冷冻胚胎移植前一天血清雌二醇和黄体酮水平与人工冷冻胚胎周期中妊娠率的关系:是否存在血清激素水平阈值来预测阴道和皮下联合黄体支持的妊娠?

IF 1.4 Q3 OBSTETRICS & GYNECOLOGY
Levent Dikbaş, Michael H Dahan
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引用次数: 0

摘要

目的:探讨人工冷冻胚胎移植(FET)前1天血清雌二醇(E2)和孕酮(P4)水平对阴道联合注射P4患者妊娠率的潜在影响。材料与方法:本回顾性队列研究分析了2022年2月至2023年10月167例接受激素替代治疗的患者FET前一天血清E2和P4水平的相关性。评估的主要结果是怀孕率和活产率。我们建立了一个基于黄体对妊娠支持的血清临界值模型。黄体支持是通过阴道栓剂和皮下注射的组合。采用多变量logistic回归检验妊娠结局与自变量之间的关系。采用受试者工作特征(ROC)分析和百分位分析评估截止值。结果:FET术前血清E2、P4水平与妊娠率无显著相关性。成功受孕组E2水平为169.0±51.9 pg/mL,未受孕组E2水平为177.7±56.9 pg/mL (p=0.45)。P4相应值分别为28.1±18.4 ng/mL和31.2±25.4 ng/mL (p=0.73)。两组间体重指数(BMI)和子宫内膜厚度均无差异。使用roc无法确定E2和P4预测妊娠的临界值。然而,血清P4水平最低的10个百分位数(范围10.0-15.6 ng/mL)中没有人怀孕。当使用多变量逻辑回归时,这一发现失去了显著性,表明低血清水平与年龄、BMI和/或其他因素有关。结论:在人工制备FET周期中,采用ROC法评价,当血清E2水平在150 ~ 300 pg/mL之间,P4水平在10 ~ 40 ng/mL之间时,胚胎移植前1天血清E2和P4水平对妊娠率无显著影响。然而,百分位数分析表明,当注射和阴道联合使用P4进行程序化FET时,血清P4水平应大于15.6 ng/mL。虽然这一发现可能是由于年龄、BMI和其他影响类固醇代谢的因素的混杂影响,但在多变量逻辑回归中加以控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The relationship between serum estradiol and progesterone levels one day before frozen embryo transfer and pregnancy rates in artificially prepared frozen embryo cycles: are there any threshold serum hormone levels to predict pregnancy in luteal support by the vaginal and subcutaneous route combined?

The relationship between serum estradiol and progesterone levels one day before frozen embryo transfer and pregnancy rates in artificially prepared frozen embryo cycles: are there any threshold serum hormone levels to predict pregnancy in luteal support by the vaginal and subcutaneous route combined?

The relationship between serum estradiol and progesterone levels one day before frozen embryo transfer and pregnancy rates in artificially prepared frozen embryo cycles: are there any threshold serum hormone levels to predict pregnancy in luteal support by the vaginal and subcutaneous route combined?

Objective: To investigate the potential influence of serum estradiol (E2) and progesterone (P4) levels, measured one day before artificially prepared frozen embryo transfer (FET), on pregnancy rates in women who received combined vaginal and injectable P4.

Material and methods: This retrospective cohort study analyzed the association between serum E2 and P4 levels on the day before FET in 167 cases prepared with hormone replacement therapy between February 2022 and October 2023. The primary outcomes assessed were the pregnancy and live birth rates. We modeled a cut-off serum value based on luteal support for pregnancy. Luteal support was through a combination of vaginal suppositories and subcutaneous injections. Multivariate logistic regression was used to test relationships between pregnancy outcomes and independent variables. Cut-off values were evaluated using receiver operating characteristic (ROC) analysis and percentile analysis.

Results: No significant relationships were found between serum E2 or P4 levels on the day before FET and pregnancy rates. The mean E2 level was 169.0±51.9 pg/mL for individuals who achieved conception and 177.7±56.9 pg/mL for individuals who did not conceive (p=0.45). The corresponding values for P4 were 28.1±18.4 ng/mL and 31.2±25.4 ng/mL, respectively (p=0.73). No differences were observed in body mass index (BMI) or endometrial thickness between the groups. Cut-off values for predicting pregnancy using E2 and P4 could not be determined using ROCs. However, no one in the lowest 10th percentile of serum P4 levels conceived (range 10.0-15.6 ng/mL). When multivariate logistic regression was used, this finding lost significance suggesting that low serum levels are related to age, BMI, and/or other factors.

Conclusion: In artificially prepared FET cycles, the serum E2 and P4 levels one day before embryo transfer do not significantly affect pregnancy rates in women with serum E2 levels between 150-300 pg/mL and P4 between 10-40 ng/mL when ROC was used for evaluation. However, percentile analysis suggests that serum P4 levels should be more than 15.6 ng/mL when combined injectable and vaginal P4 is used for programmed FET. Although this finding may be due to the confounding effects of age, BMI, and other factors affecting steroid metabolism, when controlled for in the multivariate logistic regression.

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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
56
期刊介绍: Journal of the Turkish-German Gynecological Association is the official, open access publication of the Turkish-German Gynecological Education and Research Foundation and Turkish-German Gynecological Association and is published quarterly on March, June, September and December. It is an independent peer-reviewed international journal printed in English language. Manuscripts are reviewed in accordance with “double-blind peer review” process for both reviewers and authors. The target audience of Journal of the Turkish-German Gynecological Association includes gynecologists and primary care physicians interested in gynecology practice. It publishes original works on all aspects of obstertrics and gynecology. The aim of Journal of the Turkish-German Gynecological Association is to publish high quality original research articles. In addition to research articles, reviews, editorials, letters to the editor, diagnostic puzzle are also published. Suggestions for new books are also welcomed. Journal of the Turkish-German Gynecological Association does not charge any fee for article submission or processing.
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