乳酸钙催化串联Michael加成-环化反应：合成2-氨基- 4h -铬-3-碳腈的绿色方案

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2025-09-17 DOI:10.1016/j.jics.2025.102094

Sudipta Roy , Nazir Uddin , Chayanika Chakraborty , Arun Kumar Sinha , Naba K. Nath , Paresh Nath Chatterjee

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引用次数: 0

摘要

本文介绍了一种在绿色溶剂中以无毒乳酸钙为催化剂，通过串联Michael加成-环化反应合成2-氨基- 4h -铬-3-碳腈的环保绿色方案。通过丙二腈与2-羟基查尔酮/2-(E)-2-硝基乙烯基苯酚的Michael加成反应生成2-氨基-4 -铬-3-碳腈，然后在乙醇水溶液中（1:1 v/v）进行分子内环闭合。本方法可以容忍具有不同电子性质的官能团，并产生良好到优异的收率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Calcium lactate catalyzed tandem Michael addition-cyclization reaction: A green protocol to synthesize 2-amino-4H-chromene-3-carbonitriles

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Calcium lactate catalyzed tandem Michael addition-cyclization reaction: A green protocol to synthesize 2-amino-4H-chromene-3-carbonitriles

An eco-friendly, green protocol catalyzed by non-toxic calcium lactate to synthesize 2-amino-4H-chromene-3-carbonitriles via a tandem Michael addition-cyclization reaction in green solvents is described here. The 2-amino-4H-chromene-3-carbonitriles are formed by the Michael addition reaction of malononitrile to 2-hydroxychalcones/2-(E)-2-nitrovinylphenols, followed by an intramolecular ring closure in aqueous ethanol (1:1 v/v). The present method can tolerate functional groups with different electronic properties and produce good to excellent yields of the desired chromenes.

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.