Journal of Tissue Engineering最新文献

Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach. 推进皮肤模型开发：聚焦自组装、诱导多能干细胞衍生、无异种方法。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241291848

Marla Dubau, Tarada Tripetchr, Lava Mahmoud, Vivian Kral, Burkhard Kleuser

{"title":"Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach.","authors":"Marla Dubau, Tarada Tripetchr, Lava Mahmoud, Vivian Kral, Burkhard Kleuser","doi":"10.1177/20417314241291848","DOIUrl":"10.1177/20417314241291848","url":null,"abstract":"The demand for skin models as alternatives to animal testing has grown due to ethical concerns and the need for accurate substance evaluation. These alternatives, known as New Approach Methodologies (NAMs), are increasingly used for regulatory decisions. Current skin models from primary human cells often rely on bovine collagen, raising ethical issues. This study explores self-assembled skin models (SASM) as a new method, utilizing hair follicle-derived keratinocytes reprogrammed into induced pluripotent stem cells (iPSC) and differentiated into fibroblasts and keratinocytes. The model relies on the ability of fibroblasts to secrete collagen to produce a xeno-free dermal layer and on the differentiation of keratinocytes to create a functional epidermal layer. These layers exhibited confirmed metabolic activity and the capability to withstand test substances. The successful development of SASM underscores the significance of accurate alternatives in dermatological research, providing an ethical and reliable option for substance evaluation and regulatory testing.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241291848"},"PeriodicalIF":6.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic injectable and porous hydrogels for the formation of skeletal muscle fibers: Novel perspectives for the acellular repair of substantial volumetric muscle loss. 用于形成骨骼肌纤维的可注射多孔合成水凝胶：无细胞修复大量肌肉损失的新视角。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241283148

Louise Griveau, Marion Bouvet, Emilie Christin, Cloé Paret, Lauriane Lecoq, Sylvie Radix, Thomas Laumonier, Jerome Sohier, Vincent Gache

{"title":"Synthetic injectable and porous hydrogels for the formation of skeletal muscle fibers: Novel perspectives for the acellular repair of substantial volumetric muscle loss.","authors":"Louise Griveau, Marion Bouvet, Emilie Christin, Cloé Paret, Lauriane Lecoq, Sylvie Radix, Thomas Laumonier, Jerome Sohier, Vincent Gache","doi":"10.1177/20417314241283148","DOIUrl":"10.1177/20417314241283148","url":null,"abstract":"In severe skeletal muscle damage, muscle tissue regeneration process has to face the loss of resident muscle stem cells (MuSCs) and the lack of connective tissue necessary to guide the regeneration process. Biocompatible and standardized 3D structures that can be injected to the muscle injury site, conforming to the defect shape while actively guiding the repair process, holds great promise for skeletal muscle tissue regeneration. In this study, we explore the use of an injectable and porous lysine dendrimer/polyethylene glycol (DGL/PEG) hydrogel as an acellular support for skeletal muscle regeneration. We adjusted the DGL/PEG composition to achieve a stiffness conducive to the attachment and proliferation of murine immortalized myoblasts and human primary muscle stems cells, sustaining the formation and maturation of muscle fibers in vitro. We then evaluated the potential of one selected \"myogenic-porous hydrogel\" as a supportive structure for muscle repair in a large tibialis anterior muscle defect in rats. This injectable and porous formulation filled the defect, promoting rapid cellularization with the presence of endothelial cells, macrophages, and myoblasts, thereby supporting neo-myogenesis more specifically at the interface between the wound edges and the hydrogel. The selected porous DGL/PEG hydrogel acted as a guiding scaffold at the periphery of the defect, facilitating the formation and anchorage of aligned muscle fibers 21 days after injury. Overall, our results indicate DGL/PEG porous injectable hydrogel potential to create a pro-regenerative environment for muscle cells after large skeletal muscle injuries, paving the way for acellular treatment in regenerative muscle medicine.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241283148"},"PeriodicalIF":6.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the regenerative key: Targeting stem cell factors for bone renewal. 打开再生之钥：锁定干细胞因子，促进骨骼再生

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-10-27 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241287491

Gul Karima, Hwan D Kim

{"title":"Unlocking the regenerative key: Targeting stem cell factors for bone renewal.","authors":"Gul Karima, Hwan D Kim","doi":"10.1177/20417314241287491","DOIUrl":"10.1177/20417314241287491","url":null,"abstract":"Stem cell factors (SCFs) are pivotal factors existing in both soluble and membrane-bound forms, expressed by endothelial cells (ECs) and fibroblasts throughout the body. These factors enhance cell growth, viability, and migration in multipotent cell lineages. The preferential expression of SCF by arteriolar ECs indicates that arterioles create a unique microenvironment tailored to hematopoietic stem cells (HSCs). Insufficiency of SCF within bone marrow (BM)-derived adipose tissue results in decreased their overall cellularity, affecting HSCs and their immediate progenitors critical for generating diverse blood cells and maintaining the hematopoietic microenvironment. SCF deficiency disrupts BM function, impacting the production and differentiation of HSCs. Additionally, deleting SCF from adipocytes reduces lipogenesis, highlighting the crucial role of SCF/c-kit signaling in controlling lipid accumulation. This review elucidates the sources, roles, mechanisms, and molecular strategies of SCF in bone renewal, offering a comprehensive overview of recent advancements, challenges, and future directions for leveraging SCF as a key agent in regenerative medicine.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241287491"},"PeriodicalIF":6.7,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaffold-mediated liver regeneration: A comprehensive exploration of current advances. 支架介导的肝脏再生：对当前进展的全面探索。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-10-13 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241286092

Supriya Bhatt S, Jayanthi Krishna Kumar, Shurthi Laya, Goutam Thakur, Manasa Nune

{"title":"Scaffold-mediated liver regeneration: A comprehensive exploration of current advances.","authors":"Supriya Bhatt S, Jayanthi Krishna Kumar, Shurthi Laya, Goutam Thakur, Manasa Nune","doi":"10.1177/20417314241286092","DOIUrl":"https://doi.org/10.1177/20417314241286092","url":null,"abstract":"The liver coordinates over 500 biochemical processes crucial for maintaining homeostasis, detoxification, and metabolism. Its specialized cells, arranged in hexagonal lobules, enable it to function as a highly efficient metabolic engine. However, diseases such as cirrhosis, fatty liver disease, and hepatitis present significant global health challenges. Traditional drug development is expensive and often ineffective at predicting human responses, driving interest in advanced in vitro liver models utilizing 3D bioprinting and microfluidics. These models strive to mimic the liver's complex microenvironment, improving drug screening and disease research. Despite its resilience, the liver is vulnerable to chronic illnesses, injuries, and cancers, leading to millions of deaths annually. Organ shortages hinder liver transplantation, highlighting the need for alternative treatments. Tissue engineering, employing polymer-based scaffolds and 3D bioprinting, shows promise. This review examines these innovative strategies, including liver organoids and liver tissue-on-chip technologies, to address the challenges of liver diseases.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241286092"},"PeriodicalIF":6.7,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene derivative based hydrogels in biomedical applications. 基于石墨烯衍生物的水凝胶在生物医学中的应用。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-10-11 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241282131

Feifei Ni, Yangyang Chen, Ze Wang, Xin Zhang, Fei Gao, Zengwu Shao, Hong Wang

引用次数: 0

Exosomal non-coding RNAs: Emerging insights into therapeutic potential and mechanisms in bone healing. 外泌体非编码 RNA：关于骨愈合的治疗潜力和机制的新见解。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-10-05 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241286606

Huixin Shi, Yang Yang, Hao Xing, Jialin Jia, Wei Xiong, Shu Guo, Shude Yang

{"title":"Exosomal non-coding RNAs: Emerging insights into therapeutic potential and mechanisms in bone healing.","authors":"Huixin Shi, Yang Yang, Hao Xing, Jialin Jia, Wei Xiong, Shu Guo, Shude Yang","doi":"10.1177/20417314241286606","DOIUrl":"10.1177/20417314241286606","url":null,"abstract":"Exosomes are nano-sized extracellular vesicles (EVs) released by diverse types of cells, which affect the functions of targeted cells by transporting bioactive substances. As the main component of exosomes, non-coding RNA (ncRNA) is demonstrated to impact multiple pathways participating in bone healing. Herein, this review first introduces the biogenesis and secretion of exosomes, and elucidates the role of the main cargo in exosomes, ncRNAs, in mediating intercellular communication. Subsequently, the potential molecular mechanism of exosomes accelerating bone healing is elucidated from the following four aspects: macrophage polarization, vascularization, osteogenesis and osteoclastogenesis. Then, we systematically introduce construction strategies based on modified exosomes in bone regeneration field. Finally, the clinical trials of exosomes for bone healing and the challenges of exosome-based therapies in the biomedical field are briefly introduced, providing solid theoretical frameworks and optimization methods for the clinical application of exosomes in orthopedics.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241286606"},"PeriodicalIF":6.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of bioactive peptides as therapeutic agents for skin wound repair. 发现作为皮肤伤口修复治疗剂的生物活性肽。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-09-29 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241280359

Nur Izzah Md Fadilah, Nurul Aqilah Shahabudin, Raniya Adiba Mohd Razif, Arka Sanyal, Anushikha Ghosh, Khairul Idzwan Baharin, Haslina Ahmad, Manira Maarof, Antonella Motta, Mh Busra Fauzi

{"title":"Discovery of bioactive peptides as therapeutic agents for skin wound repair.","authors":"Nur Izzah Md Fadilah, Nurul Aqilah Shahabudin, Raniya Adiba Mohd Razif, Arka Sanyal, Anushikha Ghosh, Khairul Idzwan Baharin, Haslina Ahmad, Manira Maarof, Antonella Motta, Mh Busra Fauzi","doi":"10.1177/20417314241280359","DOIUrl":"https://doi.org/10.1177/20417314241280359","url":null,"abstract":"Short sequences of amino acids called peptides have a wide range of biological functions and the potential to treat a number of diseases. Bioactive peptides can be derived from different sources, including marine organisms, and synthetic design, making them versatile candidates for production of therapeutic agents. Their therapeutic effects span across areas such as antimicrobial activity, cells proliferation and migration, synthesis of collagen, and more. This current review explores the fascinating realm of bioactive peptides as promising therapeutic agents for skin wound healing. This review focuses on the multifaceted biological effects of specific peptides, shedding light on their potential to revolutionize the field of dermatology and regenerative medicine. It delves into how these peptides stimulate collagen synthesis, inhibit inflammation, and accelerate tissue regeneration, ultimately contributing to the effective repair of skin wounds. The findings underscore the significant role several types of bioactive peptides can play in enhancing wound healing processes and offer promising insights for improving the quality of life for individuals with skin injuries and dermatological conditions. The versatility of peptides allows for the development of tailored treatments catering to specific wound types and patient needs. As continuing to delve deeper into the realm of bioactive peptides, there is immense potential for further exploration and innovation. Future endeavors may involve the optimization of peptide formulations, elucidation of underlying molecular and cellular mechanisms.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241280359"},"PeriodicalIF":6.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered pre-dentin with well-aligned hierarchical mineralized collagen fibril bundles promote bio-root regeneration. 工程预制牙本质具有排列整齐的分层矿化胶原纤维束，可促进生物根再生。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241280961

Lei Hu, Dongmei Cheng, Xin Yuan, Zhenhua Gao, Qiao Yi, Bin Zhao, Fulan Wei, Junji Xu, Zhipeng Fan, Yi Liu, Xiumei Wang, Fuzhai Cui, Chunmei Zhang, Jinsong Wang, Songlin Wang

{"title":"Engineered pre-dentin with well-aligned hierarchical mineralized collagen fibril bundles promote bio-root regeneration.","authors":"Lei Hu, Dongmei Cheng, Xin Yuan, Zhenhua Gao, Qiao Yi, Bin Zhao, Fulan Wei, Junji Xu, Zhipeng Fan, Yi Liu, Xiumei Wang, Fuzhai Cui, Chunmei Zhang, Jinsong Wang, Songlin Wang","doi":"10.1177/20417314241280961","DOIUrl":"https://doi.org/10.1177/20417314241280961","url":null,"abstract":"Stem cell-mediated bio-root regeneration is an alternative tooth replacement strategy; however, physiologically functional bio-root regeneration with distinctive dentin structure remains challenging. In this study, the distinct arrangements of collagen fibril bundles were identified that account for hierarchical structural differences between dentin, cementum, and alveolar bone. Thus, an \"engineered pre-dentin\" was fabricated, which was a dentin hierarchical structure mimicking collagen (MC) scaffold, with well-aligned hierarchical mineralized collagen fibril bundles. The results revealed that it has a stronger effect on promoting biological root regeneration in nude mice and miniature pigs with dental pulp stem cell (DPSC) and periodontal ligament stem cell (PDLSC) sheets compared to hydroxyapatite tricalcium phosphate (HA/TCP). The success rate in the MC group was also higher than that in the HA/TCP group (67% and 33%, respectively). In conclusion, the hierarchical dentin-mimicking scaffold can enhance the regeneration of bio-roots, which provides a promising strategy for tooth regeneration.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241280961"},"PeriodicalIF":6.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting ROS in osteoclasts within the OA environment: A novel therapeutic strategy for osteoarthritis management. 在 OA 环境中靶向破骨细胞中的 ROS：治疗骨关节炎的新策略

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241279935

Seungho Jeon, Tae Min Kim, Gitae Kwon, Junyoung Park, Sung Young Park, Seoung Hoon Lee, Eun-Jung Jin

{"title":"Targeting ROS in osteoclasts within the OA environment: A novel therapeutic strategy for osteoarthritis management.","authors":"Seungho Jeon, Tae Min Kim, Gitae Kwon, Junyoung Park, Sung Young Park, Seoung Hoon Lee, Eun-Jung Jin","doi":"10.1177/20417314241279935","DOIUrl":"10.1177/20417314241279935","url":null,"abstract":"This study investigated the therapeutic potential of a manganese dioxide-polymer dot (MnO2-PD)-incorporated hydrogel, designated as M-PD hydrogel, for modulating reactive oxygen species (ROS) within the osteoarthritis (OA) environment. Our research highlights the ability of the hydrogel to scavenge ROS, thereby influencing the differentiation of osteoclasts and protecting chondrocytes, offering a novel approach to osteoarthritis (OA) management. Our results indicated that the M-PD hydrogel increased electrical resistance and fluorescence recovery in the presence of osteoclasts, correlating with decreased ROS levels and suppressed expression of osteoclast differentiation markers. Coculture experiments revealed the protective effects of the hydrogel on chondrocytes by reducing the expression of matrix-degrading enzymes. In vivo application in burr holes and/or OA-induced mice revealed a significant reduction in osteoclast formation and cartilage destruction, suggesting the dual therapeutic action of the hydrogel in altering the joint microenvironment. These findings highlight the potential of targeting ROS in osteoclasts as a comprehensive therapeutic approach, offering not only symptomatic relief but also targeting the underlying mechanisms of disease progression in OA.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241279935"},"PeriodicalIF":6.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocuring 3D printing technology as an advanced tool for promoting angiogenesis in hypoxia-related diseases. 光固化三维打印技术是促进缺氧相关疾病血管生成的先进工具。

IF 6.7 1区工程技术

Journal of Tissue Engineering Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1177/20417314241282476

Sang Yoon Lee, Huynh Dai Phuc, Soong Ho Um, Rosaire Mongrain, Jeong-Kee Yoon, Suk Ho Bhang

{"title":"Photocuring 3D printing technology as an advanced tool for promoting angiogenesis in hypoxia-related diseases.","authors":"Sang Yoon Lee, Huynh Dai Phuc, Soong Ho Um, Rosaire Mongrain, Jeong-Kee Yoon, Suk Ho Bhang","doi":"10.1177/20417314241282476","DOIUrl":"https://doi.org/10.1177/20417314241282476","url":null,"abstract":"Three-dimensional (3D) bioprinting has emerged as a promising strategy for fabricating complex tissue analogs with intricate architectures, such as vascular networks. Achieving this necessitates bioink formulations that possess highly printable properties and provide a cell-friendly microenvironment mimicking the native extracellular matrix. Rapid advancements in printing techniques continue to expand the capabilities of researchers, enabling them to overcome existing biological barriers. This review offers a comprehensive examination of ultraviolet-based 3D bioprinting, renowned for its exceptional precision compared to other techniques, and explores its applications in inducing angiogenesis across diverse tissue models related to hypoxia. The high-precision and rapid photocuring capabilities of 3D bioprinting are essential for accurately replicating the intricate complexity of vascular networks and extending the diffusion limits for nutrients and gases. Addressing the lack of vascular structure is crucial in hypoxia-related diseases, as it can significantly improve oxygen delivery and overall tissue health. Consequently, high-resolution 3D bioprinting facilitates the creation of vascular structures within three-dimensional engineered tissues, offering a potential solution for addressing hypoxia-related diseases. Emphasis is placed on fundamental components essential for successful 3D bioprinting, including cell types, bioink compositions, and growth factors highlighted in recent studies. The insights provided in this review underscore the promising prospects of leveraging 3D printing technologies for addressing hypoxia-related diseases through the stimulation of angiogenesis, complementing the therapeutic efficacy of cell therapy.","PeriodicalId":17384,"journal":{"name":"Journal of Tissue Engineering","volume":"15 ","pages":"20417314241282476"},"PeriodicalIF":6.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0