Journal of studies on alcohol and drugs最新文献

{"title":"Adverse Effect-Related Language in Recreational Psychedelic and non-Psychedelic Substance Experience Reports.","authors":"Adrian Hase, Max Erdmann, Abigail Calder, Verena Limbach, Earth Erowid, Fire Erowid, Gregor Hasler","doi":"10.15288/jsad.25-00426","DOIUrl":"https://doi.org/10.15288/jsad.25-00426","url":null,"abstract":"<p><strong>Objective: </strong>In recent decades, psychedelic substances like LSD and psilocybin have been increasingly researched, but relatively few studies examined their adverse effects in recreational settings. As online substance experience reports may offer relevant information, we conducted a psycholinguistic (i.e., inferring psychologically relevant outcomes from natural language) assessment of popular psychedelic and related substances' adverse effects.</p><p><strong>Method: </strong>We applied latent semantic analysis to 4226 online substance experience reports, calculating each report's respective semantic similarity with 77 empirical literature-based adverse effect-related reference texts. We compared seven groups including ayahuasca, (isolated) DMT, ketamine, LSD, MDMA, psilocybin mushroom, and recreational antidepressant experiences (as a non-psychedelic comparator). Using sentiment analysis, we also classified each report's contextual valence (positive vs. negative) to examine its potential influence on between-substance semantic similarity differences.</p><p><strong>Results: </strong>Fifteen outcomes featured large effect sizes; with semantic similarity with vomiting-, excessive drowsiness-, cardiac event-, sleep problem-, and dissociation- or depersonalization-related terms leading the list. Report groups standing out with high scores were ayahuasca on vomiting-, ketamine on dissociation-, and MDMA on excessive drowsiness- and cardiac event-related semantic similarity. Report groups standing out with low scores were MDMA on dissociation-, ayahuasca on sleep problems-, and DMT on sleep problems- and drowsiness-related semantic similarity. A literature-driven secondary examination showed that LSD and psilocybin mushroom reports scored higher than all other groups on anxiety-related outcomes.</p><p><strong>Conclusions: </strong>Despite the limitations of the observational study context, these results provide valuable insights into adverse effect-related language in recreational psychedelic substance experience reports. They show that psycholinguistic analyses of experience reports enable relatively feasible, low-cost, and useful substance comparisons that might be difficult to realize using other research designs.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on Drug Treatment Among Indigenous Peoples in Recovery Residing in the Northern Midwest United States.","authors":"Sean T Allen, Kristin E Schneider, Molly C Reid, Maisie Conrad, Pam Hughes, Melissa Walls","doi":"10.15288/jsad.25-00390","DOIUrl":"10.15288/jsad.25-00390","url":null,"abstract":"<p><strong>Objective: </strong>Evidence-based drug treatment is a vital component of an effective response to substance use inequities in the United States (US). Unfortunately, many drug treatment models were developed in western contexts and may fail to account for Indigenous cultures and values. The experiences of Indigenous peoples in drug treatment programs have not been well studied, leading to a dearth of knowledge about factors that facilitate or impede recovery. We aim to explore perceptions about drug treatment and associated experiences among Indigenous peoples in recovery in the northern Midwest US.</p><p><strong>Method: </strong>Semi-structured interviews with Indigenous peoples in recovery and residing in the northern Midwest US (n=17) were conducted to explore perceptions about drug treatment and associated experiences and challenges. Participants were recruited on or near the reservation lands of a collaborating Tribal Nation. Interviews were analyzed using an inductive thematic analysis.</p><p><strong>Results: </strong>Indigenous peoples in recovery were often motivated to seek drug treatment after experiencing significant life events. Access to drug treatment was severely limited. Few participants reported having used medications for opioid use disorder (MOUD); however, many described conflicting attitudes about MOUD utilization with tensions arising between how they perceived it as a pathway to recovery and as replacing one form of drug dependence with another. People explained that they engaged in cultural practices while in drug treatment programs and emphasized the need for gender-specific services.</p><p><strong>Conclusions: </strong>Mitigating harms of the addiction crisis in Indigenous communities requires enhanced access to evidence-based drug treatment services.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Past-Month Substance Use in Emerging Adults: Consistency Between Timeline Followback and Monthly Surveys Varies by Substance.","authors":"Ryan M Sullivan, Anjelica Pantoja, Calan Tran, Gianna Andrade, Rachel E Baca, Alexander L Wallace, Joseph P Happer, April C May, Natasha E Wade, Kelly E Courtney, Neal Doran, Joanna Jacobus","doi":"10.15288/jsad.26-00099","DOIUrl":"10.15288/jsad.26-00099","url":null,"abstract":"<p><strong>Objective: </strong>Reliable measurement of adolescent substance use is critical for accurately characterizing developmental risk, yet the consistency of commonly use self-report methods remains uncertain. Here, consistency of past 30-day substance use self-report data (alcohol, cannabis, nicotine) was compared between the timeline follow-back and monthly retrospective surveys in a sample of adolescents and young adults.</p><p><strong>Method: </strong>N=94 participants (19-21-years-old, 62% female) were drawn from an ongoing longitudinal study. Measurements consisted of in-person timeline follow-back interview and mobile monthly retrospective surveys assessing past 30-day substance use; these timelines were harmonized to assess full overlap in reporting between modalities. Dimensions of reliability between modalities and concurrent validity with measures of substance use consequences, craving, and use disorder symptoms were analyzed.</p><p><strong>Results: </strong>Across substances (alcohol use days, cannabis use episodes, nicotine use episodes) rank correlations ranged from strong to very strong; however, significant within-person differences were observed for nicotine and cannabis. Nicotine use had poor agreement between the in-person and mobile survey modalities (ICC=0.30), while alcohol (ICC=0.91) and cannabis (ICC=0.88) were excellent and good, respectively. Concurrent validity differed between modalities for cannabis symptoms and problem outcomes but were comparable for alcohol and nicotine.</p><p><strong>Conclusions: </strong>Findings reflect nuanced measurement considerations for substance-specific patterns. While largely no differences between modalities and within-subjects were observed for alcohol use days, self-report differences emerged for cannabis and nicotine use, depending on the outcome assessed. Implications are discussed in the context of prospective, longitudinal studies of adolescents and young adults, while attempting to reduce participant burden and maintain reporting accuracy.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Most Delta-9-THC Edibles Marketed as Hemp Appear to Require THC Ingredients Classified as Marijuana Under Federal Law.","authors":"Matthew E Rossheim, Surya Voleti, Cassidy R LoParco, Yusuf Mehmood, Mansi Ghevariya, Kayla K Tillett, Stephanie Pike Moore","doi":"10.15288/jsad.26-00120","DOIUrl":"https://doi.org/10.15288/jsad.26-00120","url":null,"abstract":"<p><strong>Objective: </strong>Δ9-THC edibles are widely marketed as federally compliant industrial hemp under the 2018 Farm Bill (≤0.3% Δ9-THC by dry weight). We evaluated whether the labeled Δ9-THC content in edibles marketed as \"hemp\" could be supplied using cannabis material meeting that threshold without exceeding the mass of the edible.</p><p><strong>Method: </strong>From October 2025 to February 2026, we identified online retailers marketing Δ9-THC edibles as hemp to U.S. consumers. For each product, we examined Δ9-THC content (mg), unit weight (g), and sugar content (g) from product labels and/or laboratory reports. We calculated the minimum cannabis mass required to supply the Δ9-THC content, assuming the maximum legal concentration (0.3%). Products were classified as mathematically infeasible when required cannabis mass exceeded available non-sugar mass (primary test) or total product mass (ultra-conservative test). Prevalence estimates used bootstrap confidence intervals (2,000 replications; clustered by brand).</p><p><strong>Results: </strong>80% of products would have to contain mathematically impossible portions of cannabis (95% CI: 72-88%; n=297); the median product required cannabis material equal to 160% of available non-sugar mass. 2% required more cannabis than the total product mass (95% CI 0%-4%; n=380). Across all edible types, most appear unable to obtain their Δ9-THC content from lawful hemp material.</p><p><strong>Conclusions: </strong>Most Δ9-THC edibles marketed as \"hemp\" appear infeasible to manufacture using cannabis material containing ≤0.3% Δ9-THC by dry weight without exceeding the available product mass, even under highly conservative assumptions. Thus, most appear to depend on marijuana as an ingredient, which has substantial regulatory and public health implications.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blinded by the 'lite': Consumer perceptions of health-oriented claims on alcohol labels and self-reported impact on intended purchasing and consumption.","authors":"Victoria Kostadinov, Simone Pettigrew, Ashlea Bartram, Christina Norris, Asad Yusoff, Bella Sträuli, Paula O'Brien, Aimee Brownbill, Julia Stafford, Mark Petticrew, Michelle Jongenelis, Tim Stockwell, Jacqueline Bowden","doi":"10.15288/jsad.25-00336","DOIUrl":"https://doi.org/10.15288/jsad.25-00336","url":null,"abstract":"<p><strong>Objective: </strong>Nutrition claims are increasingly displayed on alcohol product labels. This study examined whether claims are associated with increased perceived product appeal, intent to purchase, and/or intended consumption.</p><p><strong>Method: </strong>An online survey was completed by 2,028 Australians who regularly drank alcohol. Participants viewed mocked-up alcohol labels showing eight different health-oriented claims. Participants rated their perceptions of each claim, and whether they perceived claims would impact intended purchasing/consumption. Chi-squared tests examined associations between perceptions and consumer attributes, and logistic regression identified predictors of increased intended consumption.</p><p><strong>Results: </strong>Beverages were perceived as more appealing if they included claims about sugar (51%), preservatives/additives (49%), calories (48%), and carbohydrates (45%), with similar proportions agreeing that they would be more likely to purchase a product displaying these claims. Approximately a third indicated they would drink more of a beverage if it had a sugar (33%) or calorie (31%) claim. Participants who were younger or drank at high-risk levels were more likely to agree that claims increase appeal and intended purchasing/consumption. Higher odds of increasing consumption after seeing a sugar, calorie, or carbohydrate claim were found for participants who were younger, female (sugar/calorie claims only), and had greater awareness of and exposure to claims.</p><p><strong>Conclusions: </strong>Health-oriented claims (particularly sugar and carbohydrates) were perceived by many consumers to be associated with increased beverage appeal and intent to purchase. Self-reported claim impact differed by claim type and consumer characteristics. Policy efforts are needed to ensure that health-oriented claims do not undermine public health efforts to reduce alcohol-related harms.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing PTSD-Substance Use Comorbidity Treatment Research Through Applying FAIR and FACT Data Science Frameworks in <i>Project Harmony</i>.","authors":"D A Hien, N Kassam-Adams, A de Haan, M O'Neil, J Hamblen, A A Morgan-Lopez","doi":"10.15288/jsad.26-00098","DOIUrl":"10.15288/jsad.26-00098","url":null,"abstract":"<p><strong>Objective: </strong>Posttraumatic stress (PTSD) and substance use disorder (SUD) treatment research has been hampered by heterogeneous measures, inconsistent reporting, and sensitive data governance constraints that limit data synthesis and clinical translation. This manuscript describes how integrating FAIR (Findable, Accessible, Interoperable, Reusable) principles and FACT (Fairness, Accuracy, Confidentiality, Transparency) concepts can strengthen PTSD-SUD data science, with <i>Project Harmony</i> as an applied example.</p><p><strong>Method: </strong>We identify key barriers to evidence accumulation in PTSD-SUD clinical trials and map FAIR+FACT-aligned practices across the research lifecycle (data acquisition, harmonization, analysis, sharing, and dissemination). We then illustrate implementation strategies using procedures from <i>Project Harmony's</i> (<i>PH</i>) individual participant data meta-analysis (IPD-MA), including common data element (CDE) labeling, interoperable harmonization pipelines, documentation of analytic decisions, and governance-informed access controls.</p><p><strong>Results: </strong>We identify priority points where FAIR+FACT alignment improves reproducibility and validity while reducing participant risk, particularly for populations vulnerable to confidentiality harms and stigma. The <i>PH</i> case example demonstrates feasibility of rigorous harmonization and measurement-equivalence approaches at scale and shows how transparent, provenance-preserving workflows can support comparative effectiveness analyses across diverse trials.</p><p><strong>Conclusions: </strong>FAIR+FACT integration offers a practical framework for advancing trustworthy PTSD-SUD treatment evidence. We provide specific recommendations for investigators, clinical trial networks, and funders/policymakers to institutionalize FAIR+FACT requirements and resource the personnel and infrastructure needed for ethical, reusable PTSD-SUD datasets. Routine adoption of interoperable metadata standards, rigorous documentation and code sharing, and trauma-informed governance can accelerate guideline development, strengthen policy relevance, and improve clinical decision-making for individuals with comorbid PTSD and SUD.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Interval Training Ameliorates Oxidative Stress and Mitophagy in Heart Tissue of Healthy Rats Following the Combination Use of Methylphenidate and Ethanol.","authors":"Sara Shirazpour, Gholamreza Sepehri, Farzaneh Rostamzadeh, Sobhan Mansouri, Homa Jafari, Maryam Iranpour","doi":"10.15288/jsad.25-00195","DOIUrl":"https://doi.org/10.15288/jsad.25-00195","url":null,"abstract":"<p><strong>Objective: </strong>The concurrent consumption of methylphenidate (MPD) and ethanol are prevalent among young individuals and those diagnosed with attention deficit hyperactivity disorder (ADHD). This study investigated the effects of high-intensity interval training (HIIT) on probable cardiac complications caused by the combined use of MPD and ethanol (ET), with a particular focus on oxidative stress and mitochondrial fission, fusion and mitophagy.</p><p><strong>Materials and methods: </strong>This study was carried on male Wistar rats that received saline (CTL), HIIT, MPD, ET, MPD+ET, or a combination of HIIT with MPD, ET, or MPD+ET. Cardiac tissue damage and fibrosis were assessed using hematoxylin and eosin and Masson's trichrome staining. The expression of mRNAs was quantified using Real-time PCR, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and malondialdehyde (MDA) levels were measured, calorimetrically.</p><p><strong>Results: </strong>The combination of ET and MPD increased the levels of MDA, decreased the activity of SOD and GPX, and increased mRNA expression of DRP1, PINK, and Parkin compared to the CTL group. HIIT was associated with a significant reduction in oxidative stress and mitochondrial fission and mitophagy parameters in ethanol and MPD treated groups. HIIT reduced histopathological changes in MDA+ET group and fibrosis in groups receiving ET and combination of MDA and ET.</p><p><strong>Conclusion: </strong>The findings of this study showed that HIIT intervention could be associated with significant reduction in adverse effects of concurrent consumption of MPD and ethanol on oxidative stress, mitochondrial fission and mitophagy, and injury in heart of healthy male rats.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More Restrictive State Alcohol Policies Are Associated With Lower Risk of Sexual Assault Victimization Among College Students.","authors":"David C R Kerr, Harold Bae, Kathleen A Parks, Timothy S Naimi, Marlene C Lira","doi":"10.15288/jsad.25-00392","DOIUrl":"10.15288/jsad.25-00392","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol use plays a role in college sexual assaults. Given that more restrictive state alcohol policy environments have been associated with less binge drinking we tested whether these environments were associated with reduced risk of sexual assault victimization in college students.</p><p><strong>Method: </strong>Repeated cross-sectional National College Health Assessment surveys of 876,326 students (ages 18-24) from 2008-2019 were linked to time-varying, state-level Alcohol Policy Scale (APS) scores indexing the efficacy and implementation of 29 policies. Students reported five past-year sexual victimization experiences, formed into a binary composite, as well as 2-week binge drinking.</p><p><strong>Results: </strong>Binge drinking was associated with significantly higher odds of sexual assault (OR = 2.22, <i>p</i><0.0001 for the composite measure). In states with higher APS scores (more restrictive) students had lower odds of experiencing unwanted sexual touching [OR = .93 for women; OR = .81 (stronger) for men, p<.0001] and men had lower odds of experiencing attempted non-consensual penetration (OR = .81, p<.0001).</p><p><strong>Conclusions: </strong>State alcohol policies that reduce the prevalence of binge drinking may play a role in preventing some forms of sexual assault. Findings are consistent with the importance of multi-level (state-, community-, campus-level) and multi-target (e.g., alcohol misuse, bystander training) prevention approaches.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol News Coverage Increasingly Frames Harms Over Health Benefits: Evidence from Two Leading U.S. Newspapers, 2010-2024.","authors":"David Jernigan, Emily Godin, Pamela Trangenstein","doi":"10.15288/jsad.26-00171","DOIUrl":"https://doi.org/10.15288/jsad.26-00171","url":null,"abstract":"<p><strong>Objective: </strong>News coverage of public health debates matters. This study aimed to explore whether two major newspapers in the U. S. framed alcohol as positive or negative for health from 2010 to 2024, and whether that framing changed over time.</p><p><strong>Method: </strong>We examined news stories about alcohol and health that focused on more than a single incident (i.e. non-episodic coverage) in the two largest circulation newspapers in the United States over a 15-year period. Articles were coded as framing alcohol as harmful to health, healthy, or neutral (not taking a position on health, such as stories about alcohol as a business). We calculated annual percent of news articles classified as healthy and harmful to show changes in coverage over time, and assessed these changes for statistical significance.</p><p><strong>Results: </strong>We identified and assessed 1155 articles from the <i>New York Times</i>, and 486 articles from the <i>Wall Street Journal</i>. Coverage in the latter did not change significantly, although it leaned towards alcohol being harmful to health. Coverage in the former, however, shifted from the majority of stories being about alcohol's health benefits, to alcohol being harmful to human health in 2016. This trend was statistically significant ((z=4.06; p<.001).</p><p><strong>Conclusions: </strong>Coverage of alcohol's role in human health shifted in the largest circulation newspaper in the United States, while coverage in the nation's leading business paper consistently leaned slightly toward the negative. While reported prevalence of alcohol consumption is dropping, the implications of this shifting story for alcohol policies remain to be seen.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for a Shared Vulnerability to Both Anxiety/Depression (\"Internalizing\") Disorder and Alcohol-Related Problems.","authors":"Matt G Kushner, Justin J Anker, Paul Thuras, Bryan Andrews, Erich Kummerfeld","doi":"10.15288/jsad.25-00494","DOIUrl":"https://doi.org/10.15288/jsad.25-00494","url":null,"abstract":"<p><strong>Objective: </strong>Theory and evidence indicate that some of the key dysregulations in the brain's stress and mood systems induced by substance use and resulting in addiction are also evident in those with anxiety and depression (\"internalizing\") disorder (INTD). Based on this, we hypothesized that those with INTD develop alcohol-related symptoms with greater neurobiological efficiency (i.e., with less alcohol use) than others. In support of this hypothesis, we reported earlier that, after controlling for level of alcohol use, drinkers with a current INTD experience a greater number of alcohol-related symptoms than those without INTD. However, the cross-sectional design employed in that study circumscribed the conclusions that could be drawn concerning our hypothesis. The present study extends the earlier work in a prospective nationally representative dataset.</p><p><strong>Method: </strong>Using the NESARC waves 1 and 2 datasets (the same individuals assessed approximately 3 years apart), we evaluated the association of INTD status at both waves to alcohol symptom count at wave 1, while controlling typical daily drinking level and other relevant demographic and clinical variables.</p><p><strong>Results: </strong>Those with INTD at wave 2 but not at or before wave 1 experienced more alcohol-related symptoms relative to their drinking level at wave 1 than did those who did not have INTD at either wave. The magnitude of this effect was greater when INTD was also present at wave 1.</p><p><strong>Conclusion: </strong>These findings are consistent with a shared vulnerability for the development of INTD and alcohol-related problems, which may, in part, account for their common co-occurrence.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}