{"title":"Production of hydrogen-rich gaseous product from pyrolysis of polypropylene wastes using bauxite ore catalyst: yield analysis of various products","authors":"Ravindra Kumar , Anup Kumar Sadhukhan , Biswajit Ruj","doi":"10.1016/j.jics.2025.101811","DOIUrl":"10.1016/j.jics.2025.101811","url":null,"abstract":"<div><div>The article investigates the extraction of superior-quality pyrolytic oil (PO) with considerable yield and hydrogen-rich gaseous mixtures from the pyrolysis of polypropylene waste (PPW) with and without a catalyst. Considering the presence of a mixture of metal oxides in low-cost bauxite ore, its catalytic activity towards the quality and quantity of PO and the composition of syngas has been explored experimentally. A positive selectivity towards the reduced temperature (about 10 °C) degradation of PPW with catalysts has been identified during the thermogravimetric (TGA) study. A batch reactor study was conducted with PPW with varied proportions of catalyst, temperatures (525 °C–600 °C), and heating rates (5, 10, and 15 °C/min) to quantify the effects of process conditions on end products’ characteristics and to identify the optimal process parameters. The pyrolysis temperature of 575 °C at 15 °C/min with 10 % catalyst produced the superior quality PO. The corresponding yields of PO and gaseous products were 75.14 % and 17.16 %, respectively. The analysis of PO by FTIR and GC-MS showed higher concentrations of lighter hydrocarbons suitable for gasoline range fuel, namely 2, 4-dimethyl heptane, 2, 6-dimethyl-nonane, and 2, 4-dimethyl-1-heptene, in addition to aromatics. The GC test of gaseous products showed that the presence of bauxite ore significantly enhanced the hydrogen recovery in gaseous products compared to thermal pyrolysis alone. Under optimum conditions, the hydrogen content in the gaseous product reached up to 9.8 %, fulfilling the primary aim of the study. Bauxite ore has a promising catalytic activity, making the process sustainable for hydrogen-rich gaseous products and gasoline range PO from PPW. The study backs circular economy activities by promoting the scientific use of plastic garbage for converting it into value-added clean fuels.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101811"},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dinesh Krishna Narukulla, Amrendra Kumar, Venkata Rao Kaki
{"title":"Sustainability at scale: implementing a green solvent approach for Grignard reactions in the synthesis of key intermediates for Active Pharmaceutical Ingredients (APIs)","authors":"Dinesh Krishna Narukulla, Amrendra Kumar, Venkata Rao Kaki","doi":"10.1016/j.jics.2025.101807","DOIUrl":"10.1016/j.jics.2025.101807","url":null,"abstract":"<div><div>The operational feasibility of greener ethereal solvents viz., 2-Methyltetrahydrofuran (2-MeTHF) and Cyclopentyl methyl ether (CPME) for Grignard reactions in the scale-up processes of ten API intermediates was investigated. Initially, the solubility and stability of four different Grignard reagents that are used in these processes were examined at various molar concentrations in greener solvents. Then, Grignard reactions were performed, while optimizing the reaction conditions in 2-MeTHF, CPME, and conventional solvents tetrahydrofuran (THF), THF/toluene. Evaluation of the reaction performances directs that 2-MeTHF is a better alternative solvent for these API intermediates over CPME. 2-MeTHF was efficiently recycled from the reactions and reused in subsequent batches without compromising reaction performance, which significantly reduces environmental footprints. These investigations bolster the adoption of scalable, sustainable processes in the synthesis of ten API-key intermediates.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 8","pages":"Article 101807"},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manoj Kumar , Atresh Kumar Singh , Jayoti Gupta , Satyam Singh , Rajesh K. Yadav , Atul P. Singh
{"title":"Exploring mixed-ligand cobalt(II) complexes with salicylaldehyde-based N,O-donor bidentate schiff bases and neutral N-donor Ligands: Synthesis, characterization, DFT, and antimicrobial studies","authors":"Manoj Kumar , Atresh Kumar Singh , Jayoti Gupta , Satyam Singh , Rajesh K. Yadav , Atul P. Singh","doi":"10.1016/j.jics.2025.101803","DOIUrl":"10.1016/j.jics.2025.101803","url":null,"abstract":"<div><div>This study explores the synthesis, characterization, and biological evaluation of cobalt(II) complexes derived from Schiff bases and neutral N-donor ligands, aiming to develop materials with enhanced coordination and antimicrobial properties. The complexes [Co(L<sup>n</sup>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] (<strong>C1</strong> & <strong>C2</strong>) were synthesized by reacting Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with the Schiff bases [(E)-2-((phenylimino)methyl)phenol] (<strong>HL<sup>1</sup></strong>) and [(E)-2-(((4-chlorophenyl)imino)methyl)phenol] (<strong>HL<sup>2</sup></strong>) in a 1:2 M ratio. Further reactions with imidazole, benzimidazole, or pyridine produced mixed-ligand complexes [Co(L<sup>n</sup>)<sub>2</sub> (L’)<sub>2</sub>] (<strong>C3</strong>-<strong>C8</strong>). A combination of spectral, magnetic, and analytical techniques was employed to confirm the octahedral geometry of these complexes. Infrared spectra indicated Schiff base coordination through azomethine nitrogen and phenolic oxygen, while <sup>1</sup>H and <sup>13</sup>C NMR spectra corroborated the bidentate chelation. Electronic absorption spectra revealed π-π∗, n-π∗, and d-d transitions, consistent with strong metal-ligand interactions. Mass spectrometry supported molecular formulations, and magnetic moment measurements indicated high-spin, paramagnetic cobalt(II) complexes. The study also employed DFT to optimize the structures and analyze electronic properties, revealing distorted octahedral geometries and enhanced reactivity. Furthermore, the antimicrobial results demonstrated that cobalt coordination enhanced the antimicrobial activity of <strong>HL<sup>1</sup></strong> and <strong>HL<sup>2</sup></strong>, with <strong>C2</strong> exhibiting the highest efficacy among the complexes. However, the activity remained inferior to standard drugs Ciprofloxacin and Nystatin, suggesting the need for further optimization. This research highlights the ability of Schiff bases to form stable cobalt(II) complexes with neutral N-donor ligands, offering valuable insights for future studies on metal-ligand systems with tailored biological activities.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 8","pages":"Article 101803"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Sagaya Leenu Rathi , Y. Jaya Vinse Ruban , S. Ginil Mon , P. Raja , S. Muthukrishnan
{"title":"Zirconium phosphate enriched epoxy/ unsaturated polyester composites for marine antifouling application","authors":"J. Sagaya Leenu Rathi , Y. Jaya Vinse Ruban , S. Ginil Mon , P. Raja , S. Muthukrishnan","doi":"10.1016/j.jics.2025.101808","DOIUrl":"10.1016/j.jics.2025.101808","url":null,"abstract":"<div><div>Zirconium phosphate, a versatile inorganic compound, has antibacterial activity hence it can be utilized as filler to improve the property of composites. Zirconium phosphate-enriched epoxy/unsaturated polyester composites were fabricated, characterized, and tested for antibacterial and antifouling properties in the live marine environment. In this research work, the fabricated zirconium-based composites were fitted in a panel and immersed in the live marine environment for months, and swab test samples were collected and tested for bacterial growth. Contact angle analysis was done via the sessile drop method on all the fabricated composites. The antibacterial property of the fabricated samples increases with the increment of the water contact angle. The wetting ability of the samples was elucidated, which have a good agreement with the antibacterial studies. Surprisingly the fabricated composites show good antibacterial and antifouling nature. Especially the fabricated sample EZ1 shows a bacterial count of 1.2 × 10<sup>5</sup> CFU after immersion for 96 h in marine water, and the same has the highest water contact angle and the lowest wetting ability. The fabricated samples were tested for mechanical stability which shows enhancement in tensile strength.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 8","pages":"Article 101808"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Sn incorporation on the crystallinity of TiO2 thin films and formation of DSSC","authors":"Sunil Kumar, Mangej Singh","doi":"10.1016/j.jics.2025.101798","DOIUrl":"10.1016/j.jics.2025.101798","url":null,"abstract":"<div><div>The Sol-Gel technique was used to synthesize a variety effectively contain TiO<sub>2</sub> doped with Sn, whose concentrations range from 0.5 to 1 mol%. It has been studied for its functionality as a dye-sensitized solar cell photoanode (DSSC). After annealing at 500 °C, the synthesized thin films were examined utilizing SEM with EDX, UV–Vis spectroscopy technology and XRD. Sn-doped TiO<sub>2</sub> samples exhibited anatase and rutile, whereas pure TiO<sub>2</sub> only displayed the anatase phase. The Sn dopant facilitates the phase transition of TiO<sub>2</sub>. Surface morphology and elemental identity are assessed using SEM data and confirmed by EDX analysis. The inclusion of Sn<sup>4+</sup> ions into the TiO<sub>2</sub> lattice is shown by its shift of XRD peaks seen at higher angles. A maximum decline was seen from 3.1eV for the undoped TiO<sub>2</sub> to 2.8eV in the Sn-doped TiO<sub>2</sub>, which is advantageous for enhancing V<sub>oc</sub>, according to the band gap values computed using Tauc plots. It is proven that the Sn-doped TiO<sub>2</sub> films are superior to the undoped TiO<sub>2</sub> films in terms of electron transfer rate, which is beneficial for the higher J<sub>sc</sub>. As the amount of Sn doping grows, so does the charge recombination. In light of these considerations, Sn ions were added to the TiO<sub>2</sub> thin film to increase its photocatalytic activity, resulting in a 5.4 % increase in DSSC efficiency. According to this paper, Sn-doped TiO<sub>2</sub> has promising uses in photoenergy conversion devices along with is a very interesting material.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 8","pages":"Article 101798"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design, synthesis, biological evaluation, UV–Vis absorption and computational study of bisbenzoxazinone ring-opening reactions","authors":"Zhila Abdulkareem Farhan, Mzgin Mohammed Ayoob","doi":"10.1016/j.jics.2025.101806","DOIUrl":"10.1016/j.jics.2025.101806","url":null,"abstract":"<div><div>Bis-benzoxazinone, with its ring-opening reactions, has been designed, synthesized, and its ability was tested in this study. This study is a gate and pave the way to synthesize many new bis-benzoxazine-4-ones with their ring-opening reactions forming bis-diamides, via easy procedures, with it is strong biological activity to discover new drugs. This study has started with the reaction of formaldehyde and anthranilic acid, forming bis anthranilic acid (5,5-methylenbis (2-aminobenzoic acid)), then the product has been reacted with benzoyl chloride, and acetic anhydride was used as a cyclizing agent, closing the rings and forming bis benzoxazine-4-one. Aniline with a variety of aromatic amines bearing electron-donating substituents such as p-toluidine, aniline, <em>o</em>-anisidine, <em>p</em>-anisidine, <em>m</em>-anisidine, <em>p</em>-phenetidine, and <em>o</em>-phenetidine were then employed to induce ring-opening reactions, leading to the formation of structurally diverse bis-diamides via straightforward procedures. The structures of all synthesized compounds were confirmed using a range of spectroscopic techniques, including <sup>13</sup><u>C-NMR,</u> <sup>1</sup><u>H-NMR,</u> <sup>13</sup><u>C-DEPT-NMR, FT-IR, and UV–Vis</u> absorption. The antibacterial activity of the compounds was assessed <em>in vitro</em> using the well diffusion method against Gram-negative <em>Escherichia coli</em> and Gram-positive <em>Staphylococcus aureus</em>. The results demonstrated a higher antibacterial efficacy against <em>E. coli</em>. Furthermore, <em>in silico</em> molecular docking studies were conducted to investigate the binding interactions between the synthesized compounds and bacterial target proteins, providing insights into their mechanisms of action. Overall, the synthesized bis-benzoxazine derivatives exhibited promising antibacterial properties, highlighting their potential as lead structures for the development of new antimicrobial agents.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 8","pages":"Article 101806"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ag/AgCl/BaCl2@ZnO/GO Nanocomposite: Synthesis, characterization and application in water splitting","authors":"Neeta Gurbani, Niranjan Kumar Mandawat, Rajani Meena, Neelu Chouhan","doi":"10.1016/j.jics.2025.101809","DOIUrl":"10.1016/j.jics.2025.101809","url":null,"abstract":"<div><div>In this investigation, we had prepared a hybrid assembly Ag/AgCl(BaCl<sub>2</sub>)@ZnO via one pot method by introducing barium chloride to make a plasmonic Ag-loaded AgCl on ZnO. The molecular device was further modified by addition of GO. As-synthesized Ag/AgCl(BaCl<sub>2</sub>)@ZnO hybrid and Ag/AgCl(BaCl<sub>2</sub>)@ZnO/GO ternary nanocomposites, exhibit a noticeable photocatalytic hydrogen production rate through cleavage of water, Where photo-induced electrons transferred from Ag/AgCl@ZnO to Ag/BaCl<sub>2</sub>@ZnO through the additional surface states (SURS) as well as metal induced gap states(MIGS) that resulted in low photo-generated charge-carrier recombination rate in Ag/AgCl(BaCl<sub>2</sub>)@ZnO/GO ternary nanocomposite. Which, exhibited the good hydrogen production ability (292.0 μmol H<sub>2</sub> h<sup>−1</sup>g<sup>−1</sup>) over the hybrid assembly (241.5 μmol H<sub>2</sub> h<sup>−1</sup>g<sup>−1</sup>) towards the water splitting under the visible light irradiation. The X-ray powder diffraction, UV–Vis spectroscopy, FTIR, X-ray photoelectron spectroscopy (XPS), spectroflourimetry, FESEM, and EDX are used to elucidate the electronic environment of the as-synthesized samples as well as to correlate with their photocatalytic activity in terms of water splitting.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101809"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fareeha Mushtaq , Mohsin Javed , Muhammad Aslam , Misbah Umar , Zahra Noreen , Fadi Jaber , Syed Kashif Ali , Ahmad Asimov , M. Alhabradi , M. Alruwaili , Ali Bahadur , Shahid Iqbal , Sajid Mahmood , Mohammed T. Alotaibi , Lamiaa Galal Amin
{"title":"Synthesis of ternary S-g-C3N4/Cr-doped CdS hybrid nanocomposite for enhanced photocatalytic efficiency and antimicrobial applications","authors":"Fareeha Mushtaq , Mohsin Javed , Muhammad Aslam , Misbah Umar , Zahra Noreen , Fadi Jaber , Syed Kashif Ali , Ahmad Asimov , M. Alhabradi , M. Alruwaili , Ali Bahadur , Shahid Iqbal , Sajid Mahmood , Mohammed T. Alotaibi , Lamiaa Galal Amin","doi":"10.1016/j.jics.2025.101799","DOIUrl":"10.1016/j.jics.2025.101799","url":null,"abstract":"<div><div>For harmful contaminants to be effectively treated, a reliable and effective photo catalyst must be developed. The spherical-like Cr doped CdS nanocomposites, which are intended for the efficient photo degradation of methylene blue dye, were embellished in this study. XRD, SEM, FT-IR and TEM were used to analyze the synthesized particles to comprehend their structural and morphological properties. The outcomes demonstrated that adding chromium to the CdS lattice increases photocatalytic oxidation/reduction. By fabricating composite materials, a further increase in the photocatalytic rate was observed. The antibacterial behavior of the synthesized nanocomposite was studied. CdS with 70 % S-g-C<sub>3</sub>N<sub>4</sub> assisted 5 % Cr doped CdS (5 % Cr–CdS@SCN) showed efficient pho-catalytic degradation and antibacterial potential. The synthesized nanocomposites were also assessed for antioxidant activity, and fascinatingly, they showed significant antioxidant potential of (IC<sub>50</sub> value = 76.5 ± 0.78 μM) compared with the standard Butylated hydroxy anisole. The synthesized nanocomposites showed excellent urease inhibition (IC<sub>50</sub> value = 67.4 ± 0.46 μM). The proposed study collectively enhances photodegradation and biomedical properties of the synthesized sample.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101799"},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edak K. Agi-Odey , Idongesit J. Mbonu , Uwakima S. Ikoedem , Michael O. Odey
{"title":"Chemical tailoring of silicon carbide nanotubes as sensors for polybrominated diphenyl ether (PBDE): A computational study of bismuth mono-doping and co-doping with chalcogenides","authors":"Edak K. Agi-Odey , Idongesit J. Mbonu , Uwakima S. Ikoedem , Michael O. Odey","doi":"10.1016/j.jics.2025.101800","DOIUrl":"10.1016/j.jics.2025.101800","url":null,"abstract":"<div><div>This study proposed a newly tailored silicon carbide nanotube material via bismuth mono-doping and co-doping with chalcogenides as polybrominated diphenyl ether (PBDE) sensors. The details of gas adsorption were examined through the density functional theory (DFT) approach at the M08HX/LanL2DZ level of theory. The energy gap was reduced upon adsorption, with the <strong>PSB1</strong> complex attributed with the least energy of 3.677 eV, and the greatest energy gap of 4.491 eV to the <strong>PB1</strong> complex. Again, the highest perturbation energy of 382.42 kcal/mol for the <strong>PSB1</strong> complex and a relatively high energy of 229.81 kcal/mol for <strong>PTB1</strong> indicate that these surfaces are more stabilized upon adsorption. In most cases, chemisorption phenomena of adsorption were observed, with the adsorption energy values within a relatively small range of −0.8042 to −0.9459 eV. Hence, this study gives a conclusive scientific report that Bi@SiCNT, Se–Bi@SiCNT, and Te–Bi@SiCNT surfaces are potential candidates for coupling future working sensor devices for PDBE.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101800"},"PeriodicalIF":3.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dinesh Krishna Narukulla, Lavanya Vattikonda, Venkata Rao Kaki
{"title":"Towards sustainable and scalable synthesis of amitriptyline hydrochloride, minoxidil, and pyrrolidinyl diaminopyrimidine oxide","authors":"Dinesh Krishna Narukulla, Lavanya Vattikonda, Venkata Rao Kaki","doi":"10.1016/j.jics.2025.101805","DOIUrl":"10.1016/j.jics.2025.101805","url":null,"abstract":"<div><div>Amitriptyline is a widely prescribed antidepressant, while minoxidil and its structurally related compound, pyrrolidinyl diaminopyrimidine oxide (PDO) are commonly used in hair growth formulations to treat alopecia. The growing demand for these substances necessitates the development of cost-effective and sustainable production methods. Traditional synthesis processes for amitriptyline rely on harmful solvents and energy-intensive techniques like azeotropic distillation. This study presents a novel greener approach for the synthesis of amitriptyline, utilising environmentally friendly solvents in Grignard reactions and subsequent isolation steps. These solvents are recoverable and reusable, making the process more economical and eco-friendlier. The purity of the recovered solvents was confirmed using gas chromatography. Similarly, the conventional synthesis processes for minoxidil and PDO depend on expensive oxidizing agents, limiting economic scalability and sustainability. This study introduces an innovative method for synthesizing both minoxidil and PDO using an in-house prepared oxidizing agent, monoperphthalic acid (MPA), synthesised from inexpensive and readily available reagents: phthalic anhydride and hydrogen peroxide. These novel synthetic strategies for amitriptyline, minoxidil, and PDO offer a cost-effective and sustainable alternative to traditional methods while maintaining efficiency and product quality.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 7","pages":"Article 101805"},"PeriodicalIF":3.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}