Journal of tissue viability最新文献

{"title":"A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds","authors":"Lan Chen,&nbsp;Jia Liu,&nbsp;Yaoyao He,&nbsp;Chongcong Zeng,&nbsp;Weixiang Liao,&nbsp;Chaoxi Luo","doi":"10.1016/j.jtv.2025.100917","DOIUrl":"10.1016/j.jtv.2025.100917","url":null,"abstract":"<div><h3>Aim</h3><div>Exosomes, small endosome-derived membrane vesicles, have shown significant potential as wound healing therapies. However, translating experimental research into commercially available treatments remains a challenge.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis provide a comprehensive evaluation of the current research on exosome-based wound healing therapies.</div></div><div><h3>Materials and methods</h3><div>A systematic search of PubMed and Google Scholar was conducted to identify full-text articles published between 2010 and February 2024 on mammalian-derived exosomes in wound healing. Of 138 identified studies, 19 met the inclusion criteria for meta-analysis.</div></div><div><h3>Results</h3><div>Exosome-based therapies were found to enhance wound healing by promoting angiogenesis, re-epithelialization, and collagen deposition while reducing scar formation. However, research in this area is highly variable, with differences in cell sources, biomaterials, and delivery methods.</div></div><div><h3>Conclusions</h3><div>Further comparative studies are needed to optimize cellular sources, delivery systems, and biomaterials. The reliance on rodent models remains a limitation, as progress toward large-scale testing and more advanced in vivo models has been slow. Addressing these challenges is crucial for the clinical translation of exosome-based therapies into scalable, commercially viable wound healing treatments.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100917"},"PeriodicalIF":2.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' practices in preventing medical device-related pressure injuries in neonates in Saudi Neonatal Intensive Care Units","authors":"Ahmad Ismail ,&nbsp;Ameera Suhail Alghamdi ,&nbsp;Hanadi Abdullah Alzbeedi ,&nbsp;Mashael F. Dewan ,&nbsp;Dena Attallah","doi":"10.1016/j.jtv.2025.100909","DOIUrl":"10.1016/j.jtv.2025.100909","url":null,"abstract":"<div><h3>Background</h3><div>Neonatal pressure injury due to medical devices is prevalent, especially in the Neonatal Intensive Care Units (NICU). Nurses play a significant role in preventing medical device-related pressure injuries (MDRPI) in neonates. However, NICU nurses' practices in preventing MDRPI are not well known in Saudi Arabia.</div></div><div><h3>Objective</h3><div>This study aimed to assess nurses' practices in preventing the MDRPI in the NICU in Saudi Arabia.</div></div><div><h3>Methods</h3><div>A quantitative cross-sectional design was used to capture information from 82 NICU nurses working in two hospitals in Jeddah, Saudi Arabia (private and governmental). Nurses' practices were assessed using a self-reported questionnaire of two main parts: 1) demographic and work-related factors, and 2) nurses' practices regarding preventing MDRPI. Data were analyzed using descriptive statistics, frequencies, percentages, and independent t-tests.</div></div><div><h3>Results</h3><div>The total practice score for the MDRPI was moderate (3.8/5 ± 1.4). A substantial proportion of nurses never or rarely performed some important practices to prevent MDRPI in the NICU. Nurses who received education/training on pressure ulcers and MDRPI achieved a significantly higher practice score for MDRPI prevention than those who did not (P &lt; 0.05). Nurses who reported having a policy or protocol at their units for MDRPI achieved a significantly higher practice score for MDRPI prevention than those who did not (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Although the practice score of NICU nurses to prevent MDRPI was moderate, many nurses never or rarely employed some important practices to prevent MDRPI in the NICU. Targeted interventions are needed to educate NICU nurses on MDRPI prevention. Future research should recruit more nurses from various NICUs in Saudi Arabia.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100909"},"PeriodicalIF":2.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atmospheric plasma control excessive inflammation and oxidative stress in burn wound healing in diabetes-induced rats","authors":"Jennyffer Souza ,&nbsp;Amanda Tavares Pereira ,&nbsp;Letícia de Lima ,&nbsp;Raul Wiltler ,&nbsp;Maraiara Aparecida de Oliveira ,&nbsp;Samara de Sousa Mariano ,&nbsp;Leonardo Bagne ,&nbsp;Bruno Bellotti Lopes ,&nbsp;Maria Esméria Corezola do Amaral ,&nbsp;Gustavo de Bem Silveira ,&nbsp;Laura de Roch Casagrande ,&nbsp;Paulo Cesar Lock Silveira ,&nbsp;Andrea Aparecida de Aro ,&nbsp;Thiago Antônio Moretti de Andrade","doi":"10.1016/j.jtv.2025.100918","DOIUrl":"10.1016/j.jtv.2025.100918","url":null,"abstract":"<div><div>Burns are the fourth most prevalent trauma worldwide, and their complications are significantly exacerbated when associated with diabetes, leading to increased morbidity and mortality. This study addresses the urgent need for safe and effective treatments by exploring the therapeutic potential of atmospheric plasma (AP), an ionized gas produced at atmospheric pressure, in enhancing the healing of burn wounds. We investigated the effects of AP on the repair of second-degree dorsal burns in Wistar rats, induced to diabetes with alloxan (45 mg/kg). The animals were randomly assigned to either the sham group (plasma generator off) or the AP group (treated with AP for 1 min daily until the 2nd, 7th, 14th and 21st days). Our findings indicate that AP treatment significantly reduced inflammatory cell accumulation, increased interleukin levels, controlled oxidative damage, and stimulated antioxidant responses. Furthermore, AP promoted angiogenesis, fibroblast proliferation, and collagen fiber organization. These results suggest that AP accelerates tissue healing in diabetic burns, making it a promising treatment for improving burn wound healing in diabetes-induced conditions.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100918"},"PeriodicalIF":2.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving concordance with long-term compression therapy amongst people with venous ulceration: A Delphi study- clinician cohort.","authors":"Chloe Jansz, William McGuiness, Sonja Cleary","doi":"10.1016/j.jtv.2025.100908","DOIUrl":"https://doi.org/10.1016/j.jtv.2025.100908","url":null,"abstract":"<p><p>Research by Nelson and Adderley (2016)reveals that 60-80 % of individuals affected by chronic venous insufficiency (CVI) develop venous leg ulcers (VLU). The gold standard treatment for VLU is the application of compression therapy (CT), which promotes venous return, reduces venous pressure, and minimizes stasis (Bullock & Manias, 2022). Patient concordance to CT is suboptimal, with only 40 % concordance, leading to a higher risk of VLU recurrence (Eri ckson et al., 1995; Fi nlayson et al., 2014; K app et al., 2013). This poses a significant and costly healthcare challenge (Smith & McGuiness, 2010). A Delphi study was conducted to ascertain the factors that influence concordance with CT using a clinician cohort. The study asked participants to rank factors that facilitated concordance and those that acted as barrier. Results revealed that clinicians identified 44 factors that facilitated concordance and 46 factors that acted as a barrier in the initial phase. The consensus level, measured by a Kendall W Coefficient, ranged from moderate to strong amongst the participants (Zanotti & Chiffi, 2015).</p>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":" ","pages":"100908"},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker of pressure injuries in critically ill adults based on large-scale medical Datasets:A multi-center prospective study","authors":"Lin Lv ,&nbsp;Ning Wang ,&nbsp;Yanxia Jiao ,&nbsp;Anna Wen ,&nbsp;Jie Xu ,&nbsp;Xinyue Xu ,&nbsp;Li Du ,&nbsp;Lin Han","doi":"10.1016/j.jtv.2025.100912","DOIUrl":"10.1016/j.jtv.2025.100912","url":null,"abstract":"<div><h3>Objectives</h3><div>Pressure injuries (PIs) are a global health concern, particularly in the context of an ageing population. They impose significant economic and social burdens, serve as key indicators of nursing quality, and are associated with increased mortality and morbidity.</div></div><div><h3>Methods</h3><div>We conducted a multi-center prospective descriptive study involving 3867 critically ill adults admitted to ICUs across 28 hospitals in Gansu Province, China, from April 1, 2021, to July 31, 2023. Data were collected using the “Long Hu Hui” PI risk management platform, which covers 98 indicators.</div></div><div><h3>Results</h3><div>The incidence of hospital-acquired PIs was 5.20 %. Univariate analysis identified 15 significant indicators associated with PIs, including body temperature, blood oxygen saturation, and central venous pressure. Logistic regression analysis revealed body temperature, diastolic blood pressure, blood oxygen saturation, haemoglobin, central venous pressure, and blood urea nitrogen as independent risk factors for PIs. A clinical prediction model was developed, demonstrating superior predictive performance compared to existing scales.</div></div><div><h3>Conclusions</h3><div>This study identified key physiological and biochemical markers associated with developing PIs in critically ill adults. The developed prediction model offers a more accurate tool for clinical risk assessment and may guide preventive strategies.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100912"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The power of empathy: Enhancing healing outcomes in chronic wound care","authors":"Sebastian Probst ,&nbsp;Hayley Ryan ,&nbsp;Peta Tehan","doi":"10.1016/j.jtv.2025.100911","DOIUrl":"10.1016/j.jtv.2025.100911","url":null,"abstract":"<div><h3>Aim</h3><div>This study explores the impact of healthcare providers’ empathy on patients' healing outcomes and satisfaction in chronic wound care.</div></div><div><h3>Materials and methods</h3><div>A qualitative descriptive approach was used. Ten adults with chronic wounds were recruited through purposive sampling. Semi-structured interviews were conducted in January 2025, lasting an average of 37.1 min. Data were transcribed verbatim and analyzed thematically using Braun and Clarke's six-phase framework. Rigor was ensured through systematic coding, researcher triangulation, and adherence to COREQ guidelines.</div></div><div><h3>Results</h3><div>The analysis identified three central themes: (1) The need for person-centered and consistent care, emphasizing the importance of continuity in healthcare providers to reduce emotional exhaustion and improve adherence; (2) The emotional impact of empathy in wound care, demonstrating that empathetic communication raises trust, decreases pain perception, and enhances psychological resilience; and (3) The role of communication, trust, and cultural awareness, highlighting that clear explanations and cultural competence improve patient satisfaction and engagement. Participants who felt listened to and involved in decision-making reported better motivation and adherence to treatment.</div></div><div><h3>Conclusion</h3><div>Empathy is an important component of effective wound care, influencing healing outcomes, psychological well-being, and treatment adherence. Integrating empathy into clinical practice through continuity of care, shared decision-making, and cultural competence can improve patient satisfaction and overall wound management. Healthcare systems should prioritize training and policies that support empathy-driven, person-centered care.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100911"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global perspective on the incidence, severity, and management of diaper dermatitis in neonates, infants, and young children","authors":"Ojisamola Jaiyeoba,&nbsp;Marty O. Visscher","doi":"10.1016/j.jtv.2025.100905","DOIUrl":"10.1016/j.jtv.2025.100905","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to determine the incidence and severity of diaper dermatitis (DD) among neonates, infants and young children and identify the most effective treatment strategies with a global perspective.</div></div><div><h3>Materials and methods</h3><div>We conducted a narrative review of literatures searches from PubMed, EMBASE, and SCOPUS, found 1996 citations, selected primary source papers on infants and children ≤36 months and critically reviewed reports on incidence, severity, and treatment.</div></div><div><h3>Results</h3><div>The analysis produced information on DD incidence and diaper skin care habits from 7500 subjects in 12 countries including extremely premature infants. Three studies suggested that dark-skinned infants had lower incidence and/or severity versus light-skinned subjects. Treatments were generally effective but varied somewhat in rate and/or extent of DD reduction. Variations in DD assessment methods, study design, and starting severity were limitations for comprehensive treatment comparison.</div></div><div><h3>Conclusions</h3><div>DD incidence is relatively high, ranging from 36 to 75 % in home and hospital settings, with severe cases from 1 to 24 %. The review suggests that treatments with “drying” processes or ingredients are promising strategies for improved outcomes. It highlights skin care practices that may reduce DD and prompts questions for future research to understand and manage conditions for optimum skin function in the diaper environment.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100905"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing beyond the surface: Empathy's role in chronic wound care a qualitative study","authors":"Sebastian Probst ,&nbsp;Shan Maree Bergin ,&nbsp;Peta Tehan","doi":"10.1016/j.jtv.2025.100910","DOIUrl":"10.1016/j.jtv.2025.100910","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to investigate health professionals’ perceptions of the impact of empathy on healing outcomes, patient satisfaction and delivery of wound care.</div></div><div><h3>Materials and methods</h3><div>A descriptive qualitative approach was used, employing semi-structured face-to-face interviews with 10 healthcare professionals specializing in wound care in Australia. Participants were purposively sampled, and interviews lasted between 22 and 47 min. Data collection concluded upon achieving saturation. Interviews were transcribed verbatim using CORV, a secured transcription tool, and analyzed using Braun and Clarke's six-phase thematic framework. Rigor was ensured by employing COREQ guidelines, triangulating data analysis, and including direct quotes for confirmability.</div></div><div><h3>Results</h3><div>Three key themes emerged: (1) Empathy as a Foundation for Trust, Engagement, and Collaboration where participants emphasized that empathy promotes trust, improves patient adherence, and aligns treatment goals. (2) The Dual Role of Empathy in Addressing Emotional and Physical Barriers to Healing where empathetic care alleviated psychological distress, built resilience, and improved adherence to care regimens. (3) Barriers and Facilitators to Empathy in Wound Care where time constraints, emotional fatigue, and cultural differences were identified as barriers, while mentorship, training, and supportive environments facilitated empathetic care.</div></div><div><h3>Conclusion</h3><div>Health professionals considered empathy to be a critical factor in enhancing patient satisfaction and supporting healing outcomes in wound care. By providing trust, addressing emotional barriers, and aligning care with patient needs, empathy plays a meaningful role in the care process. Additionally, addressing systemic barriers and thoughtfully integrating empathy training into clinical practice can contribute to improved outcomes in chronic wound management.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100910"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the correlation between SINBAD system score and wound pH value in diabetic foot sarcopenia","authors":"Wang Hui ,&nbsp;Yang Yaping ,&nbsp;Gong Liqing ,&nbsp;Mao Zhigang ,&nbsp;Peng yinbo ,&nbsp;Wang Jing","doi":"10.1016/j.jtv.2025.100915","DOIUrl":"10.1016/j.jtv.2025.100915","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the diagnostic value of the SINBAD system score combined with wound pH value in diabetic foot sarcopenia.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This is a cross-sectional observational clinical study. From June 2023 to June 2024, diabetic foot patients attending the outpatient clinic of Shanghai Yangpu hospital were consecutively enrolled. Data collected included skeletal muscle index, grip strength, 6-m walking speed, SINBAD system classification, and wound pH value. Based on the diagnostic criteria of the European Working Group on Sarcopenia, patients were classified into three groups: Non-sarcopenia group, pre-sarcopenia group, and sarcopenia group. Between-group comparisons were made using one-way ANOVA, Kruskal-Wallis H test, or Chi-square test. Spearman's correlation analysis was used to assess the correlation between the SINBAD system score and sarcopenia-related indicators. Pearson's correlation analysis was employed to evaluate the correlation between wound pH and sarcopenia-related indicators. Binary logistic regression was performed to analyze the factors influencing sarcopenia in diabetic foot patients. The diagnostic value of the SINBAD system score combined with wound pH value in diabetic foot sarcopenia was assessed using receiver operating characteristic (ROC) curves.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 71 diabetic foot patients were enrolled. Of these, 29 were in the Non-sarcopenia group, 13 in the pre-sarcopenia group, and 29 in the sarcopenia group. Compared with the Non-sarcopenia group and pre-sarcopenia group, the sarcopenia group had significantly longer diabetes duration and diabetic foot disease duration (P &lt; 0.05). The sarcopenia group had lower grip strength compared to both the Non-sarcopenia group and pre-sarcopenia group (P &lt; 0.05). The skeletal muscle index (SMI) of the sarcopenia group was significantly lower than that of the Non-sarcopenia group and pre-sarcopenia group (P &lt; 0.05). Pearson correlation analysis showed that wound pH value was negatively correlated with SMI (r = −0.476, P &lt; 0.001) and grip strength (r = −0.478, P &lt; 0.05). Spearman correlation analysis revealed that the SINBAD system score was negatively correlated with SMI (r = −0.716, P &lt; 0.05) and grip strength (r = −0.666, P &lt; 0.05). Binary logistic regression analysis indicated that an increased wound pH value (OR = 29.126, 95 % CI 1.234–687.583) and higher SINBAD system score (OR = 5.271, 95 % CI 2.144–12.961) were significant factors influencing the presence of sarcopenia in diabetic foot patients. ROC curve analysis showed that the combination of wound pH value and SINBAD system score had a high diagnostic value for sarcopenia in diabetic foot patients, with an area under the curve (AUC) of 0.933.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The wound pH value and SINBAD system score are associated with the occurrence of sarcopenia in diabetic foot patients and have diagnosti","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100915"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the hidden pain and daily struggles of individuals with a venous leg ulcer: a thematic analysis","authors":"Sebastian Probst ,&nbsp;Elisabeth Schobinger ,&nbsp;Camille Saini ,&nbsp;Philip Larkin ,&nbsp;Paul Bobbink","doi":"10.1016/j.jtv.2025.100906","DOIUrl":"10.1016/j.jtv.2025.100906","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to explore the experiences of pain among individuals living with venous leg ulcers (VLUs), focusing on how pain was described, its impact on daily living, and the coping strategies employed by them.</div></div><div><h3>Materials and methods</h3><div>A secondary qualitative analysis was conducted using data from a previous study on VLU self-management following nurse-led patient education. The original study employed a constructivist grounded theory approach, while this secondary analysis utilized Braun and Clarke's thematic analysis methodology. Semi-structured interviews from 22 participants were analyzed to identify emergent themes related to pain. MAXQDA® software was used to ensure traceability of coding, and rigor was ensured through triangulation and reflexive memos.</div></div><div><h3>Results</h3><div>Three themes emerged: (1) Description of Wound-Related Pain where participants described pain as persistent, multifaceted, and often excruciating, using terms such as “burning” and “stinging.” Pain intensity varied across individuals, with some comparing it to childbirth. (2) Impact on Daily Living where pain considerably affected emotional well-being, mobility, social interactions, and sleep. Many participants experienced emotional exhaustion, frustration, and social isolation due to their condition. (3) Pain Management Strategies where participants used both pharmacological (e.g., paracetamol, tramadol) and non-pharmacological methods (e.g., leg elevation, self-hypnosis) for pain relief. The role of healthcare providers was essential, though some participants felt their pain was inadequately addressed.</div></div><div><h3>Conclusion</h3><div>VLU-associated pain is a prevalent and debilitating aspect of individuals' lives, impacting both physical and psychological health. Comprehensive pain management strategies that integrate both pharmacological and psychosocial approaches should be enhanced to improve patient outcomes.</div></div>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":"34 3","pages":"Article 100906"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}