局部应用湿润烧伤膏治疗外伤性口腔溃疡的疗效：随机对照试验

IF 2.4 3区医学 Q2 DERMATOLOGY

Journal of tissue viability Pub Date : 2025-02-25 DOI:10.1016/j.jtv.2025.100877

Amany Ahmed AlAraby , Nadia Fathy Hassabou , Wessam Ibrahim Shehab Eldin

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引用次数: 0

摘要

mebo是一种镇痛、抗菌的天然药物。芝麻油提取物在伤口愈合中起着积极的作用，这可能归因于其清除自由基和抗氧化特性的能力。材料与方法本研究将湿润烧伤膏局部应用于外伤性口腔溃疡部位，观察其对疼痛缓解和伤口愈合的治疗效果。将患者随机分为两组：ⅰ组（MEBO）和ⅱ组（对照组），每组15例。采用视觉模拟评分法（VAS）记录疼痛，分别于第2、5、10天测量创面大小。细胞学分析也使用浅表上皮细胞和角化指数进行。结果MEBO组VAS评分、创面大小与对照组比较差异有统计学意义（p≤0.001）。MEBO组的细胞学结果显示，随着时间的推移，再上皮化和角化指数均有极显著改善（p≤0.00001）。结论创伤性溃疡部位应用湿润烧伤膏可显著改善创面愈合，快速提高创面再上皮化率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effectiveness of topically applied MEBO in healing of traumatic oral ulcer: Randomized controlled trial

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Effectiveness of topically applied MEBO in healing of traumatic oral ulcer: Randomized controlled trial

Background

MEBO is an analgesic and antibacterial natural agent. Sesame oil extract plays a positive effect in wound healing that may be attributed to its ability to scavenge free radicals and antioxidant properties.

Material and methods

In this study, MEBO was topically applied to the site of a traumatic oral ulcer to examine its therapeutic effect on pain relief and wound healing. Patients were randomly assigned into two equal groups: group I (MEBO), group II (control), (n = 15 patients each). Pain was recorded by using the Visual Analogue Scale (VAS), wound size was measured at days 2, 5, and 10. Cytological analysis was also performed using the superficial epithelial cell and keratinization indices.

Results

There was a statistically significant difference in VAS scores and wound size between MEBO group and control group (p ≤ 0.001). Cytological results of MEBO group showed a highly significant improvement (p ≤ 0.00001) in re-epithelization and keratinization indices over time.

Conclusion

Our results showed that the application of MEBO on traumatic ulcer sites has a significant improvement in wound healing and rapid enhancing effect on the re-epithelialization rate.

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来源期刊

Journal of tissue viability DERMATOLOGY-NURSING

CiteScore

3.80

自引率

16.00%

发文量

110

审稿时长

>12 weeks

期刊介绍： The Journal of Tissue Viability is the official publication of the Tissue Viability Society and is a quarterly journal concerned with all aspects of the occurrence and treatment of wounds, ulcers and pressure sores including patient care, pain, nutrition, wound healing, research, prevention, mobility, social problems and management. The Journal particularly encourages papers covering skin and skin wounds but will consider articles that discuss injury in any tissue. Articles that stress the multi-professional nature of tissue viability are especially welcome. We seek to encourage new authors as well as well-established contributors to the field - one aim of the journal is to enable all participants in tissue viability to share information with colleagues.