Journal of the Turkish German Gynecological Association最新文献

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Laparoscopic repair of a proximal ureteral injury during transperitoneal para-aortic lymphadenectomy: a video article. 经腹膜腹主动脉旁淋巴结切除术中输尿管近端损伤的腹腔镜修复:一篇视频文章。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-09-04 Epub Date: 2026-06-24 DOI: 10.4274/jtgga.galenos.2026.2026-2-11
Candost Hanedan, Oğuz Kaan Köksal, Hande Nur Öncü, Tuba Zengin Aksel, Vakkas Korkmaz
{"title":"Laparoscopic repair of a proximal ureteral injury during transperitoneal para-aortic lymphadenectomy: a video article.","authors":"Candost Hanedan, Oğuz Kaan Köksal, Hande Nur Öncü, Tuba Zengin Aksel, Vakkas Korkmaz","doi":"10.4274/jtgga.galenos.2026.2026-2-11","DOIUrl":"10.4274/jtgga.galenos.2026.2026-2-11","url":null,"abstract":"<p><p>Ureteral injury during advanced gynecologic laparoscopic procedures is an uncommon but potentially serious complication, particularly during para-aortic lymphadenectomy performed for oncologic staging. We describe the laparoscopic management of a proximal right ureteral transection encountered during transperitoneal para-aortic lymphadenectomy in a 56-year-old woman (body mass index 36 kg/m2) with highrisk endometrial carcinoma. The injury was recognized intraoperatively and repaired using a tension-free ureteroureterostomy over a double-J stent. Key technical steps, including exposure in obese patients and preservation of ureteral vascularity, are demonstrated. This report highlights that timely intraoperative recognition and laparoscopic repair of proximal ureteral injury can prevent major morbidity and obviate open surgery, emphasizing the importance of advanced, minimally invasive surgical expertise.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"229-230"},"PeriodicalIF":1.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perinatal outcomes in pregnancies with one abnormal oral glucose tolerance test value: a retrospective cohort study. 一次口服糖耐量试验值异常妊娠的围产期结局:一项回顾性队列研究。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 DOI: 10.4274/jtgga.galenos.2026.2025-11-12
Tural Ismayilov, Çağlayan Ateş, Ayça Kubat Küçükyurt
{"title":"Perinatal outcomes in pregnancies with one abnormal oral glucose tolerance test value: a retrospective cohort study.","authors":"Tural Ismayilov, Çağlayan Ateş, Ayça Kubat Küçükyurt","doi":"10.4274/jtgga.galenos.2026.2025-11-12","DOIUrl":"10.4274/jtgga.galenos.2026.2025-11-12","url":null,"abstract":"<p><strong>Objective: </strong>To compare perinatal, neonatal, and early childhood outcomes among pregnant women classified into three groups based on oral glucose tolerance test (OGTT) results: gestational diabetes mellitus (GDM), normal glucose tolerance, and one abnormal OGTT value.</p><p><strong>Material and methods: </strong>This single-center retrospective cohort study included singleton pregnancies screened between 24 and 28 weeks of gestation and delivered at the same institution. Participants were categorized into GDM, normal glucose tolerance, or one abnormal OGTT value. Maternal demographic data, obstetric outcomes, neonatal outcomes [birth weight, Apgar scores, neonatal intensive care unit (NICU) admission], and early childhood developmental data were collected retrospectively from hospital records. Statistical analyses were performed using the Kruskal-Wallis and chi-square tests.</p><p><strong>Results: </strong>The study included 292 pregnancies categorized into GDM (n=28), normal glucose tolerance (n=224), or one abnormal OGTT value (n=40). Women in the GDM group were significantly older and had higher gravidity and parity than those in the normal glucose tolerance group (p=0.01 and p=0.003, respectively). No significant differences were observed between the groups in terms of birth weight (p=0.651) or NICU admission rates (p=0.29). Although NICU admission rates were higher in the GDM group (12.5%) and in the group with one abnormal OGTT value (10.0%) than in the normal glucose tolerance group (5.8%), these differences did not reach statistical significance. No clinically meaningful differences were identified during early childhood follow-up.</p><p><strong>Conclusion: </strong>Pregnant women with one abnormal OGTT value did not differ significantly from those with GDM or normal glucose tolerance in terms of adverse perinatal outcomes. Larger prospective studies are required to guide clinical management.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 2","pages":"99-106"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of pathological findings in HPV-31 positive women with high-grade squamous intraepithelial lesions. HPV-31阳性女性与高级别鳞状上皮内病变的病理关系
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 DOI: 10.4274/jtgga.galenos.2026.2025-12-2
Ayşe Buran, Hüseyin Altaş, Yeşim Özkaya Uçar, Abdurrahman Alp Tokalıoğlu, Gülşah Tiryaki Güner, Okan Aytekin, Fatih Kılıç, Taner Turan
{"title":"The association of pathological findings in HPV-31 positive women with high-grade squamous intraepithelial lesions.","authors":"Ayşe Buran, Hüseyin Altaş, Yeşim Özkaya Uçar, Abdurrahman Alp Tokalıoğlu, Gülşah Tiryaki Güner, Okan Aytekin, Fatih Kılıç, Taner Turan","doi":"10.4274/jtgga.galenos.2026.2025-12-2","DOIUrl":"10.4274/jtgga.galenos.2026.2025-12-2","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate pathological findings in patients positive for human papillomavirus (HPV)-31.</p><p><strong>Material and methods: </strong>This retrospective study included patients evaluated in a tertiary colposcopy clinic. The 3,546 patients tested for high-risk HPV were evaluated from September 2019 to December 2023. The study comprised 130 (3.7%) patients who tested positive for HPV-31. Isolated HPV-31 positivity indicated the presence of HPV-31 alone. Combined positivity indicated coexistence with other high-risk HPV types. If the following lesions were positive, high-grade squamous intraepithelial lesions (HSILs), adenocarcinoma <i>in situ</i>, microinvasive cancer, and cervical cancer, we classified the final pathology as ≥HSIL. Statistical analysis was performed using IBM SPSS Statistics version 20.0.</p><p><strong>Results: </strong>The mean age was 44.4±9.24 years. Isolated HPV-31 positivity was present in 69 (53.1%) patients. The final pathologic result was ≥HSIL in 9 (6.9%) patients, with only 1 (0.8%) patient had squamous cell cervical cancer. No significant association was observed between HPV-31 positivity type (isolated or combined) and ≥HSIL (respectively, 7.2% vs. 6.6%; p=0.578).</p><p><strong>Conclusion: </strong>Approximately 7% of women positive for HPV-31 have HSIL and higher lesions. The isolated or combined HPV-31 positivity does not affect the existence of HSIL or higher lesions.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 2","pages":"120-124"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone mineral density in adolescents and young women with hypogonadism: a DXA-based comparative analysis. 性腺功能减退的青少年和年轻女性的骨矿物质密度:基于dxa的比较分析。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 DOI: 10.4274/jtgga.galenos.2026.2025-12-7
Nurşen Kurtoğlu, Neşe Hayırlıoğlu
{"title":"Bone mineral density in adolescents and young women with hypogonadism: a DXA-based comparative analysis.","authors":"Nurşen Kurtoğlu, Neşe Hayırlıoğlu","doi":"10.4274/jtgga.galenos.2026.2025-12-7","DOIUrl":"10.4274/jtgga.galenos.2026.2025-12-7","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate bone mineral density (BMD) in adolescent girls and young women with hypogonadism from a gynecologic perspective, and to compare their results with those of patients referred for clinical indications associated with bone health, such as fracture history or chronic medication use.</p><p><strong>Material and methods: </strong>This retrospective study included females aged 12-21 years who underwent dual-energy X-ray absorptiometry (DXA) between January 2020 and April 2025 in a tertiary university hospital. Patients were categorized as hypogonadal or non-hypogonadal according to the indication for DXA. Lumbar spine (L1-L4) Z-scores were compared between these groups, with height adjustment applied for patients below the 3rd percentile. Demographic characteristics, vitamin D levels, and BMD Z-scores were analyzed across groups and among hypogonadism subtypes (hypergonadotropic, congenital hypogonadotropic, and functional hypothalamic amenorrhea).</p><p><strong>Results: </strong>Of the 74 participants, 29 (39.1%) underwent DXA because of hypogonadism. Patients with primary amenorrhea had significantly lower lumbar spine Z-scores than those with secondary amenorrhea (p<0.01). The mean lumbar spine Z-score was numerically lower in the hypogonadism group (-1.95±1.04) compared with others (-1.38±1.31), however; this was not significant (p=0.051). No significant differences were observed among hypogonadism subtypes. Mean serum 25-hydroxyvitamin D levels were low across all groups (12.9±7.7 ng/mL), indicating widespread deficiency.</p><p><strong>Conclusion: </strong>Adolescent girls and young women with hypoestrogenic conditions, particularly those with primary amenorrhea exhibited lower BMD, emphasizing the essential role of estrogen in bone mass accrual during adolescence. Early diagnosis, hormone replacement, and optimization of vitamin D and calcium intake will be important for preserving bone health in this high-risk population.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 2","pages":"114-119"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Belief in sexual myths and sociocultural factors associated with vaginismus: a case-control study in Turkish women. 对性神话的信仰和与阴道痉挛相关的社会文化因素:土耳其妇女的病例对照研究。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 Epub Date: 2026-01-28 DOI: 10.4274/jtgga.galenos.2025.2025-9-9
Yeliz Kaya, Tuğba Tahta, Yunus Aydın, Coşkun Kaya
{"title":"Belief in sexual myths and sociocultural factors associated with vaginismus: a case-control study in Turkish women.","authors":"Yeliz Kaya, Tuğba Tahta, Yunus Aydın, Coşkun Kaya","doi":"10.4274/jtgga.galenos.2025.2025-9-9","DOIUrl":"10.4274/jtgga.galenos.2025.2025-9-9","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between belief in sexual myths and the presence of vaginismus, and to evaluate the influence of sociodemographic and cultural factors on sexual myth endorsement among Turkish women.</p><p><strong>Material and methods: </strong>This case-control study included women diagnosed with vaginismus and an equal number of age-matched women without sexual dysfunction. Participants completed a sociodemographic questionnaire and the sexual myths scale (SMS). Comparative analyses were conducted to assess differences in total and subscale scores between groups, and multiple regression analysis was performed to evaluate the predictive role of sociodemographic variables on belief in sexual myths.</p><p><strong>Results: </strong>Women with vaginismus (n=40) had significantly higher total scores on the SMS compared to the control group (n=40; p<0.001). Subscale analyses revealed that myths related to sexuality, gender roles, and sexual morality were more strongly endorsed by women with vaginismus. Multiple regression analysis showed that lower education level, conservative family background, and rural upbringing were significant predictors of stronger belief in sexual myths (p<0.05).</p><p><strong>Conclusion: </strong>The findings suggest that belief in sexual myths is more prevalent among women with vaginismus and is influenced by key sociodemographic and cultural factors. Addressing these beliefs through culturally sensitive education and psychosexual interventions may enhance the effectiveness of vaginismus treatment.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"84-92"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOX10 lights the path: recognizing rare vulvar schwannoma and review of the literature. SOX10照亮道路:罕见外阴神经鞘瘤的识别和文献复习。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 DOI: 10.4274/jtgga.galenos.2026.2025-10-11
Gunvanti Rathod, Sai Swetha Banka, Krishna Ramavath, Spandhana Doodati
{"title":"SOX10 lights the path: recognizing rare vulvar schwannoma and review of the literature.","authors":"Gunvanti Rathod, Sai Swetha Banka, Krishna Ramavath, Spandhana Doodati","doi":"10.4274/jtgga.galenos.2026.2025-10-11","DOIUrl":"10.4274/jtgga.galenos.2026.2025-10-11","url":null,"abstract":"","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 2","pages":"151-153"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large population-based assessment of SARS-CoV-2 teratogenicity by profiling congenital anomalies during COVID-19 pandemic. 通过分析COVID-19大流行期间的先天性异常来评估基于大量人群的SARS-CoV-2致畸性
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 DOI: 10.4274/jtgga.galenos.2026.2025-11-16
Susan Jehangir, Preethi R Navaneethan, Reka Karuppasami, Manisha Madhai Beck, Benjamin J Ross, Manish Kumar, Sridhar Santhanam, Sundeep Kisku, John Fletcher
{"title":"Large population-based assessment of SARS-CoV-2 teratogenicity by profiling congenital anomalies during COVID-19 pandemic.","authors":"Susan Jehangir, Preethi R Navaneethan, Reka Karuppasami, Manisha Madhai Beck, Benjamin J Ross, Manish Kumar, Sridhar Santhanam, Sundeep Kisku, John Fletcher","doi":"10.4274/jtgga.galenos.2026.2025-11-16","DOIUrl":"10.4274/jtgga.galenos.2026.2025-11-16","url":null,"abstract":"<p><strong>Objective: </strong>This study examined population-level trends in congenital anomalies before and during the coronavirus disease-19 (COVID-19) pandemic in India, which experienced one of the most severe COVID-19 outbreaks with multiple devastating waves.</p><p><strong>Material and methods: </strong>We conducted a retrospective analysis of prospectively collected data from the Antenatal Detection of Congenital Anomalies registry between pre-pandemic (January 2018-May 2020) and pandemic (June 2020-December 2022). Time series analysis examined temporal trends and seasonal patterns.</p><p><strong>Results: </strong>Among 175,749 prenatal scans, 2.895 congenital anomalies were detected (overall rate 16.5 per 1,000 scans). Detection rates were similar pre-pandemic (14.8 per 1,000 scans, n=1.370) and during the pandemic (18.3 per 1.000 scans, n=1.525; p=0.096). The distribution of anomalies by organ system remained consistent, with head/neck and genitourinary anomalies predominating (19-23% and 14-22% annually, respectively). A persistent seasonal pattern was observed, with peaks in the fourth quarter annually (mean November: 62.7 cases) and troughs at the beginning of each year (mean January: 36.8 cases). The Seasonal Autoregressive Integrated Moving Average model accurately predicted 2023 trends confirming the stability of the epidemiologic process.</p><p><strong>Conclusion: </strong>Our large-scale study provides compelling evidence that the COVID-19 pandemic was not associated with a change in the rate or pattern of congenital anomalies at the population level. The discovery of a robust seasonal variation in anomaly detection represents a significant finding that demands detailed delineation to inform preventive strategies.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 2","pages":"76-83"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of cervical preservation on vaginal length and female sexual function after hysterectomy for benign conditions: a retrospective cohort study. 良性子宫切除术后保留宫颈对阴道长度和女性性功能的影响:一项回顾性队列研究。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 DOI: 10.4274/jtgga.galenos.2026.2025-6-1
Ozan Doğan, Pınar Kadiroğulları, Duygu Uçar Kartal, Hüseyin Erhan Cömert, Murat Yassa
{"title":"Impact of cervical preservation on vaginal length and female sexual function after hysterectomy for benign conditions: a retrospective cohort study.","authors":"Ozan Doğan, Pınar Kadiroğulları, Duygu Uçar Kartal, Hüseyin Erhan Cömert, Murat Yassa","doi":"10.4274/jtgga.galenos.2026.2025-6-1","DOIUrl":"10.4274/jtgga.galenos.2026.2025-6-1","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate how preserving the cervix and maintaining vaginal length influenced sexual function in patients undergoing hysterectomy for benign disorders.</p><p><strong>Material and methods: </strong>This retrospective analysis included patients who had either total or subtotal hysterectomy for benign disorders between 2020 and 2022, with vaginal lengths recorded both before and after surgery. The female sexual function index (FSFI) was completed by the patients before surger y and again 24 months postoperatively, while their partners were given the International Index of Erectile Function.</p><p><strong>Results: </strong>Eighty-five patients were included, with 42 (49%) in the total hysterectomy group and the remainder in the sub-total group. While no significant change in vaginal length was observed in women who underwent subtotal hysterectomy (p>0.05), the total hysterectomy group showed a marked reduction in vaginal length postoperatively (10±1 cm vs. 6.6±1.1 cm, p<0.001). The reduction in FSFI scores for the subtotal hysterectomy group was notably lower compared to the total hysterectomy group [1.4 (0.8-2.1) vs. 9.2 (8.2-10.1), p<0.001].</p><p><strong>Conclusion: </strong>While both total and subtotal hysterectomy procedures were associated with decreased sexual function, patients who underwent total hysterectomy showed lower FSFI scores. Previous research has suggested this may be due to lack of cervical ring protection and loss of erogenous zones in the posterior vagina through nerve damage.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"27 2","pages":"107-113"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum osteopontin as a diagnostic marker for missed abortion: evidence from a prospective study. 血清骨桥蛋白作为漏产的诊断指标:来自前瞻性研究的证据。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 Epub Date: 2026-03-19 DOI: 10.4274/jtgga.galenos.2026.2025-10-13
Denizhan Bayramoğlu, Erhan Okuyan, Yusuf Başkıran, Emre Günakan, Zeynep Bayramoğlu, Celal Akdemir
{"title":"Serum osteopontin as a diagnostic marker for missed abortion: evidence from a prospective study.","authors":"Denizhan Bayramoğlu, Erhan Okuyan, Yusuf Başkıran, Emre Günakan, Zeynep Bayramoğlu, Celal Akdemir","doi":"10.4274/jtgga.galenos.2026.2025-10-13","DOIUrl":"10.4274/jtgga.galenos.2026.2025-10-13","url":null,"abstract":"<p><strong>Objective: </strong>Osteopontin (OPN) is a multifunctional molecule involved in embryo implantation and blastocyst adhesion. Given its role at the maternal-fetal interface, OPN has been proposed as a potential biomarker for early pregnancy outcomes. The aim of this study was to evaluate the association between serum OPN levels and missed abortion in women presenting with early pregnancy bleeding.</p><p><strong>Material and methods: </strong>In this prospective study, primigravid women between 6 and 11 weeks of gestation with confirmed fetal cardiac activity were enrolled. Participants were classified into three groups according to clinical presentation: normal pregnancy, threatened abortion, and missed abortion. Blood samples were obtained at admission, and serum OPN levels were measured using an enzyme-linked immunosorbent assay. Inflammatory markers including white blood cell count, neutrophil-to-lymphocyte ratio, C-reactive protein levels, and body mass index were also recorded.</p><p><strong>Results: </strong>The study cohort numbered 198 women, aged 18-42 years, with 38, 80 and 80 women in the normal pregnancy, threatened and missed abortion groups, respectively. OPN levels showed a significant and progressive increase with the lowest levels observed in normal pregnancies, higher levels in threatened abortion, and the highest levels in missed abortion (p<0.001). Receiver operating characteristic curve analysis demonstrated strong discriminative capacity of OPN for pregnancy loss (area under the curve =0.846, p<0.001). A cut-off value of 1.15 ng/mL was associated with 100% sensitivity, whereas a cut-off value of 2.15 ng/mL was associated with 100% specificity.</p><p><strong>Conclusion: </strong>Elevated serum OPN levels are associated with early pregnancy loss and may serve as a potential biomarker in missed abortion. However, these findings should be interpreted with caution given the exploratory nature of the analysis.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"93-98"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Step-by-step laparoscopic excision of cervical stump for persistent CIN and bleeding in a postmenopausal patient without uterine manipulator 腹腔镜下一步一步切除宫颈残端治疗持续性CIN和出血无子宫操纵器患者。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2026-06-02 Epub Date: 2025-10-28 DOI: 10.4274/jtgga.galenos.2025.2025-4-5
Candost Hanedan, Şahin Kaan Baydemir, Vakkas Korkmaz
{"title":"Step-by-step laparoscopic excision of cervical stump for persistent CIN and bleeding in a postmenopausal patient without uterine manipulator","authors":"Candost Hanedan, Şahin Kaan Baydemir, Vakkas Korkmaz","doi":"10.4274/jtgga.galenos.2025.2025-4-5","DOIUrl":"10.4274/jtgga.galenos.2025.2025-4-5","url":null,"abstract":"<p><p>A 51-year-old woman presented with two years of postmenopausal spotting, mainly postcoital. Although vaginal atrophy was considered, prior use of vaginal estrogen at another center had not improved her symptoms. She had a history of persistent human papillomavirus (HPV) 16 infection and abnormal cytology. Initial colposcopy showed CIN 1 but one year later, a biopsy revealed CIN 2, and loop electrosurgical excision procedure (LEEP) was performed with negative margins. At 6-month follow-up, HPV positivity and low-grade squamous intraepithelial lesion persisted, with CIN 2 on colposcopy. Despite being offered repeat LEEP, the patient opted for definitive surgery. Due to a family history of ovarian cancer, she also requested bilateral salpingo-oophorectomy. This case highlights an individualized approach to recurrent cervical dysplasia and postmenopausal bleeding. Despite long-term follow-up, cervical dysplasia persisted, necessitating surgical intervention. The procedure was completed laparoscopically without complications. Cervical stump excision is a rare but important option in patients experiencing persistent symptoms or premalignant lesions after subtotal hysterectomy (SH). This case highlights careful patient selection and thorough counseling regarding potential long-term risks, including bleeding, dysplasia, and cervical malignancy, following SH.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":" ","pages":"154-156"},"PeriodicalIF":1.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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