Journal of tissue viability最新文献

{"title":"Growth factors: Mechanistic insight of protein based biological macromolecules and its facets of delivery for diabetic wound healing.","authors":"Sandeep Prakash, Shikha Srivastava","doi":"10.1016/j.jtv.2026.101069","DOIUrl":"https://doi.org/10.1016/j.jtv.2026.101069","url":null,"abstract":"<p><p>A recent study found that there are currently 536.6 million persons worldwide with diabetes and believed to be 783.2 million till 2045. An extensive literature survey was done using Springer, Nature, and PubMed sources to compile the review based on the effectiveness and possible mechanism of action of protein based biological growth factors in diabetic wound healing. The most prevalent type of diabetic wounds is the diabetic foot ulcer (DFU), which has a recurrence incidence of 30%-50%. When it comes to diabetic wounds in particular, Growth Factors (GFs) play a significant part in poor wound healing. They have an impact on a variety of activities including alterations in inflammatory cells, macrophages etc. GFs speed up to enhance wound healing. Conclusively, all the growth factors exhibited an effective wound healing response through various mechanisms of action including fibroblast proliferation, enhancing proliferating, granulation tissue formation, re-epithelization, capillary density, tissue remodelling, detoxification of ROS and tissue formation when incorporated in diverse form of novel drug delivery systems i.e., particulates, hydrogels, scaffolds, and/or other systems. In future, the recombinant growth factors might be utilized in the healing/management of diabetic wounds i.e., acute or chronic wounds. However, more research is need to determine the effectiveness of this combination treatment approach. This is promising research to confirm the efficacy and mechanism of action of recombinant growth factors.</p>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 4","pages":"101069"},"PeriodicalIF":2.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conducting pressure ulcer prevention trials within a platform trial framework: Opportunities and lessons from the WHiTE14-PRESSURE3 trial.","authors":"Clare Greenwood, Elizabeth McGinnis, Jane Nixon, Matt Costa","doi":"10.1016/j.jtv.2026.101065","DOIUrl":"https://doi.org/10.1016/j.jtv.2026.101065","url":null,"abstract":"","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":" ","pages":"101065"},"PeriodicalIF":2.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A comprehensive study on mechanisms of action of fibroin, aloe vera, and ginger extracts through histochemical, inflammation biomarkers, and matrix metalloproteinases analysis against diabetic wounds\" [J Tissue Viability 33 (2024) 949-959].","authors":"Rida Sulayman, Shaukat Ali, Rizwan Ullah, Muhammad Summer, Ali Hassan, Hafsa Shahzad, Umaima Fiaz, Samaira Mumtaz, Tooba Nauroze, Shumaila Mumtaz","doi":"10.1016/j.jtv.2026.101030","DOIUrl":"https://doi.org/10.1016/j.jtv.2026.101030","url":null,"abstract":"","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":" ","pages":"101030"},"PeriodicalIF":2.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148382286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between microbiota and healing status in diabetes-related foot ulcers treated with Trigona honey","authors":"Sukarni Sukarni ,&nbsp;Mao Kunimitsu ,&nbsp;Kazuhiro Ogai ,&nbsp;Delima Fajar Liana ,&nbsp;Mahyarudin Mahyarudin ,&nbsp;Muhammad Aminuddin ,&nbsp;Kanae Mukai ,&nbsp;Haryanto Haryanto ,&nbsp;Suriadi Jais ,&nbsp;Makoto Oe","doi":"10.1016/j.jtv.2025.100981","DOIUrl":"10.1016/j.jtv.2025.100981","url":null,"abstract":"<div><h3>Aims</h3><div>Diabetes-related foot ulcers (DFUs) are a major complication of diabetes, and treatment with honey, which has antimicrobial properties, has been utilized in patients. However, the effects have been shown to vary, with the causes of these differences remaining unclear. Recently, microbiota has been reported to be associated with wound healing. Therefore, we hypothesized that differences in microbiota might explain the variations observed in response to honey. The present study aimed to investigate the relationship between the microbiota and the healing status in DFUs treated with Trigona honey.</div></div><div><h3>Methods</h3><div>A cohort study involving 12 DFUs categorized into healing and deteriorating groups was conducted. Wound and peri-wound microbiota observed at baseline and at 1 week later (after starting honey application) were investigated and then compared in the healing status.</div></div><div><h3>Results</h3><div><em>Enterococcus</em> was higher in the deteriorating group at baseline in the wound (<em>p</em> = 0.02), while <em>Corynebacterium</em> was higher in the healing group at 1 week later in the peri-wound skin (<em>p</em> = 0.02). Changes in the relative abundance of <em>Prevotella</em> and <em>Brevundimonas</em> in the peri-wound skin significantly differed based on the healing status.</div></div><div><h3>Conclusion</h3><div>The findings suggest that the honey's effects might differ based on the composition of the wound microbiota, and they highlight the bacterial interactions with the changes in the wound and peri-wound skin environment induced by the honey. These results also imply that honey therapy on its own may not be enough for treating DFUs. This study is limited by the small sample size and short follow-up period; further research will need to explore combined treatment strategies and long-term microbiota dynamics to improve DFU management.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100981"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying seated buttock tissue response to commercial wheelchair cushions through MRI and pressure mapping analyses","authors":"Sharon Eve Sonenblum ,&nbsp;Mary Shea-Stifel ,&nbsp;Kelly Waugh ,&nbsp;Trevor Dyson-Hudson","doi":"10.1016/j.jtv.2026.100983","DOIUrl":"10.1016/j.jtv.2026.100983","url":null,"abstract":"<div><h3>Objective</h3><div>To describe how different wheelchair cushion designs impact interface pressure and buttock tissue deformation during sitting.</div></div><div><h3>Materials &amp; methods</h3><div>43 chronic full-time wheelchair users at high risk for pressure injuries were studied in an unloaded/suspended condition and on the Acta-Embrace, HR45, Jay J2 Deep Contour, Java, Matrx Vi, and/or the Roho HP cushions in randomized order. FONAR Upright MRI scans were used to measure seated soft tissue anatomy, and interface pressure mapping was used to measure peak pressure index (PPI) and pressure gradient.</div></div><div><h3>Results</h3><div>Median unloaded bulk tissue thickness beneath the ischium was 36.0 mm, decreasing by 53% when loaded. Tissue thickness under the ischium varied significantly between the Java (an off-loading design) and other pressure redistributing cushions (HR45, J2 Deep Contour, Matrx Vi) during upright sitting.</div><div>Greater bulk tissue thickness correlated with increased proximal thigh thickness and reduced deformation under the ischium. Average PPI and pressure gradient were 116.2 ± 44.8 mmHg and 26.1 ± 17.8 mmHg, respectively. Matrx Vi exhibited significantly higher PPIs and gradients despite comparable deformation. Both PPI and gradient showed weak inverse correlations with tissue thickness (r = −0.276, p = 0.002; r = −0.321, p &lt; 0.001). Both were associated with greater immersion on most cushions.</div></div><div><h3>Conclusion</h3><div>The wheelchair cushions investigated showed comparable tissue deformation and PPI, though individuals with greater tissue thickness experienced less deformation. While participants experienced similar maximal tissue deformation across cushions, pressure gradients provided a more reliable representation of internal tissue response than PPI. Different cushion designs influenced load distribution uniquely despite similar overall tissue response, with notable differences between off-loading and pressure redistribution approaches. Regular skin checks remain essential for all wheelchair users.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100983"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Cognitive gaps and educational needs in foot self-care among patients with diabetic foot from a health literacy perspective: A qualitative study” [J Tissue Viabil 34 (2025) 100960]","authors":"Xiaodan Lin ,&nbsp;Xianghao Chen ,&nbsp;Yuantian Li ,&nbsp;Shumin He ,&nbsp;Haidan Xie ,&nbsp;Xiaozhou Zhou","doi":"10.1016/j.jtv.2025.100972","DOIUrl":"10.1016/j.jtv.2025.100972","url":null,"abstract":"","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100972"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitude and adherence to evidence-based pressure injury prevention practices of neonatal intensive care nurses in China: a cross-sectional study","authors":"Zeyao Shi ,&nbsp;Yanling Hu ,&nbsp;Xiaowen Li ,&nbsp;Ru Yang ,&nbsp;Yan Song ,&nbsp;Xushu Chen ,&nbsp;Jing Yan","doi":"10.1016/j.jtv.2025.100976","DOIUrl":"10.1016/j.jtv.2025.100976","url":null,"abstract":"<div><h3>Aim</h3><div>To explore neonatal intensive care unit (NICU) nurses’ attitude, adherence, and influencing factors to pressure injury (PI) prevention based on guidelines, and identify the relationship between the attitude and adherence.</div></div><div><h3>Methods</h3><div>A multi-site, quantitative, cross-sectional study spanning 16 provinces in China was conducted. Data were collected by a self-reported questionnaire, including three sections: demographic information, attitude towards PI prevention, and adherence to evidence-based PI prevention. The sample size was calculated using PASS 2025, and a convenience sampling method was conducted. The data were analyzed using SPSS 27, and univariate analysis and multiple logistic regression were employed to examine the relationship between demographic data and attitude and adherence to the PI prevention. Besides, the relationship between the APuP and the adherence was shown through the structural equation model (SEM), it was estimated in Amos 24.0.</div></div><div><h3>Results</h3><div>In total, 465 NICU nurses were included in this survey. The NICU nurses’ mean score of attitudes toward PI prevention was 78.06 %, with the highest mean score in the subscale of responsibility in PI prevention (85 %). The mean score of the PI prevention compliance was 132.93 ± 15.21, with a scoring rate of 88.62 %. The highest mean score was in the “skin assessment and care” subscale (41.51 ± 4.47, 92.24 %), followed by the “repositioning and mobilization” domain (22.92 ± 2.64, 91.68 %), and “medical device” domain (27.33 ± 3.29, 91.1 %). The nurses who had been trained in the PI prevention guideline were found to have 1.822 times the PI prevention attitude ≥75 % than those who did not undergo training (<em>P</em> = 0.008). In addition, clinical nurse specialist (CNS) were 1.684 times in the PI prevention practice adherence ≥90 % than those who were not (<em>P</em> = 0.028). The attitude towards PI prevention was determined to affect the adherence in the NICUs directly (β = 1.521, <em>P</em> &lt; 0.001), and a positive association was detected between attitude scores and adherence scores.</div></div><div><h3>Conclusion</h3><div>The level of attitude and the adherence of NICU nurses in China related to PI prevention were relatively desirable and poor, and a positive relationship was shown between the attitude and adherence.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100976"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADVERTISEMENT - JTV - CONFERENCE 2026 210X280MM","authors":"","doi":"10.1016/j.jtv.2026.100986","DOIUrl":"10.1016/j.jtv.2026.100986","url":null,"abstract":"","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100986"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure injury prevention knowledge in nursing professionals","authors":"Ainhoa Nieto-García ,&nbsp;Leticia Nieto-García ,&nbsp;María Alba Roca-Biosca ,&nbsp;María Teresa Moreiro-Barroso ,&nbsp;Adela Carpio-Pérez ,&nbsp;Montserrat Alonso-Sardón","doi":"10.1016/j.jtv.2025.100968","DOIUrl":"10.1016/j.jtv.2025.100968","url":null,"abstract":"<div><h3>Background</h3><div>Pressure injuries represent an important health problem in Spain, which affects all levels of care. Within nursing care, the prevention of this type of injury is considered a priority activity in which nursing staff have a primary role. Therefore, knowing the possible training needs allows planning and directing resources towards those areas where there is a greater knowledge deficit.</div></div><div><h3>Objective</h3><div>To assess nursing professionals' knowledge of pressure injury prevention guidelines.</div></div><div><h3>Method</h3><div>A descriptive cross-sectional study using the Pressure Injury Prevention Knowledge Questionnaire (PIPK), self-completed by nurses working in the Salamanca Health Area (Spain) between January 1, 2023 and December 31, 2024.</div></div><div><h3>Results</h3><div>A total of 164 respondents participated (89 % women), mean age 36 years and mean professional experience of 13 years. Of these, 132 nurses work at the University Hospital of Salamanca and 29 nurses work in primary care. The average global Knowledge Index was 85.2 % and the Ignorance Index was 7.78 %. Professionals with postgraduate or specialized nursing training (<em>P</em> = 0.003) and more years of experience (<em>P</em> = 0.004) achieved higher knowledge scores on the PIPK questionnaire, with consistent results across all services.</div></div><div><h3>Conclusion</h3><div>The level of knowledge of the nurses in the Salamanca Health Area is appropriate in relation to published literature.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100968"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of exosomes derived from platelet-rich plasma in angiogenesis of chronic diabetic wounds","authors":"Linlin Feng ,&nbsp;Yuan Xue ,&nbsp;Jingwen Kuang ,&nbsp;Huiyi Tang ,&nbsp;Pengcheng Xu","doi":"10.1016/j.jtv.2026.100985","DOIUrl":"10.1016/j.jtv.2026.100985","url":null,"abstract":"<div><div>With the ageing of the population, the incidence rate of diabetes is also increasing an-nually. Difficulties in healing chronic wounds are common complications of diabetes and are highly detrimental to people's quality of life. There are many reasons why wounds are diffi-cult to heal. Among these factors, one of the most important is the obstruction of angiogene-sis. As important players in wound healing, platelets not only promote tissue regeneration and repair but also participate in the regeneration of blood vessels, playing an important role in improving wound healing in chronic diabetes. Research has revealed that the use of exosomes derived from platelet-rich plasma can significantly improve chronic wound healing in patients with diabetes. Therefore, exosomes derived from platelet-rich plasma have emerged as new targets for the treatment of chronic diabetic wounds. However, the standardized isolation, characterization, mechanism of action, and application of exosomes derived from platelet-rich plasma in the study of angiogenesis in chronic diabetic wounds have not been systematically described. This article reviews the latest advancements in understanding the mechanism by which exosomes derived from platelet-rich plasma promote angiogenesis in chronic diabetic wounds. It also reviews the therapeutic effects of PRP-Exos (hydrogel) and other novel applications. Consequently, this study systematically examines the research status and gaps in the understanding of how exosomes derived from platelet-rich plasma promote angiogenesis in chronic diabetic wounds, aiming to provide a theoretical basis for the further development and application of these exosomes in clinical treatment.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"35 1","pages":"Article 100985"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}