Exploring the Behavioral and Emotional Manifestation of Polygenic Risk for Psychiatric Disorders Among Schoolchildren

IF 9.2 1区医学 Q1 PEDIATRICS

Journal of the American Academy of Child and Adolescent Psychiatry Pub Date : 2025-06-19 DOI:10.1016/j.jaac.2025.06.012

Silvia Alemany PhD, Rosa Bosch PhD, María Soler Artigas PhD, Judit Cabana-Domínguez PhD, Laura Vilar-Ribó PhD, Natalia Llonga MSc, Lorena Arribas BSc, Pau Carabí-Gassol MSc, Valeria Macias-Chimborazo BS, Uxue Zubizarreta-Arruti BSc, Mireia Pagerols PhD, Raquel Prat BSc, Elia Pagespetit BSc, Julia Puigbo MSc, Gemma Español-Martín MD PhD, J. Antoni Ramos-Quiroga MD PhD, Miquel Casas MD PhD, Marta Ribasés PhD.

引用次数: 0

Abstract

We examined the relationships between polygenic risk scores (PRS) for psychiatric disorders and behavioral and emotional problems. In addition, we explored whether these associations differ by sex and conducted mutually adjusted models to elucidate whether different PRS independently contribute to the same outcome.

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学童精神疾病多基因风险的行为与情绪表现探讨

我们研究了精神疾病的多基因风险评分（PRS）与行为和情绪问题之间的关系。此外，我们探讨了这些关联是否因性别而异，并进行了相互调整的模型，以阐明不同的PRS是否独立地导致相同的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Academy of Child and Adolescent Psychiatry 医学-精神病学

CiteScore

21.00

自引率

1.50%

发文量

1383

审稿时长

53 days

期刊介绍： The Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP) is dedicated to advancing the field of child and adolescent psychiatry through the publication of original research and papers of theoretical, scientific, and clinical significance. Our primary focus is on the mental health of children, adolescents, and families. We welcome unpublished manuscripts that explore various perspectives, ranging from genetic, epidemiological, neurobiological, and psychopathological research, to cognitive, behavioral, psychodynamic, and other psychotherapeutic investigations. We also encourage submissions that delve into parent-child, interpersonal, and family research, as well as clinical and empirical studies conducted in inpatient, outpatient, consultation-liaison, and school-based settings. In addition to publishing research, we aim to promote the well-being of children and families by featuring scholarly papers on topics such as health policy, legislation, advocacy, culture, society, and service provision in relation to mental health. At JAACAP, we strive to foster collaboration and dialogue among researchers, clinicians, and policy-makers in order to enhance our understanding and approach to child and adolescent mental health.