Journal of tissue viability最新文献

{"title":"Enhancing sickle cell leg ulcer healing with combined photodynamic and photobiomodulation therapies: A pilot experience","authors":"Vitor Fortuna ,&nbsp;Gabriel F. Oliveira ,&nbsp;Livia M. Xavier ,&nbsp;Daniele V. Oliveira ,&nbsp;Jaqueline G. Lima ,&nbsp;Yasmin S. Oliveira ,&nbsp;Beatriz S. Costa ,&nbsp;Giselle B. Jesus ,&nbsp;Setondji C.M.A. Yahouedehou ,&nbsp;Elissandra M. Zanchin ,&nbsp;José Roberto Meyer ,&nbsp;José V. Meneses ,&nbsp;Marilda Souza Gonçalves ,&nbsp;Vanderlei S. Bagnato","doi":"10.1016/j.jtv.2025.100879","DOIUrl":"10.1016/j.jtv.2025.100879","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the safety and efficacy of combined photodynamic therapy (PDT) and photobiomodulation (PBM) in treating sickle cell leg ulcers (SCLUs), with a focus on pain reduction and enhanced healing.</div></div><div><h3>Materials and methods</h3><div>In this prospective, open-label, uncontrolled pilot study, ten SCD patients with 17 chronic leg ulcers received PDT and PBM treatments. Ulcer severity, pain levels, and microbiome changes were monitored, and clinical data were analyzed using appropriate statistical methods.</div></div><div><h3>Results</h3><div>Among the treated ulcers, 64.7 % (11 out of 17) showed significant healing, with 9 ulcers achieving complete closure. The average reduction in ulcer size was significant, with a median healing time of 123 days. Pain levels decreased significantly in 82.3 % of treated ulcers (p &lt; 0.001), and a 75.4 % reduction in bacterial load was observed, alongside increased microbiome diversity (p &lt; 0.05). Elevated levels of IL-6 and PSGL-1 were associated with non-healing ulcers, indicating their potential as prognostic biomarkers.</div></div><div><h3>Conclusion</h3><div>The combined PDT and PBM therapy proved to be effective and safe for SCLUs, offering significant improvements in healing and pain reduction. These findings suggest that integrating PDT and PBM into standard care protocols could enhance the management of SCLUs.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100879"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive care nurses' knowledge regarding medical device-related pressure injuries and factors affecting these: A descriptive and cross-sectional study","authors":"Münevver Sönmez ,&nbsp;Nur Güven Özdemir ,&nbsp;Şirin Harkın Gemicioğlu ,&nbsp;Ayşe Aydın","doi":"10.1016/j.jtv.2025.100880","DOIUrl":"10.1016/j.jtv.2025.100880","url":null,"abstract":"<div><h3>Aim</h3><div>Nurses play a fundamental role in preventing, treating, and reducing the incidence of medical device-related pressure injuries (MDRPIs). Therefore, assessing their level of knowledge on this subject is of utmost importance. The aim of this study is to determine intensive care nurses’ levels of knowledge regarding medical device-related pressure injuries and factors affecting these.</div></div><div><h3>Materials and methods</h3><div>This descriptive and cross-sectional study was conducted with 156 intensive care unit (ICU) nurses between October 2023 and March 2024. Data were collected using the Nurses Information Form, Medical Device Related Pressure Injury Knowledge Assessment Test (MDRPI-KAT).</div></div><div><h3>Results</h3><div>The nurses had a mean score of 9.05 ± 2.54 on the MDRPI-KAT, indicating an overall correct answer percentage of 56.5 %. It was determined that nurses scored the highest in the sub-dimension of “Selection and Suitability of Medical Devices” (87.5 %) and the lowest in the sub-dimension of “Special Patient Groups” (29.5 %). The total MDRPI-KAT score for female nurses is 1.031 times higher than that of male nurses (B = 1.031, p = 0.013). Additionally, nurses with a high school, bachelor's, or postgraduate level of education have a higher total MDRPI-KAT score compared to those with an associate degree (β = 2.393, p = 0.003; β = 2.114, p = 0.005; β = 3.101, p = 0.001). Furthermore, the total MDRPI-KAT score of nurses who believe that a nursing care protocol is necessary for the prevention of MDRPIs is 1.309 times higher than that of those who do not consider it necessary.</div></div><div><h3>Conclusion</h3><div>This study found that ICU nurses' knowledge regarding MDRPIs were insufficient. We identified gender, education level, and the perceived need for a nursing care protocol for the prevention of MDRPIs as variables that influence nurses' level of knowledge. To enhance nurses' knowledge about MDRPIs and ensure the provision of safe and high-quality skin care, we recommend that intensive care nurses receive continuous and practical training on MDRPIs. This should include innovative educational methods such as simulations and case analyses, as well as the organization of online courses and webinars.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100880"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of topically applied MEBO in healing of traumatic oral ulcer: Randomized controlled trial","authors":"Amany Ahmed AlAraby ,&nbsp;Nadia Fathy Hassabou ,&nbsp;Wessam Ibrahim Shehab Eldin","doi":"10.1016/j.jtv.2025.100877","DOIUrl":"10.1016/j.jtv.2025.100877","url":null,"abstract":"<div><h3>Background</h3><div>MEBO is an analgesic and antibacterial natural agent. Sesame oil extract plays a positive effect in wound healing that may be attributed to its ability to scavenge free radicals and antioxidant properties.</div></div><div><h3>Material and methods</h3><div>In this study, MEBO was topically applied to the site of a traumatic oral ulcer to examine its therapeutic effect on pain relief and wound healing. Patients were randomly assigned into two equal groups: group I (MEBO), group II (control), (n = 15 patients each). Pain was recorded by using the Visual Analogue Scale (VAS), wound size was measured at days 2, 5, and 10. Cytological analysis was also performed using the superficial epithelial cell and keratinization indices.</div></div><div><h3>Results</h3><div>There was a statistically significant difference in VAS scores and wound size between MEBO group and control group (p ≤ 0.001). Cytological results of MEBO group showed a highly significant improvement (p ≤ 0.00001) in re-epithelization and keratinization indices over time.</div></div><div><h3>Conclusion</h3><div>Our results showed that the application of MEBO on traumatic ulcer sites has a significant improvement in wound healing and rapid enhancing effect on the re-epithelialization rate.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100877"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-one year trends in pressure injury in a Western Australian hospital","authors":"Linda L. Coventry ,&nbsp;Istvan Kabdebo ,&nbsp;Nicole Walsh ,&nbsp;Joelle Winderbaum ,&nbsp;Mark Jenkins ,&nbsp;Prachi Kaistha ,&nbsp;Diane E. Twigg ,&nbsp;Shirley Jansen ,&nbsp;Dimitri Beeckman","doi":"10.1016/j.jtv.2025.100878","DOIUrl":"10.1016/j.jtv.2025.100878","url":null,"abstract":"","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100878"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the effect of virtual reality application on pain and anxiety in the care of chronic wounds on the leg","authors":"Zehra Belhan ,&nbsp;Rabia Muhan ,&nbsp;Mehmet Emin Aksoy ,&nbsp;Emre Ozker ,&nbsp;Vesile Unver","doi":"10.1016/j.jtv.2025.100876","DOIUrl":"10.1016/j.jtv.2025.100876","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, virtual reality applications have begun to be used in many areas of the healthcare (education, treatment, etc.). It has been observed that it reduces pain and anxiety by distracting individuals during painful procedures.</div></div><div><h3>Material and methods</h3><div>The study was conducted in a wound care clinic between September 2022 and 2024 with a randomized controlled experimental design. 71 patients with chronic wounds on their legs who came to the clinic for care were randomly divided into two groups. While virtual reality glasses were applied to the patients in the experimental group during wound care, patients in the control group received standard care. Pain and anxiety levels of both groups were evaluated before and after dressing. The symptoms of patients using virtual reality glasses were examined.</div></div><div><h3>Results</h3><div>The data of 71 patients who had chronic wounds on their legs and came to the clinic for dressing were analyzed. The majority of the patients were male patients with an average age in their sixties. Most of the patients had diabetes for a long time (intervention group 19,85 ± 12,31, control group 18,96 ± 12,38) and their wounds were diabetic feet. There was no statistically significant difference in pain (Z = −,857∗∗∗; p = ,391) and anxiety levels (t = 1,94; p = ,057) between the groups before and after the procedure.</div></div><div><h3>Conclussion</h3><div>It was determined that the use of virtual reality application during dressing of patients with chronic wounds on their legs did not have a significant effect on pain and anxiety. However, no serious symptoms were observed in the patients regarding the use of virtual reality glasses.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100876"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of medical adhesive-related skin injuries in outpatients with peripherally inserted central catheters","authors":"Qi Xia ,&nbsp;Xin Chen ,&nbsp;QingHua Ma ,&nbsp;DingDing Zhang","doi":"10.1016/j.jtv.2025.100875","DOIUrl":"10.1016/j.jtv.2025.100875","url":null,"abstract":"<div><h3>Aims</h3><div>Skin exposed to the adhesives to protect catheters is prone to Medical Adhesive-Related Skin Injuries (MARSI). Occurrence of these injuries and the risk factors have not been estimated previously in outpatients with peripherally inserted central catheters. The primary aim of this study was to delineate the characteristics of MARSI and quantify 3 types of incidence rates of MARSI among outpatients with PICC placements.</div></div><div><h3>Methods</h3><div>The study sample included 299 outpatients with PICC placements from October to December 2020. The data were collected at the Sichuan Academy of Medical Sciences&amp;Sichuan Provincial People's Hospital in Chengdu, China.A three-month cross-sectional survey was conducted at the PICC center of a tertiary general hospital in Western China to analyze the occurrence of MARSI at the catheterization site and related factors. Professional nurses observed and assessed skin conditions during catheter maintenance and collected patient data that could be associated with MARSI occurrence. The relationship between independent variables and MARSI was statistically analyzed using multivariate analysis.</div></div><div><h3>Results</h3><div>Among outpatients with peripherally inserted central catheters,the incidence rate of MARSI was 14.7 %. Statistical analysis revealed that maintenance personnel (χ² = 8.683, P = 0.003), MARSI history (χ² = 4.332, P = 0.037), external fixation devices (χ² = 4.227, P = 0.04) were significantly associated with the occurrence of MARSI. Moreover, patients over the age of 50 (χ² = 4.183, P = 0.041) and the use of transparent dressing (χ² = 6.782, P = 0.009) were found to be associated with tension injuries. A multivariate analysis showed that the use of external fixation devices (OR, 2.987; 95 % CI, 1.044 to 8.547; P = 0.041) was an independent risk factor for MARSI.</div></div><div><h3>Conclusions</h3><div>Patients with PICC in the outpatient department are at a high risk of developing MARSI. To prevent and control MARSI,it is essential to enhance the professional skills of maintenance staff and to pay special attention to patients with a history of MARSI and those over the age of 50. Additionally,the use of external fixation devices and transparent dressings should also be considered.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100875"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' knowledge of skin tears: A cross-sectional survey study across four hospitals in São Paulo, Brazil","authors":"Cinthia Viana Bandeira da Silva ,&nbsp;Dimitri Beeckman ,&nbsp;Vera Lucia Conceição de Gouveia Santos","doi":"10.1016/j.jtv.2025.100874","DOIUrl":"10.1016/j.jtv.2025.100874","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess and analyze nurses' knowledge regarding Skin Tears (STs).</div></div><div><h3>Methods</h3><div>An observational, exploratory, and cross-sectional study was conducted across four hospitals in São Paulo, Brazil, encompassing diverse settings: two public hospitals (one affiliated with a university and the other serving state public service professionals) and two private hospitals (one specializing in highly complex cases and the other a general hospital). Data collection involved two instruments: one for sample characterization and another, the OASES instrument, which was translated and content-validated for use in Brazilian Portuguese, to assess nurses' knowledge on STs. Data were analyzed using measures of central tendency and variability.</div></div><div><h3>Results</h3><div>The study included 179 nurses, with an average score of 10.83 (SD = 3.32). Higher knowledge levels were observed in nurses who had received training on STs (p = 0.003) and those who participated in scientific activities (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Nurses across the four hospitals in São Paulo demonstrated a level of knowledge about STs that was slightly higher compared to international benchmarks in similar studies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100874"},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring physiological differences in injury response by skin tone: A scoping review","authors":"Pinar Avsar ,&nbsp;Zena Moore ,&nbsp;Declan Patton ,&nbsp;Tom O'Connor ,&nbsp;Lone Skoubo Bertelsen ,&nbsp;Desmond J. Tobin ,&nbsp;Giulio Brunetti ,&nbsp;Keryln Carville ,&nbsp;Vignesh Iyer ,&nbsp;Hannah Wilson","doi":"10.1016/j.jtv.2025.100871","DOIUrl":"10.1016/j.jtv.2025.100871","url":null,"abstract":"<div><h3>Aim</h3><div>To explore existing literature examining physiological differences in pressure ulcer response among individuals with differing skin tones.</div></div><div><h3>Methods</h3><div>This was a scoping review. Articles meeting the inclusion criteria were retrieved from electronic databases including PubMed, CINAHL, Scopus, Cochrane, and EMBASE, using the keywords \"pressure ulcer,\" \"skin pigmentation,\" \"melanin,\" and \"risk factor.\" Data were extracted using a predesigned data extraction tool and analysed using a narrative synthesis.</div></div><div><h3>Results</h3><div>Five papers met the inclusion criteria. Analysis of findings suggests there are potential mechanisms which may influence the skin's ability to withstand mechanical stress and its inflammatory response to damage among those with different skin tones; the structure of the stratum corneum, collagen density, fibroblast activity, mast cell density, and transepidermal water loss (TEWL). The stratum corneum can compromise skin resilience, while collagen density and fibroblast activity may impact skin strength and repair. Mast cells affect inflammation, which can exacerbate pressure ulcer damage, and increased TEWL in those with dark skin tones can result in lower water content in the stratum corneum, affecting hydration.Conversely, factors like melanosome size, hair follicle and hair fiber characteristics, sebaceous gland activity, vitamin D production, UVR protection, and desquamation rate, although relevant to overall skin health, may not directly affect the mechanical processes leading to pressure ulcer formation.</div></div><div><h3>Conclusions</h3><div>Physiological differences in skin structure may contribute to alterations in the response to pressure ulcer development among individuals with dark skin. Recognising these differences is important for targeted prevention strategies within diverse populations. However, further research is needed to explore the mechanisms underlying this association in greater detail.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100871"},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of decellularized tissues in ear regeneration","authors":"Manouchehr Avatef Fazeli ,&nbsp;Masoumeh Amiri ,&nbsp;Gelavizh Rostaminasab ,&nbsp;Vahid Akbaripour ,&nbsp;Abdolhamid Mikaeili ,&nbsp;Mohammad Othman ,&nbsp;Leila Rezakhani","doi":"10.1016/j.jtv.2025.100870","DOIUrl":"10.1016/j.jtv.2025.100870","url":null,"abstract":"<div><div>More than 5 % of people worldwide suffer from hearing disorders. Ototoxic drugs, aging, exposure to loud sounds, rupture, subperichondrial hematoma, perichondritis, burns and frostbite and infections are the main causes of hearing loss, some of which can destroy the cartilage and lead to deformation. On the other hand, disorders of the external ear are diverse and can range from dangerous neoplasms to defects that are not acceptable from a cosmetic standpoint. These issues include injuries, blockages, dermatoses, and infections, and any or all of them may be bothersome to the busy doctor. Using an implant or hearing aid is one of the treatment strategies for deafness. However, these medical devices are not useful for every eligible patient. With the right therapy, many of these issues are not life-threatening and can be treated with confidence in a positive outcome. As medical research and treatment have advanced dramatically in the past ten years, tissue engineering (TE) has emerged as a promising method to regenerate damaged tissue, raising the prospect of a permanent cure for deafness. Decellularization is now seen as a promising development for regenerative medicine, and an increasing number of applications are being found for acellular matrices. Studies on decellularization show that natural scaffolds made from decellularized tissues can serve as a suitable platform while preserving the main components, and the preparation of such scaffolds will be an important part of future bioscience research. It can have wide applications in regenerative medicine and TE. This review intends to give an overview of the status of research and alternative scaffolds in inner and outer ear regenerative medicine from both a preclinical and clinical perspective for ear disorders in order to show how ongoing TE research has the potential to advance and enhance novel disease treatments.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100870"},"PeriodicalIF":2.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerative effect of Carbazole nanocubosomes on the healing of methicillin-resistant Staphylococcus aureus-infected full-thickness wounds","authors":"Saba Samari ,&nbsp;Mohammad Reza Farahpour ,&nbsp;Zohreh Ghazi Tabatabaei","doi":"10.1016/j.jtv.2025.100869","DOIUrl":"10.1016/j.jtv.2025.100869","url":null,"abstract":"<div><h3>Background</h3><div>Bacterial infections remain a major challenge in the treatment of infected wounds due to their resistance. Novel agents are urgently needed for effective treatment. This study aimed to evaluate the effects of carbazole nanocubosomes on the healing of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA)-infected full-thickness wounds.</div></div><div><h3>Materials and methods</h3><div>Carbazole (Carbz) and cubosome/carbazole (Cubo/Carbz) structures were synthesized, and their physicochemical properties, toxicity, and in vitro antibacterial activities were assessed. The wound healing activity was evaluated by analyzing pathological parameters, including edema, immune cell infiltration, new vessel formation, fibroblast infiltration, and epithelial thickness. Additionally, the expression levels of TNF-α, Bcl-2, P-53, mTOR, cyclin D1, TGF-β, VEGF, and Col1A were measured to assess the effects of cubosomes on the wound healing process. The results confirmed the successful synthesis of cubosomes, along with the safety, antibacterial activity, and sustained release of Carbz.</div></div><div><h3>Results</h3><div>The administration of Carbz, particularly the Cubo/Carbz formulations, significantly accelerated the wound healing process by reducing bacterial counts, edema, immune cell infiltration, and the expression of Bcl-2 and TNF-α. Simultaneously, fibroblast infiltration, epithelial thickness, and the expression of P-53, mTOR, Col1A, cyclin D1, TGF-β, and VEGF were increased.</div></div><div><h3>Conclusion</h3><div>In conclusion, Cubo/Carbz accelerates the wound healing process by promoting apoptosis, reducing inflammation, and enhancing the expression of proliferative genes.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100869"},"PeriodicalIF":2.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}