual cycle alterations such, as increased cycle duration, decreased cycle duration, increased menstrual flow, dysmenorrhea, and amenorrhea. Regarding COVID-19 vaccination, menstrual irregularities have been observed in about half of the women, predominantly with a decrease in cycle duration and increased menstrual flow, but without fertility sequelae. The aim of this study was to review the most up-to-date information on the relationship between the COVID-19 pandemic and menstrual irregularities.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"259-265"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting obstetric outcomes in patients who underwent cold-knife and loop electrosurgical excision procedure conization due to cervical intraepithelial neoplasia 2 or cervical intraepithelial neoplasia 3","authors":"Mehmet Obut, Can Tekin İskender, Aykut Kından, Özge Yücel Çelik, Mevlüt Bucak, Fulya Kayıkçıoğlu, Betül Tokgöz Çakır, Sevgi Koç, Caner Çakır, Şevki Çelen, Ali Turhan Çağlar, Yaprak Engin Üstün","doi":"10.4274/jtgga.galenos.2023.2023-1-15","DOIUrl":"10.4274/jtgga.galenos.2023.2023-1-15","url":null,"abstract":"<p><strong>Objective: </strong>To determine factors affecting obstetric outcomes in pregnancies after conization by loop electrosurgical excision procedure (LEEP) or cold-knife conization (CKC) due to cervical intraepithelial neoplasia.</p><p><strong>Material and methods: </strong>The maternal and clinical characteristics and obstetric outcomes of CKC, LEEP and control groups were evaluated and compared. Risk factors for adverse pregnancy outcomes were evaluated using multiple logistic regression analyses.</p><p><strong>Results: </strong>The incidence of preterm delivery, preterm premature rupture of membranes (PPROM), low APGAR scores, fetal mortality, and late-period spontaneous abortus was highest in patients who underwent CKC (p<0.05). Cone depth of CKC was greater than LEEP (p=0.025). Cervical length (CL) at pregnancy was CKC < LEEP < controls (p=0.003). Shorter CL at pregnancy and time from conization to pregnancy (t-CP) was correlated with a high incidence of preterm delivery and PPROM (p<0.05). To predict preterm delivery, t-CP <14 months had 63.16% sensitivity and 77.42% specificity [area under the curve (AUC): 0.714, 95% confidence interval (CI): (0.603-0.809); p=0.005], and CL at pregnancy <31 mm had 65% sensitivity and 71.78% specificity [AUC: 0.731, 95% CI: (0.675-0.782); p<0.001]. To predict PPROM, t-CP <15 months had 85.71% sensitivity and 65.22% specificity [AUC: 0.730, 95% CI: (0.603-0.809); p=0.024], and CL <32 mm had 72.73% sensitivity and 61.89% spcificity [AUC: 0.685, 95% CI: (0.675-0.782); p=0.007].</p><p><strong>Conclusion: </strong>Compared with CKC, LEEP has shorter cone depth and fewer adverse pregnancy outcomes. The t-CP <14 months was a risk for preterm delivery and <15 months was a risk for PPROM. CL at pregnancy <31 mm was a risk for preterm delivery and <32 mm was a risk for PPROM.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"238-246"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138805560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does COVID-19 reduce anti-Mullerian hormone levels in women of reproductive age in late periods of infection?","authors":"Keziban Doğan, Alev Kural, İlke Özer Aslan, Aliye Erdoğan, Mazlum Gönül, Mustafa Cengiz Dura, Nazlı Helvacı, Murat Ekin","doi":"10.4274/jtgga.galenos.2023.2023-2-3","DOIUrl":"10.4274/jtgga.galenos.2023.2023-2-3","url":null,"abstract":"<p><strong>Objective: </strong>The question of whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection influences ovarian function and oocyte quality has arisen as angiotensin converting enzyme-2 receptors, which facilitates viral infection, are found on reproductive system tissues, including the vagina, placenta, uterus, and ovaries. The primary objective of this prospective study was to evaluate the impact of SARS-CoV-2, on ovarian function, with a focus on anti-Mullerian hormone (AMH) and acute phase reactant levels in patients well after recovery from coronavirus disease-2019 (COVID-19).</p><p><strong>Material and methods: </strong>This prospective cohort study was conducted in the department of obstetrics and gynecology at a single center between October 2020 and June 2021. In order to investigate the impact of COVID-19 on ovarian reserve, 34 non-pregnant women of reproductive age (24-38 years) with COVID-19 polymerase chain reaction positivity were included.</p><p><strong>Results: </strong>The difference between AMH levels measured 6 months after COVID-19 infection and baseline AMH levels was -0.31±0.80 ng/dL on average and -0.25 (-2.1-1.3) ng/dL on median. Significant correlations were observed between the change in AMH levels and white blood cell levels (r=-0.434, p=0.010), lymphocyte levels (r=-0.361, p=0.036), C-reactive protein levels (r=0.542, p=0.001), ferritin levels (r=0.570, p=0.001) and procalcitonin levels (r=0.598, p=0.001).</p><p><strong>Conclusion: </strong>We believe this is the first study to examine whether there is a correlation between the late results of COVID-19 and ovarian function. In this cohort, AMH values decreased 6-months after recovery from COVID-19 and a correlation was found between measures of disease severity and the magnitude of decrease in AMH. However, the study was underpowered and future larger studies are required to validate these findings.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"231-237"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of <i>LHCGR</i> gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment.","authors":"Sheena Mariam Thomas, Ramakrishnan Veerabathiran","doi":"10.4274/jtgga.galenos.2024.2024-6-10","DOIUrl":"10.4274/jtgga.galenos.2024.2024-6-10","url":null,"abstract":"<p><strong>Objective: </strong>Polycystic ovary syndrome (PCOS) is prevalent among reproductive-aged women and is categorized by hormonal imbalances, irregular menstrual cycles, and challenges with fertility. PCOS affects approximately 3.6% of women globally, with prevalence varying by region. The luteinizing hormone/choriogonadotropin receptor (<i>LHCGR</i>) gene, which encodes the <i>LHCGR</i>, has been implicated in PCOS pathophysiology. This study investigated the association between the <i>LHCGR</i> gene polymorphism rs2293275 and PCOS through a meta-analysis.</p><p><strong>Material and methods: </strong>An extensive literature review was carried out using Embase, PubMed, and Google Scholar databases to identify research studies exploring the association between <i>LHCGR</i> gene variants and PCOS. The review was conducted based on the PRISMA checklist. Eligible case-control studies from 2016 to 2024 were chosen based on predefined criteria. Quantitative data analysis was performed using MetaGenyo software, employing a significance threshold of p<0.05. Odds ratios (OR) and confidence intervals (CI) were calculated to evaluate the relationships. G*Power 3.1 software was employed for statistical power analysis to assess the study's strength. The meta-analysis explored the link between <i>LHCGR</i> gene variant rs2293275 and PCOS across diverse ethnic groups and genetic models.</p><p><strong>Results: </strong>Analyzing data from 10 studies involving 1,431 PCOS cases and 1,317 controls, the findings revealed no significant associations in most genetic models: allele (OR: 0.89, 95% CI: 0.54-1.49), dominant (OR: 0.74, 95% CI: 0.47-1.18), recessive (OR: 0.80, 95% CI: 0.41-1.57), and over-dominant (OR: 1.13, 95% CI: 0.69-1.85). Subgroup analyses by ethnicity (Arabs, Asians, Caucasians) consistently showed no significant correlations, except a protective effect in Caucasians (OR: 0.57, 95% CI: 0.34-0.95) in the AA vs. aa comparison. Sensitivity analyses confirmed robustness, and there was no indication of publication bias. Power analysis validated adequate sample sizes, and protein-protein interaction networks underscored biological relevance.</p><p><strong>Conclusion: </strong>The meta-analysis concluded that no significant connection was observed between the <i>LHCGR</i> gene variant rs2293275 and the risk of PCOS among different populations. This suggests a complexity in PCOS etiology and indicating that <i>LHCGR</i> may not be a significant genetic marker for PCOS. Future research should explore other genetic and environmental factors contributing to PCOS, emphasizing the importance of genetic and ethnic variability in such studies.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"25 4","pages":"207-218"},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}