Journal of the American Academy of Child and Adolescent Psychiatry最新文献

{"title":"Noninvasive Brain Stimulation in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Treatment Efficacy and Targeting Strategies","authors":"Qiuxing Chen MM, Nanfang Pan MD, Yajing Long MD, Kun Qin PhD, Arshiya Sangchooli MD MPhil, Ying Cao MM., Manpreet K. Singh MD MS, Ying Chen MD, Qiyong Gong MD PhD","doi":"10.1016/j.jaac.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.009","url":null,"abstract":"Noninvasive brain stimulation (NIBS) has emerged as a promising novel treatment for attention-deficit/hyperactivity disorder (ADHD). However, the precise effects of NIBS in ADHD, as well as optimal stimulation protocols, remain elusive. This systematic review and meta-analysis aimed to provide a rigorous evaluation and robust quantified evidence on the therapeutic efficacy of NIBS on ADHD.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"149 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis: Neurocognitive Alterations in Offspring of Individuals with Schizophrenia or Bipolar Disorder Compared to Offspring of Nonaffected Parents","authors":"Borja Pedruzo MD, Claudia Aymerich MD PhD, Carlos Martínez-Asensi MSc, Angel Yorca-Ruiz BSc MSc, Rebeca Magdaleno Herrero BSc MSc, Alexandre Diaz-Pons BSc, Victor Ortiz-García de la Foz BSc, Joaquim Radua MD PhD, Daniel Alonso-Alconada PhD, Gonzalo Salazar de Pablo MD PhD, Miguel Ángel González-Torres MD PhD, Paolo Fusar-Poli MD PhD, Ana Catalán MD PhD, Rosa Ayesa-Arriola PhD","doi":"10.1016/j.jaac.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.008","url":null,"abstract":"The aim of this study is to conduct a meta-analytic examination of neurocognitive functioning in offspring of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD), examining both their differences from healthy control offspring (HC) and from each other.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"96 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Assessment and Implications of Parasocial Relationships in Adolescents.","authors":"Ailyn D Diaz,Alicia W Leong,Sumru Bilge-Johnson,Michael Shapiro,Chaden Noureddine,Kristopher Kaliebe","doi":"10.1016/j.jaac.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.005","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"18 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the First Onset of Suicidal Thoughts and Behaviors in Adolescents Using Multimodal Risk Factors: A Four-Year Longitudinal Study.","authors":"Josh Nguyen,Dom Dwyer,Yara J Toenders,Scott D Tagliaferri,Laura S van Velzen,Scott R Clark,Isabelle Scott,Simon Hartmann,Johanna T W Wigman,Ashleigh Lin,Andrew D Thompson,Cassandra M J Wannan,Caroline X Gao,Stephen J Wood,G Paul Amminger,Alison R Yung,Nikolaos Koutsouleris,Jessica A Hartmann,Hok Pan Yuen,Christopher G Davey,Angelica Ronald,Patrick D McGorry,Christel Middeldorp,Barnaby Nelson,Lianne Schmaal","doi":"10.1016/j.jaac.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.006","url":null,"abstract":"OBJECTIVESuicide is one of the leading causes of death among youth worldwide, yet existing studies that aimed to predict the first onset of suicidal thoughts or behaviors (STB) included a limited number of data modalities, and/or focused on adult populations. We aimed to prospectively predict first-onset STB across four-year follow-ups in adolescents using (1) an existing STB history classification model that was previously applied to baseline data, and (2) a new machine learning model with 195 biopsychosocial features.METHODThe study included 7,503 unrelated adolescents (54.5% female, aged 9-11 years at baseline) from the multisite, longitudinal Adolescent Brain Cognitive Development (ABCD) project. Our existing baseline STB history classification model was applied to predict longitudinal first-onset STB versus healthy controls and clinical controls (those with mental illness but no STB). A new elastic net logistic regression model with 195 features was trained on data from 14 sites (n=5,220) and the resulting top 15 features were validated in seven independent sites (n=2,283).RESULTSOur previously developed model to classify STB lifetime history also prospectively predicted first-onset STB with an area under the curve (AUC)[95%] of 0.73[0.70,0.75], p<.001 relative to healthy controls and AUC[95%] of 0.63[0.60,0.66], p<.001 compared to clinical controls. The newly trained model with top 15 features performed similarly with AUC[95%]=0.73[0.71,0.76], p<.001 and AUC[95%]=0.64 [0.60,0.66], p<.001 for the same comparison groups. The most consistent predictors across models included female sex, sleep disturbances, and maladaptive home and school environments.CONCLUSIONOur models predicted first-onset STB in adolescents with moderate accuracy. Our study also confirmed the roles of well-established psychological risk factors for STB and identified several novel neurocognitive and brain imaging risk factors. Future studies should validate our models in large-scale diverse samples before clinical translation.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"18 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention-Deficit/Hyperactivity Disorder Subtypes Defined by Cognition Have a Distinct Neural and Clinical Profile and Differ in Response to Atomoxetine.","authors":"John E Leikauf,Kristi R Griffiths,Simon D Clarke,Michael R Kohn,Leanne Williams","doi":"10.1016/j.jaac.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.007","url":null,"abstract":"OBJECTIVEADHD is clinically and etiologically heterogeneous across multiple levels of organization. We sought to parse the heterogeneity of ADHD by identifying cognitive subtypes based on common features of ADHD, including inhibitory control, sustained attention, and working memory. We sought to validate the subtypes using constructs at other meaningful levels of organization: quantitative electroencephalogram (qEEG), clinical symptoms, and response to treatment with atomoxetine and methylphenidate.METHODHierarchical cluster analysis of cognitive measures defined clusters in one clinical sample (n=112). Replication was tested in a second, held-out clinical sample (n =336). Cluster subtypes were assessed for neural validation using resting-state qEEG and heart rate, and for clinical applicability using ADHD and anxiety symptom ratings. Further, clusters were assessed for differential treatment response after six weeks of atomoxetine or methylphenidate.RESULTSTwo clusters defined by specific cognitive profiles were identified and replicated. The inhibitory control subtype was distinguished by more activity in qEEG Delta (β = -0.47, p = 4.89*10ˆ-9), Theta (β = -0.39, p = 7.84*10ˆ-6), and Beta (β = -0.36, p = 4.21*10ˆ-7) bands, and higher resting heart rate. Clinically, this subtype also had more severe anxiety (M = 7.6, SD = 6.0) than the sustained attention subtype (M = 4.7, SD = 4.3, p = 0.02), and had a markedly better response to atomoxetine (β = 8.4, p = 0.008, Cohen's d = 0.71).CONCLUSIONCognitive performance appears effective for identifying ADHD subtypes that have a distinct neural basis and that may particularly benefit from non-stimulants such as atomoxetine.","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"52 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"64 (5) Fontanella Correction","authors":"","doi":"10.1016/j.jaac.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.002","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"7 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Four Year Combined General Psychiatry and Child and Adolescent Psychiatry Residency: A Bridge Too Far?","authors":"Jeffrey Hunt MD, Gregory K. Fritz MD, Edwin D. Williamson MD, John T. Walkup MD","doi":"10.1016/j.jaac.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.003","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"31 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Firearm Access Restriction in Children With Escalating Mental Health Symptoms: Opportunity for Common Ground","authors":"Neil G. Uspal MD, Leah E. McCartney BS., Ian Kodish MD PhD","doi":"10.1016/j.jaac.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.004","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specificity of Parenting Program Component Effects: Relational, Behavioral, and Cognitive Approaches to Children’s Conduct Problems","authors":"","doi":"10.1016/j.jaac.2025.06.025","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.06.025","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"109 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Preteens and Suicide Risk: It Doesn't Hurt to Ask.","authors":"Lisa M Horowitz,Jeffrey A Bridge,Maryland Pao","doi":"10.1016/j.jaac.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.07.001","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}