Journal of studies on alcohol and drugs最新文献

{"title":"Alcohol Policy, Commercial Influence, and the Public Health Costs of Ignoring Evidence: The Case of the Alcohol Intake and Health Study.","authors":"Robert M Vincent","doi":"10.15288/jsad.26-00142","DOIUrl":"https://doi.org/10.15288/jsad.26-00142","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":"87 4","pages":"639-641"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Perception and Susceptibility to Peer Influence Predict Substance Use in Early Adolescence: Findings From the ABCD Study.","authors":"Dakota Kliamovich, Scott A Jones, Mizan Gaillard, Amanda C Del Giacco, Arturo Lopez Flores, Bonnie J Nagel","doi":"10.15288/jsad.25-00105","DOIUrl":"10.15288/jsad.25-00105","url":null,"abstract":"<p><strong>Objective: </strong>Experimentation with alcohol and other substances during the early adolescent period is associated with myriad potentially deleterious health outcomes. The present analysis used data from the Adolescent Brain and Cognitive Development Study (ABCD Study) to examine the relationships among risk perception, susceptibility to peer influence, and substance use in early adolescence.</p><p><strong>Method: </strong>Participants completed a Social Influence Task (SIT) in which they were asked to rate the riskiness of various hypothetical scenarios. They were then presented with a risk rating purportedly provided by their peers and asked to rate each scenario again. Mixed-effects logistic regression models were used to evaluate the relationships among risk perception (initial risk rating), susceptibility to peer influence (risk rating change), and future substance use.</p><p><strong>Results: </strong>Higher initial risk perception was associated with lower odds of future substance use. Greater susceptibility to peer influence in the positive direction (i.e., being more swayed by peers to rate a scenario as more risky than the participant had originally decided) was also associated with lower odds of future substance use.</p><p><strong>Conclusions: </strong>These findings highlight the potential importance of leveraging positive peer influence to affect substance use outcomes.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"754-765"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketogenic Diet Reduces Alcohol Consumption and Improves Memory and Sociability in Mice.","authors":"Allison R Bechard, Kayla Storie, Abigail Grzeskowiak, Madison Forcier, Yovanka Nunez, Dhavan Brambhatt, Sophia Azurin, Riley Connell, Jana Kamel","doi":"10.15288/jsad.25-00285","DOIUrl":"10.15288/jsad.25-00285","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol use disorder is highly prevalent, with known associations to poor health and memory. Diet interventions are a useful tool that can help many, as they are relatively non-invasive and accessible. The ketogenic diet is a high-fat, low-carbohydrate diet that has been used for decades to reduce seizures in children with epilepsy. In the current study, the effects of 3 weeks of a ketogenic diet on alcohol use and anxiety, post-alcohol anxiety, sociability, and memory were assessed in C57BL/6J mice.</p><p><strong>Method: </strong>In Experiments 1 and 1a, mice were allowed to drink alcohol for 8 weeks using the intermittent drinking-in-the-dark paradigm. Across the last 3 weeks of drinking, mice were fed either a ketogenic diet or a standard chow diet and tested for performance in a Barnes maze. In Experiment 2, mice were fed either a ketogenic diet or a standard diet for 3 weeks and observed for anxiety and social behaviors, and memory. Experiment 2a extended this work using a small number of male mice that were injected with alcohol for 1 week before behavioral assessment.</p><p><strong>Results: </strong>Overall, our findings suggest a therapeutic effect of the ketogenic diet on alcohol consumption and post-alcohol deficits.</p><p><strong>Conclusions: </strong>Benefits were independent of effects on generalized anxiety yet support a more specific effect of the ketogenic diet to increase exploration and reduce behavioral inhibition. This study did not investigate the neurobiology underlying these effects, and future research is now needed.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"694-705"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intermittent Theta Burst on Multiple Measures of Craving in Those With Alcohol Use Disorder.","authors":"Timothy C Durazzo, Keith Humphreys, Claudia B Padula","doi":"10.15288/jsad.25-00180","DOIUrl":"10.15288/jsad.25-00180","url":null,"abstract":"<p><strong>Objective: </strong>Reduction in alcohol craving has often been specified as an outcome for alcohol use disorder (AUD) interventions. This study evaluated changes in multiple craving measures from a double-blind randomized clinical trial (RCT) evaluating the efficacy of intermittent theta burst stimulation (iTBS) to the left dorsolateral prefrontal cortex for the treatment of AUD. We predicted that veterans in AUD residential treatment, who received active iTBS (Active; <i>n</i> = 22), would show greater reductions than those who received sham iTBS (Sham; <i>n</i> = 22).</p><p><strong>Method: </strong>Twenty iTBS sessions (1,200 pulses/session) were delivered over 2 weeks. Craving measures were administered before iTBS sessions (Baseline) and following completion of sessions (Post-Assessment). Craving measures administered were the Alcohol Craving Questionnaire Short Form-Revised Total Score, Abstinence Self-Efficacy Scale (AASE) Tempted Cravings and Urges subscale, and Obsessive Compulsive Drinking Scale (OCDS).</p><p><strong>Results: </strong>All craving measures showed reductions in scores (time main effect), collapsed across Active and Sham groups; however, the absence of significant Group × Time interactions indicated that active iTBS did not produce statistically greater reductions than sham. Exploratory post hoc simple effects analyses were conducted to further examine the significant main effect of time. Active participants showed reductions on the AASE Tempted Cravings and Urges and all OCDS measures, whereas the Sham group showed no significant changes on any measure.</p><p><strong>Conclusions: </strong>Active iTBS did not produce a statistically greater reduction in craving symptomatology than sham, as indicated by the absence of significant Group × Time interactions. However, the exploratory post hoc results can guide future larger-scale transcranial magnetic stimulation RCTs for AUD on the utility of the acquired craving measures.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"682-693"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Research Influencers to Substance Use Policymakers: Bibliometrics Demonstrate Translation From Research to Policy.","authors":"Nicole M Llewellyn, Amber Weber, Supriya Kegley, Eric J Nehl, Amanda J Abraham","doi":"10.15288/jsad.25-00069","DOIUrl":"10.15288/jsad.25-00069","url":null,"abstract":"<p><strong>Objective: </strong>The public health impact of substance use is substantial, with tobacco use and excessive drinking leading as causes of death in the United States. To address this growing epidemic, governments have implemented a range of substance use-related policies. The National Institutes of Health's Clinical and Translational Science Awards (CTSA) program, which aims to accelerate the translation of research findings into health impact, may advance translation by shaping the policy literature that informs policymakers, health professionals, and the public. Using innovative bibliometric tools, this study evaluates how CTSA-supported research published from 2006 to 2023 has influenced substance use-related policy literature.</p><p><strong>Method: </strong>The authors identified 135,000 publications that acknowledged CTSA support. Those publications were queried in the Overton Policy Database, which indexes references to research publications in global policy literature.</p><p><strong>Results: </strong>Thus far, CTSA-supported publications have been cited in 3,451 policy documents identified as substance use-related according to Overton's Topics field. Substance use-related Topics were classified into the top categories of Tobacco, Opioids, Cannabis, Alcohol, and General/Other substance use. Policy documents came from 321 organizations across 49 countries-often governments, health agencies, or political think tanks, including the World Health Organization, Guidelines in PubMed Central, and the RAND Corporation. The authors present case illustrations of individual research publications that have had a notable influence on substance use policy.</p><p><strong>Conclusions: </strong>By elucidating how supported publications are applied beyond academia, bibliometrics offer a useful avenue for evaluating the translational impact of programs in specific policy areas. Our findings showcase the impact of CTSA research on the substance use-related policy literature, an important area of health policy.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"706-717"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal Thoughts and Behaviors Do Not Influence Veterans' Alcohol Use Disorder or Posttraumatic Stress Disorder Recovery Trajectories in a Randomized Controlled Trial.","authors":"Margaret M Baer, Krithika Prakash, Shannon R Forkus, Sudie E Back, Brett T Litz, John D Roache, Stacey Young-McCaughan, Terence M Keane, Alan L Peterson, Julianne C Flanagan","doi":"10.15288/jsad.25-00113","DOIUrl":"10.15288/jsad.25-00113","url":null,"abstract":"<p><strong>Objective: </strong>Suicidal thoughts and behaviors (STB) are elevated among individuals with alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). The highest STB prevalences occur among those with comorbid AUD-PTSD. STB interferes with AUD and PTSD recovery outcomes. However, no research has examined the impact of STB on recovery trajectories among those with dual AUD-PTSD, a comorbidity with a chronic and difficult-to-treat clinical profile.</p><p><strong>Method: </strong>Data from a randomized controlled trial with 141 (84.4% male) treatment-seeking Veterans with comorbid AUD-PTSD were used to compare the 12-week recovery trajectories for alcohol consumption (percent drinking days; percent heavy drinking days) and PTSD symptoms between the following groups: (a) Veterans with (<i>n</i> = 90) versus without (<i>n</i> = 51) lifetime STB and (b) Veterans with (<i>n</i> = 46) versus without (<i>n</i> = 95) current STB.</p><p><strong>Results: </strong>Compared to respective groups without STB, Veterans with lifetime and current STB had similar severity of drinking consumption over 12 weeks and similar reductions in drinking consumption and PTSD symptoms over the study period. Veterans with (vs. without) current STB reported significantly higher PTSD symptom levels throughout the 12 weeks.</p><p><strong>Conclusions: </strong>Results suggest that the presence of lifetime and current STB does increase the severity of PTSD but does not appear to impact the rates of symptom recovery across a 12-week period. Results provide important context for cross-sectional research, underscoring the greater severity of AUD-PTSD. Our longitudinal analyses indicate that Veterans can achieve symptom improvements in AUD and PTSD, even in the context of co-occurring STB.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"821-830"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Intake and Health Study: No Protective Effect at Low Levels, With Mortality Increasing to 1 in 25 at 14 Drinks Per Week.","authors":"Sinead George, Timothy S Naimi, Katherine Keyes, Priscilla Martinez-Matyszczyk, Adam J Milam, Jürgen Rehm, Alvaro Alonso, Steven Bell, Annie Britton, Laura Llamosas-Falcón, Erin Hobin, Suzanne E Judd, Amy Justice, Christopher Kahler, Suthat Liangpunsakul, Stephanie K Jones, Gregory Marcus, Katherine McGlynn, Derek Satre, Mingyang Song, Aaron Peter Thrift, Tomoko Udo, Ashley Wettlaufer, Zuo-Feng Zhang, Kevin Shield","doi":"10.15288/jsad.25-00435","DOIUrl":"https://doi.org/10.15288/jsad.25-00435","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to estimate the lifetime risk of alcohol-attributable mortality and morbidity in the United States based on a person's average lifetime weekly alcohol consumption to assess the impact of per-occasion alcohol consumption on health.</p><p><strong>Method: </strong>Lifetime risks were estimated using a cause-specific modeling approach that combined exposure data from national health surveys, relative risks, population data from the U.S. Census Bureau, mortality data from the Centers for Disease Control and Prevention, and morbidity data from the Institute for Health Metrics and Evaluation. A narrative review assessed the health impact of per-occasion alcohol consumption on health.</p><p><strong>Results: </strong>At low levels of consumption, no protective net effect of alcohol consumption on health was observed. Elevated mortality and morbidity risks were associated with alcohol consumption starting at relatively low levels. Males consuming >6.5 (95% CI [<1, 13.5]) and females consuming >7.0 (95% CI [<1, 11.5]) drinks per week had life-time alcohol-attributable mortality risks >1:1,000. At >8.5 (95% CI [2.5, 13]) drinks per week for both males and females, these risks increased to >1:100. At 14 drinks per week for males (the upper limit of the former Dietary Guidelines for males), the risk of an alcohol-caused death was 1:25 (4%). Drinking patterns also impacted risk. Above 1 drink per occasion, higher consumption was associated with progressively increased risks of breast cancer, cardiovascular disease, and injury.</p><p><strong>Conclusions: </strong>Alcohol consumption, including at what may be perceived as \"moderate\" levels, is associated with increased mortality and morbidity risks. These results support tightening alcohol use guidance in the United States, for both males and females, to no more than 1 drink per day.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":"87 4","pages":"621-638"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Pathways for Opioid Use Disorder in Commercially-Insured United States Adults from 2010-2019.","authors":"Jannat Saini, Danya M Qato, John G Rizk, Bethany DiPaula, Megan Ehret, Uzma Pathan, Abree Johnson","doi":"10.15288/jsad.25-00480","DOIUrl":"https://doi.org/10.15288/jsad.25-00480","url":null,"abstract":"<p><strong>Introduction: </strong>Longitudinal data on real-world treatment patterns for opioid use disorder (OUD) is limited. We aimed to identify and characterize granular pathways of OUD treatment.</p><p><strong>Methods: </strong>We utilized a retrospective observational cohort design using United States IBM® MarketScan® claims data from 2010-2019. The index date was the date of the first OUD diagnosis in the study period. We included commercially-insured beneficiaries, aged 18-85 years with OUD and continuous insurance eligibility for at least 6 months before (baseline period) and 3 months after (follow-up period) the index date. Independent measures were sociodemographics, clinical comorbidities, and health services utilization characteristics captured in the baseline period. Patients were categorized into one of 8 mutually exclusive categories during follow-up (dependent measures): behavioral treatment only, buprenorphine with or without behavioral treatment, methadone with or without behavioral treatment, naltrexone with or without behavioral treatment, other treatment combinations, and no treatment.</p><p><strong>Results: </strong>Of the 372,614 beneficiaries with OUD, 47% were women, with a mean age of 43 years (SD: 15.7). The predominant treatment category was behavioral treatment only (n=261,888; 70.3%), followed by buprenorphine and behavioral treatment (n=52,697; 14.1%). Nearly 10% had no evidence of treatment (n=35,322). Baseline mental health diagnosis was associated with significantly lower adjusted odds of no treatment (aOR: 0.53; 95% CI: 0.52, 0.55), behavioral treatment only (0.88; 0.86, 0.90), buprenorphine only (0.51; 0.49, 0.54), methadone with or without behavioral treatment (0.44; 0.40, 0.50), and naltrexone only (0.76; 0.67, 0.85) compared to buprenorphine and behavioral treatment. Chronic non-cancer pain was associated with significantly lower odds of all treatment categories, except behavioral treatment only, versus buprenorphine and behavioral treatment.</p><p><strong>Conclusions: </strong>Each OUD treatment pathway demonstrated unique characteristics, underscoring the importance of addressing the totality of care needs of OUD patients to optimize treatment and outcomes.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Suicidal Behavior in Severe Alcohol Use Disorder Linked to Specific Neurocognitive Deficits: The Cognition, Alcohol, Genes, and Environment Study.","authors":"Séverine Lannoy, James M Bjork, Sabrina Davis, Alexis C Edwards","doi":"10.15288/jsad.26-00011","DOIUrl":"10.15288/jsad.26-00011","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol Use Disorder (AUD) and Suicidal Thoughts and Behaviors (STB) frequently co-occur. Their association could be explained by a causal pathway and/or a shared liability related to mechanisms involved in aberrant decision-making. These pathways of risk remain to be tested and characterized.</p><p><strong>Methods: </strong>We introduce here the Cognition, Alcohol, Genes, and Environment (CAGE) study, a data collection project aiming to combine neurocognitive (cognitive and affective processes related to decision-making) and genetic data to study mechanisms contributing to the comorbidity of AUD and STB in persons recruited for a lifetime history of severe AUD. In this report, we conducted an interim analysis with the first 1,267 participants (68% females) to explore their alcohol use and the associations among AUD, STB, and neurocognitive mechanisms using correlation and regression analyses.</p><p><strong>Results: </strong>The average alcohol consumption in the sample was high (Alcohol Use Disorder Identification Test [AUDIT] total score = 9.55 [SD = 8.16]), though some participants reported alcohol abstinence (N = 230). The prevalence of STB-related items was elevated relative to previously published population-based estimates, from ~65% reporting thoughts of death to ~24% reporting a prior suicide attempt. We investigated the roles of neurocognitive variables and found that alcohol problems (AUDIT-P) were associated with inhibition and delay discounting, while the co-occurrence of AUD and suicide attempt was related to inhibition and shifting abilities.</p><p><strong>Conclusions: </strong>These preliminary findings open research avenues to study the mechanisms related to the co-occurrence of AUD and STB, with the hope of reducing STB risk in this population.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy Alcohol and Other Substance Use Are Elevated in Mass Violence-Affected Communities.","authors":"Jamison Bottomley, Angela D Moreland, Faraday Davies, Caitlin Rancher, Dean G Kilpatrick","doi":"10.15288/jsad.26-00007","DOIUrl":"https://doi.org/10.15288/jsad.26-00007","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to characterize the prevalence and correlates of legal and illicit substance use, misuse (use of prescription medication other than prescribed), and hazardous use, including alcohol, cannabis, prescription drugs, and illicit drugs, among adults residing in communities that had experienced a mass violence incident (MVI).</p><p><strong>Method: </strong>Using a household probability sample of adults (<i>N</i> = 5,991; 53.5% female; 70.6% White) from six MVI-affected communities, respondents completed surveys assessing sociodemographic characteristics, MVI-related experiences (i.e., degree of exposure), psychological risk factors (e.g., social support), probable mental health diagnoses, legal and illicit substance use, substance misuse, and hazardous use.</p><p><strong>Results: </strong>Weighted prevalence estimates indicated that approximately one in five MVI-affected residents reported past-month binge drinking, with nearly one in ten reporting heavy alcohol use. Illicit substance use, substance misuse, and hazardous use were also prevalent. Several factors were consistently associated with increased odds of substance use outcomes, including high MVI exposure (OR = 2.01, 95% CI [1.30-3.10]), low social support (OR = 1.30, 95% CI [1.08-1.56]), and co-occurring PTSD and depression (OR = 3.95, 95% CI [2.87-5.46]). These associations were generally consistent across past-month binge drinking and heavy alcohol use, as well as cannabis use, illicit substance use, and hazardous use since the MVI.</p><p><strong>Conclusions: </strong>Findings suggest that substance use, particularly heavy alcohol use and hazardous substance use, is prevalent among adults residing in MVI-affected communities. Adults with limited socioeconomic resources, fear of subsequent MVIs, prior criminal victimization, and co-occurring PTSD and depression appear most vulnerable to hazardous substance use and illicit substance use. These results can inform substance use screening and intervention efforts as part of broader community recovery planning.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}