Journal of tissue viability最新文献

{"title":"Silicone adhesive multilayer foam dressings to prevent hospital-acquired sacrum pressure ulcers: An economic evaluation based on a publicly funded pragmatic randomized controlled trial linked with real-world data","authors":"Mattias Neyt ,&nbsp;Christophe De Meester ,&nbsp;Stephan Devriese ,&nbsp;Elisabeth Marynen ,&nbsp;Dimitri Beeckman","doi":"10.1016/j.jtv.2024.08.011","DOIUrl":"10.1016/j.jtv.2024.08.011","url":null,"abstract":"<div><h3>Objectives</h3><div>To estimate the cost-effectiveness of sacrum multilayer silicone foam dressings as an adjuvant prophylactic therapy compared to standard pressure ulcer prevention in a hospital population at high risk for pressure ulcer development.</div></div><div><h3>Methods</h3><div>An economic evaluation is performed from a healthcare payer's perspective. This evaluation is based on a Belgian publicly funded pragmatic randomized controlled trial (RCT), linked with real-world data from administrative claims database and a Belgian cost analysis. A cost-consequences analysis with a one-year time horizon is performed.</div></div><div><h3>Results</h3><div>The RCT has shown that the risk of developing a new pressure ulcer on the sacrum was statistically significantly reduced by 41 % in the treatment group (RR = 0.59, 95 % CI 0.35–0.98, p = 0.04). The absolute risk reduction of 2.0 % (95 % CI -0.1–4.1 %) coincides with a number needed to treat of 50.0 to prevent one new pressure ulcer of category II or worse. The evolution of quality of life is on average negative for patients who developed a pressure ulcer before day 3, while it is positive for patients without pressure ulcers. In a scenario with conservative assumptions, i.e. without inclusion of price discounts for the multilayer silicone foam dressings and only including costs during the hospitalization, pressure ulcer prevention with dressings on the sacrum was already cost-neutral.</div></div><div><h3>Conclusions</h3><div>The preventive use of silicone adhesive multilayer foam dressings on the sacrum for a population similar to the pragmatic trial population can be supported both from a clinical and economic point of view.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 772-777"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142186013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does the training given to intensive care nurses affect their attitudes toward preventing pressure ulcers?","authors":"Handan Topan ,&nbsp;Özlem Ceyhan ,&nbsp;Meral Başaran","doi":"10.1016/j.jtv.2024.10.004","DOIUrl":"10.1016/j.jtv.2024.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to determine the effect of training in the prevention/treatment of pressure ulcers on nurses' attitudes.</div></div><div><h3>Material method</h3><div>The study was conducted experimentally in a pretest-posttest design. Training was given to nurses participating in the study with content prepared by \"Wound and Ostomy Incontinence Nurses Association\" guide. The study was conducted between August and October with nurses working in Level 3 intensive care units. The study was completed with 79 nurses. Before the training was given, the \"Nurse Introduction Form\" and \" Attitude Towards Pressure Ulcer Prevention Instrument (ATPUPI)\" form were applied to those. All nurses were re-administered the ATPUPI scale three months after the training to evaluate their attitudes. Frequency analysis, descriptive statistics, one-way ANOVA, and independent sample tests were used in statistical analyses.</div></div><div><h3>Results</h3><div>Th<strong>e</strong> mean age of the nurses was 29.62 ± 5.74 years, the mean length of service was 71.77 ± 77.19 months, 94.9 % were graduates, and 82.3 % worked in shifts. The mean scores before the training were 44.53 ± 4.13 and 45.12 ± 2.53 after the training. It was determined that there was a significant difference between the nurses who did not receive training on pressure ulcers other than undergraduate education and those who obtained training in terms of the mean score of ATPUPI. Still, after the training, the mean scores reached a similar level, and this difference disappeared. The increase in the mean scores of those who did not receive any education other than undergraduate education was found to be statistically significant.</div></div><div><h3>Conclusion</h3><div>As a result of our study, intensive care nurses' attitudes toward preventing pressure ulcers were found to be at a high level. It was found that the training given to nurses who had not received training on pressure ulcers other than undergraduate education had a significant positive effect on their attitudes. According to this result, it is recommended that in-service training should be given from the moment they start intensive care and repeated at regular intervals to ensure continuity in knowledge, attitude, and care behavior.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 802-807"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between pressure ulcer knowledge and self-efficiency among nursing students: A multicenter study","authors":"Aysun Bayram ,&nbsp;Yasemin Şara ,&nbsp;Füsun Uzgör ,&nbsp;Havva Öztürk","doi":"10.1016/j.jtv.2024.06.017","DOIUrl":"10.1016/j.jtv.2024.06.017","url":null,"abstract":"<div><h3>Aim</h3><div>To determine the relationship between the knowledge and self-efficiency regarding pressure ulcers of nursing students.</div></div><div><h3>Methods</h3><div>This descriptive and correlational study was conducted with 775 nursing students from three different universities in various regions of Turkey. The “Pressure Ulcer Knowledge Assessment Tool-Updated Version” and “Pressure Ulcer Management<span> Self‐Efficiency Scale for Nurses” tool were used to collect data between May and September 2023. The Strengthening the Reporting of Observational Studies checklist was followed to report this study.</span></div></div><div><h3>Results</h3><div>The mean knowledge score was 7.27 <strong>±</strong> 3.09, and the mean self-efficiency on pressure ulcer management score was 35.5 ± 18.3. A statistically significant positive correlation was found between nursing students' knowledge and self-efficiency mean scores regarding pressure ulcers (p &lt; 0.05). A significant difference was also found between the students’ academic levels and gender and their knowledge and self-efficiency scores regarding pressure ulcers.</div></div><div><h3>Conclusion</h3><div>In this study, where the data covers these three institutions, students' pressure ulcer knowledge and self-efficiency scores were lower compared to all academic years. Accordingly, it was also determined that students with more nursing practice experience showed higher knowledge and self-efficacy scores than students with less nursing practice experience. Additionally, the students' self-efficacy increased along with their knowledge level. Training courses may be suggested to improve students’ knowledge and self-efficiency regarding pressure ulcers.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 681-687"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's skin care behaviors: How to influence sunscreen use","authors":"Tian Chen ,&nbsp;Chao Yuan ,&nbsp;Mengzhen Zhao","doi":"10.1016/j.jtv.2024.06.015","DOIUrl":"10.1016/j.jtv.2024.06.015","url":null,"abstract":"<div><h3>Background</h3><div>It is well known that women have been plagued by various skin problems. However, research on the characteristics of women's skin at different ages is still inadequate. In addition, there is a lack of research on the extent of women's skincare habits and skin care awareness.</div></div><div><h3>Methods</h3><div>A cross-sectional survey on skin was carried out in Shanghai, China, which was conducted by means of a questionnaire. 3678 women, aged 18–59 years, participated in the study. The information collected focused on the importance they place on their skin, the skin problems they have, and their use and perception of skin care products.</div></div><div><h3>Results</h3><div>Before the age of 25, the most common skin problems that women face are dryness and oiliness, while after the age of 30, skin-ageing issues begin to appear and worsen with age. In addition, the higher the level of education, the higher the frequency of and compliance with sunscreen<span> use, and the economy also affects women's use of sunscreen. Importantly, the importance women place on their skin and the level of sunscreen awareness affects women's use of sunscreen.</span></div></div><div><h3>Conclusions</h3><div>This study was conducted to understand the skin characteristics of women of different age groups as well as to determine the factors that influence the use of sunscreens, which will not only promote women's skin care practices and product development, but also provide important clues for future activities on sunscreen use and health promotion.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 840-845"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of social isolation in patients with varicose veins of the lower extremities: A scoping review","authors":"Yunjiao Wang ,&nbsp;Rui Li ,&nbsp;Liping Bai ,&nbsp;Zhuanfang Zou ,&nbsp;Chunyan Zheng ,&nbsp;Feijin Peng ,&nbsp;Shuzhen Wang ,&nbsp;Yujin Yang","doi":"10.1016/j.jtv.2024.09.012","DOIUrl":"10.1016/j.jtv.2024.09.012","url":null,"abstract":"<div><h3>Objectives</h3><div>To undertake a scoping review of the literature on social alienation in patients with lower extremity varicose veins in order to serve as a reference for future studies in the field.</div></div><div><h3>Methods</h3><div>With a focus on the phenomenon of social alienation in patients with varicose veins of the lower extremities, a systematic search of Chinese and English databases was carried out using the scoping review methodology as a framework. The included literature was summarized and analyzed with a time frame from database construction to June 24, 2024.</div></div><div><h3>Results</h3><div>A total of 15 publications were included, demonstrating that social alienation is a frequent occurrence in people with varicose veins of the lower extremities but has not yet received much attention. In individuals with varicose veins of the lower limbs, demographic factors, illness issues, psychological problems, and social factors are the key influences on social alienation.</div></div><div><h3>Conclusion</h3><div>Social alienation is a common phenomenon that is unevenly distributed in patients with varicose veins of the lower leg and is influenced by a number of different circumstances. In order to better meet the social needs of patients, healthcare professionals should pay attention to the issue of social alienation in patients with varicose veins of the lower extremity, identify and implement intervention strategies quickly, and actively explore a new model of treatment and care for social alienation.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 930-937"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of COVID-19 on the care of diabetic foot ulcers: A scoping review","authors":"Sinead Flynn ,&nbsp;Ellen Kirwan ,&nbsp;Claire MacGilchrist ,&nbsp;Caroline McIntosh","doi":"10.1016/j.jtv.2024.06.016","DOIUrl":"10.1016/j.jtv.2024.06.016","url":null,"abstract":"<div><h3>Aim</h3><div>The aims and objectives of this scoping review were to conduct a systematic search of the literature to identify the nature and extent of the research evidence to which the COVID-19 pandemic impacted and disrupted the care of Diabetic Foot Ulcers (DFU) and the subsequent impact on patient outcomes. Secondly, to identify transformation in models of care and service delivery, adoption of innovative technologies and new models of service innovations, including modalities such as telehealth that were adopted during the pandemic.</div></div><div><h3>Methods</h3><div>This systematic scoping review was conducted in accordance with the Joanna Briggs Institute methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping reviews (PRISMA-ScR).</div></div><div><h3>Results</h3><div>Nineteen papers were included. These studies explored aspects of care for DFUs during the COVID-19 pandemic. The focus of these studies ranged from exploring new modalities of care such as telehealth, reporting of clinical outcomes, development of triage systems and patient behaviors during COVID-19.</div></div><div><h3>Conclusion</h3><div>Ten of twelve studies reported on DFU outcomes and reported a worsening of outcomes compared to pre-pandemic times. Reduced DFU presentations, alongside an increase in urgent hospitalisations and amputation, were key themes that emerged from this review. More high-quality evidence is needed to establish any longer-lasting effects of the Covid-19 pandemic on people living with DFU. Further, there is a lack of evidence relating to the feasibility and success of telemedicine and limited data on changes to service delivery, including triage systems in this patient cohort.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 521-529"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterising mobility and pressure exposure in community dwelling residents with pressure ulcers using monitoring technology and intelligent algorithm","authors":"Silvia Caggiari ,&nbsp;Nicci Aylward-Wotton ,&nbsp;Bridie Kent ,&nbsp;Peter R. Worsley","doi":"10.1016/j.jtv.2024.07.005","DOIUrl":"10.1016/j.jtv.2024.07.005","url":null,"abstract":"<div><h3>Aim</h3><div>Individuals in the community with reduced mobility are at risk of exposure to prolonged lying and sitting postures, which may cause pressure ulcers. The present study combines continuous pressure monitoring technology and intelligent algorithms to evaluate posture, mobility, and pressure profiles in a cohort of community dwelling patients, who had acquired pressure ulcers.</div></div><div><h3>Materials and methods</h3><div>This study represents a secondary analysis of the data from the Quality Improvement project ‘Pressure Reduction through COntinuous Monitoring In the community SEtting (PROMISE)’. 22 patients with pressure ulcers were purposely selected from 105 recruited community residents. Data were collected using a commercial continuous pressure monitoring system over a period of 1–4 days, and analysed with an intelligent algorithm using machine learning to determine posture and mobility events. Duration and magnitude of pressure signatures of each static posture and exposure thresholds were identified based on a sigmoid relationship between pressure and time.</div></div><div><h3>Results</h3><div>Patients revealed a wide range of ages (30–95 years), BMI (17.5–47 kg/m²) and a series of co-morbidities, which may have influenced the susceptibility to skin damage. Posture, mobility, and pressure data revealed a high degree of inter-subject variability. Largest duration of static postures ranged between 1.7 and 19.8 h, with 17/22 patients spending at least 60 % of their monitoring period in static postures which lasted &gt;2 h. Data revealed that many patients spent prolonged periods with potentially harmful interface pressure conditions, including pressure gradients &gt;60 mmHg/cm.</div></div><div><h3>Conclusion</h3><div>This study combined posture, mobility, and pressure data from a commercial pressure monitoring technology through an intelligent algorithm. The community residents who had acquired a pressure ulcer at the time of monitoring exhibited trends which exposed their skin and subdermal tissues to prolonged high pressures during static postures. These indicators need further validation through prospective clinical trials.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 693-700"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can thermography predict diabetic foot ulcer risk in patients with diabetes mellitus? A systematic review","authors":"Divyeshz Thakku Sivakumar ,&nbsp;Bridget Murray ,&nbsp;Zena Moore ,&nbsp;Declan Patton ,&nbsp;Tom O'Connor ,&nbsp;Pinar Avsar","doi":"10.1016/j.jtv.2024.06.018","DOIUrl":"10.1016/j.jtv.2024.06.018","url":null,"abstract":"<div><h3>Background</h3><div>There is a growing prevalence of diabetic foot ulcers (DFUs) in patients with diabetes mellitus and the use of thermography has sparked interest in a non-invasive diagnostic method for early DFU risk assessment and management.</div></div><div><h3>Aim</h3><div>This systematic review aims to assess the use of thermography in predicting diabetic foot ulcer risk in patients with diabetes mellitus.</div></div><div><h3>Methods</h3><div>A systematic search of publications using MEDLINE, CINAHL, and Cochrane databases was conducted in April 2023, and relevant articles were reviewed. Data was extracted and a narrative synthesis was undertaken. The evidence-based librarianship (EBL) checklist assessed the methodological quality of the studies included. Reviewing these articles to the primary and secondary outcomes of this literature review. The primary outcome focused on the predictive capabilities of thermography for DFU prediction, while the secondary outcome assessed the feasibility, usability, and effectiveness of thermography.</div></div><div><h3>Results</h3><div>Eight studies were conducted from 1994 to 2021 with an emphasis on the predictability of thermography in predicting DFU risk. All eight studies focused on temperature variations associated with DFU development. Six of the included studies compared the effectiveness of DFU occurrence in diabetic patients and non-DFU use. The overall results showed that employing thermography in DFU prevention might allow for early detection and intervention, offering a non-invasive and effective means to reduce the risk of DFU development and its associated complications in patients with diabetes mellitus.</div></div><div><h3>Conclusion</h3><div>The systematic review indicates that thermography holds promise for predicting DFU risk, with studies showcasing predictive capabilities and patient benefits. Despite some challenges and limitations, the evidence suggests thermography's value in assessing DFU risk in diabetes patients, warranting further research on device types and locations.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 530-541"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges to therapeutic footwear usage for foot ulcer prevention among type 2 diabetes patients: A qualitative study","authors":"Wangqiao Zhu ,&nbsp;Khanitta Nuntaboot ,&nbsp;Jia Liu ,&nbsp;Liuxue Lu ,&nbsp;Qiuhuan Huang","doi":"10.1016/j.jtv.2024.04.011","DOIUrl":"10.1016/j.jtv.2024.04.011","url":null,"abstract":"<div><h3>Objective</h3><div>Many contemporary designs solely prioritize the therapeutic function of footwear, neglecting other crucial social and environmental considerations. The study aimed to explore challenges to therapeutic footwear usage for foot ulcer prevention.</div></div><div><h3>Methods</h3><div>A qualitative critical ethnography design was used in this study. Fourteen participants were recruited at the local hospital in Baise City, China. Data were collected through in-depth interview. A thematic analysis approach was conducted for data analyzing.</div></div><div><h3>Results</h3><div>This study identified two themes: (1) workplace and physical condition, (2) diverse cultural practice. It was worth noting that slipper as a convenient and cheap wearing choice, decreased the usage of therapeutic footwear. The emerging activity of modern square dancing resulted in more requirements for its design. And the symbolic meaning of hard working in barefoot was also challengeable to therapeutic footwear utilization to some extent.</div></div><div><h3>Conclusions</h3><div>Therapeutic footwear intervention design should not only focus on the therapeutic functionality, but also consider about individuals’ demands towards working environment and physical status, and particular insights regarding culture and social background. We expected these findings could be evidence for improving therapeutic footwear usage in the future.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 515-520"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140827019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the diagnostic accuracy of inflammatory markers for infected diabetic foot ulcer","authors":"Hua Chen ,&nbsp;Shasha Mei ,&nbsp;Yu Zhou ,&nbsp;Jiezhi Dai","doi":"10.1016/j.jtv.2024.09.007","DOIUrl":"10.1016/j.jtv.2024.09.007","url":null,"abstract":"<div><h3>Background</h3><div>The aim was to evaluate the diagnostic value of ESR, CPR, PCT, and WBC in patients with infected diabetic foot ulcer (DFU).</div></div><div><h3>Methods</h3><div>The MEDLINE, Embase, BIOSIS, Cochrane databases, and Web of Knowledge databases were searched, without language restriction, to July 2023. Original studies were selected that reported the performance of ESR, CPR, PCT, and WBC in diagnosing infected DFU. To assess the diagnostic value of biomarkers for infected DFU, pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (ROC-AUC) were calculated.</div></div><div><h3>Results</h3><div>Ten studies with 765 patients were identified in our meta-analysis. The pooled sensitivity and specificity of ESR was 0.82 (95 % CI: 0.68–0.91) and 0.83 (95 % CI: 0.69–0.91) respectively. The pooled sensitivity and specificity of CRP was 0.81 (95 % CI: 0.65–0.91) and 0.91 (95 % CI: 0.79–0.96) respectively. The pooled sensitivity and specificity of PCT was 0.76 (95 % CI: 0.65–0.85) and 0.89 (95 % CI: 0.78–0.95) respectively. The pooled sensitivity and specificity of WBC was 0.75 (95 % CI: 0.64–0.83) and 0.79 (95 % CI: 0.67–0.88) respectively. CRP showed the best diagnostic accuracy at distinguishing infected DFU from noninfected DFU with an AUC of 0.93, followed by PCT (AUC of 0.89), ESR (AUC of 0.89), and WBC (AUC of 0.84).</div></div><div><h3>Conclusion</h3><div>CPR levels had high efficiency in distinguishing infected DFU from noninfected DFU, followed by PCT, ESR and WBC. All of these biomarkers could be helpful for early diagnosis of infected DFU. New biomarkers for improving medical decision in diagnosis of infected DFU are highly desirable.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"33 4","pages":"Pages 598-607"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}