Journal of studies on alcohol and drugs最新文献

{"title":"Erythropoietin Attenuates Anxiety and Neurodevelopmental Neurotoxicity in Male Rats with Fetal Alcohol Spectrum Disorder via Increased BDNF-Positive Cells, Astrogliosis Suppression, and Reduced Hippocampal Cell Death.","authors":"Raheleh Rafaiee, Fahimeh Mohseni","doi":"10.15288/jsad.24-00389","DOIUrl":"https://doi.org/10.15288/jsad.24-00389","url":null,"abstract":"<p><strong>Objective: </strong>The term \"fetal alcohol spectrum disorder\" (FASD) refers to a variety of negative consequences that may develop in children born to women who have consumed alcohol during pregnancy. Anxiety disorders are common in FASD. Animals exposed to alcohol exhibit anxiety-like traits. Erythropoietin (EPO) is produced by the kidneys and liver. The synthesis of EPO by immature neurons also plays a crucial role in the embryonic stage. In addition, EPO inhibits astrogliosis and cell death while increasing the number of brain-derived neurotrophic factor (BDNF)-positive cells, which is linked to reductions in anxiety-like behavior and neuronal damage. This study investigated the protective effects of EPO on ethanol-induced neurotoxicity in the hippocampus of rat pups.</p><p><strong>Method: </strong>The intubation of the total daily dose of ethanol (5/27 g/kg/day) was started from PD 2 to PD 10 (corresponding to the third trimester of pregnancy in humans). After intubation, 1000 and 2000 U/kg EPO were injected subcutaneously. The elevated plus maze (EPM) was performed 39 days after the birth of the pups to determine the levels of anxiety. Immunohistochemical staining was then performed to determine GFAP and BDNF levels 40 days after birth. Nissl staining was done to measure necrotic cell death.</p><p><strong>Results: </strong>EPO administration significantly improved the anxious behavior associated with FASD (P< 0.001). EPO significantly increased BDNF levels (P< 0.001), decreased GFAP expression (P< 0.001), and attenuated alcohol neurotoxicity-induced necrotic cell death (P< 0.001).</p><p><strong>Conclusions: </strong>EPO treatment providing protection against ethanol neurotoxicity, which consequently leads to lower anxiety levels.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Veteran perspectives on treatment and recovery from co-occurring anxiety disorders, posttraumatic stress disorder and unhealthy alcohol use.","authors":"Anthony H Ecker, Haley Kolp, Lindsey Poe, Erin P Finley, Raven Pigee, Megan M Kelly, Drew A Helmer, Michael A Cucciare, Jeffery A Cully","doi":"10.15288/jsad.24-00278","DOIUrl":"https://doi.org/10.15288/jsad.24-00278","url":null,"abstract":"<p><strong>Objective: </strong>Veterans experience high rates of co-occurring anxiety disorders, posttraumatic stress disorder (PTSD), and unhealthy alcohol use. The goal of this study was to improve the understanding of veterans' beliefs about recovery from co-occurring anxiety/PTSD and alcohol use to direct treatment adaptation and implementation for providers.</p><p><strong>Methods: </strong>Semistructured qualitative interviews were conducted with 20 veterans, analyzed with rapid qualitative analysis and inductive coding.</p><p><strong>Results: </strong>Veterans' responses reflected themes related to improvement in functioning, including use of coping skills and communication skills, engagement in therapy, and connection with other veterans. Veterans also described barriers and facilitators related to effective treatment for both disorders.</p><p><strong>Conclusions: </strong>Specific elements in treatment (e.g., coping and communication skills) and broader considerations (e.g., building community among others in recovery) contribute to relationship and occupational recovery from co-occurring disorders among veterans. Ensuring that these factors are considered in behavioral treatment and treatment programs more broadly for veterans with co-occurring disorders has the potential to enhance functional recovery by aligning with veterans' perspectives and priorities.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Cannabis and Alcohol Use Influence Sexual Behavior Among Men Who Have Sex with Men (MSM): A Secondary Data Analysis Using Ecological Momentary Assessment.","authors":"Maria J Bustamante, Tibor P Palfai, Jeffrey S Simons, Stephen A Maisto, Brooke Z Beckius, Kawon Kim","doi":"10.15288/jsad.24-00172","DOIUrl":"10.15288/jsad.24-00172","url":null,"abstract":"<p><strong>Background: </strong>Heavy drinking is common among men who have sex with men (MSM) and significantly increases HIV acquisition risk. MSM who report heavy drinking also report higher cannabis use, which has also been associated with sexual behaviors known to elevate HIV transmission risk. Despite evidence of associations at the between- subjects' level, the effects of alcohol and cannabis use on sexual risk behavior among MSM who engage in heavy drinking are largely unknown. The current study used ecological momentary assessment (EMA) to examine the between- and within-subject associations of heavy drinking, cannabis use and sexual behavior.</p><p><strong>Methods: </strong>This is a secondary data analysis of a study on alcohol intoxication on sexual decision making (Maisto et al., 2021) that included 115 MSM who reported cannabis use and were not using PrEP at the baseline. Participants reported daily alcohol and cannabis use and sexual activities over six weeks. Multilevel multinomial regression was used to evaluate how alcohol and cannabis use were associated with sexual behaviors.</p><p><strong>Results: </strong>Higher alcohol use was associated with higher rates of intercourse at the between-persons level and higher likelihood of all sexual behavior at the event-level. In contrast, cannabis use at the between-person level was associated with an increased rate of CAI relative to both anal intercourse with a condom as well as no sex. At the within-person level, cannabis was associated with increased likelihood of anal sex with or without a condom relative to no sex.</p><p><strong>Conclusions: </strong>Cannabis and alcohol may have independent effects on sexual risk behavior among MSM. Interventions addressing sexual health among MSM who engage in heavy drinking should also consider the additive risks of cannabis use.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Associations Between Psychopathology Symptoms and Substance Use Across Race/Ethnicity and Gender: A Test of the Cross-Cultural Equivalence of Measurement.","authors":"William Rozum, Evelyn M Hernandez Valencia, Jodi M Sutherland Charvis, Chrystal Vergara-Lopez, Hector I Lopez-Vergara","doi":"10.15288/jsad.24-00285","DOIUrl":"10.15288/jsad.24-00285","url":null,"abstract":"<p><strong>Objective: </strong>The internalizing (e.g., depression/anxiety) pathway to substance use is a prominent hypothesis, but its evidence critiqued for neglecting correlated dimensions of mental health such as externalizing (e.g., aggressive, rule-breaking) and attention deficit/hyperactivity (ADH) problems. Furthermore, most research has been conducted in predominantly White samples limiting generalizability. We examine associations between substance use and psychopathology symptoms across intersectional race/ethnicity and gender identities.</p><p><strong>Method: </strong>Participants (<i>n</i>=1,187; 16.26% Black women, 17.61% Latina women, 15.67% White women, 16.68% Black men, 17.10% Latino men, and 16.68% White men) aged 18-26 completed online surveys. Alcohol and cannabis factors were indicated by six pattern of use items (e.g., frequency/quantity); psychopathology symptoms via the Adult Self-Report. Differential item functioning was tested before making comparisons in univariate and multivariate models.</p><p><strong>Results: </strong>Differential item functioning was detected; the degree of bias was modeled via partial metric invariance allowing for latent inferences. At the univariate level: externalizing symptoms predicted alcohol and cannabis across all groups except Black and Latino men, whereas internalizing and AHD symptoms predicted cannabis use in White women and White men only. In a multivariate model, internalizing symptoms inversely predicted alcohol use for White women and White men, externalizing symptoms predicted alcohol use in all groups except Latino men, and externalizing symptoms predicted cannabis use in all groups except Black women and Latino men. ADH showed no significant associations in the multivariate model.</p><p><strong>Conclusions: </strong>The conceptualized structure of mental health has implications for research on substance use. Intersectionality minded methods may provide a more generalizable scientific base.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Maltreatment, Internalizing and Externalizing Symptoms, and Later Drug Use.","authors":"Magda Javakhishvili, Cathy Spatz Widom","doi":"10.15288/jsad.24-00266","DOIUrl":"https://doi.org/10.15288/jsad.24-00266","url":null,"abstract":"<p><strong>Objective: </strong>Numerous studies have reported associations between child maltreatment and drug use and abuse. We ask whether internalizing and externalizing symptoms during young adulthood mediate the relationship between childhood maltreatment and illicit drug use and use of prescribed medications later in middle adulthood.</p><p><strong>Method: </strong>Utilizing a prospective cohort design, a large group of court-substantiated cases of childhood maltreatment (ages 0 -11) and demographically matched controls were followed into adulthood. Internalizing symptoms (depression and anxiety), externalizing symptoms (antisocial personality disorder), and drug abuse and dependence symptoms were assessed in young adulthood (M_age = 29) in interviews during 1989-1995 (<i>N</i> = 1,196). Information about the use of illicit drugs and prescribed medications was obtained in middle adulthood in interviews during 2003-2005 (N = 807, M_age = 41). Parallel mediation models were tested for depression and anxiety separately using path analysis.</p><p><strong>Results: </strong>Childhood maltreatment predicted more internalizing and externalizing symptoms during young adulthood. Internalizing symptoms during young adulthood mediated the effect of childhood maltreatment on prescription drug use in middle adulthood, whereas externalizing symptoms mediated the relationship between childhood maltreatment and illicit drug use in middle adulthood, despite controls for drug abuse/dependence symptoms in young adulthood.</p><p><strong>Conclusions: </strong>These new findings suggest that efforts should be directed at reducing internalizing symptoms of anxiety and depression and externalizing symptoms in maltreated children to reduce risk for drug use later in life. The unique mediating effects of internalizing versus externalizing symptoms on prescription drug and illicit drug use, respectively, suggest the need for tailored interventions for different kinds of drug use.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Substance Misuse and Sexual Victimization History on Sexual Violence Risk Perception in Men Who Have Sex With Men: A Novel Paradigm.","authors":"Brooke E Wells, Damon Mitchell, D J Angelone, Dustin Fife, Megan Korovich, Elizabeth Pakan, Justin Sitron","doi":"10.15288/jsad.24-00019","DOIUrl":"10.15288/jsad.24-00019","url":null,"abstract":"<p><strong>Objective: </strong>Sexual victimization (SV) is common among men who have sex with men (MSM), as is dating and sexual networking (DSN) app use. We developed a novel laboratory paradigm (\"G-Date\") of sexual violence risk perception in DSN app environments and explored its validity and the role of substance misuse and SV history on sexual violence risk perception.</p><p><strong>Method: </strong>Using convenience sampling, we recruited 145 MSM to use G-Date to interact with two bogus speed dates whose responses were scripted to be risky or nonrisky. Risky dates displayed several cues indicating risk for sexual violence perpetration. Dependent variables included pre/post changes in ratings of their dating partner's appeal, ratings of the presence of each embedded risk cue, and the duration of the speed dates.</p><p><strong>Results: </strong>Compared with nonrisky dates, participants terminated risky dates significantly sooner, rated them higher in each risk cue, and gave them pre- to postdate ratings of partner appeal that declined significantly more. Participants' drug misuse was associated with reduced interest in the nonrisky date but not the risky date and predicted shorter speed date length and lower partner appeal ratings across date types. Substance-facilitated SV history interacted with alcohol misuse and date type to predict sexual violence risk perception.</p><p><strong>Conclusions: </strong>Results provide evidence for the paradigm's validity and suggest that drug misuse and substance-facilitated SV history shape MSM's risk perception in DSN apps. Efforts to prevent SV among MSM should consider individual characteristics, including substance misuse, in risk perception.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"195-205"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Acceptability of a Bar-Staff Bystander Intervention Training Program for Reducing Sexual Aggression.","authors":"Karyn Roberts, Kelly Cue Davis, Mary P Koss, Elise C Lopez","doi":"10.15288/jsad.24-00031","DOIUrl":"10.15288/jsad.24-00031","url":null,"abstract":"<p><strong>Objective: </strong>This article explores the challenges, opportunities, and successes encountered in implementing <i>Safer Bars</i>, a bystander intervention training program to prevent sexual aggression in bars. The study aims to assess the feasibility of program implementation and its acceptability among bar staff and bar owners/managers.</p><p><strong>Method: </strong>Using a mixed-methods approach, the study assessed the feasibility of <i>Safer Bars</i> by documenting bar participation, reasons for declination, and the time elapsed during recruitment, offering insights into experienced challenges and successes. Acceptability was gauged through posttraining surveys for bar staff (<i>N</i> = 220) and owners/managers (<i>N</i> = 22), including Likert-scale questions on various aspects of the program and open-ended inquiries about the training's best aspects and potential improvements.</p><p><strong>Results: </strong>Despite challenges in bar enrollment due to time constraints and financial considerations, the program demonstrated high acceptability among participating bars. Bar staff expressed confidence in applying acquired bystander skills, emphasizing the importance of skilled and knowledgeable trainers. The qualitative analysis of participant feedback revealed valuable insights into the practicality and reception of the intervention.</p><p><strong>Conclusions: </strong>This study provides data from implementation to guide upscaling <i>Safer Bars</i>. Despite feasibility challenges amidst the COVID-19 pandemic, the program showed high acceptability among bar staff and owners/managers, indicating its potential impact on addressing sexual aggression in nightlife settings. Future efforts must consider the reality of the alcohol-serving industry and focus on innovative strategies to overcome additional industry-specific barriers to enhance program feasibility.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"238-245"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrative Model of Alcohol-Facilitated Intimate Partner Aggression Perpetration in Sexual and Gender Diverse Couples.","authors":"Dominic Parrott, Ruschelle M Leone, Amy Hequembourg, Ryan C Shorey, Christopher Eckhardt, Gregory L Stuart","doi":"10.15288/jsad.24-00008","DOIUrl":"10.15288/jsad.24-00008","url":null,"abstract":"<p><strong>Objective: </strong>Sexual and gender diverse (SGD) individuals are at heightened risk for intimate partner aggression (IPA) perpetration relative to their heterosexual and cisgender peers. Alcohol is a well-established cause of IPA perpetration in cisgender, heterosexual couples; however, minimal research has investigated the alcohol-IPA perpetration link in SGD couples. The relative lack of work in this area is a major barrier to addressing this health disparity. SGD individuals experience unique stressors related to their and/or their partner's intersecting minoritized identities that are crucial to understanding alcohol-IPA etiology and informing culturally affirming intervention programming.</p><p><strong>Method: </strong>We advance prior work by members of the authorship team to propose an integrative theoretical model that invokes (a) the I³ Model to organize risk and resilience factors at the individual and dyadic level and (b) alcohol myopia theory to explain the mechanism by which proximal alcohol use facilitates IPA as a function of individual differences in those factors.</p><p><strong>Results: </strong>This integrative model provides a framework to understand how the confluence of stigma, minority stressors, proximal alcohol use, and other factors contribute to IPA perpetration in SGD couples.</p><p><strong>Conclusions: </strong>Application of this integrative model has the potential to facilitate more rigorous research (e.g., intensive longitudinal designs, dyadic analysis) focused on putative risk and resilience factors across the social ecology. Further, the model provides guidance for intervention development by identifying how individual (e.g., minority stress), relationship (e.g., relationship functioning), and structural factors (e.g., SGD stigma) interactively contribute to alcohol-facilitated IPA perpetration.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"218-228"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and Sexual and Intimate Partner Violence: A Review, Current Trends, and a Look Toward the Future.","authors":"Jennifer P Read","doi":"10.15288/jsad.25-00079","DOIUrl":"10.15288/jsad.25-00079","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"161-165"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Men's Coercive Condom Use Resistance: The Roles of Alcohol and Emotional Factors.","authors":"Kelly Cue Davis, Mitchell Kirwan, Weiqi Chen, Julia F Hammett, Nolan Eldridge, Cynthia A Stappenbeck","doi":"10.15288/jsad.23-00413","DOIUrl":"10.15288/jsad.23-00413","url":null,"abstract":"<p><strong>Objective: </strong>Men's coercive condom use resistance (CUR) with female partners is common and is associated with greater alcohol consumption than men's noncoercive CUR engagement. Prior research indicates that emotion-related factors are relevant to alcohol-involved coercive CUR. Thus, in this alcohol administration study, we examined emotional factors as distal and proximal predictors of alcohol-involved coercive CUR among young men who have sex with women.</p><p><strong>Method: </strong>Non-problem-drinking young adult men who have sex with women (<i>N</i> = 282) were recruited from the local community, and as part of a larger study, completed a background survey and an in-lab alcohol administration session that included a mood induction and sexual scenario task using a 2 (sober vs. intoxicated) × 2 (positive mood vs. negative mood) experimental design.</p><p><strong>Results: </strong>Path analysis testing a moderated mediation model revealed that for participants in the sober, positive mood conditions and the intoxicated, negative mood conditions, there was a positive association between distal emotion regulation difficulties and motives to have sex to cope with negative emotions. In addition, distal emotion regulation difficulties were positively associated with proximal difficulties modulating one's emotions among intoxicated participants. Among those with greater proximal difficulties modulating their emotions, state anger was positively associated with coercive CUR intentions.</p><p><strong>Conclusions: </strong>Results demonstrate the importance of alcohol intoxication, emotions and emotion regulation, and sexual coping motives in men's coercive CUR likelihood, demonstrating potential malleable targets for prevention efforts.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"271-280"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}