Journal of studies on alcohol and drugs最新文献

{"title":"Lifetime Cannabis Use Is Associated With Brain Volume and Cognitive Function in Middle-Aged and Older Adults.","authors":"Anika Guha, Zening Fu, Vince Calhoun, Kent E Hutchison","doi":"10.15288/jsad.25-00346","DOIUrl":"10.15288/jsad.25-00346","url":null,"abstract":"<p><strong>Objective: </strong>Cannabis use has increased among older adults, yet the neurocognitive effects in this demographic remain unclear. Prior work has suggested that cannabis may increase brain volume in areas rich in cannabinoid (CB1) receptors, although negative effects are often reported in adolescents. This study sought to clarify the relationship between cannabis use and brain health among middle-aged and older adults.</p><p><strong>Method: </strong>Using data from the UK Biobank, which includes health information from more than 500,000 adults, associations between cannabis use, regional brain volume, and cognition in participants ages 40-69 years (mean age = 54.5) were evaluated.</p><p><strong>Results: </strong>Lifetime cannabis use was positively associated with regional brain volume in CB1-rich regions, including the caudate, putamen, hippocampus, and amygdala. Greater lifetime use was also linked to better performance in learning, processing speed, and short-term memory. Individuals reporting use limited to adolescence also showed larger regional volumes and better cognitive performance than nonusers. Sex differences in cannabis effects on brain volume and cognition were also observed.</p><p><strong>Conclusions: </strong>Results highlight that cannabis may influence brain health differently across the life span, potentially offering protective effects in older age while posing risks earlier in development. Protective effects may result from endocannabinoid-mediated modulation of inflammation, immune function, and neurodegeneration. Observed sex differences likely reflect variation in the endocannabinoid system and underscore the importance of considering sex as a biological variable in studies of cannabis and brain health.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"739-751"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining Alcohol Misuse and Sexual Assault Prevention Enhances Training Outcomes in a U.S. Military Service Academy.","authors":"Emily A Schmied, Marni L Kan, Shannon M Blakey, Ken W Robinson, Colleen J Watson, Hee-Jin Jun, Katie E L Grimes, Kristen Henretty, Leslie Wilson, Richard Moyer, Mark B Reed, Nichole M Scaglione","doi":"10.15288/jsad.25-00176","DOIUrl":"10.15288/jsad.25-00176","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol misuse and sexual assault are prevalent in the U.S. military, including in military service academies. As these behaviors frequently co-occur, there is an urgent need to develop and test prevention programs that address risk factors for both and that are also appropriately tailored for military cadets. The purpose of this study was to compare the efficacy of a combined alcohol misuse and sexual assault prevention program to that of an alcohol misuse prevention program plus a healthy skills program, a standalone sexual assault prevention program, and a standalone healthy skills program.</p><p><strong>Method: </strong>A four-arm quasi-experimental study was conducted at the U.S. Air Force Academy with two incoming classes of cadets (<i>N</i> = 1,985). Participants completed pre- and posttest surveys to assess alcohol misuse- and sexual assault-related knowledge and attitudes. Mixed-effects multilevel models tested changes over time by condition; interactions were examined to determine whether program effects were moderated by sex or prior alcohol use.</p><p><strong>Results: </strong>Several significant differences in pre-to posttest changes were observed, with most indicating greater improvement in the combined condition than in other conditions. Alcohol readiness to change improved in the combined program compared with the alcohol misuse prevention and healthy skills program (<i>p</i> < .05); knowledge regarding sexual assault and self-efficacy to resist unwanted sexual advances increased significantly more in the combined program than in all others (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>This study provides initial evidence to support combined, tailored alcohol misuse and sexual assault training in military academy settings.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"801-811"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13326738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Class Analysis of Substance Use Behaviors and Associations of Class Membership With Gender Affirmation, Social Determinants of Health, and HIV Status Among Transfeminine Adults in the Eastern and Southern United States.","authors":"Jack Andrzejewski, Heather L Corliss, Heather A Pines, Ravi Goyal, Eileen Pitpitan, Britt Skaathun, Andrea L Wirtz, Sari L Reisner","doi":"10.15288/jsad.25-00133","DOIUrl":"10.15288/jsad.25-00133","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to identify latent classes of substance use behaviors (i.e., alcohol and illicit drug use) and their correlates among transgender women and transfeminine nonbinary adults.</p><p><strong>Method: </strong>Baseline data (March 2018 to August 2020; <i>n</i> = 1,614) from The LITE Study were used to identify latent substance use classes and report latent class membership probabilities (γ) and item-response probabilities (ρ). We assigned participants to the class with their highest probability of class membership and assessed associations with socioeconomic conditions. We reported adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for each correlate.</p><p><strong>Results: </strong>Mean age was 33.0 years (<i>SD</i> = 12.1), and 45.3% were non-Latina/e, White. We identified four classes: no illicit drug use (γ = .63), alcohol misuse and cannabis use (γ = .26), polysubstance use (γ = .062), and opioid and cannabis use (γ = .046). Compared with the \"no illicit drug use\" class, the need for medical gender affirmation was associated with lower odds of being in the polysubstance use and opioid and cannabis use classes, and housing security and lack of arrest were associated with lower odds of being in the alcohol misuse and cannabis use, polysubstance use, and opioid and cannabis use classes. For example, compared with those who were food insecure most or all of the time, those who were never food insecure had lower odds of being in the polysubstance use class (aOR = 0.22, 95% CI [0.09, 0.52]) versus the no illicit drug use class. Living with HIV was associated with greater odds of polysubstance use.</p><p><strong>Conclusions: </strong>For transfeminine adults, having met need for medical gender affirmation and better socioeconomic conditions may be protective for alcohol misuse and/or polysubstance use. Interventions aimed at improving socioeconomic conditions among transgender women and transfeminine nonbinary adults may improve substance use outcomes.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"840-852"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Network Analysis Reveals Alcohol-Related Regulation of Cellular Senescence and Immune Signaling Pathways.","authors":"Seyedeh Shima Moosavi, Ayeh Bolouki, Negar Azarpira, Samaneh Reiszadeh Jahromi","doi":"10.15288/jsad.25-00168","DOIUrl":"10.15288/jsad.25-00168","url":null,"abstract":"<p><strong>Objective: </strong>Prolonged alcohol consumption is associated with immune system alterations, high blood pressure, and neurotoxicity. Alcohol use disorder (AUD) is a devastating disease worldwide that leads to several changes in the neurochemical balance within the brain. Moreover, the high incidence of certain cancers and the prevalence of infectious diseases among individuals with AUD demonstrate how alcohol impairs the immune system. Our research offers a new perspective on the important pathways and genes involved in the dynamic alterations of AUD progression.</p><p><strong>Method: </strong>The methods used in this research include microarray data collection from the Gene Expression Omnibus (GEO) database, functional enrichment analysis of gene sets, weighted gene co-expression network analysis to find regulated modules, and analysis of modules and identification of hub genes.</p><p><strong>Results: </strong>The findings showed that alcohol affects the expression of a wide range of genes, leading to significant changes in the regulation of biological processes and signaling pathways related to the cell cycle and cellular senescence. Some of the pathways significantly affected are polyubiquitination, NF-κB, FOXO, mTOR, P53, calcium, and PPAR signaling.</p><p><strong>Conclusions: </strong>The expression of genes associated with cellular senescence is likely altered by alcohol and its related disorders.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"655-668"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145635147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Substance-Specific Parenting With Substance Use in the Offspring: A Meta-Analysis.","authors":"Martin Pinquart, Teolina Dzhuvanova","doi":"10.15288/jsad.25-00469","DOIUrl":"10.15288/jsad.25-00469","url":null,"abstract":"<p><strong>Objective: </strong>Parental behaviors have been suggested to affect substance use in their offspring. The present meta-analysis examines associations between five types of substance-specific parental behaviors and the offspring's consumption of psychoactive substances.</p><p><strong>Method: </strong>Studies were identified through a systematic search of the electronic databases PsycInfo, Medline, Web of Science, and Google Scholar, and cross-referencing. Hierarchical meta-analyses were computed on 770 studies using a random-effects model.</p><p><strong>Results: </strong>Permissive parental attitudes showed the strongest association with substance use in their offspring (<i>r</i> = .222; confidence interval [CI] [.203, .240]), followed by parental consumption (<i>r</i> = .157; CI [.149, .165]) and parental provision of substances to the offspring (<i>r</i> = .140; CI [.083, .196]). Parental substance-specific control was associated with lower use (<i>r</i> = -.165; CI [-.194, -.135]), whereas associations between parent-child communication about substance use and youth consumption varied depending on the content of the communication. The analysis of cross-lagged associations found very small bidirectional links between parenting and youth consumption. Moderating effects were found for the type of substance (alcohol, nicotine, cannabis/mixed), child age and gender, and whether analyses focused on the parental dyad rather than individual parents.</p><p><strong>Conclusions: </strong>Substance-specific parenting is a relevant target for prevention and intervention. However, to optimize outcomes, multiple parental behaviors should be addressed, and parent-focused interventions may be combined with offspring-focused interventions.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"783-792"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening Children for Risk of Frequent Substance Use in Young Adulthood: A 17-Year Prospective, National Study.","authors":"Athena Nooney, Meghan Dontha, William E Pelham","doi":"10.15288/jsad.25-00025","DOIUrl":"10.15288/jsad.25-00025","url":null,"abstract":"<p><strong>Objective: </strong>There is no externally validated instrument for predicting which children will show frequent substance use in young adulthood. This study evaluated whether an instrument previously shown to predict substance use outcomes in mid-adolescence could also predict substance use outcomes in young adulthood, comparing performance across ages and demographics.</p><p><strong>Method: </strong>The Loeber Risk Score (LRS) is a five-item, parent-completed screener indexing risk of future substance use in children. We evaluated the predictive performance of the LRS in a nationally representative longitudinal birth cohort (<i>N</i> = 4,898, 48% female). Parents completed the LRS when the child was about 5 and about 9 years old. Subsequently, the youth reported their substance use at about 22 years old.</p><p><strong>Results: </strong>The LRS at age 9 predicted several outcomes at age 22 better than chance (<i>p</i>s < .05): daily cigarette use (area under the receiver operating characteristic curve [AUROC] = 0.71-0.75), cannabis use ≥3 days per week (AUROC = 0.59), vaping ≥3 days per week (AUROC = 0.55), and receipt of treatment for an alcohol/drug problem (AUROC = 0.60). Performance was no better than chance for alcohol outcomes (AUROCs = 0.47-0.50). Children with LRS scores ≥2 were 1.3-2.0 times more likely to display frequent substance use outcomes. There were no consistent performance differences when the LRS was measured at age 5 versus age 9 or by the child's sex, race, or ethnicity.</p><p><strong>Conclusions: </strong>The LRS would be an improvement over random or ad hoc selection, but screening accuracy is generally low. Much more accurate screeners are needed.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"766-774"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Trial Shows Smartphone Support App for DWI Offenders and Their Families Reduced Alcohol Use and Ignition Interlock Device Lockouts.","authors":"W Gill Woodall, Barbara S McCrady, Vern Westerberg, Julia Berteletti, Lila Martinez, Marita Brooks, Thomas Starke, Noah Chirico","doi":"10.15288/jsad.25-00171","DOIUrl":"10.15288/jsad.25-00171","url":null,"abstract":"<p><strong>Objective: </strong>Driving while intoxicated (DWI) remains a preventable source of morbidity and mortality in the United States. Ignition interlock devices (IIDs) are used to prevent DWI offenders from driving while intoxicated during a mandated installation period and are effective during that time. Once IIDs are removed, DWI rates are similar to levels for offenders who had no IID. This study tested the efficacy of a smartphone app (B-SMART) for DWI offenders with an IID and concerned family members (CFMs), with the goal of reducing IID lockout events and alcohol consumption.</p><p><strong>Method: </strong>Four B-SMART app modules were developed: (a) Life with Interlock, (b) Supporting Changes in Drinking, (c) Doing Things Together, and (d) Effective Communication. Participants (pairs of DWI offenders and CFMs) were randomly assigned to receive the B-SMART app (<i>n</i> = 58) or referral to a state IID information page (usual and customary [UC] condition, <i>n</i> = 65) and followed for 9 months after randomization. IID data (failed tests and lockout events) were obtained from IID providers as the primary outcome variables. Offender and CFM reports of alcohol consumption in the last 30 days before assessment were secondary measures.</p><p><strong>Results: </strong>IID data were collected on 62% (<i>N</i> = 76) of participants. B-SMART participants had significantly fewer lockout events than UC participants. B-SMART offenders and their CFMs reported significantly less likelihood of DWI offender drinking at 9 months.</p><p><strong>Conclusions: </strong>Results suggest that the B-SMART app reduced IID lockout events and DWI offender alcohol consumption. These outcomes are important because fewer IID lockout events predict lower DWI recidivism.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"812-820"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents Use Online Communities to Seek Guidance on Child Substance Use, Parental Use, and Family Substance Use Challenges: A Content Analysis of Reddit Posts.","authors":"Alex M Russell, Samuel F Acuff, Dana M Litt, John F Kelly, Jason B Colditz, Danny Valdez, Jon-Patrick Allem","doi":"10.15288/jsad.25-00310","DOIUrl":"10.15288/jsad.25-00310","url":null,"abstract":"<p><strong>Objective: </strong>Parents play a role in shaping their children's beliefs and behaviors around substance use. When faced with unfamiliar or challenging situations, many parents turn to peers for advice. This study characterized the substance use-related advice parents sought from peers in an online parenting forum.</p><p><strong>Method: </strong>We conducted a content analysis of substance use-related posts from the r/parenting subreddit. Among the advice-seeking posts included in this study (<i>n</i> = 156), thematic coding assessed the presence (yes/no) of seven themes: (1) general communication with children about alcohol and other drugs, (2) parental substance use, (3) responding to a child's substance use, (4) permissiveness of a child's substance use under adult supervision, (5) pregnancy or breastfeeding and substance use, (6) nicotine and tobacco use around children, and (7) dealing with an adult family member who is using substances or getting help for substance use problems. Posts could be coded into multiple themes. Two coders independently annotated posts (kappa = .75).</p><p><strong>Results: </strong>Parents asked about responding to a child's substance use (67/156; 42.9%), parental substance use in parenting contexts (54/156; 34.6%), and navigating other adult family members' substance use (54/156; 34.6%). Parents sought advice about general communication with children about alcohol and other drugs (21/156; 13.5%), nicotine and tobacco use around children (19/156; 12.2%), permissiveness of adolescent substance use under adult supervision (18/156; 11.5%), and substance use during pregnancy or breastfeeding (4/156; 2.6%).</p><p><strong>Conclusions: </strong>Findings may inform the development of targeted resources, guide public health messaging, and support the use of social media data in ongoing research relevant to family development.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"793-800"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonmedical Use of Prescription Opioids: Use to Experience Subjective Effects Versus Other Nonmedical Use Among Adults in Ontario, Canada From 2020 to 2024.","authors":"Yeshambel T Nigatu, Samantha Wells, Leslie Buckley, Lena C Quilty, Nikki Bozinoff, Farihah Ali, Sameer Imtiaz, Hayley A Hamilton","doi":"10.15288/jsad.25-00213","DOIUrl":"10.15288/jsad.25-00213","url":null,"abstract":"<p><strong>Objective: </strong>The opioid crisis remains an important public health concern, with nonmedical use of prescription opioids (NMUPO) playing a significant role. However, limited evidence exists on how adults engaging in NMUPO for subjective effects differ from those who use them for other nonmedical reasons. This study aims to identify and examine factors associated with engagement in NMUPO for subjective effects.</p><p><strong>Method: </strong>Data were from the 2020 to 2024 CAMH Monitor study, a repeated cross-sectional survey of adults age 18 and older (<i>N</i> = 7,655). The surveys used a Qualtrics-based web survey to assess NMUPO, sociodemographic factors, substance use, and mental health. Data were analyzed using multivariate multinomial logistic regression.</p><p><strong>Results: </strong>About 3% of adults engaged in NMUPO for subjective effects/to get high, and 15% of participants engaged in NMUPO for other nonmedical purposes during 2020 and 2024. These percentages remained stable over the years. The risk of NMUPO for subjective effects, compared with NMUPO for other purposes, was significantly higher among Asian people compared with their White counterparts (relative risk ratio [RRR] = 1.80, 95% CI [1.08, 3.01]) and among those with children (RRR = 2.53, 95% CI [1.64, 3.92]). Similarly, individuals with low household income, current other substance use, and psychological distress exhibited a higher risk of NMUPO, after adjusting for covariates.</p><p><strong>Conclusions: </strong>Individuals who use prescription opioids nonmedically for subjective effects or other reasons differ by race/ethnicity, parental status, income, substance use, and level of psychological distress. These findings suggest the need for targeted prevention and intervention strategies to address the unique needs and behaviors of different user groups.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"831-839"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fostering Long-Term International Collaborations Through Short-Term Exchange Programs for Early-Career Addiction Researchers.","authors":"Lindsay M Squeglia, Louise Mewton","doi":"10.15288/jsad.25-00304","DOIUrl":"10.15288/jsad.25-00304","url":null,"abstract":"<p><strong>Objective: </strong>International mobility and collaborations are a cornerstone of the academic career trajectory, as well as a pathway to better science. This article aims to advocate for strengthening global connections among early-career investigators to advance science and accelerate discovery in addiction research. Drawing on the authors' experiences, we offer specific recommendations to help addiction researchers design international exchange programs for early-career investigators.</p><p><strong>Method: </strong>The program consisted of four key components: (a) pre-exchange participant matching of early-career investigators at each institution, (b) individualized goal setting for participants, (c) a structured orientation program on the first day of the in-person exchange, and (d) 2 weeks of research-focused, in-person collaborations and networking activities. Quantitative and qualitative data are presented, including 2-year outcomes from the program (<i>N</i> = 8).</p><p><strong>Results: </strong>The exchange program had both immediate and sustained impacts on professional development and research productivity. Participants reported increased confidence in international collaboration, a broader global perspective, and enhanced scholarly output, and all emphasized the importance of in-person interaction. Two years after exchange, participants reported a more than threefold increase in internationally co-authored publications, a newly awarded international grant, and the establishment of four new formal mentorship relationships. All participants reported changes in their research focus, scientific approach, or lab management practices as a result of the exchange program. Unexpected benefits included strengthened collaboration within home research teams and the emergence of broader institutional partnerships in both the United States and Australia.</p><p><strong>Conclusions: </strong>Understanding and addressing addiction requires a global perspective, and engaging early-career researchers in international exchange programs can foster lasting collaborations and encourage globally focused research. Even short-term exchanges can be cost-effective in promoting long-term productivity in international addiction research.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"853-860"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}