Journal of the American Academy of Child and Adolescent Psychiatry最新文献

{"title":"Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.","authors":"Janna Marie Bas-Hoogendam, Rachel A Bernstein, Brenda E Benson, Samuel E C Frank, Kristin A Buss, Kelley E Gunther, Koraly Pérez-Edgar, Giovanni A Salum, Andrea Jackowski, Rodrigo A Bressan, André Zugman, Kathryn A Degnan, Courtney A Filippi, Nathan Fox, Heather A Henderson, Alva Tang, Selin Zeytinoglu, Anita Harrewijn, Manon H J Hillegers, Ryan L Muetzel, Tonya White, Marinus H van IJzendoorn, Carl Robert Emden Schwartz, Julia Felicione, Kathryn A DeYoung, Alexander J Shackman, Jason F Smith, Rachael Tillman, Yvonne H M van den Berg, Antonius H N Cillessen, Karin Roelofs, Anna Tyborowska, Shirley Y Hill, Marco Battaglia, Marco Tettamanti, Lea R Dougherty, Jingwen Jin, Daniel N Klein, Hoi-Chung Leung, Suzanne N Avery, Jennifer Urbano Blackford, Jacqueline A Clauss, James M Bjork, John M Hettema, Ashlee A Moore, Roxann Roberson-Nay, Chelsea Sawyers, Elizabeth P Hayden, Pan Liu, Matthew R J Vandermeer, H Hill Goldsmith, Elizabeth M Planalp, Thomas E Nichols, Paul M Thompson, P Michiel Westenberg, Nic J A van der Wee, Nynke A Groenewold, Dan J Stein, Anderson M Winkler, Daniel S Pine","doi":"10.1016/j.jaac.2025.06.026","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.026","url":null,"abstract":"<p><strong>Objective: </strong>Childhood inhibited temperament (cIT) is associated with an increased risk for developing internalizing psychopathology. Neurobiological characteristics identified by structural magnetic resonance imaging (MRI) may elucidate the neural substrates for cIT, but studies are scarce and often focus on particular regions of interest. Moreover, current findings lack replication. This pre-registered analysis from the ENIGMA-Anxiety Working Group examined structural brain characteristics associated with cIT using a comprehensive whole-brain approach.</p><p><strong>Method: </strong>Temperament assessments (behavioral observations, parental/teacher reports or self-reports on cIT before age 13) and MRI-data (age at scan: 6-25 years) from international research sites (Europe, North America, South America) were pooled for mega-analysis. Following image processing and quality control, associations between cIT and brain structure were examined in 3,803 participants. Subcortical volumes, cortical thickness and surface area (main analyses) and detailed subcortical characteristics (e.g. subnuclei, subfields, partial volume effects; exploratory analyses) were considered.</p><p><strong>Results: </strong>In the full sample, cIT showed no relation with brain structure, neither as a main effect nor in interactions with sex or age. Subgroup analyses (based on cIT-assessment type) revealed cIT by sex interactions on mean cortical thickness (p_MC-FWER = 0.037) and thickness of the right superior parietal region (p_MC-FWER = 0.029) in youth with parental/teacher reports on cIT-levels. Exploratory analyses revealed findings in hippocampus, putamen and caudate, but most did not survive statistical correction for multiple testing.</p><p><strong>Conclusion: </strong>This mega-analysis found no consistent associations between cIT and regional brain structure, although the role of parietal regions warrants further investigation. Future studies should consider brain function in cIT, preferably using longitudinal designs.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review: The Psychosocial Impacts of Autism-Related Genetic Testing.","authors":"Ben Curran Wills,Margaret M Matthews,Josephine Johnston,Isabel Bolo,Ruth Ottman,Paul S Appelbaum","doi":"10.1016/j.jaac.2025.06.024","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.024","url":null,"abstract":"OBJECTIVETo perform a systematic literature review of the psychosocial impacts on parents and autistic people of receiving autism-related genetic test results.METHODSystematic searches of MEDLINE, PsycINFO, CINAHL, Web of Science Core Collection, Sociological Index, and Scopus were conducted for articles appearing through October 27, 2024. The authors screened 3,606 articles. The quality of the included articles was assessed with the QuADS appraisal tool.RESULTSTwenty-two articles met inclusion criteria. Across research and clinical settings, articles assessed impacts of receiving actual (n=18) or hypothetical (n=4) genetic test results. Twenty articles assessed impacts on parents and prospective parents, while two assessed impacts on autistic adults. Psychological impacts of receiving results varied and included relief, peace of mind, reduced guilt, disappointment, fear, frustration, stress, blame, and guilt. Comparison of the frequencies of these responses was limited by heterogeneous assessment methods, variable reporting formats, and inconsistent outcome measures across studies. Receiving results sometimes confirmed diagnoses, led to altered care plans, influenced family planning, or impacted the decision to end or continue a pregnancy. Most articles reported low-to-mild or highly variable satisfaction with the testing experience. Studies of autistic adults reported strong concerns about testing without consent and discriminatory uses of genetics.CONCLUSIONImpacts on parents and prospective parents appear relatively modest, albeit with mixed valences-a finding broadly similar to return-of-results studies for other complex genetic conditions. Although the findings of the two studies of autistic adults differ substantially, they suggest that autistic people and current and prospective parents of autistic children may have significantly different experiences and perspectives. Clinicians should recognize these differences and help parents understand and weigh them in decision-making.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"31 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centanafadine for Attention-Deficit/Hyperactivity Disorder in Adolescents: A Randomized Clinical Trial.","authors":"Caroline L Ward,Ann C Childress,Na Jin,Osman Turkoglu,Taisa Skubiak,Timothy E Wilens","doi":"10.1016/j.jaac.2025.06.023","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.023","url":null,"abstract":"OBJECTIVEThis randomized, double-blind, placebo-controlled trial evaluated the efficacy, safety, and tolerability of centanafadine-a norepinephrine, dopamine, serotonin reuptake inhibitor-in the treatment of attention-deficit/hyperactivity disorder (ADHD) in adolescents.METHODAdolescents (ages 13-17 years, inclusive) with a primary diagnosis of ADHD were randomized to once-daily centanafadine 164.4 mg, 328.8 mg, or placebo for 6 weeks. Dosing was not titrated. The primary endpoint was change from baseline in the ADHD Rating Scale, version 5 (ADHD-RS-5) symptoms total raw score at Week 6. This trial is registered with ClinicalTrials.gov (NCT05257265).RESULTSOf 459 participants (centanafadine 164.4 mg, n=155; 328.8 mg, n=155; placebo, n=149), 451 received ≥1 dose of study drug and 371 (80.8%) completed the trial. At Week 6, improvements in ADHD-RS-5 symptoms total raw score were significantly greater with centanafadine 328.8 mg than with placebo (-18.50 [0.93] vs -14.15 [0.93]; p=0.0006); centanafadine 164.4 mg did not meet the primary endpoint. Centanafadine 328.8 mg showed separation from placebo at Week 1, the first post-baseline timepoint, with the effect maintained throughout the study. Treatment-emergent adverse events (TEAEs) occurred in 48/153 (31.4%, 164.4 mg), 76/151 (50.3%, 328.8 mg), and 35/147 (23.8%, placebo) participants. The most common (≥5% any group) TEAEs were decreased appetite, nausea, headache, and rash. Most TEAEs were of mild or moderate severity; 3 events were severe: liver function test increased (n=1, 164.4 mg); aggression (n=1, 164.4 mg); and somnolence (n=1, placebo).CONCLUSIONCentanafadine 328.8 mg was efficacious for ADHD treatment in adolescents. Both doses were generally safe and well tolerated.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"48 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: First, Do No Harm: Findings from a 16-year Study on Juvenile Detainees","authors":"Camille A. Tastenhoye MD, Anne B. McBride MD","doi":"10.1016/j.jaac.2025.06.021","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.021","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"20 6 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Uniformity Before Prediction: The Unfinished Science of Attention-Deficit/Hyperactivity Disorder Forecasting","authors":"Arthur Caye PhD","doi":"10.1016/j.jaac.2025.06.020","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.020","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"148 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waves of Change: A Nationwide Analysis of Acute Pediatric Healthcare Encounters Attributed to Substance Use Before, During, and Following the COVID-19 Pandemic","authors":"Sara W. Kelly PhD MPH, Dale L. Smith PhD, Zachary Davis MD, Robin Mermelstein PhD, Niranjan S. Karnik MD PhD","doi":"10.1016/j.jaac.2025.06.019","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.019","url":null,"abstract":"To examine changes in acute healthcare encounters and identify risk factors associated with substance use among the pediatric population before, during, and after the COVID-19 pandemic.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"12 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preadolescent Benefits of Parent-Child Interaction Therapy Emotion Development for Preschool Depression: 4-Year Follow-up.","authors":"Mei Elansary, Deanna M Barch, Rebecca Tillman, Carolina Badke Dandrea, Alecia C Vogel, Meghan Rose Donohue, Laura Hennefield, Kirsten Gilbert, Joan L Luby","doi":"10.1016/j.jaac.2025.06.011","DOIUrl":"10.1016/j.jaac.2025.06.011","url":null,"abstract":"<p><strong>Objective: </strong>Childhood depression can arise as early as age 3 years and is a chronic and relapsing disorder, with high rates of comorbidity and functional impairment. Previous research demonstrated a high rate of sustained gains in remission from preschool depression 18 weeks after completion of a novel intervention for depression, Parent-Child Interaction Therapy-Emotion Development (PCIT-ED). However, there have been no data regarding longer-term outcomes. We investigated whether response to PCIT-ED was evident 4 years after treatment completion and whether individuals who were remitted had decreases in mental health service use and psychotropic prescriptions compared to nonresponders.</p><p><strong>Method: </strong>We followed participants into preadolescence 4 years after participation in a randomized controlled trial of PCIT-ED delivered during the preschool period. Potential predictors of depression remission, obtained from pre-therapy and post-therapy assessments, were investigated using logistic regression models. Characteristics of participants in remission at preadolescence were compared to those not in remission. We also tracked psychiatric care.</p><p><strong>Results: </strong>There was a high rate of remission at preadolescence (57.1%). Post-therapy externalizing symptoms predicted relapse. Participants with remission at preadolescence had significantly lower rates of lifetime use of α-agonist, antidepressant, and atypical antipsychotic medication as well as decreased use of intensive mental health interventions.</p><p><strong>Conclusion: </strong>PCIT-ED for preschool depression had effects at long-term follow-up in a majority of young children. Early intervention, when effective, was associated with reduced psychotropic and intensive mental health service use. PCIT-ED, as a brief early intervention, may be a cost-effective way to minimize relapse and to decrease subsequent mental health interventions.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0890-8567(25)00187-X","DOIUrl":"10.1016/S0890-8567(25)00187-X","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 7","pages":"Page A1"},"PeriodicalIF":9.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child and Youth Artwork","authors":"","doi":"10.1016/S0890-8567(25)00190-X","DOIUrl":"10.1016/S0890-8567(25)00190-X","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 7","pages":"Page A6"},"PeriodicalIF":9.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Council Page","authors":"","doi":"10.1016/S0890-8567(25)00188-1","DOIUrl":"10.1016/S0890-8567(25)00188-1","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 7","pages":"Page A2"},"PeriodicalIF":9.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}