Journal of tissue viability最新文献

{"title":"Exploration of current practice and context for the prevention and treatment of incontinence associated dermatitis for adults living in care homes and community settings: a qualitative study","authors":"Sue Woodward ,&nbsp;Tanya Graham ,&nbsp;Sangeeta Sooriah ,&nbsp;Christopher Chatterton ,&nbsp;Mandy Fader ,&nbsp;Joanne M. Fitzpatrick ,&nbsp;Hilary Gadd ,&nbsp;Ruth Harris ,&nbsp;Farzana Kausir ,&nbsp;Christine Norton ,&nbsp;Peter R. Worsley","doi":"10.1016/j.jtv.2025.100925","DOIUrl":"10.1016/j.jtv.2025.100925","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to explore current practice and context for the prevention and treatment of incontinence associated dermatitis (IAD), identify challenges and solutions, current prevention and treatment strategies, and products used.</div></div><div><h3>Materials and methods</h3><div>Using a qualitative cross-sectional approach online focus groups were conducted with stakeholders including experts by experience of IAD (n = 5) and health/care professionals (n = 16). Verbatim transcripts were coded independently by two researchers and analysed using framework analysis.</div></div><div><h3>Results</h3><div>Four themes and two sub-themes were identified: (1) Impact of IAD: “significant” damage could occur in a short space of time; (2) Uncertainty, is it IAD? Correct diagnosis of IAD was challenging, especially in people with black skin. Uncertainty was underpinned by a lack of education and clear guidance on skin inspection. (3) Lack of resources (sub-themes human resources and product resources): Lack of human resources related to the number of staff available, deficiency of knowledgeable and skilled staff, and limited leadership. Lack of availability of pads was a challenge and carers reduced the number of pad changes to “conserve pads”; (4) Variation in practice, both for cleansing skin and applying a leave-on ‘barrier’ product.</div></div><div><h3>Conclusion</h3><div>Care for adults with incontinence to prevent and/or treat IAD is challenging in the social care sector. Wide variation in practice exists and there is a need for educational interventions in the sector, targeting an international and transient workforce.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100925"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of enteral nutritional enriched with n-3 polyunsaturated fatty acids on postoperative wound infection following gastrointestinal surgery: A meta-analysis","authors":"Ming Zhang ,&nbsp;Hui-Juan Xiao ,&nbsp;Yue Li,&nbsp;Ping Zheng,&nbsp;Hua-Ying Yan","doi":"10.1016/j.jtv.2025.100919","DOIUrl":"10.1016/j.jtv.2025.100919","url":null,"abstract":"<div><h3>Background and aim</h3><div>Postoperative wound infections remain a significant challenge in gastrointestinal surgery, with substantial implications for prolonged hospital stays and healthcare costs. Immunonutrition with n-3 polyunsaturated fatty acids (PUFAs) offers potential preventive benefits through modulation of inflammatory responses. This study aimed to explore the impact of enteral nutritional enriched with n-3 PUFAs on wound infection in patients undergoing gastrointestinal surgery.</div></div><div><h3>Methods</h3><div>A thorough search was carried out, from databases to December 2023, across Cochrane Library, Embase, CNKI, Google Scholar, Wanfang, and PubMed on randomized controlled trials (RCTs) examining the impacts of enteral nutritional enriched with n-3 PUFAs for treatment of patients with gastrointestinal surgery. Two independent researchers conducted literature screening, data extraction, and quality assessments. The primary outcome measures were wound infection and complications. Statistical analysis was conducted in Stata 17.0 and RevMan 5.4 software.</div></div><div><h3>Results</h3><div>Fifteen RCTs involving 1442 patients who underwent gastrointestinal surgery were included. The analysis revealed the application of enteral nutritional enriched with n-3 PUFAs markedly decreased the occurrence of complications (odds ratio [OR] = 0.56, 95 % confidence intervals [CI]: 0.44–0.71, <em>P</em> &lt; 0.001) and wound infection (OR = 0.68, 95 %CI: 0.47–0.98, <em>P</em> = 0.04) in patients who underwent gastrointestinal surgery.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that postoperative support with enteral nutritional enriched with n-3 PUFAs can effectively decrease the occurrence of wound infections and postoperative complications following gastrointestinal surgery. These findings suggest that n-3 PUFAs supplementation should be considered as a standard component of perioperative nutritional protocols to improve surgical outcomes in patients undergoing gastrointestinal procedures.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100919"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare workers' knowledge, attitudes, practices, and influencing factors in the prevention of medical device-related pressure injuries: A scoping review","authors":"Yanling Hu ,&nbsp;Hanmei Peng ,&nbsp;Xia Li ,&nbsp;Xuemei Guo ,&nbsp;Ying-Xin Li ,&nbsp;Xi Huang ,&nbsp;Ru Yang ,&nbsp;Zeyao Shi ,&nbsp;Yuan Li","doi":"10.1016/j.jtv.2025.100916","DOIUrl":"10.1016/j.jtv.2025.100916","url":null,"abstract":"<div><h3>Objectives</h3><div>Medical device-related pressure injuries (MDRPIs) represent a significant iatrogenic complication in healthcare settings. Healthcare workers' competency in device management is crucial for MDRPI prevention, yet evidence regarding their preventive knowledge, attitudes, and practices remains fragmented. This study aims to synthesize evidence on assessment methods, current status, and influencing factors of healthcare workers' knowledge, attitudes, and practices in MDRPI prevention.</div></div><div><h3>Methods</h3><div>A scoping review was conducted following the Arksey and O'Malley framework. We systematically searched Medline, Embase, Web of Science, Scopus, and CINAHL databases from inception to December 18, 2024. Studies were considered if they examined healthcare workers' knowledge, attitudes, practices, or influencing factors regarding MDRPI prevention. Two independent researchers performed study selection and data extraction, with narrative synthesis of findings.</div></div><div><h3>Results</h3><div>Analysis of 20 studies across nine countries revealed substantial methodological heterogeneity in assessment approaches. While healthcare workers maintained positive attitudes toward prevention, knowledge assessment identified significant deficits, particularly in MDRPI concepts, staging classification, and preventive measures. Practice implementation varies considerably, with notable gaps in device repositioning, protective dressing application, and prevention strategy documentation. Prevention competencies were significantly influenced by individual factors (e.g., age, education, clinical experience) and institutional characteristics (e.g., hospital grade, department type).</div></div><div><h3>Conclusions</h3><div>This review identified substantial heterogeneity in assessment methods for MDRPI prevention competencies. While healthcare workers demonstrated positive attitudes, significant knowledge deficits persisted, with practice implementation showing considerable variations. Prevention initiatives should focus on developing standardized assessment tools and implementing targeted educational interventions, while considering both individual and institutional factors that influence prevention competencies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100916"},"PeriodicalIF":2.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition and quality of life in patients with a diabetes-related foot ulcer","authors":"Nada Bechara ,&nbsp;Fiona Hawke ,&nbsp;Jenny E. Gunton ,&nbsp;Peta Ellen Tehan","doi":"10.1016/j.jtv.2025.100913","DOIUrl":"10.1016/j.jtv.2025.100913","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to compare cognitive function and quality of life (QoL) in individuals with diabetes and a diabetes-related foot ulcer (DFU) to a control group with diabetes and no active foot ulceration.</div></div><div><h3>Materials &amp; methods</h3><div>A cross-sectional case-control study was conducted between December 2022 and August 2024. Forty-two adults with diabetes and an active DFU were compared to forty age- and sex-matched controls with diabetes but no DFU. Cognitive function was assessed using the Trail Making Test (TMT), and QoL was measured using the EuroQol EQ-5D-5L. Statistical analyses included Mann-Whitney U tests, logistic regression, and correlation analyses to evaluate differences and associations between cognitive function and QoL.</div></div><div><h3>Results</h3><div>Individuals with a DFU demonstrated significantly poorer cognitive function compared to controls, taking approximately twice as long to complete the TMT (p &lt; 0.001). Both rote memory (TMT-A) and executive functioning (TMT-B) were significantly impaired in the DFU group. QoL scores were also significantly lower in the DFU group (p = 0.005), with a notable association between cognitive impairment and reduced QoL (p = 0.01, r = −0.29). Logistic regression indicated that longer TMT completion time was associated with 4.13 increased odds of DFU (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Cognitive function is significantly impaired in individuals with DFU and is associated with poorer QoL. These findings highlight the need to integrate cognitive assessments into DFU management to optimise adherence and improve patient outcomes.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100913"},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance treatment continuum: A proposed clinical outcome to boost concordance with compression therapy","authors":"Chloe Jansz ,&nbsp;William McGuiness ,&nbsp;Sonja Cleary","doi":"10.1016/j.jtv.2025.100907","DOIUrl":"10.1016/j.jtv.2025.100907","url":null,"abstract":"<div><div>Research by MacGregor (2013)and shows that 1–3 % of the population experience chronic venous insufficiency (CVI). Among these individuals, 60–80 % develop venous leg ulcers (VLU), according to Nelson and Adderley (2016). However, patient adherence to compression therapy (CT)—the gold standard treatment for VLUs—remains low at 39.9 %, even for those whose ulcers have healed. This lack of concordance heightens the risk of ulcer recurrence (Erickson et al., 1995; Finlayson et al., 2014; Kapp et al., 2013), presenting a significant and costly challenge for healthcare systems (Smith &amp; McGuiness, 2010). Compression therapy works by enhancing venous return and reducing both venous pressure and stasis.</div><div>Two Delphi studies conducted revealed a combined 105 overall factors. Whilst clinicians and patients identified different factors that influence long term concordance, there was consensus around factors that contribute to comfort, motivation, access to health care, and clinician attributes. Further research is needed to combine these elements into a concise clinical guideline, a concordance treatment continuum, to assist both the clinician and patient to achieve long term concordance with CT, to improve clinical outcomes of VLU reoccurrence.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100907"},"PeriodicalIF":2.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds","authors":"Lan Chen,&nbsp;Jia Liu,&nbsp;Yaoyao He,&nbsp;Chongcong Zeng,&nbsp;Weixiang Liao,&nbsp;Chaoxi Luo","doi":"10.1016/j.jtv.2025.100917","DOIUrl":"10.1016/j.jtv.2025.100917","url":null,"abstract":"<div><h3>Aim</h3><div>Exosomes, small endosome-derived membrane vesicles, have shown significant potential as wound healing therapies. However, translating experimental research into commercially available treatments remains a challenge.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis provide a comprehensive evaluation of the current research on exosome-based wound healing therapies.</div></div><div><h3>Materials and methods</h3><div>A systematic search of PubMed and Google Scholar was conducted to identify full-text articles published between 2010 and February 2024 on mammalian-derived exosomes in wound healing. Of 138 identified studies, 19 met the inclusion criteria for meta-analysis.</div></div><div><h3>Results</h3><div>Exosome-based therapies were found to enhance wound healing by promoting angiogenesis, re-epithelialization, and collagen deposition while reducing scar formation. However, research in this area is highly variable, with differences in cell sources, biomaterials, and delivery methods.</div></div><div><h3>Conclusions</h3><div>Further comparative studies are needed to optimize cellular sources, delivery systems, and biomaterials. The reliance on rodent models remains a limitation, as progress toward large-scale testing and more advanced in vivo models has been slow. Addressing these challenges is crucial for the clinical translation of exosome-based therapies into scalable, commercially viable wound healing treatments.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100917"},"PeriodicalIF":2.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' practices in preventing medical device-related pressure injuries in neonates in Saudi Neonatal Intensive Care Units","authors":"Ahmad Ismail ,&nbsp;Ameera Suhail Alghamdi ,&nbsp;Hanadi Abdullah Alzbeedi ,&nbsp;Mashael F. Dewan ,&nbsp;Dena Attallah","doi":"10.1016/j.jtv.2025.100909","DOIUrl":"10.1016/j.jtv.2025.100909","url":null,"abstract":"<div><h3>Background</h3><div>Neonatal pressure injury due to medical devices is prevalent, especially in the Neonatal Intensive Care Units (NICU). Nurses play a significant role in preventing medical device-related pressure injuries (MDRPI) in neonates. However, NICU nurses' practices in preventing MDRPI are not well known in Saudi Arabia.</div></div><div><h3>Objective</h3><div>This study aimed to assess nurses' practices in preventing the MDRPI in the NICU in Saudi Arabia.</div></div><div><h3>Methods</h3><div>A quantitative cross-sectional design was used to capture information from 82 NICU nurses working in two hospitals in Jeddah, Saudi Arabia (private and governmental). Nurses' practices were assessed using a self-reported questionnaire of two main parts: 1) demographic and work-related factors, and 2) nurses' practices regarding preventing MDRPI. Data were analyzed using descriptive statistics, frequencies, percentages, and independent t-tests.</div></div><div><h3>Results</h3><div>The total practice score for the MDRPI was moderate (3.8/5 ± 1.4). A substantial proportion of nurses never or rarely performed some important practices to prevent MDRPI in the NICU. Nurses who received education/training on pressure ulcers and MDRPI achieved a significantly higher practice score for MDRPI prevention than those who did not (P &lt; 0.05). Nurses who reported having a policy or protocol at their units for MDRPI achieved a significantly higher practice score for MDRPI prevention than those who did not (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Although the practice score of NICU nurses to prevent MDRPI was moderate, many nurses never or rarely employed some important practices to prevent MDRPI in the NICU. Targeted interventions are needed to educate NICU nurses on MDRPI prevention. Future research should recruit more nurses from various NICUs in Saudi Arabia.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100909"},"PeriodicalIF":2.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atmospheric plasma control excessive inflammation and oxidative stress in burn wound healing in diabetes-induced rats","authors":"Jennyffer Souza ,&nbsp;Amanda Tavares Pereira ,&nbsp;Letícia de Lima ,&nbsp;Raul Wiltler ,&nbsp;Maraiara Aparecida de Oliveira ,&nbsp;Samara de Sousa Mariano ,&nbsp;Leonardo Bagne ,&nbsp;Bruno Bellotti Lopes ,&nbsp;Maria Esméria Corezola do Amaral ,&nbsp;Gustavo de Bem Silveira ,&nbsp;Laura de Roch Casagrande ,&nbsp;Paulo Cesar Lock Silveira ,&nbsp;Andrea Aparecida de Aro ,&nbsp;Thiago Antônio Moretti de Andrade","doi":"10.1016/j.jtv.2025.100918","DOIUrl":"10.1016/j.jtv.2025.100918","url":null,"abstract":"<div><div>Burns are the fourth most prevalent trauma worldwide, and their complications are significantly exacerbated when associated with diabetes, leading to increased morbidity and mortality. This study addresses the urgent need for safe and effective treatments by exploring the therapeutic potential of atmospheric plasma (AP), an ionized gas produced at atmospheric pressure, in enhancing the healing of burn wounds. We investigated the effects of AP on the repair of second-degree dorsal burns in Wistar rats, induced to diabetes with alloxan (45 mg/kg). The animals were randomly assigned to either the sham group (plasma generator off) or the AP group (treated with AP for 1 min daily until the 2nd, 7th, 14th and 21st days). Our findings indicate that AP treatment significantly reduced inflammatory cell accumulation, increased interleukin levels, controlled oxidative damage, and stimulated antioxidant responses. Furthermore, AP promoted angiogenesis, fibroblast proliferation, and collagen fiber organization. These results suggest that AP accelerates tissue healing in diabetic burns, making it a promising treatment for improving burn wound healing in diabetes-induced conditions.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100918"},"PeriodicalIF":2.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving concordance with long-term compression therapy amongst people with venous ulceration: A Delphi study- clinician cohort.","authors":"Chloe Jansz, William McGuiness, Sonja Cleary","doi":"10.1016/j.jtv.2025.100908","DOIUrl":"https://doi.org/10.1016/j.jtv.2025.100908","url":null,"abstract":"<p><p>Research by Nelson and Adderley (2016)reveals that 60-80 % of individuals affected by chronic venous insufficiency (CVI) develop venous leg ulcers (VLU). The gold standard treatment for VLU is the application of compression therapy (CT), which promotes venous return, reduces venous pressure, and minimizes stasis (Bullock & Manias, 2022). Patient concordance to CT is suboptimal, with only 40 % concordance, leading to a higher risk of VLU recurrence (Eri ckson et al., 1995; Fi nlayson et al., 2014; K app et al., 2013). This poses a significant and costly healthcare challenge (Smith & McGuiness, 2010). A Delphi study was conducted to ascertain the factors that influence concordance with CT using a clinician cohort. The study asked participants to rank factors that facilitated concordance and those that acted as barrier. Results revealed that clinicians identified 44 factors that facilitated concordance and 46 factors that acted as a barrier in the initial phase. The consensus level, measured by a Kendall W Coefficient, ranged from moderate to strong amongst the participants (Zanotti & Chiffi, 2015).</p>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":" ","pages":"100908"},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker of pressure injuries in critically ill adults based on large-scale medical Datasets:A multi-center prospective study","authors":"Lin Lv ,&nbsp;Ning Wang ,&nbsp;Yanxia Jiao ,&nbsp;Anna Wen ,&nbsp;Jie Xu ,&nbsp;Xinyue Xu ,&nbsp;Li Du ,&nbsp;Lin Han","doi":"10.1016/j.jtv.2025.100912","DOIUrl":"10.1016/j.jtv.2025.100912","url":null,"abstract":"<div><h3>Objectives</h3><div>Pressure injuries (PIs) are a global health concern, particularly in the context of an ageing population. They impose significant economic and social burdens, serve as key indicators of nursing quality, and are associated with increased mortality and morbidity.</div></div><div><h3>Methods</h3><div>We conducted a multi-center prospective descriptive study involving 3867 critically ill adults admitted to ICUs across 28 hospitals in Gansu Province, China, from April 1, 2021, to July 31, 2023. Data were collected using the “Long Hu Hui” PI risk management platform, which covers 98 indicators.</div></div><div><h3>Results</h3><div>The incidence of hospital-acquired PIs was 5.20 %. Univariate analysis identified 15 significant indicators associated with PIs, including body temperature, blood oxygen saturation, and central venous pressure. Logistic regression analysis revealed body temperature, diastolic blood pressure, blood oxygen saturation, haemoglobin, central venous pressure, and blood urea nitrogen as independent risk factors for PIs. A clinical prediction model was developed, demonstrating superior predictive performance compared to existing scales.</div></div><div><h3>Conclusions</h3><div>This study identified key physiological and biochemical markers associated with developing PIs in critically ill adults. The developed prediction model offers a more accurate tool for clinical risk assessment and may guide preventive strategies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100912"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}