Journal of the Pediatric Infectious Diseases Society最新文献

{"title":"Pediatric Osteoarthritis Requires Advanced Diagnostic Methods.","authors":"Pablo Yagupsky","doi":"10.1093/jpids/piaf032","DOIUrl":"https://doi.org/10.1093/jpids/piaf032","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"14 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Tuberculosis Infection-Related Outpatient Clinical Outcomes Across Neighborhood-Level Deprivation Quartiles.","authors":"Melissa E Day, Qing Duan, Mary Carol Burkhardt, Melissa Klein, Elizabeth P Schlaudecker, Andrew F Beck","doi":"10.1093/jpids/piaf020","DOIUrl":"10.1093/jpids/piaf020","url":null,"abstract":"<p><strong>Background: </strong>Pediatric tuberculosis infection (TBI) disproportionately affects those in complex social situations. Neighborhood characteristics may influence access to care and TBI-related outcomes. We sought to examine links between neighborhood-level socioeconomic deprivation and clinical outcomes.</p><p><strong>Methods: </strong>In this retrospective cohort study, we identified children with TBI treated at our pediatric infectious diseases clinics between 2012 and 2023. We geocoded each child's address to identify neighborhood-level material community deprivation index (MCDI) scores. Outcomes included missed clinic visits, missed antibiotic doses, and changes in antibiotic therapy due to adherence concerns. We assessed the time between referral and first visit, first and second visits, and first and last visits. Kruskal-Wallis rank sum test and chi-squared tests examined relationships between DI quartile and clinical outcomes. Log-rank testing and Cox proportional hazard regression models evaluated time-to-event analyses.</p><p><strong>Results: </strong>We identified 150 children with TBI. There were no differences across MCDI quartiles in rates of missed clinic visits, missed antibiotic doses, changed therapy, or therapy completion. Higher deprivation was associated with a longer time between referral and first visit (median 12 days for low/moderate-low deprivation quartiles vs. 24 days for high/moderate-high deprivation quartiles, P = .004). The high/moderate-high deprivation category had a 39% lower hazard of getting to the first clinic visit after referral compared to the low/moderate-low deprivation category (HR 0.61; 95% CI, .43, .85) after adjustment for race, insurance, and language.</p><p><strong>Conclusions: </strong>Children with TBI from socioeconomically deprived neighborhoods have longer times from referral to first clinical evaluation. Exploring drivers of differences could promote more equitable TBI care.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic Variations in Incidence of Kingella kingae: Selection Bias or Reality?","authors":"Ian C Michelow, Zaid Alhinai, Pablo J Sánchez","doi":"10.1093/jpids/piaf034","DOIUrl":"https://doi.org/10.1093/jpids/piaf034","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"14 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric COVID-19 in Hawai'i: A Brief Report on Unique Hospitalization Characteristics.","authors":"Kyra A Len, Tiffany Wang, Cheryl K Okado, Diane Pan, Shelby S Tadaki, Chieko Kimata, Andrea M Siu, Natascha Ching, Jessica S Kosut","doi":"10.1093/jpids/piaf030","DOIUrl":"10.1093/jpids/piaf030","url":null,"abstract":"<p><p>While COVID-19 has been well-studied in other populations, there is a lack of information about the virus in Native Hawaiian and Pacific Islanders. This retrospective study identified characteristics of this population in hospitalized pediatric patients in Hawai'i. This study also reviews vaccinations within this unique population.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"14 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Demographics Are Associated With Testing for Group A Streptococcal Pharyngitis in Children.","authors":"Kareena Kloek, Ritu Banerjee, Meng Xu, Sophie E Katz","doi":"10.1093/jpids/piaf029","DOIUrl":"10.1093/jpids/piaf029","url":null,"abstract":"<p><p>Among a retrospective cohort of 65 786 outpatient encounters for children >3 years with acute respiratory tract infection at an academic institution in 2023, 38 790 (59%) had a rapid group A streptococcal (GAS) test ordered. Testing rates differed significantly by race, ethnicity, insurance type, social vulnerability index, visit location, and clinician type, and children in historically underserved and socially vulnerable groups were less likely to undergo GAS testing compared to their social counterparts.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Infectious Disease Outpatient Telehealth: An Accepted Model of Care.","authors":"Celisse Zabalo, Athanasios Tsalatsanis, Ambuj Kumar, Claudia Espinosa, Amol Purandare, Carina A Rodriguez, Christina Olson, Claudia Gaviria-Agudelo","doi":"10.1093/jpids/piaf012","DOIUrl":"10.1093/jpids/piaf012","url":null,"abstract":"<p><p>This retrospective cohort study assessed the differences between in-person vs telehealth (TH) services in pediatric infectious diseases. TH was noted to be used more frequently by Hispanic patients and established patients. TH decreased travel distance and no-show/cancellation rates. TH offers a valuable outpatient option for pediatric infectious disease patients.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Billing for and Documentation of Provider-to-Provider Interprofessional Consults in Infectious Diseases.","authors":"Caitlin Naureckas Li, Taylor Heald-Sargent, Kathleen Murtagh, Erin Claussen, Ravi Jhaveri","doi":"10.1093/jpids/piaf033","DOIUrl":"10.1093/jpids/piaf033","url":null,"abstract":"<p><p>Infectious diseases providers are frequently asked to provide \"curbside\" advice for patients they have not seen. We describe our experience in implementing a process for documentation of and billing for these provider-to-provider consultations.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics and Safety of Single-Dose Sotrovimab in High-Risk Children and Adolescents With Mild-to-Moderate COVID-19.","authors":"Jennifer Moore, Daren Austin, Alicia Aylott, Jerzy Daniluk, Leah A Gaffney, Marjan Hezareh, Ahmed Nader, Nadia Noormohamed, Charlene Parado, Amanda Peppercorn, Yessica Sachdeva, Scott Segal, Klaudia Steplewski, Phillip J Yates, Jill Walker, Andrew Skingsley","doi":"10.1093/jpids/piaf027","DOIUrl":"10.1093/jpids/piaf027","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric and Adolescent Hepatitis C Care Cascade and Real-World Treatment Outcomes Utilizing an Integrated Health System Specialty Pharmacy Model.","authors":"Alicia B Carver, Cori Edmonds, Kristen Whelchel, Ryan Moore, Leena Choi, Lynette A Gillis","doi":"10.1093/jpids/piaf042","DOIUrl":"https://doi.org/10.1093/jpids/piaf042","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the cascade of care (CoC) and real-world efficacy of direct-acting antivirals (DAAs) for hepatitis C treatment in pediatric and adolescent patients utilizing an integrated health system specialty pharmacy (HSSP) to assist with medication selection, insurance approval, swallowing practice, initiation, and monitoring.</p><p><strong>Methods: </strong>This single-center, retrospective, observational cohort study included chronic hepatitis C patients <18 years old evaluated by pediatric hepatologists at an academic health system between 1/1/2017 and 9/30/2022. The primary endpoint was sustained virologic response (SVR) ≥12 weeks following treatment completion in patients initiating DAAs. Secondary endpoints were CoC advancement, variables impacting DAA initiation, patient-reported side effects, and adherence. An ordinal logistic regression model assessed whether initiation time was associated with a patient's ability to swallow, prior authorization outcome, and medication availability to HSSP at referral. The odds ratio reflects the likelihood of a shift in time to initiation for a given group relative to its respective reference group.</p><p><strong>Results: </strong>Of 98 patients evaluated by a hepatologist, 73 (75%) were referred to the HSSP. Loss to follow-up was the primary reason (88%; 22/25) for non-referral, most commonly (73%; 16/22) in those aged ≤5 years. Following HSSP referral, 88% (64/73) initiated DAA and 92% (59/64) of those achieved SVR. Time from HSSP referral to medication initiation was impacted by DAA availability [OR=41.47; 95% CI: 9.51, 180.87; p<0.001] and inability to swallow the dosage form at evaluation [OR=3.94; 95% CI: 1.56, 9.98; p=0.004]. Over half (53%; 34/64) of patients initiating DAA reported ≥1 adverse event; none discontinued treatment. Most (69%; 44/64) reported no missed doses.</p><p><strong>Conclusion: </strong>The largest CoC drop-off occurred following initial clinic evaluation, primarily in children ≤5 years. Enhanced linkage to care efforts are needed in these patients. Conversely, nearly all patients referred to the HSSP were initiated on DAA, completed therapy, and achieved SVR.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus (CMV) Saliva Shedding Kinetics in Children with Congenital CMV Infection (cCMV).","authors":"Swetha Pinninti, Sunil Pati, Zdenek Novak, Karen Fowler, Suresh Boppana, Shannon Ross","doi":"10.1093/jpids/piaf040","DOIUrl":"https://doi.org/10.1093/jpids/piaf040","url":null,"abstract":"<p><strong>Background: </strong>Congenital CMV (cCMV) is a common congenital viral infection worldwide and the most common cause of childhood non-genetic sensorineural hearing loss (SNHL). The kinetics of CMV detection (shedding) from mucosal surfaces have not been extensively described in children with cCMV due to a lack of systematic newborn CMV screening and follow-up protocols. The aim of this study is to describe the natural history of saliva CMV shedding in a cCMV cohort, which was identified through universal newborn screening.</p><p><strong>Methods: </strong>As part of the CMV and Hearing Multicenter Screening study (CHIMES), 100,332 newborns were screened, and those confirmed to have cCMV were followed prospectively every six months for four years to determine hearing outcomes. Saliva CMV DNA shedding kinetics, including duration, viral load (VL), and intermittent shedding are described and compared between groups with and without newborn symptoms and hearing loss in children with ≥ 5 visits.</p><p><strong>Results: </strong>The 197 children with confirmed cCMV shed CMV DNA in saliva for a median of 20 months with CMV shedding frequency decreasing from 100% at cCMV confirmation to 9.5% four years after enrollment. Similarly, median CMV DNA VL levels decreased from 8.89X106 IU/ml at the confirmation visit to 1.64X103 IU/ml at the 4-year follow-up visit. Saliva CMV shedding duration was similar between children with or without newborn symptoms (median 20 months for both groups; p = 0.57) or between those with SNHL vs normal hearing (p = 0.8). A third of the cohort intermittently shed CMV DNA in saliva (64/197, 32.5%).</p><p><strong>Conclusions: </strong>In this large cohort of children with cCMV identified by universal CMV newborn screening, CMV DNA was detectable in saliva for a median of 20 months, irrespective of newborn symptoms or hearing outcomes. Intermittent shedding was noted in a third of the cohort.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}