Journal of tissue viability最新文献

{"title":"Critical analysis of hot topics in diabetic nephropathy related experimental research: A bibliometric analysis from 2018 to 2024","authors":"Youduo Jia ,&nbsp;Yunfei Gu ,&nbsp;Lijun Wang ,&nbsp;Nan Jiang ,&nbsp;Xiumei Yu ,&nbsp;Hu Tian","doi":"10.1016/j.jtv.2025.100854","DOIUrl":"10.1016/j.jtv.2025.100854","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and a leading cause of end-stage renal disease worldwide. Understanding trends in experimental research on DN is crucial for advancing knowledge and clinical management.</div></div><div><h3>Objective</h3><div>This study aimed to explore current trends in DN related experimental research, utilizing CiteSpace, VOSviewer, and Bibliometrix to identify key contributors, influential countries, and noteworthy topics. The objective was to provide valuable insights for healthcare professionals and researchers in the field.</div></div><div><h3>Methods</h3><div>Relevant publications from the Web of Science Core Collection Science Citation Index Expanded were retrieved for the period between 2018 and 2024. CiteSpace, VOSviewer, and Bibliometrix were employed for data analysis, including identifying top authors, institutions, countries, keywords, co-cited authors, journals, references, and research trends.</div></div><div><h3>Results</h3><div>A total of 1501 relevant articles were included in the study. DN related experimental research exhibited an upward trend, reaching its peak in 2023. Key contributors such as Kretzler Matthias, Li Ping, and Rossing Peter emerged. China, the United States and Japan have the most publications. Keyword analysis revealed \"activated protein kinase\" as the most central keyword, while \"diabetic nephropathy\" had the highest citation rate. Recent focus shifted towards keywords like \"Traditional Chinese Medicine\" and \"molecular docking.\"</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis provides insights into trends in experimental research on DN from 2018 to 2024. Notable contributors and influential countries were identified, emphasizing global collaboration. Key topics demonstrate diverse approaches and emerging trends, supporting informed decision-making and innovation in combatting DN and enhancing patient outcomes.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 1","pages":"Article 100854"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting medical device-related pressure ulcers: An international Delphi consensus study","authors":"Ewa Crunden ,&nbsp;Susanne Coleman ,&nbsp;Lisette Schoonhoven ,&nbsp;Peter R. Worsley","doi":"10.1016/j.jtv.2024.11.006","DOIUrl":"10.1016/j.jtv.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Pressure ulcers that are caused from the application of medical devices for diagnostic or therapeutic purposes are commonly observed in acute care environments. Despite an improved understanding of the factors causing these wounds, there is no current consensus on reporting.</div></div><div><h3>Objective</h3><div>To develop an international consensus for reporting medical device related pressure ulcers.</div></div><div><h3>Design</h3><div>A modified RAND/UCLA Delphi study.</div></div><div><h3>Settings</h3><div>International experts from clinical, academic and industrial stakeholder.</div></div><div><h3>Participants</h3><div>95 international clinicians and tissue viability experts.</div></div><div><h3>Methods</h3><div>A Delphi survey was developed through literature review and qualitative synthesis. It was electronically disseminated through gate keepers to international experts in the field, with three rounds of consensus feedback. Median values and Disagreement Index from Likert scales were used to establish consensus.</div></div><div><h3>Results</h3><div>The panel achieved consensus for reporting MDRPUs which included 30 items across 5 Themes which included i) Recording medical device care, ii) Reporting medical device-related pressure ulcer, iii) Device specific reporting, iv) Ulcer reporting and v) patient information.</div></div><div><h3>Conclusions</h3><div>This is the first international study to develop consensus on medical device related pressure ulcer reporting. This could be used to support standardised international reporting to improve care standards.</div></div><div><h3>Tweetable abstract</h3><div>This international Delphi consensus study established a core reporting data set for medical device related pressure ulcers. This study will inform the design of future reporting tools to support standardised practice.e.g. Tweetable abstract: international consensus on medical device related pressure injury monitoring <span><span>@EPUAP</span><svg><path></path></svg></span> <span><span>@NPIAP</span><svg><path></path></svg></span> <span><span>@SkinSensing</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 1","pages":"Article 100834"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean platelet volume as a prognostic indicator in skin graft viability: A clinical study and retrospective analysis","authors":"Percin Caskan ,&nbsp;Semra Bulbuloglu ,&nbsp;Ozge Deryol","doi":"10.1016/j.jtv.2024.11.008","DOIUrl":"10.1016/j.jtv.2024.11.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Skin grafting is the transplantation of partial-thickness or full-thickness skin from the donor to the recipient site, aiming to close tissue defects. However, skin graft transplantation surgery is not always successful and graft loss may occur after a while.</div></div><div><h3>Objective</h3><div>This study aimed to investigate mean platelet volume (MPV) as a prognostic criterion in patients who underwent wound reconstruction with skin graft.</div></div><div><h3>Method</h3><div>This study was cross-sectional and descriptive. The study sample consisted of n = 66 patients who underwent skin grafting for tissue loss. Wound and graft characteristics and some blood parameters were analyzed. Friedman, Kruskal Wallis, and Bonferroni tests were used for data analysis.</div></div><div><h3>Results</h3><div>The results of this study showed that MPV levels were higher in complex wounds and graft loss than in the others. MPV level was higher in patients with full-thickness skin grafts than in patients with split-thickness grafts. The mean MPV of patients who underwent multiple grafting was higher than single-shot (p &lt; 0.01). There was a positive, strong and statistically significant correlation between serum PCT and MPV in the preoperative period (r = 0.288, p = 0.041) and between MPV and CRP on the 5th postoperative day (r = 0.294, p = 0.045).</div></div><div><h3>Conclusion</h3><div>In this study, MPV increased with increasing wound and graft complexity. Additionally, multiple grafting was statistically associated with an increase in MPV. There was a strong correlation between MPV and serum PCT and CRP at varying measurement times. These results suggest that MPV has the potential to increase in the presence of inflammation just like CRP and serum PCT.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 1","pages":"Article 100836"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adults living with dementia and chronic wounds, wound types, care challenges, and impact across dementia stages: A scoping review protocol","authors":"Kimberly LeBlanc ,&nbsp;Kevin Woo ,&nbsp;Georgina Gethin ,&nbsp;Dimitri Beeckman ,&nbsp;Corey Heerschap ,&nbsp;Madhuri Reddy ,&nbsp;Christina Parker ,&nbsp;Margaret MacAndrew ,&nbsp;Foy White-Chu ,&nbsp;Samantha Wiesenfeld","doi":"10.1016/j.jtv.2024.12.009","DOIUrl":"10.1016/j.jtv.2024.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this scoping review is to map the existing evidence on the epidemiology, care challenges, and impacts of various wound types among individuals living with dementia across different stages of the disease.</div></div><div><h3>Introduction</h3><div>Dementia is a growing global health concern, projected to rise significantly as the population ages. This condition not only affects cognitive function but also increases the risk of chronic wounds in part due to impairments in mobility, self-care, and communication. Current wound care guidelines inadequately address the specific needs of individuals with dementia. This scoping review seeks to fill this gap by comprehensively exploring the intersection between dementia and wound care.</div></div><div><h3>Inclusion criteria</h3><div>This review will include studies involving adults aged 18 and older diagnosed with dementia or cognitive impairment who are experiencing alterations in skin integrity, such as pressure injuries, venous and arterial ulcers, and diabetic ulcers. Both qualitative and quantitative studies will be considered, as well as studies focusing on the challenges faced by caregivers in managing wounds in this population. Excluded are studies such as editorials and opinion articles.</div></div><div><h3>Methods</h3><div>A comprehensive search strategy will be employed across multiple electronic databases, including MEDLINE, CINAHL, PsycINFO, EMBASE, and PubMed, as well as grey literature sources like ProQuest Dissertations &amp; Theses Global and OpenGrey. The search will include studies published in English and French without date restrictions. Data will be extracted using a pilot-tested tool and presented in graphical, diagrammatic, and tabular formats. A narrative summary will accompany these visuals, providing context and insights into the data in relation to the review's objectives.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 1","pages":"Article 100845"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the dynamics of postoperative edema in free flaps: A hyperspectral insight through linear mixed models","authors":"Lukas Viktor Dirschedl,&nbsp;Cosima Prahm,&nbsp;Adrien Daigeler,&nbsp;Jonas Kolbenschlag,&nbsp;Ruth Christine Schäfer","doi":"10.1016/j.jtv.2024.11.004","DOIUrl":"10.1016/j.jtv.2024.11.004","url":null,"abstract":"<div><h3>Aims of the study</h3><div>This prospective cohort study investigates postoperative fluid accumulation in free flaps using hyperspectral imaging, analyzed through linear mixed models. Effects of edema on flap viability and microcirculatory changes during the critical postoperative phase should be detected.</div></div><div><h3>Materials and methods</h3><div>Patients who underwent free tissue transfer were monitored for six postoperative days (POD) using hyperspectral imaging to quantify tissue water index (TWI) for viable and failing flaps and the recipient site. Secondarily, oxygen saturation (StO2), near-infrared perfusion index (NPI) and tissue hemoglobin index (THI) were assessed. Microvascular blood flow was recorded with laser Doppler flowmetry. Linear mixed models generated prototypical TWI growth curves for estimation of TWI dynamics. Independent predictors of TWI were examined. Simple regression analysis explored correlations between flap TWI and microcirculation parameters.</div></div><div><h3>Results</h3><div>41 free flaps were monitored, with 4 requiring revision surgery. TWI of viable flaps (<em>b</em>=48.70); <em>p</em>=&lt;.001) increased linearly (<em>b=</em>.76; <em>p</em>=&lt;.001), reaching +9.4 % on POD 6. In contrast, revision flaps, while similar at baseline (<em>b</em>=-.95; <em>p</em>=.854), demonstrated a negative trend (<em>b</em>=-3.34; <em>p</em>=.005), ending at -33.6 % on POD 6. Male sex was associated with higher TWI at the recipient site (<em>b</em>=-3.34; <em>p</em>=.005). Notably, TWI showed no significant correlation with StO2 (<em>p</em>=&gt;.999), NPI (<em>p=</em>.110), blood flow (<em>p</em>=.120) or THI (<em>p</em>=.140).</div></div><div><h3>Conclusion</h3><div>Hyperspectral imaging is feasible for bedside flap monitoring, enabling quantification of tissue edema progression. Although the sample size of failing flaps was limited, these findings highlight the potential of low TWI as a warning sign and may offer insights into mechanisms involved in ischemia-reperfusion injury.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 1","pages":"Article 100832"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients’ perceptions with high-risk diabetic foot on early access to medical care: A qualitative study","authors":"Na Li ,&nbsp;Honglin Wang ,&nbsp;Ying Ye ,&nbsp;Weiwei Dai ,&nbsp;Qiuhong Zhou","doi":"10.1016/j.jtv.2025.100863","DOIUrl":"10.1016/j.jtv.2025.100863","url":null,"abstract":"<div><h3>Aims</h3><div>To explore the perception of patients with high-risk diabetic foot on early access to medical care.</div></div><div><h3>Design</h3><div>Qualitative interview study.</div></div><div><h3>Methods</h3><div>We conducted a qualitative exploratory and descriptive study involving 11 community-based patients with high-risk diabetic foot residing in Hunan, China. Interviews were systematically coded and categorized into thematic groups using Colaizzi's method.</div></div><div><h3>Results</h3><div>There were five main themes and nine subthemes, namely, (1) Attitude toward healthcare-seeking, (2) Lack of disease knowledge: (a) low symptom alertness, (b) necessity of health education, (3) Hospital visits: (a) doctor-patient relationship, (b) level of medical institutions, (c) obstacles in seeking healthcare, (4) Financial consideration: (a) apprehension about adding to family burden, (b) medical insurance to ease financial stress, (5)Environmental impact: (a) family and social supports, (b) communication between patients.</div></div><div><h3>Conclusions</h3><div>Patients with high-risk diabetic foot have barriers to early intention to seek medical care, and it is the result of a combination of many factors. Healthcare providers should provide relevant interventions for patients, and health insurance systems should be improved to increase coverage to facilitate timely access.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100863"},"PeriodicalIF":2.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a stress ball on pain and anxiety during sharp debridement in patients with diabetic foot ulcers: A randomized controlled, single-blind study","authors":"Fatma Aslan ,&nbsp;Betul Tosun ,&nbsp;Neşe Altınok Ersoy ,&nbsp;Nurten Ozen","doi":"10.1016/j.jtv.2025.100861","DOIUrl":"10.1016/j.jtv.2025.100861","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the effect of using a stress ball during sharp debridement on the pain and anxiety in patients with diabetic foot ulcers.</div></div><div><h3>Methods</h3><div>This study with a randomized, controlled and single-blind design was conducted at a single-center on patients diagnosed with diabetic foot ulcers who were being treated at the endocrinology and metabolic diseases clinic of a university hospital. Patients in the intervention group started using a stress ball before the debridement procedure and continued to use it until the procedure ended. No intervention was made to the patients in the control group. Data were collected by using the Descriptive Information Form, Diabetic Foot Meggit-Wagner Classification, Visual Analogue Scale (VAS), and State Anxiety Inventory (STAI).</div></div><div><h3>Results</h3><div>The study was completed with a total of 76 patients, 38 each in the intervention and control groups. The use of stress balls led to a reduction in anxiety and pain symptoms in the intervention group. The anxiety score of the patients in the intervention group was also found to be statistically significantly lower than those in the control group after the procedure (p = 0.008; η2 = 0,091). The VAS scores of the patients in the intervention group were found to be statistically significantly lower than those in the control group both during (p &lt; 0.001; η2 = 0.348) and after (p &lt; 0.001; η2 = 0.438) the procedure.</div></div><div><h3>Conclusions</h3><div>The use of a stress ball was found to be an effective method of reducing the level of pain and anxiety that occurs during the sharp debridement procedure. Stress ball application is a practical, easy, and cost-effective non-pharmacological method.</div></div><div><h3>Clinical trial number</h3><div>The study was recorded in the ClinicalTrials.gov website with the number NCT06316115.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100861"},"PeriodicalIF":2.4,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of physical activity on tissue perfusion in patients with diabetes mellitus: Systematic review and meta-analysis","authors":"Laura Palacios-Abril ,&nbsp;Aroa Tardáguila-García ,&nbsp;Francisco Javier Álvaro-Afonso ,&nbsp;Sara García-Oreja ,&nbsp;Sol Tejeda-Ramírez ,&nbsp;José Luis Lázaro-Martínez","doi":"10.1016/j.jtv.2025.100855","DOIUrl":"10.1016/j.jtv.2025.100855","url":null,"abstract":"<div><h3>Aims</h3><div>The objective of this systematic review and meta-analysis is to identify and assess the literature exploring the impact of physical activity on enhancing tissue perfusion in the feet of patients with diabetes mellitus (DM).</div></div><div><h3>Materials and methods</h3><div>All the selected studies were evaluated using the Cochrane risk of bias tool, to assess the risk of bias for randomized controlled trials. A thorough search was conducted in April 2024 through PubMed and Web of Science to identify randomized clinical trials (RCTs) and comparative studies that assessed the effect of physical activity enhancing tissue perfusion. Data analysis was performed using RevMan v5.4., employing the Mantel-Haenszel method for dichotomous outcomes.</div></div><div><h3>Results</h3><div>A total of nine studies compared changes in microcirculation before and after physical exercise in patients with DM. A meta-analysis of the data collected from seven studies estimated a mean difference of 4.87 (95 % CI 2.37–7.38) favouring the improvement of microvascular parameters post-exercise, with a minor level of heterogeneity (x² = 10.54, df = 6, p = 0.1, I² = 43 %) and a statistically significant difference between the two groups (p ≤ 0.001). However, a second evaluation, which included four studies involving patients with and without DM, indicated high heterogeneity (x² = 661.32, df = 3, p ≤ 0.00001, I² = 100 %) with no observable statistically significant differences between the two groups (p = 0.62).</div></div><div><h3>Conclusion</h3><div>Physical activity in patients with DM may be effective in improving blood microcirculation in the lower limbs.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100855"},"PeriodicalIF":2.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of surgical nurses’ knowledge and attitudes towards pressure ulcer prevention","authors":"Gülbanu Zencir ,&nbsp;Tuğçe Yeşilyaprak ,&nbsp;Esin Peri Ünal ,&nbsp;Berken Akın ,&nbsp;Fadime Gök","doi":"10.1016/j.jtv.2025.100862","DOIUrl":"10.1016/j.jtv.2025.100862","url":null,"abstract":"<div><h3>Background</h3><div>Pressure ulcers are an indicator of healthcare quality. The knowledge and attitudes of nurses are important in the prevention of pressure ulcers.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the knowledge and attitudes of surgical nurses regarding the prevention of pressure ulcers.</div></div><div><h3>Design</h3><div>The research is descriptive and cross-sectional in nature.</div></div><div><h3>Setting</h3><div>The study was conducted at a university hospital in Turkey between May and November 2022.</div></div><div><h3>Participants</h3><div>The research population consisted of 310 nurses working in the surgical clinic and intensive care units of a university hospital.</div></div><div><h3>Methods</h3><div>The study included 203 nurses. Data were collected between May 2022 and November 2022 using the “Descriptive Information Form”, the “Knowledge Towards Pressure Ulcers Prevention Scale”, and the “Attitude Towards Pressure Ulcers Prevention Scale”. The data analysis utilized frequency, percentage, mean, independent groups <em>t</em>-test, one-way ANOVA, Pearson correlation, and linear regression analysis.</div></div><div><h3>Results</h3><div>The knowledge levels of surgical nurses regarding pressure ulcer prevention were inadequate. Nurses had a positive attitude towards preventing pressure ulcers; however, this positive attitude was not at a satisfactory level. The nurses’ knowledge level was a predictor of their positive attitude.</div></div><div><h3>Conclusions</h3><div>This study revealed that surgical nurses had insufficient knowledge about preventing pressure ulcers and exhibited a positive attitude that was not at the desired level.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100862"},"PeriodicalIF":2.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing burn wound healing with an innovative in situ gelling probiotic microparticle formulation employing quality by design (QbD) principles","authors":"Fatemeh Moraffah ,&nbsp;Nasrin Samadi ,&nbsp;Mohammad Abdollahi ,&nbsp;Seyed Naser Ostad ,&nbsp;Roshanak Dolatabadi ,&nbsp;Maryam Pirouzzadeh ,&nbsp;Alireza Vatanara","doi":"10.1016/j.jtv.2025.100860","DOIUrl":"10.1016/j.jtv.2025.100860","url":null,"abstract":"<div><div>Scientists investigated probiotic-containing dressings to address the challenges associated with burn injuries, namely infection and antimicrobial resistance. The present investigation sought to evaluate the impact of innovative probiotic-loaded microparticles with <em>in situ</em> gelling characteristics on infected burns. The strain, <em>Lactiplantibacillus plantarum</em>, was selected due to its demonstrated wound-healing potential. Subsequently, a formulation was designed to sustain the growth capacity of probiotics. Polymers with a high moisture absorption capacity were exclusively used to avoid powder dispersion from wounds. The formulation was stabilized through the reduction of water content using the spray-drying process. The ideal composition was identified by analyzing the influence of the spray-drying inlet temperature, polymer type, and concentrations on probiotic viability, process efficiency, swelling ratio, and flow properties of powders. Morphological analysis showed the presence of microparticles with significant exchangeable surface areas. The rheological properties of the formulation demonstrated its ability to withstand high temperatures and mechanical stress. Moreover, FTIR and DCS spectra provided evidence of interconnection between the polymers. Examination of the growth profiles of both formulated and free probiotics revealed a consistent growth rate and an extended lag time. Animal studies have shown that the optimal microparticles exhibited superior efficacy compared to the control groups across all parameters and displayed enhanced effectiveness against <em>Pseudomonas aeruginosa</em>. The proposed delivery method, with its simple application and prevention of normal flora transmission, may have the potential to improve burn wound infection treatments.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 2","pages":"Article 100860"},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}