Journal of the American Academy of Child and Adolescent Psychiatry最新文献

{"title":"Understanding Motor Stereotypies as a Transdiagnostic Phenotype.","authors":"Nathalia Garrido-Torres, Amy Giguere Carney, Megan Lyons, Suzanne Macari, Chelsea Morgan, Kelly Powell, Mariana Torres-Viso, Angelina Vernetti, Katarzyna Chawarska, Thomas V Fernandez","doi":"10.1016/j.jaac.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.003","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Where are the Trials on Adolescent Self-Harm and Suicide?","authors":"Kristina T Kumpf, Michael H Bloch","doi":"10.1016/j.jaac.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.002","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Diagnosis and Intervention is Critical, so What's Taking so Long?","authors":"Yumi Kovic, Gabrielle D Dallas, Joanne L Andrade, Lindsay A Lloveras, Kerri P Peters, Takahiro Soda","doi":"10.1016/j.jaac.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.03.001","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Structural Determinants of School Discipline: A Call to Action.","authors":"Brittany E Bryant","doi":"10.1016/j.jaac.2025.02.014","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.02.014","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Esketamine on Depressive Symptoms in Adolescents with Major Depressive Disorder at Imminent Suicide Risk: A Randomized Psychoactive-Controlled Study.","authors":"Colette Kosik-Gonzalez, Dong-Jing Fu, Li Nancy Chen, Rosanne Lane, Michael H Bloch, Melissa DelBello, Carmen Moreno, Wayne C Drevets, Carla M Canuso","doi":"10.1016/j.jaac.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.02.015","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy, safety, and tolerability of esketamine nasal spray versus psychoactive placebo (oral midazolam) in rapidly reducing depressive symptoms in adolescents with major depressive disorder at imminent risk for suicide.</p><p><strong>Method: </strong>This double-blind, double-dummy, phase 2b study randomized (1:1:1:2) 147 adolescents (12 to <18 years old) to esketamine (28, 56, or 84 mg) or midazolam twice-weekly for 4 weeks. Participants concomitantly received comprehensive standard-of-care (SOC), including initial hospitalization, oral antidepressant, and evidenced-based psychotherapy. The primary efficacy endpoint - change in Children's Depression Rating Scale-Revised (CDRS-R) total score from baseline to 24 hours post-first dose was analyzed using ANCOVA, according to a pooled sequential multiple-testing procedure.</p><p><strong>Results: </strong>All participants were moderately-to-severely depressed at enrollment; approximately 95% were moderately-to-extremely suicidal. Pooled esketamine doses (56 and 84 mg) showed superiority over midazolam in reducing CDRS-R total score at 24 hours post-first dose (between-group difference of LS means [95% CI]: -5.8 [-11.19, -0.35]; p=0.037). The between-group differences for individual 84 mg and 56 mg esketamine doses versus midazolam were -5.7 ([-12.91, 1.55], p=0.123) and -5.9 ([-12.25, 0.53], p=0.072), respectively. Severity of suicidality, per Clinical Global Impression-Severity of Suicidality Revised, improved in all 4 groups (between-group difference of LS means [95% CI]: -0.2 [-0.90, 0.41], -0.3 [-0.93, 0.31], 0.0 [-0.69, 0.72] for esketamine 28, 56, and 84 mg, respectively, at 24 hours post-first dose). Common adverse events (incidence ≥20%) reported for esketamine were dizziness, nausea, dissociation, headache, dysgeusia, somnolence, vomiting, hypoesthesia, and intentional self-injury.</p><p><strong>Conclusion: </strong>The primary efficacy endpoint of the study was met for the pooled esketamine doses (56 and 84 mg): Esketamine in conjunction with comprehensive SOC rapidly improved depressive symptoms among adolescents at imminent risk for suicide.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The Power of Racial-Ethnic Socialization in Promoting Adolescent Resilience.","authors":"Amanda E Baker","doi":"10.1016/j.jaac.2025.02.016","DOIUrl":"https://doi.org/10.1016/j.jaac.2025.02.016","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Bridging Generations: The Role of Executive Function in Intergenerational Transmission of Depression.","authors":"Eric A Youngstrom","doi":"10.1016/j.jaac.2025.02.011","DOIUrl":"10.1016/j.jaac.2025.02.011","url":null,"abstract":"<p><p>Maternal depression casts long shadows across generations, influencing cognitive, emotional, and behavioral outcomes in children. Yet, understanding the precise pathways of intergenerational transmission remains a challenge for researchers and clinicians alike. In their recent study, Han et al.¹ offer valuable insights into one such pathway: the mediating role of executive function (EF) deficits in the relationship between maternal depressive symptoms and childhood depression. This investigation not only advances the field's understanding of EF but also suggests a role for interventions targeting EF to mitigate the transmission of depressive symptoms.</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Historical Trauma and Resilience: The Importance of Narrative Change.","authors":"John T Walkup","doi":"10.1016/j.jaac.2025.02.010","DOIUrl":"10.1016/j.jaac.2025.02.010","url":null,"abstract":"<p><p>Before commenting on the paper specifically, I would like to provide some context for the work of the authorship team of \"Intergenerational Impacts of Historical Trauma on Contemporary Depression Symptoms Among Indigenous Communities.\"¹ In addition, I would like to discuss efforts to define historical trauma since it was first postulated to explain the current health and mental health of Indigenous peoples; and finally, to discuss ways to conceptualize the paper's report of diverse depression outcomes in the context of narrative change and \"posttraumatic growth.\"</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Council Page","authors":"","doi":"10.1016/S0890-8567(24)02040-9","DOIUrl":"10.1016/S0890-8567(24)02040-9","url":null,"abstract":"","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":"64 3","pages":"Page A2"},"PeriodicalIF":9.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Reciprocal Causality in Parent-Child Relationships.","authors":"David J Miklowitz","doi":"10.1016/j.jaac.2025.02.009","DOIUrl":"10.1016/j.jaac.2025.02.009","url":null,"abstract":"<p><p>The question of whether family dysfunction predates or is a consequence of individual psychopathology is almost as old as the mind-body problem. In traditional family systems views, individual psychopathology emerges from pathology in the family as a whole and is best alleviated by treating the familial context. Medical models view family system disturbances as reflecting caregiver distress in managing the psychiatric symptoms of another family member. In transactional developmental psychopathology models, dynamic processes within the family interact with the psychological and biological vulnerabilities of high-risk individuals, interactions that change at different points of cognitive, social, or emotional development.¹ Transactional models are recursive: psychiatric symptoms or behaviors in an ill family member affect the psychological health and relationships of other family members, and the reactions of these family members affect the functioning of the ill person.².</p>","PeriodicalId":17186,"journal":{"name":"Journal of the American Academy of Child and Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}