Rhianna R Vergeer, Bethany L Stangl, Matthew E Sloan, Christina C Kennard, Shyamala K Venkatesh, Paule V Joseph, Melanie L Schwandt, Marta Yanina Pepino, Nancy Diazgranados, Vijay A Ramchandani
{"title":"The Relationship between Body Mass Index and Level of Response to Alcohol Across the Spectrum of Alcohol Use: Total Body Water and Beyond.","authors":"Rhianna R Vergeer, Bethany L Stangl, Matthew E Sloan, Christina C Kennard, Shyamala K Venkatesh, Paule V Joseph, Melanie L Schwandt, Marta Yanina Pepino, Nancy Diazgranados, Vijay A Ramchandani","doi":"10.15288/jsad.23-00134","DOIUrl":"https://doi.org/10.15288/jsad.23-00134","url":null,"abstract":"<p><strong>Background: </strong>A low level of response (LR) to alcohol is a known risk factor for alcohol use disorder (AUD). Although higher total body water (TBW) is associated with lower blood alcohol concentrations and reduced responses following alcohol consumption, the relationship between morphometric measures such as body mass index (BMI) and LR is less clear. This study aimed to examine the relationship between BMI and LR to alcohol, and the contribution of TBW to this relationship.</p><p><strong>Methods: </strong>Participants (n=1,086) enrolled in the NIAAA Natural History Protocol were assessed for LR to alcohol using the Self-Rating of the Effects of Alcohol (SRE) Questionnaire. BMI was estimated using height and weight, and TBW was estimated from height, weight, age and sex. Participants were categorized based on BMI into 3 groups: normal weight (18.5-25.0 kg/m<sup>2</sup>; n=430), overweight (25.0-30.0 kg/m<sup>2</sup>; n=403), and obese (≥30.0 kg/m<sup>2</sup>; n=253). Associations between BMI group and SRE scores for the most recent three-month period (SRE-Recent), and the effect of TBW, were analyzed using ANOVA. Linear regression analysis was conducted to estimate the proportion of variation in SRE-Recent explained by BMI and TBW.</p><p><strong>Results: </strong>BMI category was associated with LR, with the normal weight group showing higher responses (lower SRE-Recent scores) to alcohol than the overweight or obese groups. After controlling for TBW, the relationship became non-significant. Linear regression models confirmed these findings.</p><p><strong>Conclusions: </strong>Higher BMI is associated with lower LR to alcohol. However, TBW seems to account for this relationship, suggesting that concentrations achieved following alcohol consumption may be the primary determinant of BMI-related differences in LR. Future work should replicate these findings and examine these relationships throughout the lifespan and in individuals with AUD.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Dyar, Elise Green, Isaac C Rhew, Christine M Lee
{"title":"Event-level differences in quantity, frequency, and consequences of cannabis use by modes of use: Moderation by differences in how often individuals use each mode among sexual minority women and gender diverse individuals.","authors":"Christina Dyar, Elise Green, Isaac C Rhew, Christine M Lee","doi":"10.15288/jsad.24-00348","DOIUrl":"https://doi.org/10.15288/jsad.24-00348","url":null,"abstract":"<p><strong>Background: </strong>A handful of studies have examined differences in the subjective effects and consequences of utilizing different modes of cannabis (e.g., smoking vs. vaping) at the daily level. However, results have been mixed and recent research suggests that there may be individual-level differences in these effects based on how often individuals use each mode. We aimed to determine within-person associations between mode of cannabis use (i.e., smoking, vaping plant material, vaping concentrates, dabbing, edibles, multiple modes) and quantity, subjective intoxication, consequences, contexts of cannabis use, and co-use with alcohol or tobacco varied based on how often individuals used each mode.</p><p><strong>Methods: </strong>We used data from a 30-day EMA study of cannabis use with 338 sexual minority women and gender diverse young adults assigned female at birth, populations at high risk for cannabis use disorder.</p><p><strong>Results: </strong>Several associations between mode of cannabis use and outcomes differed based on how frequently individuals used each mode. People who used edibles less frequently experienced more consequences when using edibles compared to smoking cannabis, while people who used edibles more frequently did not. People who used multiple modes more frequently took fewer hits when using multiple mode, while those who used multiple modes less frequently did not.</p><p><strong>Conclusions: </strong>Analyses suggest that frequency, quantity, and consequences of some modes of use differed based on how frequently individuals used each mode. Further research is needed to identify protective behavioral strategies that may be utilized by individuals who use particular modes more often.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delvon T Mattingly, Marisa D Booty, Osayande Agbonlahor, Nancy L Fleischer
{"title":"Racial and ethnic discrimination and DSM-5 substance use disorders among U.S. adults.","authors":"Delvon T Mattingly, Marisa D Booty, Osayande Agbonlahor, Nancy L Fleischer","doi":"10.15288/jsad.24-00247","DOIUrl":"https://doi.org/10.15288/jsad.24-00247","url":null,"abstract":"<p><strong>Objective: </strong>Racial and ethnic discrimination is a risk factor for substance use among United States adults. However, whether discrimination is associated with substance use disorders (SUDs) overall and by race and ethnicity is less understood.</p><p><strong>Methods: </strong>We used data from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III (n=35,355) and defined past-year discrimination as a summary scale (range: 0-4). Past-year SUDs included alcohol use disorder (AUD), tobacco use disorder (TUD), cannabis use disorder (CUD), and illicit drug use disorder (IDUD) based on DSM-5 criteria, and number of SUDs included one, two, or three or more SUDs. We estimated associations between discrimination and each SUD outcome using logistic and multinomial logistic regression and examined effect modification by race and ethnicity.</p><p><strong>Results: </strong>Discrimination was associated with each substance-specific SUD (OR range: 1.36-1.78) and with one, two, and three or more number of SUDs (OR range: 1.34-2.19). Models stratified by race and ethnicity revealed that discrimination was associated with AUD among all groups (OR range: 1.42-1.52), with TUD only among adults who were non-Hispanic White, non-Hispanic Black and another non-Hispanic race, with CUD only among non-Hispanic White and non-Hispanic Black adults, and with only IDUD among Hispanic, non-Hispanic White, and non-Hispanic Black adults. In addition, discrimination was associated with three or more number of SUDs among all groups.</p><p><strong>Conclusions: </strong>Discrimination was associated with all SUD outcomes, with variation in these relationships by race and ethnicity. Understanding this heterogeneity can inform efforts to prevent problematic substance use and promote health equity.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scott Graupensperger, Brian H Calhoun, Katherine Walukevich-Dienst, Christine M Lee
{"title":"What's the harm in starting early?: Daily and long-term risks of daytime drinking in young adults.","authors":"Scott Graupensperger, Brian H Calhoun, Katherine Walukevich-Dienst, Christine M Lee","doi":"10.15288/jsad.24-00312","DOIUrl":"https://doi.org/10.15288/jsad.24-00312","url":null,"abstract":"<p><strong>Background: </strong>There is a robust body of work demonstrating that certain drinking practices, such as pregaming or playing drinking games, are linked to heavier, riskier patterns of drinking among college students. However, less attention has been paid to other drinking practices that are relatively common among undergraduates, such as daytime drinking (i.e., drinking before 4:00 PM).</p><p><strong>Method: </strong>Using data from an intensive longitudinal study (bursts of daily data over the course of 12 months; 6,842 total days of data) collected from a high-risk sample of college students (<i>N</i>=403), the present study tested daytime drinking as both a proximal (daily level drinking outcomes) and distal (AUD symptoms) risk factor for hazardous drinking.</p><p><strong>Results: </strong>Daytime drinking was reported by over 70% of the sample and on approximately 15% of drinking days. Daily-level findings indicated that compared to non-daytime drinking days, daytime drinking days were significantly associated with more drinks consumed, more high-risk drinking practices (i.e., heavy episodic or high intensity drinking), and greater subjective intoxication. Longitudinal analyses identified frequent daytime drinking as a risk factor for increased hazardous drinking behavior, particularly among individuals who were younger or reported lower hazardous drinking at baseline.</p><p><strong>Conclusions: </strong>Findings add to a sparse literature supporting daytime drinking as a risky drinking practice among college students. Future work should aim to further characterize contextual and psychosocial factors associated with daytime drinking practices.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heather Gould, Claudia Zaugg, M Antonia Biggs, Katie Woodruff, Wilma Long, Kieran Mailman, Jeanette Vega, Sarah C M Roberts
{"title":"Mandatory Warning Signs for Cannabis: Perspectives and Preferences of Pregnant and Recently Pregnant People Who Use Cannabis.","authors":"Heather Gould, Claudia Zaugg, M Antonia Biggs, Katie Woodruff, Wilma Long, Kieran Mailman, Jeanette Vega, Sarah C M Roberts","doi":"10.15288/jsad.23-00214","DOIUrl":"10.15288/jsad.23-00214","url":null,"abstract":"<p><strong>Objective: </strong>Five U.S. states where recreational cannabis is legal require mandatory warning signs for cannabis use during pregnancy (MWS-cannabis) to be posted in cannabis dispensaries. Previous research has found adverse health consequences associated with MWS-cannabis and that people lack trust in information on signs. This qualitative study explores people's perspectives and preferences regarding MWS-cannabis.</p><p><strong>Method: </strong>We conducted in-depth interviews with 34 pregnant or recently pregnant individuals from multiple states with varying policy climates in the United States who used cannabis before or during pregnancy. We asked participants about their perspectives on MWS-cannabis and reactions to specific messages. We reviewed transcripts using thematic analysis.</p><p><strong>Results: </strong>Participants reported mostly negative views on MWS-cannabis, suggesting that they may have stigmatizing and negative impacts on pregnant people who use cannabis, discouraging them from seeking care. Many said that the scientific evidence is not strong enough to justify MWS-cannabis and that they are unlikely to deter pregnant people from using cannabis. Participants asserted that vague or fear-based messages, distrust of government, and the location and timing of the signs undermine the goals of MWS-cannabis. When reacting to specific messages, participants preferred messages that are evidence-based, clear, specific, and aligned with autonomous decision-making.</p><p><strong>Conclusions: </strong>Pregnant and recently pregnant people who use cannabis have mostly negative perceptions of MWS-cannabis and believe they have negative consequences. More work is needed to develop health information resources that meet the needs of people who use cannabis during pregnancy without increasing stigma.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"75-84"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Rodríguez-Espinosa, Ainhoa Coloma-Carmona, Ana Pérez-Carbonell, José Francisco Román-Quiles, José Luis Carballo
{"title":"Profile of Chronic Pain Patients With Opioid Withdrawal Syndrome According to Psychological Factors: A Latent Class Analysis.","authors":"Sara Rodríguez-Espinosa, Ainhoa Coloma-Carmona, Ana Pérez-Carbonell, José Francisco Román-Quiles, José Luis Carballo","doi":"10.15288/jsad.24-00106","DOIUrl":"10.15288/jsad.24-00106","url":null,"abstract":"<p><strong>Objective: </strong>Withdrawal syndrome stands out as the strongest risk factor for prescription opioid-use disorder (POUD) and is related to psychological and pain impairment in the chronic pain population. This study aimed to identify profiles of chronic pain patients with opioid withdrawal based on psychological factors and to explore the association between the classes and demographic, clinical, and substance use variables.</p><p><strong>Method: </strong>This cross-sectional descriptive study involved 391 patients, 221 with interdose withdrawal (mean age = 57.91±13.61 years; 68.3% female). Latent class analysis and bivariate and logistic regression analyses were performed.</p><p><strong>Results: </strong>Two latent classes were identified (Bayesian information criterion = 4020.72, entropy = .70, likelihood ratio tests <i>p</i> < .01): Withdrawal syndrome with No Psychological Distress (WNPD; 45.2%, <i>n</i> = 100) and Withdrawal syndrome with Psychological Distress (WPD; 54.8%, <i>n</i> = 121). The WPD class was more likely to experience craving, anxiety, and depression and to report higher levels of pain intensity and interference (<i>p</i> < .01). Patients in this class were younger, visited a higher number of specialists, and showed higher rates of high-dose opioid use, misuse, moderate-severe POUD, and tobacco and anxiolytics use (<i>p</i> < .05). Only moderate-severe POUD (odds ratio [OR] = 2.64) and tobacco use (OR = 2.28) increased the risk of WPD class membership.</p><p><strong>Conclusions: </strong>Although it is common for chronic pain patients to experience withdrawal symptoms during opioid treatment, more than half of the participants reported concomitant psychological distress. Establishing differential profiles can help to improve withdrawal syndrome management during the treatment of chronic pain with opioids.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"58-67"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do We Need Additional Indicators for the Sustainable Development Goal Target 3.5 on Strengthening the Prevention and Treatment of Substance Abuse? An Analysis of Recent Submissions to the UN Inter-Agency and Expert Group.","authors":"Jürgen Rehm, Kevin Shield","doi":"10.15288/jsad.24-00353","DOIUrl":"10.15288/jsad.24-00353","url":null,"abstract":"","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"149-152"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine Walukevich-Dienst, Annie N Hoang, Anne M Fairlie, Melissa A Lewis, Christine M Lee
{"title":"Examining Whether Young Adults Differ in Their Endorsement and Subjective Evaluation of Alcohol Consequences by Age, Drinking Frequency, and Current Undergraduate Status.","authors":"Katherine Walukevich-Dienst, Annie N Hoang, Anne M Fairlie, Melissa A Lewis, Christine M Lee","doi":"10.15288/jsad.23-00372","DOIUrl":"10.15288/jsad.23-00372","url":null,"abstract":"<p><strong>Objective: </strong>There is considerable variability in how young adults (YAs) perceive drinking-related consequences, and some researcher-identified \"negative\" consequences are viewed by YAs as neutral or even somewhat positive. Little is known about individual difference factors that may influence subjective evaluations of alcohol consequences.</p><p><strong>Method: </strong>We tested whether endorsement and subjective evaluation (\"extremely negative\" to \"extremely positive\") of 24 alcohol-related negative consequences differed by age (18-20, 21-27), past-3-month drinking frequency (three times/month or less, weekly or more), and current undergraduate status (4-year undergraduate, nonstudent). YAs were recruited for a longitudinal ecological momentary assessment study on cognitions and alcohol use. Participants in the analytic sample (<i>N</i> = 640; 48.1% White non-Hispanic/Latinx, 50.0% female, <i>M</i> age = 22.2 years, <i>SD</i> = 2.3) reported past-3-month drinking. Past-3-month drinking frequency, negative consequences (total and item-level), and subjective evaluations of consequences were assessed cross-sectionally.</p><p><strong>Results: </strong>Compared with YAs age 18-20, YAs 21 and older experienced fewer total consequences, were significantly less likely to endorse experiencing physical/behavioral consequences, and rated these consequences more negatively if they were endorsed. YAs who drank weekly or more reported experiencing more consequences and were significantly more likely to experience all 24 consequences in comparison with YAs who drank three times/month or less. Subjective evaluation ratings did not significantly differ by drinking frequency. There were few differences between 4-year undergraduates and non-undergraduates; non-undergraduates rated several health/responsibility-related consequences more negatively.</p><p><strong>Conclusions: </strong>Findings highlight the importance of identifying individual difference factors that contribute to subjective evaluation ratings and may be useful for tailoring brief, personalized alcohol interventions for YAs.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"124-135"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhishek Ghosh, Debasish Basu, Simranjit Kaur, Shalini S Naik, B N Subodh, Surendra K Mattoo
{"title":"Trends of Buprenorphine Prescribing for Opioid Dependence Before and During the Early and Later Part of the COVID-19 Pandemic: A Study From a Large, Publicly Funded Opioid Agonist Treatment Service in India.","authors":"Abhishek Ghosh, Debasish Basu, Simranjit Kaur, Shalini S Naik, B N Subodh, Surendra K Mattoo","doi":"10.15288/jsad.23-00343","DOIUrl":"10.15288/jsad.23-00343","url":null,"abstract":"<p><strong>Objective: </strong>The COVID-19 pandemic has affected the availability of and access to medications for opioid dependence (OD). We examined the monthly trends in new buprenorphine/naloxone (BNX) treatment episodes, number of clinical visits for BNX, BNX dispensed per person, and BNX prescription over 56 months, which included the pre-pandemic period and the early and later parts of the pandemic (January 2017 to August 2022).</p><p><strong>Method: </strong>Research data were collected from the pharmacy database of a large publicly funded treatment center in India. A flexible, low-threshold service was adopted in April 2020 in response to the lockdown implemented on March 25, 2020. Change point analyses were performed to examine monthly trends visually and statistically. We used autoregressive integrated moving averages to forecast trends from April to August 2020 and March to August 2022, using January 2017 to March 2020 and March 2020 to February 2022 as training data sets.</p><p><strong>Results: </strong>A total of 993 patients were started on BNX treatment; 40,452 BNX clinic attendances were made; 1,401,393 BNX tablets were dispensed; and 6,795 new patients with OD were registered. The observed data for clinic attendance for BNX was significantly lower than the projected estimates in April to August 2020; however, observed new treatment episodes and monthly BNX prescriptions were within the 95% projected estimates; BNX dispensed per person was significantly more than the projected estimate. In contrast, observed BNX prescription trends surpassed the upper limit of the 95% confidence interval in March to August 2022.</p><p><strong>Conclusions: </strong>A low-threshold and flexible-treatment service could mitigate the unintended consequences of pandemic-induced restrictions.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"48-57"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhaleh Jamali, Ahmad Salimi, Saleh Khezri, Pirasteh Norozi, Behzad Garmabi, Mehdi Khaksari
{"title":"Protective Role of Ellagic Acid Against Ethanol-Induced Neurodevelopmental Disorders in Newborn Male Rats: Insights into Maintenance of Mitochondrial Function and Inhibition of Oxidative Stress.","authors":"Zhaleh Jamali, Ahmad Salimi, Saleh Khezri, Pirasteh Norozi, Behzad Garmabi, Mehdi Khaksari","doi":"10.15288/jsad.24-00118","DOIUrl":"10.15288/jsad.24-00118","url":null,"abstract":"<p><strong>Objective: </strong>Ellagic acid (EA) exerts neuroprotective, mitoprotective, anti-oxidative, and anti-inflammatory effects. We evaluated the protective effect of EA on ethanol-induced fetal alcohol spectrum disorders (FASD).</p><p><strong>Method: </strong>A total of 35 newborn male rats were used, divided into five groups, including control (normal saline), ethanol (5.25 g/kg per day), ethanol (5.25 g/kg per day) + EA (10 mg/kg), ethanol (5.25 g/kg per day) + EA (20 mg/kg), and ethanol (5.25 g/kg per day) + EA (40 mg/kg). Thirty-six days after birth, behavioral tests (Morris water maze and Elevated Plus Maze), tumor necrosis factor-alpha (TNF-alpha) levels, oxidative markers (malondialdehyde, glutathione, and superoxide dismutase), and mitochondrial examination such as succinate dehydrogenases activity, mitochondrial swelling, mitochondrial membrane potential, and reactive oxygen species formation were analyzed.</p><p><strong>Results: </strong>The results revealed that ethanol exposure adversely affected cognitive and mitochondrial functions and induced oxidative stress and inflammation in brain tissue. However, EA (20 and 40 mg/kg) administration effectively prevented the toxic effects of ethanol in the FASD model.</p><p><strong>Conclusions: </strong>These findings demonstrate that ethanol application significantly impairs brain development via mitochondrial dysfunction and induction of oxidative stress. These data indicate that EA might be a useful compound for the prevention of alcohol-induced FASD.</p>","PeriodicalId":17159,"journal":{"name":"Journal of studies on alcohol and drugs","volume":" ","pages":"95-105"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}