Journal of the Turkish German Gynecological Association最新文献

筛选
英文 中文
Levonorgestrel-releasing intrauterine device to treat abnormal uterine bleeding; not one treatment option fits all. 治疗异常子宫出血的左炔诺孕酮释放宫内节育器;并非一种治疗方案适合所有情况。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-12-06 DOI: 10.4274/jtgga.galenos.2023.2022-12-12
Zeliha Atak, Sakine Rahımlı Ocakoğlu, Gökhan Ocakoğlu
{"title":"Levonorgestrel-releasing intrauterine device to treat abnormal uterine bleeding; not one treatment option fits all.","authors":"Zeliha Atak, Sakine Rahımlı Ocakoğlu, Gökhan Ocakoğlu","doi":"10.4274/jtgga.galenos.2023.2022-12-12","DOIUrl":"10.4274/jtgga.galenos.2023.2022-12-12","url":null,"abstract":"<p><strong>Objective: </strong>Initially, medical treatment options are preferred in patients with abnormal uterine bleeding (AUB) who are hemodynamically stable. The aim of the present study was to investigate the effectiveness of a levonorgestrel-releasing intrauterine device (LNG-IUD) in reducing bleeding symptoms in patients with AUB stratified by underlying pathology.</p><p><strong>Material and methods: </strong>In line with the polyp, adenomyosis, leiomyoma, malignancy (and hyperplasia), coagulopathy, ovulatory disorders, endometrial, iatrogenic and not otherwise classified classification system, patients who were administered LNG-IUD due to adenomyosis, endometrial hyperplasia, leiomyoma and AUB due to not otherwise classified causes were included in the study.</p><p><strong>Results: </strong>A total of 172 otherwise patients with a mean age of 42.58±5.00 years were included. The distributions in the adenomyosis, endometrial hyperplasia, leiomyoma and otherwise unclassified groups were 30.8%, 12.8%, 26.2%, and 30.2%, respectively. Overall effectiveness of LNG-IUD in reducing menstrual bleeding was 82%. The proportion whose bleeding decreased was 95.50% in the endometrial hyperplasia group, 88.70% in the adenomyosis group, 55.60% in the leiomyoma group and 92.30% in the not otherwise classified group. The power of the current study was 99%. The efficacy of LNG-IUD was significantly less in the leiomyoma group (p<0.05) and thus this group were more likely to require surgical intervention. The overall incidence of spotting was 50%. Amenorrhea developed in 14% of patients.</p><p><strong>Conclusion: </strong>While LNG-IUD was more effective in reducing symptoms of AUB in patients with adenomyosis, endometrial hyperplasia and not otherwise classified causes, LNG-IUD was less effective in cases of leiomyoma.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 4","pages":"246-251"},"PeriodicalIF":1.4,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138487863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic endometritis diagnosed using a cut-off of ≥5 CD138 plasma cells significantly affects the reproductive outcomes of frozen embryo transfer: a case-control study. 一项病例对照研究:CD138浆细胞检测≥5个诊断为慢性子宫内膜炎显著影响冷冻胚胎移植的生殖结局。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2022-9-20
Hasan Bulut, Tamer Yeğinaltay, Mustafa Tunç, Murat Berkkanoğlu, Hande Töre, Kevin Coetzee, Kemal Özgür
{"title":"Chronic endometritis diagnosed using a cut-off of ≥5 CD138 plasma cells significantly affects the reproductive outcomes of frozen embryo transfer: a case-control study.","authors":"Hasan Bulut,&nbsp;Tamer Yeğinaltay,&nbsp;Mustafa Tunç,&nbsp;Murat Berkkanoğlu,&nbsp;Hande Töre,&nbsp;Kevin Coetzee,&nbsp;Kemal Özgür","doi":"10.4274/jtgga.galenos.2023.2022-9-20","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2022-9-20","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical significance of a diagnosis of chronic endometritis (CE) made using a diagnostic cut-off of ≥1 or ≥5 CD138 plasma cells per high power field (HPF) in asymptomatic patients undergoing in vitro fertilization (IVF) with frozen embryo transfer (FET).</p><p><strong>Material and methods: </strong>In this retrospective case-control study, 1,865 patients underwent freeze-all-IVF treatment between January and December 2019, with 419 undergoing endometrial biopsies at oocyte retrieval. Of the 419 biopsy-patients, 301 have since undergone first FET. The processed endometrial biopsies of the 301 patients underwent immunohistochemical (IHC) examination with anti-CD138 to count CD138+ plasma cells per HPF. CE diagnosis was defined as 0 CD138 plasma cells (control-group), ≥1 CD138 plasma cells (CE<sup>control</sup>-group) or ≥5 CD138 plasma cells (CE<sup>disease</sup>-group) per HPF.</p><p><strong>Results: </strong>Twenty-six (8.6%) patients were retrospectively diagnosed having ≥1 CD138 plasma cells, and five patients (1.7%) having ≥5 CD138 plasma cells (CE<sup>disease</sup>-group) per HPF. The live birth and pregnancy loss rates of the three groups were 52.7% and 27.9%, 53.8% and 26.3% and 20.0% and 66.7%, respectively. The antral follicle count (AFC) of the three groups were 15.0 (9.0-22.0), 10.5 (7.75-15.25), and 6.0 (5.0-14.0), respectively.</p><p><strong>Conclusion: </strong>Asymptomatic patients diagnosed with CE with ≥5 CD138 plasma cells per HPF, had the lowest live birth and highest pregnancy loss rates, with these patients also having significantly reduced AFC.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"165-171"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/c7/JTGGA-24-165.PMC10493815.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The oncologic outcomes of endometrial cancer metastasizing to the adrenal gland and kidney: from case to analysis. 子宫内膜癌转移到肾上腺和肾脏的肿瘤预后:从病例到分析。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2022-11-3
Okan Aytekin, Fatih Kılıç, Burak Ersak, Mehmet Ünsal, Serra Akar, Osman Türkmen, Günsu Kimyon Cömert, Kamil Hakan Müftüoğlu, Taner Turan
{"title":"The oncologic outcomes of endometrial cancer metastasizing to the adrenal gland and kidney: from case to analysis.","authors":"Okan Aytekin,&nbsp;Fatih Kılıç,&nbsp;Burak Ersak,&nbsp;Mehmet Ünsal,&nbsp;Serra Akar,&nbsp;Osman Türkmen,&nbsp;Günsu Kimyon Cömert,&nbsp;Kamil Hakan Müftüoğlu,&nbsp;Taner Turan","doi":"10.4274/jtgga.galenos.2023.2022-11-3","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2022-11-3","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the oncologic outcomes of endometrial cancer metastasis to the adrenal gland and kidney, based on a case study and review of the literature.</p><p><strong>Material and methods: </strong>A systematic review of the medical literature was performed to identify articles about metastatic endometrial cancer to the adrenal gland and kidney from 1975 until 2021.</p><p><strong>Results: </strong>A 55-year-old female patient was admitted to our center. On pelvic examination, a mass protruding out of the cervix was observed, which was shown to be endometrioid carcinoma on biopsy. Disease stage was IVB, based on radiological and pathological results and the International Federation of Gynecology and Obstetrics 2018 staging. Neo-adjuvant chemotherapy was given. After therapy, the patient underwent type 2 hysterectomy, bilateral salpingo-oophorectomy, total omentectomy and lymph node dissection. Left nephrectomy, left adrenalectomy and left hemicolectomy were also performed because the conglomerate tumor invaded the left kidney, left adrenal gland, and left colon mesentery. Pathological findings were consistent with metastasis of endometrioid carcinoma in the left adrenal gland, left kidney parenchyma and hilum.</p><p><strong>Conclusion: </strong>Metastasis of endometrial cancer to the adrenal gland and kidney is extremely rare and metastasis to the kidney has been reported in only two previous cases. When there is an intraperitoneal spread of endometrial cancer, as well as ovarian cancer, cytoreductive surgery without leaving a residual tumor should be undertaken andshould include adrenalectomy and nephrectomy, if necessary.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"172-176"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/04/JTGGA-24-172.PMC10493816.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gestational trophoblastic neoplasia with concurrent metastasis to the mother and child: a systematic literature review. 伴随母婴转移的妊娠滋养细胞瘤:系统的文献综述。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2023-5-2
Mishu Mangla, Emine A Rahiman, Harpreet Kaur, Poojitha Kanikaram
{"title":"Gestational trophoblastic neoplasia with concurrent metastasis to the mother and child: a systematic literature review.","authors":"Mishu Mangla,&nbsp;Emine A Rahiman,&nbsp;Harpreet Kaur,&nbsp;Poojitha Kanikaram","doi":"10.4274/jtgga.galenos.2023.2023-5-2","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2023-5-2","url":null,"abstract":"<p><p>Gestational trophoblastic neoplasia (GTN) arising in the placenta and presenting as a metastatic disease concurrently in the mother and the baby is extremely rare. GTN poses a diagnostic dilemma to the treating clinicians. In the current review, an electronic search of Scopus, PubMed, Embase and other databases was conducted for case reports and case series of GTN co-existing or metastatic to both the mother and the baby, published to date. Globally, a total of twenty-two cases of GTN with metastasis to both the mother and baby was found. The previous history of histopathology confirmed molar pregnancy was present in 4/22 cases. The median time to diagnose GTN in the mother was six weeks post-partum. In the majority of cases, diagnosis of maternal disease was made after the infant presented with clinical manifestation. Overall survival was reported in 17/22 mothers up to varying latest follow-up and in 6/22 infants. A knowledge of the varied clinical presentation, eliciting a history of previous pregnancy loss/term pregnancy and serum beta human chorionic gonadotrophin (β-hCG) estimations were helpful for early diagnosis. The concurrent presence of GTN in the mother and baby is a rare entity and poses a diagnostic dilemma. Diagnosis in the mother often follows diagnosis in the baby after an infant presents with clinical manifestations. GTN is a highly chemo-sensitive tumour, but the main prognostic factors determining survival are the time to diagnosis following previous pregnancy and serum β-hCG levels.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"206-219"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/bc/JTGGA-24-206.PMC10493811.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ARID4B loss leads to activated STAT1-dependent interferon pathway in mouse embryonic stem cells and during meso/endodermal differentiation. ARID4B缺失导致小鼠胚胎干细胞和中胚层/内胚层分化过程中stat1依赖性干扰素通路激活。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2023-7-5
Nihal Terzi Çizmecioğlu
{"title":"ARID4B loss leads to activated STAT1-dependent interferon pathway in mouse embryonic stem cells and during meso/endodermal differentiation.","authors":"Nihal Terzi Çizmecioğlu","doi":"10.4274/jtgga.galenos.2023.2023-7-5","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2023-7-5","url":null,"abstract":"<p><strong>Objective: </strong>Proper deactivation of the pluripotency network and activation of a lineage-specific gene expression program are critical for mouse embryonic stem cell (mESC) differentiation. This is achieved by the coordinated action of transcription and chromatin factors. Our previous work identified ARID4B as a critical chromatin factor for mesoderm and endoderm differentiation. As part of a histone deacetylase complex, ARID4B plays a role in transcriptional suppression of its direct targets. Here, we investigated the mechanism of ARID4B function in mESC differentiation by focusing on genes and pathways that are upregulated in its absence.</p><p><strong>Material and methods: </strong>We analyzed transcriptomic results of wild-type and arid4bΔ endoderm or mesoderm differentiated cells through integrative genomics viewer and ingenuity pathway analysis. We performed real-time quantitative polymerase chain reaction for selected genes. To understand pathway activation, we performed Western blot for candidate proteins during the time-course of differentiation. We also analyzed H3K4me3, H3K27me3 and H3K27Ac ChIP-seq results to understand changes in the chromatin environment.</p><p><strong>Results: </strong>Interferon-related genes were activated in arid4bΔ mESCs and endoderm or mesoderm directed cells. Consistent with this, higher phosphorylated STAT1 levels were found in arid4bΔ mESCs while a related phosphorylated STAT3 was unchanged. Finally, we observed a significant increase in H3K4me3 around interferon-related distal gene regulatory regions with a combination of either upregulation of H3K27Ac level or downregulation of H3K27me3 level.</p><p><strong>Conclusion: </strong>These results provide evidence that ARID4B is involved in the suppression of interferon-related genes in mESCs and during meso/endoderm differentiation through modulation, mainly of H3K4me3. This regulation might be important for successful mESC differentiation.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"187-196"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/cc/JTGGA-24-187.PMC10493817.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal malignant melanoma: surgical challenge and need for combination treatment. 阴道恶性黑色素瘤:手术的挑战和需要联合治疗。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2023-3-11
Christos Iavazzo, Panagiotis Peitsidis, Ioannis D Gkegkes
{"title":"Vaginal malignant melanoma: surgical challenge and need for combination treatment.","authors":"Christos Iavazzo,&nbsp;Panagiotis Peitsidis,&nbsp;Ioannis D Gkegkes","doi":"10.4274/jtgga.galenos.2023.2023-3-11","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2023-3-11","url":null,"abstract":"DOI: 10.4274/jtgga.galenos.2023.2023-3-11 Address for Correspondence: Ioannis D. Gkegkes e.mail: ioannisgkegkes@gmail.com ORCID: orcid.org/0000-0001-8637-5679 To the Editor, We read the article entitled “Laparoscopic radical hysterectomy and total vaginectomy for vaginal malignant melanoma with cervical metastasis” by Vardar et al. (1) with a great deal of interest. The authors present a step-bystep surgical approach for such a challenging case. Mucosal melanomas are a rare type of melanomas in comparison to cutaneous melanomas (2). For this reason, optimal management of locally advanced vaginal melanoma is poorly understood, including exenteration procedures, adjuvant radiotherapy, chemotherapy and immunotherapy with agents such as ipilimumab or nivolumab (3). A recent systematic review analyzed 15 patients with vaginal melanoma and reported that, in contrast to cutaneous melanoma, there were fewer BRAF mutations and more PI3K/AKT/mTOR pathway alterations, and so early stage and surgical extirpation affected the prognosis (4). However, a combination treatment including application of immune checkpoint inhibitors, radiotherapy and/or anti-angiogenic therapy, may have a synergistic effect in the treatment of patients with advanced vaginal melanoma (5). Moreover, a recent large cohort study from MD Anderson Cancer Center found that mitotic rate >10/mm2, nodal involvement and non-vulvar anatomic subsite were related to poor outcomes, independently of the combination of treatment (6). More specifically, the study reports 46% local control, 53% nodal control, 36% distant metastasis-free survival, 49% melanomaspecific survival and 48% overall survival (6). Once again, we would like to congratulate the authors for their excellent anatomic approach/surgery and for raising awareness of such a rare entity. Christos Iavazzo1, Panagiotis Peitsidis2,3, Ioannis D. Gkegkes4,5","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"226-227"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/34/JTGGA-24-226.PMC10493810.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effectiveness of non-invasive prenatal test technology and the prenatal screening algorithm based on various methods for determining foetal aneuploidy. 无创产前检测技术的有效性及基于多种方法的产前筛查算法对胎儿非整倍体的检测。
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2022-10-4
Leila Sadvakassova, Zhanar Kurmangali, Vyacheslav Beloussov, Zere Rakisheva, Milan Terzic
{"title":"The effectiveness of non-invasive prenatal test technology and the prenatal screening algorithm based on various methods for determining foetal aneuploidy.","authors":"Leila Sadvakassova,&nbsp;Zhanar Kurmangali,&nbsp;Vyacheslav Beloussov,&nbsp;Zere Rakisheva,&nbsp;Milan Terzic","doi":"10.4274/jtgga.galenos.2023.2022-10-4","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2022-10-4","url":null,"abstract":"<p><strong>Objective: </strong>The purpose was to evaluate the effectiveness of a non-invasive prenatal test (NIPT) using mass parallel sequencing (MPS) to detect trisomy 13, 18, 21 and fetal sex chromosome abnormalities in maternal blood samples by isolating freely circulating foetal extracellular DNA (eDNA), and to develop an algorithm for prenatal screening.</p><p><strong>Material and methods: </strong>The research methods used included blood sampling from patients, isolation of eDNA, determination of DNA concentration and quality, library preparation for sequencing, MPS using an Illumina HiSeq2000, positive and negative control samples, monitoring, and analysis of results using the distributed algorithms platform based on calculations of z-value and the average absolute deviation. Pregnant women were divided into two groups based on gestational age at sampling, group 1; 9-14 weeks and group 2; 15-27 weeks.</p><p><strong>Results: </strong>A total of 377 pregnant women were included with a mean (range) age of 33 (23-44) years. The mean gestational age at the time of blood sampling in group 1 was 11 (9-14) weeks, and in group 2 was 21 (15-27) weeks. In the first group, three cases of trisomy 18 chromosomes were detected in patients aged 43 years old, and female children were subsequently born with Edwards syndrome. In the second group, one case of trisomy 21 was detected in a patient aged 36 years and the pregnancy was terminated at 25 weeks.</p><p><strong>Conclusion: </strong>The analysis of freely circulating foetal eDNA was a sensitive method for detecting chromosomal abnormalities. The study has a practical significance, since the NIPT for frequent aneuploidy considerably exceeds the effectiveness of traditional screening methods and allows identifying chromosomal disorders starting from the 9th week of the gestation period.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"152-158"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/89/JTGGA-24-152.PMC10493820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10569465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity and reliability of a Turkish version of the human papillomavirus knowledge scale: a methodological study. 土耳其版人乳头瘤病毒知识量表的有效性和可靠性:一项方法学研究
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2022-10-9
Feyza Demir Bozkurt, Serpil Özdemir
{"title":"Validity and reliability of a Turkish version of the human papillomavirus knowledge scale: a methodological study.","authors":"Feyza Demir Bozkurt,&nbsp;Serpil Özdemir","doi":"10.4274/jtgga.galenos.2023.2022-10-9","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2022-10-9","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to test validity and reliability of the Human Papilloma Virus Knowledge Scale (HPV-KS) in Turkish.</p><p><strong>Material and methods: </strong>The methodological study was conducted with 920 participants at a training and research hospital in Ankara, Turkey, between February and May 2019. The data collection form consisted of descriptive characteristics of the participants and HPV-KS. Guidelines for the Process of Cross-Cultural Adaptation of Self-Reported Measures were followed for the language and cultural adaptation of the scale. Content validity, exploratory, and confirmatory factor analyses were performed to test the validity of the scale. The scale's reliability was assessed using the item-total correlation, Cronbach's alpha, and test-retest analysis.</p><p><strong>Results: </strong>In line with the experts' suggestions, two item were excluded from the scale. The scale content validity index was found to be 0.96. The exploratory factor analysis determined the four subscales of the scale with 33-items. The explained variance was found to be 64.56%. In the confirmatory factor analysis, all the goodness of fit indexes had acceptable values. The item-total correlations determined that each item was positively correlated with the total scale ranging from 0.53 to 0.80. The Cronbach's alpha coefficient calculated for the overall scale was 0.96. It was found that there was a statistically significant positive relationship between test and retest (r=0.166; p=0.05).</p><p><strong>Conclusion: </strong>The scale was shown to be a valid and reliable standard measurement that can be used to accurately evaluate the efficacy of health education provided by healthcare professionals.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"177-186"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/42/JTGGA-24-177.PMC10493809.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10569464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the ovarian reserve in patients with beta-thalassemia major: a prospective longitudinal study 重度-地中海贫血患者卵巢储备的评估:一项前瞻性纵向研究
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2022-12-2
Aykut Özcan, Varol Gülseren, Esin Özcan, Emrah Toz, Volkan Turan
{"title":"Assessment of the ovarian reserve in patients with beta-thalassemia major: a prospective longitudinal study","authors":"Aykut Özcan,&nbsp;Varol Gülseren,&nbsp;Esin Özcan,&nbsp;Emrah Toz,&nbsp;Volkan Turan","doi":"10.4274/jtgga.galenos.2023.2022-12-2","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2022-12-2","url":null,"abstract":"<p><strong>Objective: </strong>Repeated blood transfusions in women with beta-thalassemia major (BTM) may lead to iron overload and increase oxidative stress, consequently resulting in ovarian damage. The aim was to evaluate alterations in ovarian reserve in transfusion-dependent BTM patients over a time period of one year and to compare levels of anti-Mullerian hormone (AMH) in women with BTM and their healthy peers.</p><p><strong>Material and methods: </strong>This longitudinal prospective study was conducted in women with transfusion-dependent BTM at a tertiary level hospital. The hospital database was interogated for women diagnosed with BTM between 1996 and 2021. AMH levels were assessed at baseline and one year later.</p><p><strong>Results: </strong>Forty-one women with BTM were identified, of whom 25 (60.9%) had amenorrhea and 16 (39.1%) had normal cycles. The mean AMH level of all women was 2.7±1.8 ng/mL at baseline, significantly lower than the age-matched nomogram value of 4.0±0.4 ng/mL for a healthy population (p=0.001). The baseline AMH level of patients with amenorrhea were significantly lower than patients with normal menstrual cycles (2.1±1.8 vs. 3.6±1.5 ng/mL, p=0.009). After one-year follow-up, there was a trend towards a decrease in the AMH levels of patients with normal menstrual cycles.</p><p><strong>Conclusion: </strong>Serum AMH values are decreased in patients with transfusion-dependent BTM. BTM patients should be educated about the possible effects of repeated blood transfusions on fertility.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"159-164"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/70/JTGGA-24-159.PMC10493813.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of laparoscopic pectopexy with the standard laparoscopic sacropexy for apical prolapse: an exploratory randomized controlled trial 腹腔镜椎弓根切除术与标准腹腔镜椎弓根切除术治疗根尖脱垂的比较:一项探索性随机对照试验
IF 1.4
Journal of the Turkish German Gynecological Association Pub Date : 2023-09-07 DOI: 10.4274/jtgga.galenos.2023.2022-12-15
Kavita Khoiwal, Kanhu Charan Dash, Amrita Gaurav, Jaya Chaturvedi
{"title":"Comparison of laparoscopic pectopexy with the standard laparoscopic sacropexy for apical prolapse: an exploratory randomized controlled trial","authors":"Kavita Khoiwal,&nbsp;Kanhu Charan Dash,&nbsp;Amrita Gaurav,&nbsp;Jaya Chaturvedi","doi":"10.4274/jtgga.galenos.2023.2022-12-15","DOIUrl":"https://doi.org/10.4274/jtgga.galenos.2023.2022-12-15","url":null,"abstract":"<p><strong>Objective: </strong>To compare laparoscopic pectopexy with the standard laparoscopic sacropexy in women with symptomatic apical prolapse.</p><p><strong>Material and methods: </strong>An interim analysis of an exploratory randomized controlled trial with the primary objective of comparing mesh fixation time and secondary objectives were to compare total operating time, blood loss, and intra-operative and post-operative complications. Additionally, patients completed the Prolapse Quality of Life (P-QOL) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) questionnaires before surgery and during six months follow-up visit to evaluate the overall improvement in quality of life and sexual function. Patient Global Impression of Improvement (PGI-I) score was calculated on the 7-10<sup>th</sup> day post-operatively and then at six months to assess the level of improvement.</p><p><strong>Results: </strong>The study included 30 patients; 15 underwent laparoscopic sacropexy, and 15 underwent laparoscopic pectopexy. Baseline characteristics were comparable in both groups. The mean duration of mesh fixation was significantly less with laparoscopic pectopexy (45.00±11.34 minutes) than laparoscopic sacropexy (54.67±9.35 minutes) (p=0.019). The total operating time and blood loss tended to be less in the pectopexy group, but not significantly so. Only one patient in the pectopexy group had a bladder injury. No patient in either group had any post-operative complications. One case in each group had a relapse of apical prolapse. All the domains of PISQ-12, P-QOL, and PGI-I scores improved significantly after both procedures.</p><p><strong>Conclusion: </strong>Laparoscopic pectopexy is a safe, feasible, and comfortable alternative procedure to the standard sacropexy for apical prolapse. We noted significantly less mesh fixation time and less operating time, while blood loss tended to be less with laparoscopic pectopexy than with laparoscopic sacropexy. Post-operative parameters were comparable between techniques. Both corrective techniques for prolapse improved the PGI-I, P-QOL, and PISQ-12 scores.</p>","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"24 3","pages":"144-151"},"PeriodicalIF":1.4,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/ad/JTGGA-24-144.PMC10493818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信