宫颈上皮内瘤变妇女多部位HPV感染:一项探索性分析。

IF 1.4 Q3 OBSTETRICS & GYNECOLOGY
Tuğba Akçaoğlu, Yağmur Soykan, Neslihan Bayramoğlu Tepe, Ozan Doğan
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引用次数: 0

摘要

目的:人乳头瘤病毒(HPV)阳性与宫颈癌、口咽癌和肛门癌有关。关于从宫颈HPV阳性患者获得口咽和肛门拭子以检测潜在病理的有效性,没有足够的已发表证据。我们的目的是分析这种潜在筛选方案在试点群体中的可行性。材料和方法:在这个横断面探索性分析中,被诊断为宫颈上皮内瘤变(CIN) 1级、2级或3级的妇女被招募。为了评估宫颈以外的HPV感染,收集了组织病理学证实CIN的HPV阳性妇女的口咽和肛门拭子样本。结果:共有30名提供知情同意的妇女被纳入本初步研究。HPV 16是所有CIN级别中主要的宫颈HPV类型(46.7%的病例),但HPV基因型与CIN病变的严重程度没有显著相关性(p=0.786)。宫颈HPV感染与肛门HPV感染无统计学意义(p=0.427)。口腔HPV阳性很少见(6.7%),同样与宫颈HPV感染无显著相关性(p=0.499)。结论:这些发现为该人群多位点HPV筛查的有效性提供了初步数据。未来需要更大规模的研究来确定宫颈HPV阳性女性检测宫颈外HPV是否会影响临床管理决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multi-site HPV infection in women with cervical intraepithelial neoplasia: an exploratory analysis.

Objective: Human papillomavirus (HPV) positivity is associated with cervical, oropharyngeal, and anal cancers. There is insufficient published evidence regarding the effectiveness of obtaining oropharyngeal and anal swabs from patients with cervical HPV positivity to detect potential pathologies. Our aim was to analyze the feasibility of this potential screening protocol in a pilot group.

Material and methods: In this cross-sectional exploratory analysis, women diagnosed with cervical intraepithelial neoplasia (CIN) grades 1, 2, or 3 were recruited. In order to evaluate HPV infection beyond the cervix, oropharyngeal and anal swab samples from HPV-positive women presenting to the obstetrics and gynecology clinic with histopathologically confirmed CIN were collected.

Results: A total of 30 women who provided informed consent were included in this pilot study. HPV 16 was the predominant cervical HPV type across all CIN grades (46.7% of cases), but HPV genotype did not significantly correlate with the severity of CIN lesions (p=0.786). No statistically significant association was found between cervical and anal HPV infections (p=0.427). Oral HPV positivity was rare (6.7%) and similarly showed no significant correlation with cervical HPV infection (p=0.499).

Conclusion: These findings provide preliminary data on the effectiveness of multi-site HPV screening in this population. Future larger-scale studies are needed to determine whether detecting extra-cervical HPV in women with cervical HPV positivity will influence clinical management decisions.

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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
56
期刊介绍: Journal of the Turkish-German Gynecological Association is the official, open access publication of the Turkish-German Gynecological Education and Research Foundation and Turkish-German Gynecological Association and is published quarterly on March, June, September and December. It is an independent peer-reviewed international journal printed in English language. Manuscripts are reviewed in accordance with “double-blind peer review” process for both reviewers and authors. The target audience of Journal of the Turkish-German Gynecological Association includes gynecologists and primary care physicians interested in gynecology practice. It publishes original works on all aspects of obstertrics and gynecology. The aim of Journal of the Turkish-German Gynecological Association is to publish high quality original research articles. In addition to research articles, reviews, editorials, letters to the editor, diagnostic puzzle are also published. Suggestions for new books are also welcomed. Journal of the Turkish-German Gynecological Association does not charge any fee for article submission or processing.
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