Journal of the Pediatric Infectious Diseases Society最新文献

{"title":"Response to: Pediatric Coccidioidomycosis: Disease Spectrum and Implications for Antifungal Therapy.","authors":"Sanchi Malhotra, Paul Krogstad","doi":"10.1093/jpids/piag044","DOIUrl":"https://doi.org/10.1093/jpids/piag044","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"15 7","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Inpatient Influenza Vaccination Before, During, and After the COVID-19 Pandemic.","authors":"Suchitra Rao, Ravi Jhaveri, Angela Dunn, Christina R Studts, Alexa Mendoza, Bryan Strub, Marisa Payan, Ashleigh Lewis, Laura Pyle, Annika M Hofstetter","doi":"10.1093/jpids/piag050","DOIUrl":"10.1093/jpids/piag050","url":null,"abstract":"<p><p>In this multi-site retrospective study, we evaluated influenza vaccination of hospitalized children during the 2018-2019 through 2023-2024 seasons. While screening varied across sites, influenza vaccine administration was lower in the pandemic and post-pandemic period for all sites. These results highlight the need for strategies to promote vaccination in hospitalized children.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Antibiotic Prescribing Patterns for Children with Acute Otitis Media Based on Patient, Clinician, and Clinic Characteristics.","authors":"Alexander S Plattner, Sonja O'Leary, Sophie E Katz, Leisha M Andersen, Evan E Facer, Timothy C Jenkins, Amy B Stein, Gale Thomas, Nancy Koenig, Holly M Frost","doi":"10.1093/jpids/piag042","DOIUrl":"10.1093/jpids/piag042","url":null,"abstract":"<p><strong>Objectives: </strong>Children with common infections receive varying care based on their backgrounds; however, data for acute otitis media (AOM) management are limited. Our study aimed to evaluate differences in antibiotic prescribing rate and treatment duration for children (≥2 years) with uncomplicated AOM based on patient, clinician, and clinic characteristics.</p><p><strong>Methods: </strong>Retrospective study of health record data from two health systems (123 total sites) from 2019 to 2022. Primary outcomes included: (1) whether an antibiotic was prescribed, and (2) if so, the duration prescribed. Analyses were performed to assess whether differences in prescribing occurred among individual patients, clinicians, or clinics.</p><p><strong>Results: </strong>Among 66,382 encounters for AOM, children who were races other than White, Hispanic, or had public insurance or self-pay were more likely to be prescribed an antibiotic than children who were White (87% vs. 83%, OR 1.43 [1.12, 1.84]), non-Hispanic (88% vs. 82%, OR 1.54 [1.06, 2.23]), or had commercial/private insurance (87% vs. 83%, OR 1.35 [1.10, 1.67]). The mean treatment duration was ~9 days for all groups, however statistical significance was seen with shorter courses for children who were races other than White, Hispanic, had a primary language other than English, or had public insurance or self-pay. Duration differences were seen among clinicians, with those who prescribed the shortest durations seeing, on average, a greater proportion of children who were races other than White, Hispanic, spoke a non-English primary language, and had public insurance or self-pay.</p><p><strong>Conclusions: </strong>Children with AOM who were races other than White, Hispanic, or had public insurance or self-pay were more likely to be prescribed an antibiotic. However, shorter durations were more common among these children, primarily because clinicians serving this population tended to prescribe shorter durations to all patients, regardless of child sociodemographic characteristics.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Clinical Epidemiology and Microbiology of Orbital Cellulitis in Children.","authors":"","doi":"10.1093/jpids/piag055","DOIUrl":"https://doi.org/10.1093/jpids/piag055","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"15 7","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disinvestment in Global Health Threatens Global Security and Children's Health Everywhere.","authors":"Dorothy Dow, Rachel Martin-Blais, Jonathan Strysko, Gavin Yamey, Blandina T Mmbaga","doi":"10.1093/jpids/piag045","DOIUrl":"10.1093/jpids/piag045","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activity of Isavuconazole and Comparator Agents Against Pediatric Isolates From Invasive Fungal Infections.","authors":"Marisa L Winkler, Paul Rhomberg, Kelley Fedler, Samuel Edeker, Abby L Klauer, Mariana Castanheira","doi":"10.1093/jpids/piag053","DOIUrl":"10.1093/jpids/piag053","url":null,"abstract":"<p><strong>Background: </strong>Invasive fungal infections (IFIs) are a rising problem among pediatric patients. Antifungal agents have data supporting treatment in pediatric patients of varying ages and infection types but in vitro susceptibility data for large collections of pediatric isolates are lacking, which limits empiric treatment. We describe in vitro antifungal susceptibility testing of 900 contemporary yeast and mold isolates collected from IFIs in patients ≤ 17 years of age as a part of the SENTRY Antifungal Surveillance Program.</p><p><strong>Methods: </strong>A total of 900 isolates (743 yeasts and 157 molds) were collected from 28 countries between 2017 and 2024. Antifungal susceptibility testing was performed by broth microdilution according to Clinical and Laboratory and Standards Institute (CLSI) methodology.</p><p><strong>Results: </strong>A total of 33.4% of isolates were from patients ≤ 1 year old, 22.1% from patients aged 2-5 years old, 24.4% from patients aged 6-12 years old, and 20.0% from patients aged 13-17 years old. In total, 63.0% of yeasts were recovered from patients ≤ 5 years old; 79.6% of molds were from patients ≥ 6 years old. Most yeast isolates (72.5%) were from bloodstream infections; most mold isolates (61.8%) were from the respiratory tract. By CLSI breakpoints, 88.5% and 87.5% of Aspergillus fumigatus isolates were susceptible to voriconazole and isavuconazole, respectively. Against Mucorales, the isavuconazole minimum inhibitory concentration (MIC)50 value was 4 mg/L, whereas the MIC50 values for voriconazole and posaconazole were > 8 mg/L. All agents had low MICs against most yeasts collected and there were few resistant or non-wildtype yeasts.</p><p><strong>Conclusions: </strong>Broth microdilution among a diverse collection of isolates obtained from IFIs among pediatric patients showed low rates of resistance to echinocandins or azoles. Across species, the lowest MICs were observed for voriconazole and isavuconazole in yeasts. All triazoles were highly active against Aspergillus spp. Against non-Aspergillus molds, isavuconazole, posaconazole, and amphotericin B were the most active agents. These data can guide the antifungal treatment of IFIs in pediatric patients when susceptibility testing is unavailable.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection-Related Adverse Drug Reactions Reported with Biologic Disease Modifying Anti-Rheumatic Drugs in Pediatric Patients: Analysis of the EudraVigilance database.","authors":"Carolina Vilafanha, Sofia Ferreira Azevedo, Ana Rita Prata, Inês Cunha, Anabela Barcelos","doi":"10.1093/jpids/piag043","DOIUrl":"10.1093/jpids/piag043","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Outcomes of Mycobacterium abscessus Infections in Immunocompetent Children in Singapore.","authors":"Christopher Wen-Xing Seow, Kai-Qian Kam, Xue Fen Valerie Seah, Li-Hwei Sng, Matthias Maiwald, Karen Donceras Nadua, Chee Fu Yung, Koh Cheng Thoon, Jiahui Li, Natalie Woon Hui Tan, Chia Yin Chong","doi":"10.1093/jpids/piag047","DOIUrl":"10.1093/jpids/piag047","url":null,"abstract":"<p><p>We describe Mycobacterium abscessus infections in immunocompetent children with cervicofacial lymphadenitis and localized soft tissue infections. The presence of multi-nodal disease was significantly associated with refractory infection in cervicofacial lymphadenitis. Almost all children were treated with both antimicrobials and surgery, and close to half required repeat surgery.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Molecular analysis of AmpC-producing Escherichia coli isolated from pediatric patients.","authors":"","doi":"10.1093/jpids/piag039","DOIUrl":"10.1093/jpids/piag039","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"15 6","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of Candida viswanathii Bloodstream Infections Due to Drug Contamination in an Italian Children's Hospital (April-October 2025).","authors":"Lara Ricotta, Carmen D'Amore, Gaetano Ciliento, Gianluca Vrenna, Paola Bernaschi, Carlo Federico Perno, Tiziana Corsetti, Massimiliano Raponi, Marta Luisa Ciofi Degli Atti","doi":"10.1093/jpids/piag049","DOIUrl":"10.1093/jpids/piag049","url":null,"abstract":"<p><p>An outbreak of Candida viswanathii bloodstream infections in a pediatric hospital was linked to a contaminated milrinone lot. Retrospective analysis showed an 8.5% attack rate, with infection risk independently associated with longer milrinone treatment duration.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}