Journal of the Pediatric Infectious Diseases Society最新文献

{"title":"Post-COVID-19 Conditions and Vaccination in Children and Adolescents during the Omicron Outbreak: A Case-Control Study in Sapporo, Japan.","authors":"Satoshi Sunohara, Takashi Kimura, Hana Wakasa, Isaku Kurotori, Satoshi Oshima, Shun Ozawa, Masayuki Saijo, Hiroyasu Iso, Akiko Tamakoshi","doi":"10.1093/jpids/piag068","DOIUrl":"10.1093/jpids/piag068","url":null,"abstract":"<p><p>Persistent symptoms attributed to post-COVID-19 conditions were more frequent among COVID-19-positive individuals, especially smell and taste dysfunction. Vaccination before infection was associated with a lower risk of post-COVID-19 conditions, particularly smell/taste dysfunction, nausea, and hair loss.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vaccine Age Restrictions on Rotavirus Vaccine Coverage, Vaccine Safety Datalink 2018-2024.","authors":"Jordan E Cates, Jacob Haapala, Julia M Baker, Gabriela Vazquez-Benitez, Matthew F Daley, Bruno Lewin, Nicola P Klein, Allison L Naleway, Lisa A Jackson, Joshua T B Williams, Maria E Sundaram, Eric S Weintraub, Elyse O Kharbanda, Umesh Parashar, Malini DeSilva, Jacqueline E Tate","doi":"10.1093/jpids/piag056","DOIUrl":"10.1093/jpids/piag056","url":null,"abstract":"<p><strong>Background: </strong>Rotavirus vaccines (RVs) are coadministered in the United States with diphtheria-tetanus-acellular pertussis (DTaP) vaccines but have age restrictions for the first and last doses. We examined how delays in preventive care visits for vaccination affected RV initiation and series completion.</p><p><strong>Methods: </strong>We compared the timeliness of DTaP vaccination relative to RV in children born January 1, 2018 to June 30, 2023 across 8 US health systems. Adjusted risk ratios (aRRs) were estimated using modified Poisson regression to identify risk factors for delayed DTaP vaccination and no RV vaccination.</p><p><strong>Results: </strong>Among 391 892 children who initiated DTaP, 12 546 (3.2%) did not initiate RV. Of these, 7721 (61.5%) children had delayed DTaP initiation and were age-ineligible for RV at the time of DTaP initiation. Children who became eligible for RV during the early stage of the COVID-19 pandemic (March to May 2020) had a higher risk of delayed DTaP and no RV initiation (aRR = 2.20; 95% CI, 1.98-2.45), as did children with fewer than 5 primary care visits within the first year of life (aRR = 4.03; 95% CI, 3.81-4.26), and Medicaid recipients (aRR = 2.34; 95% CI, 2.23-2.45). Similar factors were associated with failure to complete the RV series due to age restrictions.</p><p><strong>Conclusions: </strong>Age restrictions may have contributed to lack of RV initiation and series completion in this cohort. Public health strategies tailored to populations at risk for delayed vaccination may be needed to promote timely administration of RV.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting the Initial Serum Concentration of Teicoplanin in Pediatric Patients: A Single-Center Retrospective Analysis.","authors":"Tatsuo Kataoka, Takanori Taogoshi, Yoko Hiyama, Kana Miyamoto, Takashi Tomita, Kazutaka Oda, Hiroaki Matsuo","doi":"10.1093/jpids/piag069","DOIUrl":"10.1093/jpids/piag069","url":null,"abstract":"<p><strong>Background: </strong>The glycopeptide antibiotic teicoplanin (TEIC) is used to treat infections caused by methicillin-resistant Staphylococcus aureus and other gram-positive bacteria. Because higher target trough concentrations are now recommended, higher loading dose (LD) regimens have been proposed. However, the factors affecting trough concentration (Ctrough) levels and the safety of high-dose regimens remain unclear. This study aimed to investigate the factors that should be considered in the LD regimen of TEIC in pediatric patients and assess the safety of a higher LD.</p><p><strong>Methods: </strong>We enrolled pediatric patients aged 1-14 years with available TEIC concentrations measured between August 2013 and December 2024. Factors affecting the initial Ctrough and the initial Ctrough divided by LD per kilogram of body weight (C/D ratio) were investigated. Safety assessment included serious adverse reactions at the time of initial Ctrough measurement.</p><p><strong>Results: </strong>In total, 108 patients were enrolled in this study. Of 108 enrolled patients, 64 patients were measured initial Ctrough on day 4. Fifty-four patients received higher LD (average 54.2 mg/kg/3 days) than the standard regimen, with 33 patients (52%) not achieving an initial Ctrough of 15 μg/mL. Linear regression analysis showed that the initial Ctrough was associated with age (P = .008), estimated glomerular filtration rate (eGFR; P < .001), and serum albumin level (P = .017). The C/D ratio on day 4 was associated with eGFR (P < .001) and the presence or absence of febrile neutropenia (FN) (P = .046). Further analysis restricted to patients with FN indicated that bone marrow transplantation (BMT) (P = .046) affected the C/D ratio. Serious adverse reactions occurred in 5 cases.</p><p><strong>Conclusions: </strong>Clinical conditions, such as FN and BMT, which cause an increase in eGFR, may affect the initial Ctrough in pediatric patients. Moreover, a higher LD was well-tolerated. When determining the LD, clinical conditions must be considered.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Impact of Shortened Treatment for Nonsevere Pediatric Tuberculosis in the State of Georgia.","authors":"Collin Dubick, Russell R Kempker, Marcos C Schechter","doi":"10.1093/jpids/piag063","DOIUrl":"10.1093/jpids/piag063","url":null,"abstract":"<p><p>Our 15-year retrospective review of reported pediatric tuberculosis (TB) cases in the state of Georgia indicates that most children in our state have nonsevere TB, and implementing a 4-month rifampin, isoniazid, pyrazinamide, and ethambutol-based regimen for drug-susceptible nonsevere TB would substantially reduce the burden of directly observed therapy.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Genomics of Herpes Simplex Virus 2 Isolated from a Maternal-Neonatal Dyad Reveals High Consensus Sequence Homology as Well as Minor Variant Diversity.","authors":"Reem Abu Rass, Lacy M Simons, Christopher D Bowen, Haley S Carter, Daniel W Renner, Moriah L Szpara, Lisa N Akhtar","doi":"10.1093/jpids/piag064","DOIUrl":"10.1093/jpids/piag064","url":null,"abstract":"<p><p>Neonatal herpes simplex virus disease most often occurs following mother-to-neonate transmission during childbirth. However, genomic differences between the maternal and neonatal viral populations are poorly understood. Here, we performed deep whole-genome sequencing of clinical HSV-2 samples obtained from a maternal-neonatal dyad to investigate viral population dynamics during transmission.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Bacterial Epidemiology at Three Primary Ciliary Dyskinesia Clinical Centers.","authors":"Yaron Fireizen","doi":"10.1093/jpids/piag074","DOIUrl":"10.1093/jpids/piag074","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Recommendations for Measles, Mumps, Rubella Vaccination, and Vitamin A Administration in the Setting of Measles Outbreaks.","authors":"Samiksha Tarun, Jason G Newland, Philip M Polgreen, Isaac Benowitz, Susan E Beekmann, Matthew C Washam","doi":"10.1093/jpids/piag054","DOIUrl":"10.1093/jpids/piag054","url":null,"abstract":"<p><p>A survey of Emerging Infections Network members conducted in June 2025 of 169 pediatric infectious disease physician respondents practicing in the United States demonstrated that risk assessments drove pre-travel measles, mumps, rubella vaccine recommendations. Hospitalization, oral formulation availability, oral administration, and vitamin A deficiency influenced vitamin A recommendations.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Coccidioidomycosis: Disease Spectrum and Implications for Antifungal Therapy.","authors":"Gokhan Kalkan","doi":"10.1093/jpids/piag041","DOIUrl":"https://doi.org/10.1093/jpids/piag041","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"15 7","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Pediatric Coccidioidomycosis: Disease Spectrum and Implications for Antifungal Therapy.","authors":"Sanchi Malhotra, Paul Krogstad","doi":"10.1093/jpids/piag044","DOIUrl":"https://doi.org/10.1093/jpids/piag044","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"15 7","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Inpatient Influenza Vaccination Before, During, and After the COVID-19 Pandemic.","authors":"Suchitra Rao, Ravi Jhaveri, Angela Dunn, Christina R Studts, Alexa Mendoza, Bryan Strub, Marisa Payan, Ashleigh Lewis, Laura Pyle, Annika M Hofstetter","doi":"10.1093/jpids/piag050","DOIUrl":"10.1093/jpids/piag050","url":null,"abstract":"<p><p>In this multi-site retrospective study, we evaluated influenza vaccination of hospitalized children during the 2018-2019 through 2023-2024 seasons. While screening varied across sites, influenza vaccine administration was lower in the pandemic and post-pandemic period for all sites. These results highlight the need for strategies to promote vaccination in hospitalized children.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}