Journal of tissue viability最新文献

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IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-07-21 DOI: 10.1016/S0965-206X(25)00089-0
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引用次数: 0
The power of empathy: Enhancing healing outcomes in chronic wound care 移情的力量:提高慢性伤口护理的愈合效果
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-04-12 DOI: 10.1016/j.jtv.2025.100911
Sebastian Probst , Hayley Ryan , Peta Tehan
{"title":"The power of empathy: Enhancing healing outcomes in chronic wound care","authors":"Sebastian Probst ,&nbsp;Hayley Ryan ,&nbsp;Peta Tehan","doi":"10.1016/j.jtv.2025.100911","DOIUrl":"10.1016/j.jtv.2025.100911","url":null,"abstract":"<div><h3>Aim</h3><div>This study explores the impact of healthcare providers’ empathy on patients' healing outcomes and satisfaction in chronic wound care.</div></div><div><h3>Materials and methods</h3><div>A qualitative descriptive approach was used. Ten adults with chronic wounds were recruited through purposive sampling. Semi-structured interviews were conducted in January 2025, lasting an average of 37.1 min. Data were transcribed verbatim and analyzed thematically using Braun and Clarke's six-phase framework. Rigor was ensured through systematic coding, researcher triangulation, and adherence to COREQ guidelines.</div></div><div><h3>Results</h3><div>The analysis identified three central themes: (1) The need for person-centered and consistent care, emphasizing the importance of continuity in healthcare providers to reduce emotional exhaustion and improve adherence; (2) The emotional impact of empathy in wound care, demonstrating that empathetic communication raises trust, decreases pain perception, and enhances psychological resilience; and (3) The role of communication, trust, and cultural awareness, highlighting that clear explanations and cultural competence improve patient satisfaction and engagement. Participants who felt listened to and involved in decision-making reported better motivation and adherence to treatment.</div></div><div><h3>Conclusion</h3><div>Empathy is an important component of effective wound care, influencing healing outcomes, psychological well-being, and treatment adherence. Integrating empathy into clinical practice through continuity of care, shared decision-making, and cultural competence can improve patient satisfaction and overall wound management. Healthcare systems should prioritize training and policies that support empathy-driven, person-centered care.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100911"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Exploring physiological differences in injury response by skin tone: A scoping Review” [J Tissue Viabil (2025) 100871] [J].中国生物医学工程学报(自然科学版),2011,(1):1 - 4。
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-05-07 DOI: 10.1016/j.jtv.2025.100896
Pinar Avsar , Zena Moore , Declan Patton , Tom O'Connor , Lone Skoubo Bertelsen , Desmond J. Tobin , Giulio Brunetti , Keryln Carville , Vignesh Iyer , Hannah Wilson
{"title":"Corrigendum to “Exploring physiological differences in injury response by skin tone: A scoping Review” [J Tissue Viabil (2025) 100871]","authors":"Pinar Avsar ,&nbsp;Zena Moore ,&nbsp;Declan Patton ,&nbsp;Tom O'Connor ,&nbsp;Lone Skoubo Bertelsen ,&nbsp;Desmond J. Tobin ,&nbsp;Giulio Brunetti ,&nbsp;Keryln Carville ,&nbsp;Vignesh Iyer ,&nbsp;Hannah Wilson","doi":"10.1016/j.jtv.2025.100896","DOIUrl":"10.1016/j.jtv.2025.100896","url":null,"abstract":"","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100896"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concordance treatment continuum: A proposed clinical outcome to boost concordance with compression therapy 一致性治疗的连续性:一个建议的临床结果,以促进一致性与压迫治疗
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-04-17 DOI: 10.1016/j.jtv.2025.100907
Chloe Jansz , William McGuiness , Sonja Cleary
{"title":"Concordance treatment continuum: A proposed clinical outcome to boost concordance with compression therapy","authors":"Chloe Jansz ,&nbsp;William McGuiness ,&nbsp;Sonja Cleary","doi":"10.1016/j.jtv.2025.100907","DOIUrl":"10.1016/j.jtv.2025.100907","url":null,"abstract":"<div><div>Research by MacGregor (2013)and shows that 1–3 % of the population experience chronic venous insufficiency (CVI). Among these individuals, 60–80 % develop venous leg ulcers (VLU), according to Nelson and Adderley (2016). However, patient adherence to compression therapy (CT)—the gold standard treatment for VLUs—remains low at 39.9 %, even for those whose ulcers have healed. This lack of concordance heightens the risk of ulcer recurrence (Erickson et al., 1995; Finlayson et al., 2014; Kapp et al., 2013), presenting a significant and costly challenge for healthcare systems (Smith &amp; McGuiness, 2010). Compression therapy works by enhancing venous return and reducing both venous pressure and stasis.</div><div>Two Delphi studies conducted revealed a combined 105 overall factors. Whilst clinicians and patients identified different factors that influence long term concordance, there was consensus around factors that contribute to comfort, motivation, access to health care, and clinician attributes. Further research is needed to combine these elements into a concise clinical guideline, a concordance treatment continuum, to assist both the clinician and patient to achieve long term concordance with CT, to improve clinical outcomes of VLU reoccurrence.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100907"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global perspective on the incidence, severity, and management of diaper dermatitis in neonates, infants, and young children 新生儿、婴儿和幼儿尿布皮炎的发生率、严重程度和管理的全球视角
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-04-12 DOI: 10.1016/j.jtv.2025.100905
Ojisamola Jaiyeoba, Marty O. Visscher
{"title":"Global perspective on the incidence, severity, and management of diaper dermatitis in neonates, infants, and young children","authors":"Ojisamola Jaiyeoba,&nbsp;Marty O. Visscher","doi":"10.1016/j.jtv.2025.100905","DOIUrl":"10.1016/j.jtv.2025.100905","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to determine the incidence and severity of diaper dermatitis (DD) among neonates, infants and young children and identify the most effective treatment strategies with a global perspective.</div></div><div><h3>Materials and methods</h3><div>We conducted a narrative review of literatures searches from PubMed, EMBASE, and SCOPUS, found 1996 citations, selected primary source papers on infants and children ≤36 months and critically reviewed reports on incidence, severity, and treatment.</div></div><div><h3>Results</h3><div>The analysis produced information on DD incidence and diaper skin care habits from 7500 subjects in 12 countries including extremely premature infants. Three studies suggested that dark-skinned infants had lower incidence and/or severity versus light-skinned subjects. Treatments were generally effective but varied somewhat in rate and/or extent of DD reduction. Variations in DD assessment methods, study design, and starting severity were limitations for comprehensive treatment comparison.</div></div><div><h3>Conclusions</h3><div>DD incidence is relatively high, ranging from 36 to 75 % in home and hospital settings, with severe cases from 1 to 24 %. The review suggests that treatments with “drying” processes or ingredients are promising strategies for improved outcomes. It highlights skin care practices that may reduce DD and prompts questions for future research to understand and manage conditions for optimum skin function in the diaper environment.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100905"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pattern analysis of hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis 医院护士对尿失禁相关性皮炎的知识、态度和做法的模式分析
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-04-03 DOI: 10.1016/j.jtv.2025.100899
Weifang Xu , Xujing Wu , Shi Xu , Yali Yan , Chao Liu , Yen-Ching Chuang , Fuman Cai
{"title":"Pattern analysis of hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis","authors":"Weifang Xu ,&nbsp;Xujing Wu ,&nbsp;Shi Xu ,&nbsp;Yali Yan ,&nbsp;Chao Liu ,&nbsp;Yen-Ching Chuang ,&nbsp;Fuman Cai","doi":"10.1016/j.jtv.2025.100899","DOIUrl":"10.1016/j.jtv.2025.100899","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis (KAP-IAD).</div></div><div><h3>Methods</h3><div>This study utilized responses from hospital nurses to the Knowledge, Attitudes, and Practices of Incontinence-Associated Dermatitis Questionnaire (KAP-IAD-Q). Three clustering methods, Hierarchical Clustering on Principal Components (HCPC), K-means, and Partitioning Around Medoids (PAM), were applied to analyze the correlations of KAP-IAD. A classification method was used to explain the underlying behavioral patterns behind these correlations.</div></div><div><h3>Results</h3><div>Two clusters were found to be most appropriate. Decision attributes (D) were generated for the KAP-IAD data using the three clustering methods: HCPC, K-means, and PAM. Three datasets with categorical labels were generated, and predictive models and decision rules were established for each dataset using the Rough Set (RS) method. The PAM method demonstrated the highest accuracy among the three datasets. After five rounds of stochastic modeling, 57 decision rules were generated. Additionally, patterns or rules with a support threshold of 50 or more, as discussed by domain experts, were considered the primary behaviors or rules.</div></div><div><h3>Conclusions</h3><div>Our study suggests clear decision rules for KAP-IAD nursing practice, which have been absent in previous research. The key variables and rules identified can serve as a guide for KAP-IAD nursing practice, as well as for recognizing the etiology, risk factors, and key influences of dermatitis associated with KAP-IAD in nursing practice. This study provides an important management approach for the prevention and treatment of incontinence-associated dermatitis.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100899"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the structural and histopathological challenges of binary electrospun PET-based nanofibers for tissue engineering applications 组织工程应用中基于pet的二元电纺纳米纤维的结构和组织病理学挑战评估
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-03-25 DOI: 10.1016/j.jtv.2025.100888
Afsaneh Jahani , Davod Mohebbi-Kalhori , Farkhonde Sarhaddi , Gholam Hosein Kazemzadeh , Reza Taheri , Mehdi Ahmadi , Nafiseh Jirofti
{"title":"Assessment of the structural and histopathological challenges of binary electrospun PET-based nanofibers for tissue engineering applications","authors":"Afsaneh Jahani ,&nbsp;Davod Mohebbi-Kalhori ,&nbsp;Farkhonde Sarhaddi ,&nbsp;Gholam Hosein Kazemzadeh ,&nbsp;Reza Taheri ,&nbsp;Mehdi Ahmadi ,&nbsp;Nafiseh Jirofti","doi":"10.1016/j.jtv.2025.100888","DOIUrl":"10.1016/j.jtv.2025.100888","url":null,"abstract":"<div><div>Tissue engineering and regenerative medicine aim to address tissue lesions and organ degenerations, enhancing clinical outcomes by restoring damaged tissues and functionalities. Recent progress in materials science and medicine has led to the development of regenerative engineering, revolutionizing the production of polymeric artificial scaffolds by electrospinning method, which mimic the extracellular matrix (ECM). Polyurethane (PU) is recognized for its elastic nature, comprising soft and hard segments, and possesses bioactive as well as biocompatible properties. Polycaprolactone (PCL), on the other hand, is a non-toxic polymer with a viscous nature, known for its favorable mechanical properties. This study focuses on the comprehensive histological evaluation of binary electrospun PET-based nanofiber scaffolds, as widely used in tissue engineering. The structural analysis involved FE-SEM imaging, porosity measurement, FTIR, and DSC examinations. In vitro assessments included degradation rates, water uptake, cell viability, morphological cell examination, and cell attachment studies. Additionally, scaffolds were subcutaneously implanted in rats for pathological examination. After a 30 days implantation period, histological and pathological parameters such as edema, inflammation, foreign body giant cell reaction, fibrosis, necrosis, and calcification were evaluated. The results highlight the successful application of blend electrospinning in producing PET/PCL and PET/PU nanofiber scaffolds with various composition ratios. FE-SEM imaging revealed uniform nanostructures without bead formation. Histological analysis showed favorable biocompatibility, with the PET/PCL (25:75) composition demonstrating superior structural characteristics compared to other ratios. The cell studies indicated that PET-based nanofiber scaffolds exhibited suitable cell viability and attachment, underscoring their potential for tissue engineering applications.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100888"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A health economic analysis of ‘A novel implementation of best evidence practice for incontinence-associated dermatitis’ (IMBED) “失禁相关性皮炎最佳证据实践的新实施”(IMBED)的卫生经济学分析
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-06-07 DOI: 10.1016/j.jtv.2025.100930
Michelle Cunich , Michelle Barakat-Johnson , Sheena Arora , Jody Church , Michelle Lai , John Stephenson , Shifa Basjarahil , Jayne L. Campbell , Gary Disher , Samara Geering , Natalie Ko , Catherine Leahy , Thomas Leong , Eve McClure , Melissa O'Grady , Joan Walsh , Kate White , Fiona Coyer
{"title":"A health economic analysis of ‘A novel implementation of best evidence practice for incontinence-associated dermatitis’ (IMBED)","authors":"Michelle Cunich ,&nbsp;Michelle Barakat-Johnson ,&nbsp;Sheena Arora ,&nbsp;Jody Church ,&nbsp;Michelle Lai ,&nbsp;John Stephenson ,&nbsp;Shifa Basjarahil ,&nbsp;Jayne L. Campbell ,&nbsp;Gary Disher ,&nbsp;Samara Geering ,&nbsp;Natalie Ko ,&nbsp;Catherine Leahy ,&nbsp;Thomas Leong ,&nbsp;Eve McClure ,&nbsp;Melissa O'Grady ,&nbsp;Joan Walsh ,&nbsp;Kate White ,&nbsp;Fiona Coyer","doi":"10.1016/j.jtv.2025.100930","DOIUrl":"10.1016/j.jtv.2025.100930","url":null,"abstract":"<div><h3>Aim</h3><div>To assess resource usage and other outcomes of implementing a bundle of evidence-based, clinician-led incontinence-associated dermatitis interventions, ‘IMBED’ intervention.</div></div><div><h3>Methods</h3><div>Patients with incontinence recruited from 6 public hospitals in Australia in pre-intervention (1 February-31 March 2020) and post-intervention periods (1 May-30 June 2021). For the health economic study, nurses/research officers recorded resource usage for a random sample of incontinence care episodes each week.</div></div><div><h3>Results</h3><div>799 patients with incontinence (9645 incontinence care episodes). There were significant differences in the proportion of incontinence care episodes using specific product-types between the pre- and post-intervention groups, with the greatest increase for treatment/prevention products (55.2 % versus 82.8 %; p &lt; 0.001) and decrease for underpads/bed pads (28.5 % versus 12.9 %; p &lt; 0.001). There was a significant decrease in mean total product cost per incontinence care episode between these groups (AU$2.64 versus AU$2.35; p &lt; 0.001). There was a significant increase in mean staff cost per incontinence care episode between these groups (AU$9.65 versus AU$10.09; p = 0.001), driven by increases in the mean number of staff and time spent per episode. There was an increase in mean total cost per incontinence care episode (AU$0.15) between these groups but not significant (p = 0.344).</div></div><div><h3>Conclusion</h3><div>There was a significant decrease in mean total product cost per incontinence care episode in the intervention group. There was no significant change in mean total incontinence care cost per episode associated with the intervention, suggesting hospitals adopted IMBED with minimal extra expenses. There was streamlined resource usage and reductions in products not supported by evidence-based guidelines.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100930"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation methods of pressure injury stages: A systematic review and meta-analysis 压力损伤阶段的评价方法:系统回顾和荟萃分析
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-03-21 DOI: 10.1016/j.jtv.2025.100894
Qianwen Chao , Juhong Pei , Yuting Wei , Zhuang Yang , Xiaorui Wang , Li Du , Lin Han
{"title":"Evaluation methods of pressure injury stages: A systematic review and meta-analysis","authors":"Qianwen Chao ,&nbsp;Juhong Pei ,&nbsp;Yuting Wei ,&nbsp;Zhuang Yang ,&nbsp;Xiaorui Wang ,&nbsp;Li Du ,&nbsp;Lin Han","doi":"10.1016/j.jtv.2025.100894","DOIUrl":"10.1016/j.jtv.2025.100894","url":null,"abstract":"<div><h3>Background</h3><div>Pressure injury is prevalent in clinical settings and demands precise staging for optimal care. Subjectivity and imprecision in traditional visual assessments have sparked the creation of advanced technology-based evaluation tools.</div></div><div><h3>Aims</h3><div>To systematically assess pressure injury staging methods, analyze their evaluation results, and provide reference for clinical practice.</div></div><div><h3>Design</h3><div>Systematic review and meta-analysis.</div></div><div><h3>Data sources</h3><div>PubMed, Embase, Cochrane Library, Web of Science, CINAHL, and manual searches of academic journals and conference proceedings were utilized.</div></div><div><h3>Methods</h3><div>The study conducted a systematic search of databases in April 2024, utilizing Endnote X9 to document findings. Two reviewers independently extracted data and evaluated its quality using the QUADAS-2 tool. The meta-analysis, conducted in Meta-disc, focused on metrics such as AUC, sensitivity, and specificity. Heterogeneity among the studies was assessed using Cochran's Q and <em>I</em><sup><em>2</em></sup> tests.</div></div><div><h3>Results</h3><div>This review screened 15312 articles and ultimately included 15 studies. These studies described methods for pressure injury staging, including visual assessment, 29 machine learning models, and human-model integrated evaluation. The accuracy of traditional visual assessment was relatively low and showed significant variability. Eight studies involving 24 machine learning models were included in the meta-analysis, demonstrating significantly high accuracy, with an AUC of 0.93, and the combined sensitivity, specificity, and diagnostic odds ratio were 0.81, 0.87, and 20.48, respectively.</div></div><div><h3>Conclusion</h3><div>The review underscores the advantages of machine learning in diagnosing pressure injuries, offering higher accuracy over traditional methods. Integrating clinical expertise with machine learning enhances medical service quality and efficiency.</div></div><div><h3>Prospero registration number</h3><div>CRD42023462951.</div></div><div><h3>Prospero registration link</h3><div><span><span>crd.york.ac.uk/prospero/display_record.php?ID=CRD42023462951</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100894"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effects of epidermal and fibroblast growth factor-infused collagen patches on wound healing in a full-thickness rat model 表皮与成纤维细胞生长因子灌注胶原贴片对大鼠全层模型创面愈合的影响
IF 2.4 3区 医学
Journal of tissue viability Pub Date : 2025-08-01 Epub Date: 2025-04-03 DOI: 10.1016/j.jtv.2025.100903
Fahri Sabanciogullarindan , Mehmet Bozkurt , Nilsen Yildirim Erdogan , Yasar Samet Gokceoglu , Percin Karakol
{"title":"Comparative effects of epidermal and fibroblast growth factor-infused collagen patches on wound healing in a full-thickness rat model","authors":"Fahri Sabanciogullarindan ,&nbsp;Mehmet Bozkurt ,&nbsp;Nilsen Yildirim Erdogan ,&nbsp;Yasar Samet Gokceoglu ,&nbsp;Percin Karakol","doi":"10.1016/j.jtv.2025.100903","DOIUrl":"10.1016/j.jtv.2025.100903","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of Epidermal Growth Factor (EGF)- and Fibroblast Growth Factor (FGF)-infused collagen patches on wound healing in an experimental rat model. The focus was on acute and chronic inflammation, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and collagen remodeling.</div></div><div><h3>Methods</h3><div>Full-thickness cranial wounds (12 mm) were created on the dorsal regions of 21 male Wistar rats and divided into four groups: Group 1 (collagen patch alone), Group 2 (collagen + EGF), Group 3 (collagen + FGF). The kaudal defects served as a chronic wound model with secondary intention healing, monitored for 21 days. Tissue biopsies were collected on days 3, 7, and 21. Histopathological evaluation included inflammation scores, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and Type 1/Type 3 collagen ratio. Data were analyzed using one-way ANOVA, Kruskal–Wallis test, and other appropriate post hoc tests. Statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Acute inflammation significantly decreased in Group 3 on day 7 (p = 0.001), while chronic inflammation was minimal by day 21 in Groups 1 and 3. Group 2 showed the highest granulation tissue formation on day 21 (p &lt; 0.05). Fibroblast maturation peaked in Group 3 on day 21 (p = 0.004). Re-epithelialization was complete in Groups 1 and 3 by day 21, significantly outperforming Group 2 (p &lt; 0.005). Group 3 demonstrated superior collagen deposition and the highest Type 1/Type 3 collagen ratio (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>FGF-infused collagen patches significantly improved fibroblast maturation, epithelialization, and collagen remodeling, outperforming EGF and standalone collagen patches. These findings highlight the potential of FGF as a therapeutic agent in wound healing.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100903"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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