Journal of the American Academy of Child and Adolescent Psychiatry最新文献

{"title":"Editorial: Meta-Analysis of Individual Participant Data from Trials of Selective Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder: A Gold Standard Approach.","authors":"Gail A Bernstein","doi":"10.1016/j.jaac.2025.03.016","DOIUrl":"10.1016/j.jaac.2025.03.016","url":null,"abstract":"<p><p>Pediatric obsessive-compulsive disorder (OCD) is a common (2% prevalence) and potentially debilitating condition.¹ Early identification and intervention are critical because they may improve outcomes for children and adolescents with OCD and prevent long-term morbidity. The individual participant data (IPD) meta-analysis by Cohen and colleagues² explores the efficacy of short-term trials of selective serotonin reuptake inhibitors (SSRIs) compared to placebo for treating children and adolescents with OCD. It also investigates the moderating effects of baseline patient variables on treatment outcome.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors' Note.","authors":"","doi":"10.1016/j.jaac.2025.03.017","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.017","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Pearls of Evaluation and Treatment of Adolescents and Emerging Adults with Scrupulosity Obsessive-Compulsive Disorder.","authors":"Carol R Chen, Sara Byczek, Emily Bilek","doi":"10.1016/j.jaac.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.015","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder.","authors":"Sarah B Abdallah, Emily Olfson, Carolina Cappi, Samantha Greenspun, Gwyneth Zai, Maria C Rosário, A Jeremy Willsey, Roseli G Shavitt, Euripedes C Miguel, James L Kennedy, Margaret A Richter, Thomas V Fernandez","doi":"10.1016/j.jaac.2025.03.014","DOIUrl":"10.1016/j.jaac.2025.03.014","url":null,"abstract":"<p><strong>Objective: </strong>Pediatric obsessive-compulsive disorder (OCD) is a common neuropsychiatric disorder for which genetic factors play an important role. Recent studies have demonstrated an enrichment of rare de novo DNA single nucleotide variants in OCD cases compared to controls, and larger studies have examined copy-number variants (CNVs) using microarray data. Our study examines rare de novo CNVs using whole-exome sequencing (WES) data to provide additional insight into genetic factors and biological processes underlying OCD.</p><p><strong>Method: </strong>We detected CNVs using whole-exome DNA sequencing (WES) data from 183 OCD trio families (unaffected parents and children with OCD) and 771 control families to test the hypothesis that rare de novo CNVs are enriched in OCD cases compared to controls. Our primary analysis used the eXome-Hidden Markov Model (XHMM) to identify CNVs in silico. We performed burden analyses comparing individuals with OCD vs. controls and downstream biological systems analyses of CNVs in probands with OCD. We then used a second algorithm (GATK-gCNV) to confirm our primary analysis.</p><p><strong>Results: </strong>Our findings demonstrate a higher rate of rare de novo CNVs detected by WES in individuals with OCD (0.07 CNVs per proband) compared to controls (0.005) (corrected rate ratio = 11.7 95% CI, 3.6-50.0, p = 4.00x10^-6). We confirmed this enrichment using GATK-gCNV. The majority of these rare de novo CNVs in OCD cases are predicted to be pathogenic or likely pathogenic, and an examination of genes disrupted by rare de novo CNVs in OCD cases finds enrichment of several gene-ontology sets.</p><p><strong>Conclusion: </strong>This study shows for the first time an enrichment of rare de novo CNVs detected by WES in OCD, complementing previous larger CNV studies and providing additional insight into genetic factors underlying OCD risk.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Embracing Complexity When Examining the Social Construct of Race: Nuanced Strategies are Needed to Reduce Harm and Improve Neurodevelopmental Science.","authors":"Amanda Noroña-Zhou, Michael Coccia, Nicole R Bush","doi":"10.1016/j.jaac.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.008","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations When Accounting for Race and Ethnicity in Studies of Poverty and Neurodevelopment.","authors":"Clementine Semanaz, Akhgar Ghassabian, Scott Delaney, Fang Fang, David R Williams, Henning Tiemeier","doi":"10.1016/j.jaac.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.007","url":null,"abstract":"<p><strong>Objective: </strong>Poverty and systemic racism within rare intertwined. Children of marginalized racial and ethnic identities experience higher levels of poverty and adverse psychiatric outcomes. Thus, in models of poverty and neurodevelopment, race and ethnicity-as proxies for exposure to systemic disadvantage-are regularly considered confounders. Recently, however, some researchers claimed that using race and ethnicity as confounders is statistically dubious, and potentially socially damaging. Instead, they argue for the use of variables measuring other social determinants of health (SDoH). We explore this approach.</p><p><strong>Method: </strong>Data are from 7,836 10-year-olds in the Adolescent Brain and Cognitive Development study. We fit mixed regression models for the association of household poverty measures with psychiatric symptoms, magnetic resonance imaging-derived (MRI) cortical measures, and cognition with and without (1) race and ethnicity adjustment; (2); poverty-by-race and ethnicity interaction terms and (3) alternative SDoH variables. Propensity-based weights were used to calibrate the sample to key US demographics.</p><p><strong>Results: </strong>For psychiatric and cognitive outcomes, poverty-outcome relationships differed across racial and ethnic groups (poverty-by-race-and-ethnicity interaction p<0.05). For MRI outcomes, adjusting for race and ethnicity changed the estimate of poverty's impact. Alternative SDoH adjustment could not fully account for the impact of race and ethnicity on the associations explored.</p><p><strong>Conclusion: </strong>Poverty and race and ethnicity combine to influence neurodevelopment. Results suggest effects of poverty are generally inconsistent across race and ethnicity, which supports prior research demonstrating the non-equivalence of SDoH indicators by race and ethnicity. Studies exploring these relationships should assess interaction between poverty and race and ethnicity and/or stratify when appropriate. Replacing race and ethnicity with alternative SDoH may induce bias.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Leveraging Understudied Biological Risk Factors to Enhance Prediction of Suicidal Thoughts, Suicide Attempts, and Nonsuicidal Self-Injury in Preadolescents.","authors":"Katherine L Sarkisian, Jennifer L Hughes, Jeffrey A Bridge","doi":"10.1016/j.jaac.2025.03.006","DOIUrl":"10.1016/j.jaac.2025.03.006","url":null,"abstract":"<p><p>Despite the prevailing perception that preadolescent children do not experience suicidal thoughts and behaviors, 13.2% of children aged 9 to 10 years report that they have experienced suicidal thoughts at some point in their life, 9.1% report a history of nonsuicidal self-injury (NSSI), defined as deliberate self-harming behavior without suicidal intent, and 1.3% report making a suicide attempt.¹ In addition, suicide rates for children aged 8 to 12 years have been increasing since 2008, and suicide is now the fifth leading cause of death in this age group.² However, relatively little is known about risk and protective factors for self-injurious thoughts and behaviors (SITBs) among preadolescents. The biological underpinnings of suicidal ideation, suicidal behavior, and NSSI have been studied extensively (see Mann and Currier for a review³). Importantly, these studies focus almost exclusively on adolescent and adult samples, and translation of biologically based findings into clinical practice remains a challenge. Across clinical settings, suicide risk screening is increasingly being implemented with preadolescents, but there is a relative lack of developmentally sensitive screening and intervention tools,⁴ and detecting child suicide risk as completely and efficiently as possible remains a challenge. Thus, finding ways to bridge biological findings and suicide risk screening is a promising, yet underutilized, approach with great potential. With the emergence of more large, longitudinal studies that capture a combination of biological, psychological, and social risk factors for SITBs, it is becoming increasingly possible to examine an array of risk and protective factors simultaneously and evaluate the relative strength of these predictors.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Motor Stereotypies as a Transdiagnostic Phenotype.","authors":"Nathalia Garrido-Torres, Amy Giguere Carney, Megan Lyons, Suzanne Macari, Chelsea Morgan, Kelly Powell, Mariana Torres-Viso, Angelina Vernetti, Katarzyna Chawarska, Thomas V Fernandez","doi":"10.1016/j.jaac.2025.03.003","DOIUrl":"10.1016/j.jaac.2025.03.003","url":null,"abstract":"<p><p>Motor stereotypies (MS) are repetitive, rhythmic actions varying in complexity and presentation. Parents and teachers often notice these movements in children at home or in the classroom, prompting clinical attention. Concerns typically arise regarding the potential adverse consequences of these movements on the child, their impact on others, and whether they signal chronic neurodevelopmental conditions such as autism spectrum disorder (ASD). This Clinical Perspective emphasizes MS as a common, transdiagnostic phenotype. It is crucial for clinicians and families to understand their characteristics, typical course, and potential co-occurring conditions, and that MS do not always signify a neurodevelopmental disorder nor always require intervention.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Where Are the Trials on Adolescent Self-Harm and Suicide?","authors":"Kristina T Kumpf, Michael H Bloch","doi":"10.1016/j.jaac.2025.03.002","DOIUrl":"10.1016/j.jaac.2025.03.002","url":null,"abstract":"<p><p>Self-harm and suicide are a major public health problem, particularly among adolescents. Suicide is the third leading cause of death in adolescents in the United Kingdom and the United States, and nonsuicidal self-injury (NSSI) remains a significant source of morbidity and mortality in this population.¹^,² Despite relative consensus about the acuity of this public health problem, we lack evidence-based treatments for patients struggling with self-harm. This scarcity of effective treatments for self-harm in adolescents is highlighted by an important meta-analysis in this issue of the Journal.³ Wright-Hughes and colleagues identified 39 randomized control trials (RCTs) comparing a therapeutic intervention for self-harm to control with 26 studies providing individual patient data (IPD; 3,448 participants) and 7 providing only aggregate data (698 participants). Their 2-stage random-effects meta-analysis of studies with IPD found no significant difference in efficacy between therapeutic interventions and control treatment for preventing self-harm at 12 months. Secondary analyses incorporating aggregate data similarly showed no difference in efficacy and no strong evidence regarding moderators of treatment effect.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rapid Autism Assessment: Reducing Barriers to Behavioral Intervention Services.","authors":"Yumi Kovic, Gabrielle D Dallas, Joanne L Andrade, Lindsay A Lloveras, Kerri P Peters, Takahiro Soda","doi":"10.1016/j.jaac.2025.03.001","DOIUrl":"10.1016/j.jaac.2025.03.001","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}