Journal of tissue viability最新文献

{"title":"Impact on management performance outcomes of standardizing wound care using integrated care bundles – results of a retrospective analysis","authors":"Theresa Hurd ,&nbsp;Sophie Berry ,&nbsp;Julie Murdoch","doi":"10.1016/j.jtv.2025.100914","DOIUrl":"10.1016/j.jtv.2025.100914","url":null,"abstract":"<div><h3>Aim</h3><div>Integrated care bundles (ICBs) are interventions that used together synergistically improve care outcomes through standardized care pathways and can help to optimize healthcare expenditure. For wound care, ICBs may need to incorporate low or non-adherent dressings for patients with fragile and/or sensitive skin to help reduce the risk of damage. This retrospective analysis of real-world data assessed the impact on wound management outcomes of an ICB where a specific non-adhesive foam dressing was selected for patients with fragile skin and appropriate wound types.</div></div><div><h3>Method</h3><div>A comprehensive wound care program using ICBs was implemented and tracked using a real-time electronic database at two large healthcare organizations in Ontario, Canada (December 2015 to March 2018). Anonymized patient data were analyzed retrospectively.</div></div><div><h3>Results</h3><div>4421 patients with chronic wounds received an ICB including a non-adhesive foam dressing; 2242 patients did not receive an ICB. With use of the ICB including a non-adhesive foam dressing versus no ICB: mean Bates-Jensen Wound Assessment Tool (BWAT) Score was lower (27.4 vs 33.2); mean time to healing was shorter (12.7 vs 25.5 weeks) and mean time between dressing changes was longer (3.1 vs 1.9 days). Mean labor costs were lower with use of the ICB including a non-adhesive foam dressing (CAD 1766 vs 6488; p &lt; 0.05). No adverse events related to the non-adhesive foam dressing were reported and the overall safety profile improved with use of the ICB.</div></div><div><h3>Conclusion</h3><div>Implementing ICBs can help to improve wound management outcomes and reduce labor costs compared with non-standardized care without an ICB.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100914"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating alternating pressure air mattress effectiveness through the measurement of skin redness and blood perfusion","authors":"Sukhveer Singh Sandhu ,&nbsp;Dawn L. Denny ,&nbsp;Rhoda A. Owens ,&nbsp;Kristi L. Jean ,&nbsp;Bo Liang ,&nbsp;MD Hasib Fakir ,&nbsp;Victor Moreno Lozano ,&nbsp;Mina Molani ,&nbsp;Mary Labuhn ,&nbsp;Charisse Vetsch ,&nbsp;Darlene Hanson ,&nbsp;Prakash Parthiban Selvakumar ,&nbsp;Pantea Tavakolian","doi":"10.1016/j.jtv.2025.100904","DOIUrl":"10.1016/j.jtv.2025.100904","url":null,"abstract":"<div><div>This study presents a unique method to evaluate the effectiveness of Alternating Pressure Air Mattresses (APAMs) in preventing Pressure Injuries (PIs). We employed a Laser Speckle Blood Flow and Tissue Oxygenation Imager with color image gathering capabilities by Moor Instruments to quantify skin redness and blood perfusion (flux) in a research study involving 29 healthy participants across three surgical support surfaces: foam, gel, and APAM.</div><div>The methodology combined multimodal imaging with image segmentation and thresholding techniques to correlate visible skin redness with the underlying microcirculatory changes in perfusion (flux).</div><div>The results showed that APAMs exhibited the most significant initial increase in redness compared to baseline but also demonstrated the faster dissipation of concentrated redness and recovery of blood perfusion (flux) after offloading. A strong correlation (r = 0.63, P &lt; 0.001) was observed between concentrated redness and blood flux for APAMs.</div><div>This approach goes beyond traditional incidence-based evaluations, providing insights into the dynamic tissue responses to different support surfaces. Our findings suggest that quantifying redness could be a practical and effective way to monitor individual patient responses to support surfaces, potentially leading to more personalized and effective PI prevention strategies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100904"},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A discharge planning program to prevent infection among patients with diabetic foot ulcers in Taiwan: A randomized controlled trial study","authors":"Yen-Fan Chin ,&nbsp;Jiun-Ting Yeh ,&nbsp;Hsing-Yi Yu ,&nbsp;Brend Ray-Sea Hsu ,&nbsp;Yu-Jr Lin","doi":"10.1016/j.jtv.2025.100901","DOIUrl":"10.1016/j.jtv.2025.100901","url":null,"abstract":"<div><h3>Trial and protocol registration</h3><div>This study is registered with <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, No. NCT04467606.</div></div><div><h3>Background</h3><div>Patients hospitalized for foot ulcers have a high readmission rate due to wound infections, and treating these infections is costly.</div></div><div><h3>Aims</h3><div>This study aimed to investigate the effect of a discharge planning program that uses a motivational interviewing strategy (MI) on infection prevention in patients with diabetes-related foot ulcers (DFUs).</div></div><div><h3>Methods</h3><div>A randomized controlled trial was conducted at a hospital in Taiwan from August 2020 to October 2022. A total of 132 hospitalized adult patients with DFUs were recruited and randomized into either MI or control group in a 1:1 ratio by block randomization, with 66 patients in each group. In the MI group, the interview was conducted at least one day before discharge, within three days after discharge, and then weekly for the first month and every one to three months thereafter. The control group received the usual care. The Diabetes Foot Self-Care Behavior Scale (DFSBS) and Diabetes-related Foot Ulcer Self-Management Behavior Scale (DFUSMB) were used to collect foot self-care and DFU self-management behaviors. Infectious status was determined according to the IWGDF/IDSA classification. Cox regression and generalized estimating equation (GEE) were used for data analysis.</div></div><div><h3>Results</h3><div>After adjusting for significant variables, the univariate Cox regression analysis results showed no statistically significant difference in foot infection or readmission rates between the two groups. In the GEE analysis, after adjusting for covariates, the results showed that the foot self-care behaviors of patients in the intervention group after discharge were better than those in the control group, reaching statistical significance. However, behaviors specific to DFU self-management were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Although motivational interviewing has shown to be effective in promoting foot self-care behaviors, more research is needed on how to reduce post-discharge foot infections and hospitalizations.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100901"},"PeriodicalIF":2.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors aggravating the stage of pressure injury in dyspneic patients","authors":"Jung Eun Hong ,&nbsp;Mi-Ock Shim ,&nbsp;Heejung Choi ,&nbsp;Yeongju Been ,&nbsp;Seungmi Park","doi":"10.1016/j.jtv.2025.100898","DOIUrl":"10.1016/j.jtv.2025.100898","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to identify the aggravating factors of pressure injuries and provide basic data for prevention and effective nursing interventions for patients with dyspnea.</div></div><div><h3>Materials and methods</h3><div>This secondary analysis using electronic medical records from patients with dyspnea who developed pressure injuries after admission to the general wards of five hospitals in Korea between March 2022 and May 2022. Data were collected using a standardized case report form to gather information on clinical characteristics and pressure injuries.</div></div><div><h3>Results</h3><div>The mean age of the 214 patients was 71.6 ± 10.99 years. Common comorbidities included diabetes mellitus (43.4 %) and cardiovascular diseases (21.5 %). Most patients (94.4 %) required oxygen therapy. At the time of pressure injury occurrence, the Braden scale scores ≤16 was 74.3 % at pressure injury occurrence. Pressure injuries were classified as stage 1 (25.5 %), stage 2 or higher (58.4 %), and unstageable (18.1 %). The multivariate analysis revealed that fecal incontinence (odds ratio [OR]: 0.12, 95 % confidence interval [CI]: 0.04–0.42), albumin ≥3.5 g/dl (OR: 0.57, 95 % CI: 0.34–0.95) and use of restraints (OR: 3.57, 95 % CI: 1.53–8.30) were significant predictive factors for advanced stage pressure injury.</div></div><div><h3>Conclusions</h3><div>This study identified fecal incontinence, albumin level, the use of restrains as a significant predictive factors for advanced stage pressure injury in dyspneic patients. These highlight the need for tailored preventive strategies and monitoring, particularly for patients requiring restraints, to reduce the incidence and severity of pressure injury in this population.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100898"},"PeriodicalIF":2.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern analysis of hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis","authors":"Weifang Xu ,&nbsp;Xujing Wu ,&nbsp;Shi Xu ,&nbsp;Yali Yan ,&nbsp;Chao Liu ,&nbsp;Yen-Ching Chuang ,&nbsp;Fuman Cai","doi":"10.1016/j.jtv.2025.100899","DOIUrl":"10.1016/j.jtv.2025.100899","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze hospital nurses' knowledge, attitudes, and practices regarding incontinence-associated dermatitis (KAP-IAD).</div></div><div><h3>Methods</h3><div>This study utilized responses from hospital nurses to the Knowledge, Attitudes, and Practices of Incontinence-Associated Dermatitis Questionnaire (KAP-IAD-Q). Three clustering methods, Hierarchical Clustering on Principal Components (HCPC), K-means, and Partitioning Around Medoids (PAM), were applied to analyze the correlations of KAP-IAD. A classification method was used to explain the underlying behavioral patterns behind these correlations.</div></div><div><h3>Results</h3><div>Two clusters were found to be most appropriate. Decision attributes (D) were generated for the KAP-IAD data using the three clustering methods: HCPC, K-means, and PAM. Three datasets with categorical labels were generated, and predictive models and decision rules were established for each dataset using the Rough Set (RS) method. The PAM method demonstrated the highest accuracy among the three datasets. After five rounds of stochastic modeling, 57 decision rules were generated. Additionally, patterns or rules with a support threshold of 50 or more, as discussed by domain experts, were considered the primary behaviors or rules.</div></div><div><h3>Conclusions</h3><div>Our study suggests clear decision rules for KAP-IAD nursing practice, which have been absent in previous research. The key variables and rules identified can serve as a guide for KAP-IAD nursing practice, as well as for recognizing the etiology, risk factors, and key influences of dermatitis associated with KAP-IAD in nursing practice. This study provides an important management approach for the prevention and treatment of incontinence-associated dermatitis.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100899"},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of epidermal and fibroblast growth factor-infused collagen patches on wound healing in a full-thickness rat model","authors":"Fahri Sabanciogullarindan ,&nbsp;Mehmet Bozkurt ,&nbsp;Nilsen Yildirim Erdogan ,&nbsp;Yasar Samet Gokceoglu ,&nbsp;Percin Karakol","doi":"10.1016/j.jtv.2025.100903","DOIUrl":"10.1016/j.jtv.2025.100903","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of Epidermal Growth Factor (EGF)- and Fibroblast Growth Factor (FGF)-infused collagen patches on wound healing in an experimental rat model. The focus was on acute and chronic inflammation, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and collagen remodeling.</div></div><div><h3>Methods</h3><div>Full-thickness cranial wounds (12 mm) were created on the dorsal regions of 21 male Wistar rats and divided into four groups: Group 1 (collagen patch alone), Group 2 (collagen + EGF), Group 3 (collagen + FGF). The kaudal defects served as a chronic wound model with secondary intention healing, monitored for 21 days. Tissue biopsies were collected on days 3, 7, and 21. Histopathological evaluation included inflammation scores, granulation tissue formation, fibroblast maturation, re-epithelialization, neovascularization, and Type 1/Type 3 collagen ratio. Data were analyzed using one-way ANOVA, Kruskal–Wallis test, and other appropriate post hoc tests. Statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Acute inflammation significantly decreased in Group 3 on day 7 (p = 0.001), while chronic inflammation was minimal by day 21 in Groups 1 and 3. Group 2 showed the highest granulation tissue formation on day 21 (p &lt; 0.05). Fibroblast maturation peaked in Group 3 on day 21 (p = 0.004). Re-epithelialization was complete in Groups 1 and 3 by day 21, significantly outperforming Group 2 (p &lt; 0.005). Group 3 demonstrated superior collagen deposition and the highest Type 1/Type 3 collagen ratio (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>FGF-infused collagen patches significantly improved fibroblast maturation, epithelialization, and collagen remodeling, outperforming EGF and standalone collagen patches. These findings highlight the potential of FGF as a therapeutic agent in wound healing.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100903"},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing Patient engagement in preventing pressure injuries: A cross-sectional study in Orthopedic inpatients","authors":"Ying Liu ,&nbsp;Rong Hu ,&nbsp;Peifang Li ,&nbsp;Lin Zhang ,&nbsp;Liqun Wang ,&nbsp;Junhong Qu ,&nbsp;Xingcui Pu ,&nbsp;Ning Ning ,&nbsp;Jiali Chen","doi":"10.1016/j.jtv.2025.100902","DOIUrl":"10.1016/j.jtv.2025.100902","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to explore the level of patients’ engagement behaviours in preventing pressure injury (PI) and the influencing factors related to it.</div></div><div><h3>Background</h3><div>The importance of “Patient and Family Engagement” was recognized as one of the key components in the outline of the 2023 Global Patient Safety Report. PIs were common and concerning patient safety events in Orthopaedics department. Active patient participation behaviour can effectively prevent the occurrence of PIs.</div></div><div><h3>Method</h3><div>This was a cross-sectional study involving 366 participants from Orthopaedics in China who has high level of risk in PI. The behavioural level of patients' participation in PI prevention was measured using a research tool designed by the research team. Based on the theory of planned behaviour, the possible influencing factors were determined, and the corresponding research tools were selected for evaluation. Univariate analysis, correlation analysis and multiple stepwise regression were used to determine the influencing factors of patients’ participation behaviour with SPSS 25.0.</div></div><div><h3>Results</h3><div>The total score of orthopaedic inpatients participating in PI preventive behaviour was 89.45 ± 10.64, with a scoring rate of 85.19 % (actual score/maximum possible score × 100 %), indicating relatively high adherence. Multiple regression analysis revealed that social support showed the strongest positive association (β = 0.291, P &lt; 0.001), suggesting enhanced support networks facilitate engagement. Participation attitude (β = 0.211, P &lt; 0.001) and health literacy (β = 0.233, P &lt; 0.001) were key cognitive facilitators. Unexpectedly, cohabitation with children exhibited negative correlation (β = −0.141, P = 0.001), potentially indicating caregiving role transfer. Inter-hospital transfers (β = −0.120, P = 0.004) and medium-length stays (4–7 days, β = −0.089, P = 0.010) were inversely related, possibly reflecting care continuity challenges. Social Security recipients demonstrated greater participation (β = 0.108, P = 0.009), highlighting socioeconomic influences.</div></div><div><h3>Conclusion</h3><div>Our findings may guide clinical healthcare providers to develop more targeted interventions to promote patient engagement in self-care, including encouraging family members to involve in PI prevention with patients, improving patients’ attitude of participation, and supporting more health education of PI prevention. It was a potential suggestion for patient participation behaviour in medical services to prevent other types of adverse events as well.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100902"},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the effects of far infrared radiation on muscle injury caused by centrifugal exercise","authors":"Lin Ren ,&nbsp;Ran He","doi":"10.1016/j.jtv.2025.100900","DOIUrl":"10.1016/j.jtv.2025.100900","url":null,"abstract":"<div><h3>Objective</h3><div>Explore the recovery effect of FIR on high-intensity centrifugal contraction or lower limb muscle fiber injury caused by long-term endurance exercise.</div></div><div><h3>Methods</h3><div>Collect and organize relevant literature on FIR, and explore the recovery effect and possible mechanism of FIR intervention on subtle muscle fiber damage caused by exercise.</div></div><div><h3>Result</h3><div>FIR can reduce COX-2, inhibit PGE₂, accelerate hydrogen peroxide clearance, alleviate pain caused by various conditions, promote cell proliferation, and increase blood flow; Among the two main processing tools of FIR, FIR lighting fixtures that are exposed to radiation for 30 min a day after exercise can effectively alleviate the human induced DOMS condition, while FIR clothing needs to be worn for 9 h a day to have the effect of slowing down DOMS.</div></div><div><h3>Conclusion</h3><div>FIR may be developed into one of the auxiliary strategies for warm-up before competitions and after intermission in the future.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100900"},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized clinical trial of the efficacy of the EmoLED medical device in the treatment of stage 2 and stage 3 pressure ulcers: The RISE_UP study","authors":"Hamilton Dollaku ,&nbsp;Mara Dalladonna ,&nbsp;Marika Giuliano ,&nbsp;Michele Rossi ,&nbsp;Paola Barbetti ,&nbsp;Maria Sipontina Marcolongo ,&nbsp;Emanuele Buccione ,&nbsp;Paolo Iovino ,&nbsp;Claudio Macchi","doi":"10.1016/j.jtv.2025.100895","DOIUrl":"10.1016/j.jtv.2025.100895","url":null,"abstract":"<div><h3>Aim of the study</h3><div>Pressure ulcers are an important public health issue, impacting quality of life and causing health deterioration. Blue light photobiomodulation has been shown promoting wound healing in vascular, diabetic, rheumatologic ulcers and lesions in spinal cord injury patients. Based on these preliminary results, this study was developed to assess the effectiveness of blue light therapy in second and third stage pressure ulcers.</div></div><div><h3>Materials and methods</h3><div>This study was a randomized controlled trial enrolling hospitalized patients with poor mobility. The intervention group included blue light treatment in addition to standard care, three times a week, for 4 consecutive weeks. The primary objective is the difference in the healing process by measuring the average difference of the lesion's PUSH score between the first and the last visit.</div></div><div><h3>Results</h3><div>The analysis shows that the mean PUSH reduction and the probability of belonging to responder patients were higher in the treatment group. A latent profile analysis that identifies two trajectory classes based on treatment response, shows an association in the probability of following best trajectory for the treatment group (30 % vs 2 %).</div></div><div><h3>Conclusions</h3><div>The result shows that blue light photobiomodulation promotes recovery of tissue repair in pressure ulcers, and in stabilizing wounds that would otherwise worsen despite standard of care treatment. This therapy may be a valuable contribution to the daily management of pressure lesions since it has an excellent safety profile and the addition of this therapy to a treatment program may speed healing, improving the quality of life.</div><div>(<span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> Ref. numb.: NCT05130814)</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100895"},"PeriodicalIF":2.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the structural and histopathological challenges of binary electrospun PET-based nanofibers for tissue engineering applications","authors":"Afsaneh Jahani ,&nbsp;Davod Mohebbi-Kalhori ,&nbsp;Farkhonde Sarhaddi ,&nbsp;Gholam Hosein Kazemzadeh ,&nbsp;Reza Taheri ,&nbsp;Mehdi Ahmadi ,&nbsp;Nafiseh Jirofti","doi":"10.1016/j.jtv.2025.100888","DOIUrl":"10.1016/j.jtv.2025.100888","url":null,"abstract":"<div><div>Tissue engineering and regenerative medicine aim to address tissue lesions and organ degenerations, enhancing clinical outcomes by restoring damaged tissues and functionalities. Recent progress in materials science and medicine has led to the development of regenerative engineering, revolutionizing the production of polymeric artificial scaffolds by electrospinning method, which mimic the extracellular matrix (ECM). Polyurethane (PU) is recognized for its elastic nature, comprising soft and hard segments, and possesses bioactive as well as biocompatible properties. Polycaprolactone (PCL), on the other hand, is a non-toxic polymer with a viscous nature, known for its favorable mechanical properties. This study focuses on the comprehensive histological evaluation of binary electrospun PET-based nanofiber scaffolds, as widely used in tissue engineering. The structural analysis involved FE-SEM imaging, porosity measurement, FTIR, and DSC examinations. In vitro assessments included degradation rates, water uptake, cell viability, morphological cell examination, and cell attachment studies. Additionally, scaffolds were subcutaneously implanted in rats for pathological examination. After a 30 days implantation period, histological and pathological parameters such as edema, inflammation, foreign body giant cell reaction, fibrosis, necrosis, and calcification were evaluated. The results highlight the successful application of blend electrospinning in producing PET/PCL and PET/PU nanofiber scaffolds with various composition ratios. FE-SEM imaging revealed uniform nanostructures without bead formation. Histological analysis showed favorable biocompatibility, with the PET/PCL (25:75) composition demonstrating superior structural characteristics compared to other ratios. The cell studies indicated that PET-based nanofiber scaffolds exhibited suitable cell viability and attachment, underscoring their potential for tissue engineering applications.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100888"},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}