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Journal of the Pediatric Infectious Diseases Society最新文献

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Infections and Antibiotic Resistance in Malawian Children Under Five-Years Old Hospitalized With Severe Acute Malnutrition. 马拉维五岁以下严重急性营养不良住院儿童的感染和抗生素耐药性。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae120
Bryan J Vonasek, Mwawi Nyirongo, Alexander Kondwani, Tiwonge Kamvaunamwali, Doris Ng'oma, Emily J Ciccone, James Kaphatika, Amazing-Grace Tepeka, Mercy Kumwenda, Jens Eickhoff, Anthony J Garcia-Prats, Tisungane Mvalo
{"title":"Infections and Antibiotic Resistance in Malawian Children Under Five-Years Old Hospitalized With Severe Acute Malnutrition.","authors":"Bryan J Vonasek, Mwawi Nyirongo, Alexander Kondwani, Tiwonge Kamvaunamwali, Doris Ng'oma, Emily J Ciccone, James Kaphatika, Amazing-Grace Tepeka, Mercy Kumwenda, Jens Eickhoff, Anthony J Garcia-Prats, Tisungane Mvalo","doi":"10.1093/jpids/piae120","DOIUrl":"10.1093/jpids/piae120","url":null,"abstract":"<p><p>This prospective cohort study from Malawi updates our understanding of the burden of bacterial infections and drug resistance in children <5 years hospitalized with severe acute malnutrition. Urinary tract infection was diagnosed in 20% and bacteremia in 10%. Resistance to first- and second-line antibiotics occurred in >1/3 of the bacteria isolated.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal of the Pediatric Infectious Diseases Society and the Journal of Infectious Diseases Collaboration: The First Fruits From a New Tree. 《儿科传染病学会杂志》和《传染病合作杂志：新树上的第一批果实》。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae106
Ravi Jhaveri, Cynthia L Sears
{"title":"Journal of the Pediatric Infectious Diseases Society and the Journal of Infectious Diseases Collaboration: The First Fruits From a New Tree.","authors":"Ravi Jhaveri, Cynthia L Sears","doi":"10.1093/jpids/piae106","DOIUrl":"10.1093/jpids/piae106","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Two Interferon-Gamma Release Assays for Pediatric Tuberculosis Infection. 两种干扰素释放法检测儿童结核感染的比较。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae135
James T Gaensbauer, Randall R Reves, Dolly Katz, Amina Ahmed, Thara Venkatappa
{"title":"Comparison of Two Interferon-Gamma Release Assays for Pediatric Tuberculosis Infection.","authors":"James T Gaensbauer, Randall R Reves, Dolly Katz, Amina Ahmed, Thara Venkatappa","doi":"10.1093/jpids/piae135","DOIUrl":"10.1093/jpids/piae135","url":null,"abstract":"<p><strong>Introduction: </strong>Identifying tuberculosis infection (TBI) using interferon-gamma release assays (IGRAs) is a primary component of clinical and public health efforts to prevent pediatric tuberculosis (TB). Pediatric data comparing the 2 IGRAs in the United States are very limited. We compared the performance of the 2 IGRAs among a large pediatric cohort tested for TBI and assessed whether discordance might be due to quantitative results close to test cutoff values.</p><p><strong>Methods: </strong>Children aged 0-15 years with both T-SPOT.TB (T-SPOT) and QuantiFERON-TB Gold In-Tube (QFT-GIT) tests were identified from a US multicenter study enrolling people at elevated risk of TBI or progression to TB disease. Results were compared using McNemar's Chi-square tests with stratification by age category and testing reason. Percent agreement and kappa statistics were also calculated. We characterized quantitative test results among children with discordant QFT-GIT-positive/T-SPOT-negative results.</p><p><strong>Results: </strong>Among 3793 children, a higher number had positive QFT-GIT than T-SPOT (10.1% vs 7.4%, P < .001). This difference was noted for all age categories except <2 years, and for children with close-contact and non-close contact test indications. Among discordant QFT-GIT-positive/T-SPOT-negative children, lowering the positive threshold for T-SPOT to include borderline spot counts (5-7) did not eliminate the discordance, nor were QFT-GIT antigen-minus-nil results concentrated in the range just above the standard cutoff of 0.35 IU/mL.</p><p><strong>Conclusions: </strong>In a large pediatric cohort tested for TBI, QFT-GIT had a higher proportion of positive results than T-SPOT, and discordance was not related to quantitative results close to the established diagnostic cutoffs.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enterovirus and Parechovirus Neurologic Infections in Children: Clinical Presentations and Neuropathogenesis. 儿童肠病毒和Parechovirus神经系统感染：临床表现和神经发病机制。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae069
Megan Culler Freeman, Kevin Messacar
{"title":"Enterovirus and Parechovirus Neurologic Infections in Children: Clinical Presentations and Neuropathogenesis.","authors":"Megan Culler Freeman, Kevin Messacar","doi":"10.1093/jpids/piae069","DOIUrl":"10.1093/jpids/piae069","url":null,"abstract":"<p><p>Enteroviruses (EVs) and parechoviruses (PeVs) are common pathogens of childhood. Enteroviral infections cause a range of clinical syndromes from mild illness to neurologic manifestations of meningitis, encephalitis, and acute flaccid myelitis. Disease manifestations are driven by a combination of viral replication and host immune response. Despite ubiquitousness and clinical importance, there are no approved targeted therapies for these viruses and most are without an available vaccine. Studies of EV neuropathogenesis began with poliovirus and are ongoing for other nonpolio EVs and PeVs. Many unanswered questions remain with regard to cellular tropism, mechanisms of dissemination, receptor usage, immunologic control, and cellular death. This review describes what is known about epidemiology, clinical presentations, and neuropathogenesis of these important pathogens.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anaerobe-Targeted Antibiotic Therapy in the Neonatal Intensive Care Unit. 新生儿重症监护室的厌氧菌靶向抗生素疗法。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae109
Matthew B Green, Alvaro Zevallos Barboza, Sagori Mukhopadhyay, Jeffrey S Gerber, Michael J Morowitz, Karen M Puopolo, Dustin D Flannery
{"title":"Anaerobe-Targeted Antibiotic Therapy in the Neonatal Intensive Care Unit.","authors":"Matthew B Green, Alvaro Zevallos Barboza, Sagori Mukhopadhyay, Jeffrey S Gerber, Michael J Morowitz, Karen M Puopolo, Dustin D Flannery","doi":"10.1093/jpids/piae109","DOIUrl":"10.1093/jpids/piae109","url":null,"abstract":"<p><p>Anaerobe-targeted antibiotic (ATA) therapy may adversely impact the developing neonatal microbiome. We describe utilization patterns, potential indications, and related outcomes of ATA therapy in neonatal intensive care units across the United States over 13 years. While overall antibiotic use decreased, ATA use was unchanged. Potentially associated indications were inconsistent.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practice Variability in Uptake and Implementation of New U.S. DHHS Guidelines for Feeding of HIV-Exposed Infants. 在接受和实施新的美国卫生与公众服务部艾滋病毒暴露婴儿喂养指南的实践可变性。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae133
Ilan Rozen Eisenberg, Jeffrey I Campbell, Diana Clarke, Ellen R Cooper, Stephen I Pelton, Sharon S Vuppula
{"title":"Practice Variability in Uptake and Implementation of New U.S. DHHS Guidelines for Feeding of HIV-Exposed Infants.","authors":"Ilan Rozen Eisenberg, Jeffrey I Campbell, Diana Clarke, Ellen R Cooper, Stephen I Pelton, Sharon S Vuppula","doi":"10.1093/jpids/piae133","DOIUrl":"10.1093/jpids/piae133","url":null,"abstract":"<p><p>New U.S. guidelines support shared decision-making regarding breastfeeding for mothers living with HIV and their neonates. We surveyed Pediatric Infectious Diseases Society members about the implementation of these guidelines. We found heterogeneity in uptake, variability in clinical practice, and concerns about implementation. Future research should address these policy-practice gaps.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic Management and Imaging Practices of Sinusitis-Related Epidural Empyema Among Pediatric Centers. 儿科中心鼻窦炎相关硬膜外脓肿的抗生素管理和影像学实践。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae128
Jenna Tan, Matthew P Kronman, Adam W Brothers, Daniel J Pak, Derry McDonald, Scott J Weissman, Jeffrey S Gerber, Adam L Hersh, Jason G Newland, Ann L Wirtz, Victoria J L Konold
{"title":"Antibiotic Management and Imaging Practices of Sinusitis-Related Epidural Empyema Among Pediatric Centers.","authors":"Jenna Tan, Matthew P Kronman, Adam W Brothers, Daniel J Pak, Derry McDonald, Scott J Weissman, Jeffrey S Gerber, Adam L Hersh, Jason G Newland, Ann L Wirtz, Victoria J L Konold","doi":"10.1093/jpids/piae128","DOIUrl":"10.1093/jpids/piae128","url":null,"abstract":"<p><p>A survey of pediatric infectious diseases clinicians from 49 children's hospitals demonstrated variability across institutions in the treatment of epidural empyema from sinus extension, including antibiotic route, selection, and impact of neuroimaging on determining duration of therapy.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrolide-Resistant Mycoplasma pneumoniae, North Dakota 2024. 耐大环内酯肺炎支原体，北达科他州 2024 年。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae117
Miltiadis Douvoyiannis, Tanner E Rothstein, Robin Patel
{"title":"Macrolide-Resistant Mycoplasma pneumoniae, North Dakota 2024.","authors":"Miltiadis Douvoyiannis, Tanner E Rothstein, Robin Patel","doi":"10.1093/jpids/piae117","DOIUrl":"10.1093/jpids/piae117","url":null,"abstract":"<p><p>A cluster of macrolide-resistant Mycoplasma pneumoniae -causing community-acquired pneumonia was observed in children in North Dakota in 2024. Suspicion was raised by non-response to macrolides, with confirmation via a polymerase-chain reaction assay. Prompt improvement occurred after the initiation of alternative antibiotics.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions of the Pneumococcus with the Central Nervous System: Postnatal Meningitis Versus Fetal Neurodevelopment. 肺炎球菌与中枢神经系统的相互作用：产后脑膜炎与胎儿神经发育。
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae068
Amy Davis, Elaine Tuomanen
{"title":"Interactions of the Pneumococcus with the Central Nervous System: Postnatal Meningitis Versus Fetal Neurodevelopment.","authors":"Amy Davis, Elaine Tuomanen","doi":"10.1093/jpids/piae068","DOIUrl":"10.1093/jpids/piae068","url":null,"abstract":"<p><p>In young children, pneumococcal meningitis epitomizes the paradigm of a destructive innate inflammatory response in the central nervous system: a five-alarm fire. In contrast, cell-free bacterial components reaching the fetal brain from an infected mother signal a quiet, noninflammatory immune response that drives abnormal neurodevelopment, changing brain architecture through neuroproliferation. This review addresses the difference between prenatal and postnatal bacterial-host signaling within the brain.</p>","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Treat or Not to Treat? And for How Long? 治疗还是不治疗？能维持多久？
IF 2.5 4区 医学
Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-01-20 DOI: 10.1093/jpids/piae130
Ellen R Wald
{"title":"To Treat or Not to Treat? And for How Long?","authors":"Ellen R Wald","doi":"10.1093/jpids/piae130","DOIUrl":"10.1093/jpids/piae130","url":null,"abstract":"","PeriodicalId":17374,"journal":{"name":"Journal of the Pediatric Infectious Diseases Society","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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