Journal of tissue viability最新文献

{"title":"A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds","authors":"Lan Chen,&nbsp;Jia Liu,&nbsp;Yaoyao He,&nbsp;Chongcong Zeng,&nbsp;Weixiang Liao,&nbsp;Chaoxi Luo","doi":"10.1016/j.jtv.2025.100917","DOIUrl":"10.1016/j.jtv.2025.100917","url":null,"abstract":"<div><h3>Aim</h3><div>Exosomes, small endosome-derived membrane vesicles, have shown significant potential as wound healing therapies. However, translating experimental research into commercially available treatments remains a challenge.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis provide a comprehensive evaluation of the current research on exosome-based wound healing therapies.</div></div><div><h3>Materials and methods</h3><div>A systematic search of PubMed and Google Scholar was conducted to identify full-text articles published between 2010 and February 2024 on mammalian-derived exosomes in wound healing. Of 138 identified studies, 19 met the inclusion criteria for meta-analysis.</div></div><div><h3>Results</h3><div>Exosome-based therapies were found to enhance wound healing by promoting angiogenesis, re-epithelialization, and collagen deposition while reducing scar formation. However, research in this area is highly variable, with differences in cell sources, biomaterials, and delivery methods.</div></div><div><h3>Conclusions</h3><div>Further comparative studies are needed to optimize cellular sources, delivery systems, and biomaterials. The reliance on rodent models remains a limitation, as progress toward large-scale testing and more advanced in vivo models has been slow. Addressing these challenges is crucial for the clinical translation of exosome-based therapies into scalable, commercially viable wound healing treatments.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100917"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker of pressure injuries in critically ill adults based on large-scale medical Datasets:A multi-center prospective study","authors":"Lin Lv ,&nbsp;Ning Wang ,&nbsp;Yanxia Jiao ,&nbsp;Anna Wen ,&nbsp;Jie Xu ,&nbsp;Xinyue Xu ,&nbsp;Li Du ,&nbsp;Lin Han","doi":"10.1016/j.jtv.2025.100912","DOIUrl":"10.1016/j.jtv.2025.100912","url":null,"abstract":"<div><h3>Objectives</h3><div>Pressure injuries (PIs) are a global health concern, particularly in the context of an ageing population. They impose significant economic and social burdens, serve as key indicators of nursing quality, and are associated with increased mortality and morbidity.</div></div><div><h3>Methods</h3><div>We conducted a multi-center prospective descriptive study involving 3867 critically ill adults admitted to ICUs across 28 hospitals in Gansu Province, China, from April 1, 2021, to July 31, 2023. Data were collected using the “Long Hu Hui” PI risk management platform, which covers 98 indicators.</div></div><div><h3>Results</h3><div>The incidence of hospital-acquired PIs was 5.20 %. Univariate analysis identified 15 significant indicators associated with PIs, including body temperature, blood oxygen saturation, and central venous pressure. Logistic regression analysis revealed body temperature, diastolic blood pressure, blood oxygen saturation, haemoglobin, central venous pressure, and blood urea nitrogen as independent risk factors for PIs. A clinical prediction model was developed, demonstrating superior predictive performance compared to existing scales.</div></div><div><h3>Conclusions</h3><div>This study identified key physiological and biochemical markers associated with developing PIs in critically ill adults. The developed prediction model offers a more accurate tool for clinical risk assessment and may guide preventive strategies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100912"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning methods for determining skin age: A systematic review","authors":"Eric McMullen ,&nbsp;Rokhshid Aflaki ,&nbsp;Pranav Jignesh Khatri ,&nbsp;Dea Metko ,&nbsp;Kyle Storm ,&nbsp;Abu Bakar Butt ,&nbsp;Mahan Maazi ,&nbsp;Raghav Gupta ,&nbsp;Rajan Grewal ,&nbsp;Trevor Champagne","doi":"10.1016/j.jtv.2025.100887","DOIUrl":"10.1016/j.jtv.2025.100887","url":null,"abstract":"<div><h3>Aim</h3><div>This systematic review explores how machine learning is used in determining skin aging, aiming to evaluate accuracy, limitations, and gaps in the current literature.</div></div><div><h3>Materials and methods</h3><div>OVID Embase, OVID Medline, IEEE Xplore, and ACM Digitial Library were searched from inception to March 16, 2024.</div></div><div><h3>Results</h3><div>A total of 1467 non-duplicate articles were screened, and 27 were ultimately included in the systematic review. The machine learning models exhibited a range of accuracies from a mean absolute error of 2.30–8.16 years. The most common approach was full facial image analysis, followed by non-image-based studies utilizing biomarkers such as the methylome and the proteome. The incorporation of dynamic facial expressions in the analysis was shown to improve the accuracy of age estimation, with a mean absolute error of 3.74. Confocal microscopy demonstrated potential for accurate skin aging estimation, with some studies achieving up to 85 % accuracy. Many studies were found with high PROBAST risk of bias scores, most commonly due to small sample sizes.</div></div><div><h3>Conclusion</h3><div>Future studies should aim for greater diversity in ethnicity and variables within datasets to improve generalizability.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100887"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification and validation of the Bluebelle Wound Healing Questionnaire (WHQ) for assessing surgical site infection in wounds healing by secondary intention","authors":"Rhiannon Macefield ,&nbsp;Laura Mandefield ,&nbsp;Jane M. Blazeby ,&nbsp;Caroline Fairhurst ,&nbsp;Kalpita Baird ,&nbsp;Catherine Arundel ,&nbsp;Ian Chetter ,&nbsp;Belen Corbacho Martin ,&nbsp;Catherine Hewitt ,&nbsp;Athanasios Gkekas ,&nbsp;Andrew Mott ,&nbsp;Dr Pedro Saramago Goncalves ,&nbsp;Samantha Swan ,&nbsp;David Torgerson ,&nbsp;Jacqueline Wilkinson ,&nbsp;Sabeen Zahra ,&nbsp;Stephen Dixon ,&nbsp;Josie Hatfield ,&nbsp;Angela Oswald ,&nbsp;Jo Dumville ,&nbsp;E. Packer","doi":"10.1016/j.jtv.2025.100889","DOIUrl":"10.1016/j.jtv.2025.100889","url":null,"abstract":"<div><h3>Background</h3><div>Surgical wounds healing by secondary intention are common. Healing is often complicated by surgical site infection (SSI). SSI assessment is important to guide treatment but existing methods generally require in-person assessment, making them resource intensive. A validated patient-reported SSI outcome measure may be useful to overcome this limitation.</div></div><div><h3>Aim</h3><div>To modify and validate the Bluebelle Wound Healing Questionnaire (WHQ) for wounds healing by secondary intention.</div></div><div><h3>Methods</h3><div>The 18-item Bluebelle WHQ developed for wounds healing by primary intention was modified to make it applicable to secondary healing wounds. Testing was performed as part of the SWHSI-2 randomised trial assessing negative pressure wound dressings versus standard care. Participants completed the WHQ at five timepoints; in-person (baseline, post-healing) and by post (3, 6, 12 months). A reference SSI assessment was performed by a research nurse at the time of wound healing. Acceptability and criterion validity (ability of the Bluebelle WHQ to discriminate between SSI/no SSI) were explored by examining questionnaire return rates, levels of missing data and total score sensitivity/specificity values (receiver operating characteristic curve (ROC)).</div></div><div><h3>Results</h3><div>Baseline in-person questionnaire return rates were highest (672/686; 98 %), with postal return rates of 428/615 (68.5 %), 274/416 (65.9 %) and 186/296 (62.8 %) at follow up points. Overall, low levels of item-missing data were observed with few problems completing the questionnaire reported. Ability to discriminate between SSI/no SSI was good (Area under ROC = 0.796).</div></div><div><h3>Conclusion</h3><div>The modified Bluebelle WHQ is a valuable tool for post-discharge assessment of wounds healing by secondary intention. It is recommended for use in research and clinical practice.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100889"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cuff pressure and protective padding material selection on the prevention of skin complications associated with pneumatic tourniquet application in upper extremity surgery: A randomized controlled clinical trial","authors":"Sevgi Vermisli Ciftci ,&nbsp;Zeki Gunsoy ,&nbsp;Fatma Demir Korkmaz","doi":"10.1016/j.jtv.2025.100931","DOIUrl":"10.1016/j.jtv.2025.100931","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigated the effect of cuff pressure and the selection of protective padding material (PPM) on the prevention of skin complications associated with pneumatic tourniquet (PT) application in upper extremity surgery.</div></div><div><h3>Methods</h3><div>This randomized controlled trial was conducted between October 2022 and September 2023 at the Hand Surgery Clinic of Bursa City Hospital. Standard tourniquet pressure (STP) or limb occlusion pressure (LOP) was applied as PT cuff pressure. Cotton pad (CP) or elastic stockinette (ES) was used for PPM under the cuff. Patients were categorized into four groups; (i) STP with a CP; (ii) STP with an ES; (iii) LOP with a CP; and (iv) LOP with an ES. Total of 200 patients were included in the study, with 50 patients in each group. Skin complications were evaluated postoperatively at 0, 30, and 180 min.</div></div><div><h3>Results</h3><div>Four different skin complications were observed: redness, tourniquet scar, petechiae, and bullae. Redness was higher at 0 min in the group with STP using a CP and at 30 min in the group with LOP using an ES. Tourniquet scar was less in the LOP using an ES at 0 and 30 min. Petechiae was more in the STP group with the CP than in the LOP group at 180 min. Bullae were more in the group with STP using a CP at 0, 30, and 180 min.</div></div><div><h3>Conclusion</h3><div>LOP for the purposes of cuff pressure and the use of an ES as a PPM are recommended to reduce skin complications associated with PT application.</div></div><div><h3>The CTRN</h3><div>2022–12/5(ClinicalTrials.gov).</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100931"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of core exercises on shoulder rotator strength, core endurance and suprasipinatus structure in tennis players with rotator cuff injuries","authors":"Emine Merve Ersever ,&nbsp;Bayram Goktas","doi":"10.1016/j.jtv.2025.100934","DOIUrl":"10.1016/j.jtv.2025.100934","url":null,"abstract":"<div><h3>Objective</h3><div>— Tennis is a demanding sport that requires proper physical conditioning to prevent injuries in players with rotator cuff issues. This study aims to evaluate the effects of an eight-week core exercise training program on pain, core endurance, rotator strength, and muscle architecture in rotator cuff tennis players.</div></div><div><h3>Materials and methods</h3><div>— The study group consisted of 41 subjects (22 women, 19 men) with a mean age of 42.06 ± 8.17. The core exercise group trained with core exercises in addition to routine training 3 times a week for 8 weeks; The control group only performed routine training 3 times a week for the same duration. Assessments of pain, muscle endurance, strength, and architecture were conducted before and after the 8-week intervention.</div></div><div><h3>Results</h3><div>— Data analysis revealed a significant improvement in the experimental group compared to the control group. This indicates a large effect size (p &lt; 0.05) in pain, muscle strength, endurance, and muscle architecture length (excluding pennation angle).</div></div><div><h3>Conclusions</h3><div>—The results of this study demonstrate that core exercise training is an effective method for reducing pain and improving functional outcomes in tennis players with rotator cuff lesions. Furthermore, the findings highlight the importance of targeted and comprehensive core stability training in minimizing the risk of re-injury.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100934"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of enteral nutritional enriched with n-3 polyunsaturated fatty acids on postoperative wound infection following gastrointestinal surgery: A meta-analysis","authors":"Ming Zhang ,&nbsp;Hui-Juan Xiao ,&nbsp;Yue Li,&nbsp;Ping Zheng,&nbsp;Hua-Ying Yan","doi":"10.1016/j.jtv.2025.100919","DOIUrl":"10.1016/j.jtv.2025.100919","url":null,"abstract":"<div><h3>Background and aim</h3><div>Postoperative wound infections remain a significant challenge in gastrointestinal surgery, with substantial implications for prolonged hospital stays and healthcare costs. Immunonutrition with n-3 polyunsaturated fatty acids (PUFAs) offers potential preventive benefits through modulation of inflammatory responses. This study aimed to explore the impact of enteral nutritional enriched with n-3 PUFAs on wound infection in patients undergoing gastrointestinal surgery.</div></div><div><h3>Methods</h3><div>A thorough search was carried out, from databases to December 2023, across Cochrane Library, Embase, CNKI, Google Scholar, Wanfang, and PubMed on randomized controlled trials (RCTs) examining the impacts of enteral nutritional enriched with n-3 PUFAs for treatment of patients with gastrointestinal surgery. Two independent researchers conducted literature screening, data extraction, and quality assessments. The primary outcome measures were wound infection and complications. Statistical analysis was conducted in Stata 17.0 and RevMan 5.4 software.</div></div><div><h3>Results</h3><div>Fifteen RCTs involving 1442 patients who underwent gastrointestinal surgery were included. The analysis revealed the application of enteral nutritional enriched with n-3 PUFAs markedly decreased the occurrence of complications (odds ratio [OR] = 0.56, 95 % confidence intervals [CI]: 0.44–0.71, <em>P</em> &lt; 0.001) and wound infection (OR = 0.68, 95 %CI: 0.47–0.98, <em>P</em> = 0.04) in patients who underwent gastrointestinal surgery.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that postoperative support with enteral nutritional enriched with n-3 PUFAs can effectively decrease the occurrence of wound infections and postoperative complications following gastrointestinal surgery. These findings suggest that n-3 PUFAs supplementation should be considered as a standard component of perioperative nutritional protocols to improve surgical outcomes in patients undergoing gastrointestinal procedures.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100919"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the effects of far infrared radiation on muscle injury caused by centrifugal exercise","authors":"Lin Ren ,&nbsp;Ran He","doi":"10.1016/j.jtv.2025.100900","DOIUrl":"10.1016/j.jtv.2025.100900","url":null,"abstract":"<div><h3>Objective</h3><div>Explore the recovery effect of FIR on high-intensity centrifugal contraction or lower limb muscle fiber injury caused by long-term endurance exercise.</div></div><div><h3>Methods</h3><div>Collect and organize relevant literature on FIR, and explore the recovery effect and possible mechanism of FIR intervention on subtle muscle fiber damage caused by exercise.</div></div><div><h3>Result</h3><div>FIR can reduce COX-2, inhibit PGE₂, accelerate hydrogen peroxide clearance, alleviate pain caused by various conditions, promote cell proliferation, and increase blood flow; Among the two main processing tools of FIR, FIR lighting fixtures that are exposed to radiation for 30 min a day after exercise can effectively alleviate the human induced DOMS condition, while FIR clothing needs to be worn for 9 h a day to have the effect of slowing down DOMS.</div></div><div><h3>Conclusion</h3><div>FIR may be developed into one of the auxiliary strategies for warm-up before competitions and after intermission in the future.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100900"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating alternating pressure air mattress effectiveness through the measurement of skin redness and blood perfusion","authors":"Sukhveer Singh Sandhu ,&nbsp;Dawn L. Denny ,&nbsp;Rhoda A. Owens ,&nbsp;Kristi L. Jean ,&nbsp;Bo Liang ,&nbsp;MD Hasib Fakir ,&nbsp;Victor Moreno Lozano ,&nbsp;Mina Molani ,&nbsp;Mary Labuhn ,&nbsp;Charisse Vetsch ,&nbsp;Darlene Hanson ,&nbsp;Prakash Parthiban Selvakumar ,&nbsp;Pantea Tavakolian","doi":"10.1016/j.jtv.2025.100904","DOIUrl":"10.1016/j.jtv.2025.100904","url":null,"abstract":"<div><div>This study presents a unique method to evaluate the effectiveness of Alternating Pressure Air Mattresses (APAMs) in preventing Pressure Injuries (PIs). We employed a Laser Speckle Blood Flow and Tissue Oxygenation Imager with color image gathering capabilities by Moor Instruments to quantify skin redness and blood perfusion (flux) in a research study involving 29 healthy participants across three surgical support surfaces: foam, gel, and APAM.</div><div>The methodology combined multimodal imaging with image segmentation and thresholding techniques to correlate visible skin redness with the underlying microcirculatory changes in perfusion (flux).</div><div>The results showed that APAMs exhibited the most significant initial increase in redness compared to baseline but also demonstrated the faster dissipation of concentrated redness and recovery of blood perfusion (flux) after offloading. A strong correlation (r = 0.63, P &lt; 0.001) was observed between concentrated redness and blood flux for APAMs.</div><div>This approach goes beyond traditional incidence-based evaluations, providing insights into the dynamic tissue responses to different support surfaces. Our findings suggest that quantifying redness could be a practical and effective way to monitor individual patient responses to support surfaces, potentially leading to more personalized and effective PI prevention strategies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100904"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of topical insulin therapy on diabetic foot ulcers: A systematic review and meta-analysis","authors":"Shibei Hu ,&nbsp;Yan Gong ,&nbsp;Huiqi Zhang ,&nbsp;Xiujing Guo ,&nbsp;Peiyan Li","doi":"10.1016/j.jtv.2025.100932","DOIUrl":"10.1016/j.jtv.2025.100932","url":null,"abstract":"<div><h3>Aims</h3><div>To systematically analyze the effect of topical insulin therapy on diabetic foot ulcers and to offer guidance for clinical practice.</div></div><div><h3>Methods</h3><div>We conducted a quantitative systematic review of the study in 9 representative databases for the effect of topical insulin therapy on diabetic foot ulcers. Meta-analysis was performed with Review-Manager. 5.4. This study has been registered on the official Prospero website, and the registration code is CRD42024581466.</div></div><div><h3>Results</h3><div>Twelve studies involving 731 patients were included. The meta-analysis results showed that compared with conventional treatment, topical insulin therapy can reduce wound healing time (<em>P</em> &lt; 0.001), and wound area (<em>P</em> &lt; 0.001), inflammatory factors (serum interleukin-1, interleukin-6, tumor necrosis factor-α(<em>P</em> &lt; 0.001), advanced glycation end products (<em>P</em> &lt; 0.001). Additionally, it improved the degree of granulation tissue regeneration (<em>P</em> &lt; 0.001), microvascular density (<em>P</em> &lt; 0.001), vascular endothelial growth factor (<em>P</em> &lt; 0.001), and the expression of β-catenin in wound tissue (<em>P</em> &lt; 0.001). However, there was no statistically significant difference in fasting plasma glucose (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Topical insulin therapy is effective in promoting wound healing and reducing inflammation in DFU patients, but its impact on blood glucose control remains uncertain. Further, high-quality RCTs are needed to confirm these findings.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100932"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}