Journal of Surgical Oncology最新文献_第7页

Impact of proton pump inhibitors on pathologic response rates following fluoropyrimidine‐based neoadjuvant chemotherapy in pancreatic cancer patients 质子泵抑制剂对胰腺癌患者氟嘧啶新辅助化疗后病理反应率的影响

IF 2.5 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI: 10.1002/jso.27837

Jessica A. Steadman, Ahmer Sultan, Courtney N. Day, Marie A. Parish, Susanne G. Warner, Michael L. Kendrick, Mark J. Truty, Zhaohui Jin, Cornelius A. Thiels

{"title":"Impact of proton pump inhibitors on pathologic response rates following fluoropyrimidine‐based neoadjuvant chemotherapy in pancreatic cancer patients","authors":"Jessica A. Steadman, Ahmer Sultan, Courtney N. Day, Marie A. Parish, Susanne G. Warner, Michael L. Kendrick, Mark J. Truty, Zhaohui Jin, Cornelius A. Thiels","doi":"10.1002/jso.27837","DOIUrl":"https://doi.org/10.1002/jso.27837","url":null,"abstract":"BackgroundProton pump inhibitors (PPIs) negatively impact fluoropyrimidine‐based chemotherapy efficacy in colorectal cancer. This study assessed PPI impact on major pathologic response (mPR) rates of pancreatic adenocarcinoma (PDAC) patients receiving fluoropyrimidine‐based chemotherapy.MethodsAn institutional retrospective review of resected PDAC patients receiving neoadjuvant fluoropyrimidine‐based chemotherapy (98% FOLFIRINOX) from 2011 to 2021 was conducted. Outcomes were stratified by use or nonuse of PPIs within 6 months of neoadjuvant chemotherapy initiation. Primary outcome was mPR defined as complete or near complete response.ResultsAmong 540 patients included, the median age was 64 (IQR: 60–70) years, 297 (55%) were male, and 202 (37%) were PPI users. 170 (31%) patients had mPR with similar rates among PPI users and nonusers (29% vs. 33%, p = 0.38). No difference in mPR was seen between PPI users and nonusers receiving chemoradiation (35% vs. 36%, p = 0.89) or ≥8 cycles of NAC (33% vs. 36%, p = 0.55). Median OS for PPI users was 30.9 versus 31.7 months for nonusers (p = 0.62). On multivariable analysis, PPI therapy was not associated with decreased survival.ConclusionPPI usage did not significantly influence mPR or OS following neoadjuvant fluoropyrimidine‐based chemotherapy in resected PDAC patients. Further analysis of all patients, not just those who underwent resection, is required.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re: Contemporary Report of Surgical Outcomes After Single‐Stage Total Pancreatectomy: A 10‐Year Experience 关于单段全胰切除术后手术效果的当代报告：十年经验

IF 2.5 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI: 10.1002/jso.27888

Zaki Boudiaf, Kamel Bentabak

引用次数: 0

Management of Peritoneal Surface Malignancies in Saudi Arabia: An Update 沙特阿拉伯腹膜表面恶性肿瘤的治疗：最新情况

IF 2.5 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI: 10.1002/jso.27879

Hadeel Helmi, Mohammad Alyami, Thamer Bin Traiki, Tarek Amin, Abdulaziz Alzahrani, Mamdouh Alnahawi, Nayef Alzahrani

引用次数: 0

Relationship of Surgical Approach With Financial Toxicity in Patients With Resected Lung Cancer 手术方法与切除肺癌患者经济毒性的关系

IF 2.5 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI: 10.1002/jso.27870

Nathaniel Deboever, Michael A. Eisenberg, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Jack A. Roth, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Ravi Rajaram

{"title":"Relationship of Surgical Approach With Financial Toxicity in Patients With Resected Lung Cancer","authors":"Nathaniel Deboever, Michael A. Eisenberg, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Jack A. Roth, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Ravi Rajaram","doi":"10.1002/jso.27870","DOIUrl":"https://doi.org/10.1002/jso.27870","url":null,"abstract":"IntroductionMinimally invasive surgery (MIS) reduces lengths of stay, complications, and potentially perioperative hospital costs. However, the impact of MIS on financial toxicity (FT), defined as the costs resulting from oncologic care and their negative effects on quality of life, in patients with lung cancer is unknown. Our objective was to investigate the association between surgical approach and FT in this population.MethodsA single‐institution study was performed evaluating resected lung cancer patients (2016–2021). FT was assessed using the Comprehensive Score for Financial Toxicity (COST) questionnaire. The relationship between surgical approach (MIS vs. thoracotomy) and FT was evaluated using propensity score‐matched (PSM) regression analysis. A sensitivity analysis involving the entire cohort was also performed using an inverse probability‐weighted generalized linear model.ResultsAs reported previously, of 1477 patients surveyed, 463 responded (31.3%) with FT reported in 196 patients (42.3%). Resection was performed by thoracotomy in 53.3% (n = 247), and by MIS in the remainder (n = 216, 46.7%; video‐assisted thoracoscopic surgery [VATS] = 115; robotic‐assisted = 101). There was no difference in FT in patients who underwent VATS and robotic‐assisted surgery (p = 0.515). In the PSM analysis, MIS was not associated with FT (odds ratio [OR]: 0.980, 95% confidence interval [CI]: 0.628–1.533, p = 0.929). Similar results were found on sensitivity analysis (OR: 1.488, CI: 0.931–2.378, p = 0.096).ConclusionsCompared to MIS, thoracotomy was not associated with FT in patients with resected lung cancer. Though there are several benefits from MIS, it does not appear to be a meaningful strategy to alleviate FT in this population.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistics of Visceral Sarcoma in Japan: Report From the Population‐Based National Cancer Registry (NCR) in Japan 日本内脏肉瘤统计数据：日本基于人口的国家癌症登记处（NCR）报告

IF 2.5 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI: 10.1002/jso.27867

Shudai Muramatsu, Koichi Ogura, Chigusa Morizane, Tomoyuki Satake, Yu Toda, Shintaro Iwata, Eisuke Kobayashi, Takahiro Higashi, Masahiko Ikeuchi, Akira Kawai

{"title":"Statistics of Visceral Sarcoma in Japan: Report From the Population‐Based National Cancer Registry (NCR) in Japan","authors":"Shudai Muramatsu, Koichi Ogura, Chigusa Morizane, Tomoyuki Satake, Yu Toda, Shintaro Iwata, Eisuke Kobayashi, Takahiro Higashi, Masahiko Ikeuchi, Akira Kawai","doi":"10.1002/jso.27867","DOIUrl":"https://doi.org/10.1002/jso.27867","url":null,"abstract":"Background and ObjectivesSarcomas developing in the visceral organs are extremely rare, with no previous reports to describe their national epidemiology. We analyzed Japanese domestic statistics for visceral sarcoma, using the National Cancer Registry (NCR) in Japan, a population‐based database launched in 2016.MethodsWe identified 3245 cases of visceral sarcomas in the NCR dated 2016–2019 to analyze demographic and disease information, initial diagnostic process, volume and type of the hospitals, treatment, and prognosis.ResultsVisceral sarcoma shows a higher prevalence in the older generation (60+ years), with a significant male predominance (p = 0.006). Leiomyosarcomas occurred frequently in the gastrointestinal tract (N = 240; 39.5%), and angiosarcomas in the liver, gall bladder, pancreas, and spleen (N = 244; 43.9%). Visceral sarcomas were often treated in facilities of lower volume without specific adjuvant treatments (p < 0.001). The cumulative 3‐year overall survival was 44.8%, and several factors such as surgery or absence of chemotherapy positively affected survival.ConclusionsThis is the first nationwide study in Japan to analyze the inclusive epidemiology of visceral sarcomas. Visceral sarcomas are characterized by senior and male predominance with relatively poor prognosis, often managed in nonspecialized facilities and rarely with adjuvant therapies. Several histologic subtypes had the propensity to develop in specific organs.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy, an Update From the International PSOGI Registry. 腹腔镜细胞再生手术和腹腔内热化疗，国际 PSOGI 登记的最新进展。

IF 2.5 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-10 DOI: 10.1002/jso.27881

M Duran-Martínez,M Bergillos-Giménez,L Rodríguez-Ortíz,A Arjona-Sánchez,

{"title":"Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy, an Update From the International PSOGI Registry.","authors":"M Duran-Martínez,M Bergillos-Giménez,L Rodríguez-Ortíz,A Arjona-Sánchez,","doi":"10.1002/jso.27881","DOIUrl":"https://doi.org/10.1002/jso.27881","url":null,"abstract":"INTRODUCTIONCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are established treatments for peritoneal surface malignancies, traditionally performed via laparotomy. Recent advancements in laparoscopic approaches (L-CRS + HIPEC) have shown promising results in selected patients.METHODSThe PSOGI registry, established in November 2019, collects data from specialized centers performing L-CRS + HIPEC. Data were collected prospectively and analyzed retrospectively, excluding risk-reducing procedures without peritoneal disease. The learning curve was assessed using a 14-cases cutoff.RESULTSToday, 323 patients have been registered, 193 were included finally. Perioperative outcomes improved after 14 cases: Length of hospital stay was 7.78 ± 3.64 days (consolidation) versus 8.8 ± 8.79 days (learning) and major morbidity was 0% (consolidation) versus 5% (learning), (p = n.s.). Estimated blood loss was lower in the consolidation phase. Oncological outcomes also improved: Recurrence rate was 8.7% (consolidation) versus 17.8% (learning). Disease-free survival 5 years, 65% (learning) versus 88% (consolidation) (p = 0.012).CONCLUSIONThe L-CRS + HIPEC is a safe procedure with non-inferior oncologic outcomes which it is evaluating in an IDEAL setting by an international group. The validation of the learning curve, gives us the knowledge that a mentoring program must be setup to reduce the learning curve impact in oncologic failure.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment On: "Assessing Breast Cancer-Related Lymphedema Screening and Treatment Gaps in a Safety-Net Hospital". 评论："评估一家安全网医院中与乳腺癌相关的淋巴水肿筛查和治疗差距"。

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-09 DOI: 10.1002/jso.27894

Hua Zhao, Jiayue Xu, Yuejun Zhou

引用次数: 0

Implementation of Hepatic Artery Infusion Pump Therapy: Real-World Single-Center Experience. 肝动脉输注泵疗法的实施：真实世界的单中心经验

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-06 DOI: 10.1002/jso.27859

Robert Connor Chick, Samantha M Ruff, Julia Monasterio, Taylor Neilson, Susan Tsai, Aslam Ejaz, Allan Tsung, Alex C Kim

{"title":"Implementation of Hepatic Artery Infusion Pump Therapy: Real-World Single-Center Experience.","authors":"Robert Connor Chick, Samantha M Ruff, Julia Monasterio, Taylor Neilson, Susan Tsai, Aslam Ejaz, Allan Tsung, Alex C Kim","doi":"10.1002/jso.27859","DOIUrl":"https://doi.org/10.1002/jso.27859","url":null,"abstract":"Background and objectives: Hepatic artery infusion pump (HAIP) therapy is an available option at highly specialized centers to treat unresectable liver tumors (e.g., colorectal liver metastases [CRLM]). This study describes the safety and outcomes of HAIP program implementation at an academic-based cancer center.Methods: Patients who underwent HAIP placement (2021-2023) were included. Categorical and continuous variables were compared using Chi-square and Kruska-Wallis tests, respectively. Survival and variables associated with survival were calculated using the Kaplan-Meier method and Cox proportional hazards model, respectively.Results: Of the 26 HAIP procedures for unresectable CRLM, four were done as adjuvant therapy. Median duration of HAIP therapy was 9.2 months and four patients subsequently underwent hepatectomy. Complication rate was 37.5%, with biliary complication rate of 23.1%. Median overall survival (OS) from date of diagnosis was 55.2 months. Concurrent primary tumor resection was associated with inferior OS (p = 0.030). Multivariable regression did not identify independent predictors of OS. Progression-free survival from time of HAIP placement was 7.8 months.Conclusions: HAIP placement was technically successful in most patients with an acceptable complication rate. Survival outcomes were comparable with those described in the literature for HAIP therapy in combination with systemic therapy. The significant difference in outcomes for those with concurrent colectomy warrants further investigation.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of Baseline Magnetic Resonance Imaging for Staging Rectal Cancer Patients Proceeding Directly to Surgery. 对直接进行手术的直肠癌患者进行基线磁共振成像分期的准确性

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-05 DOI: 10.1002/jso.27852

Elasma Milanzi, Rachel M Pelly, Ian P Hayes, Peter Gibbs, Ian Faragher, Jeanette C Reece

{"title":"Accuracy of Baseline Magnetic Resonance Imaging for Staging Rectal Cancer Patients Proceeding Directly to Surgery.","authors":"Elasma Milanzi, Rachel M Pelly, Ian P Hayes, Peter Gibbs, Ian Faragher, Jeanette C Reece","doi":"10.1002/jso.27852","DOIUrl":"https://doi.org/10.1002/jso.27852","url":null,"abstract":"Background and objectives: High-resolution magnetic resonance imaging (MRI) accuracy for staging preoperative rectal cancer varies across studies. We examined MRI accuracy for T- and N-staging of rectal cancer compared with final histopathology of the resected specimen in a large Australian cohort who did not receive neoadjuvant therapy or radiation.Methods: Retrospective analysis of prospectively-collected clinical data from 153 rectal adenocarcinomas locally staged by high-resolution MRI between January 2012 and December 2019 that did not undergo chemoradiotherapy or radiation before surgery. T- and N-stage agreement between MRI and final histopathology was assessed using Kappa statistic. Agreement at each T-stage was evaluated using log-linear modeling. N-staging accuracy was examined using positive and negative predictive values.Results: Overall agreement between MRI and final histopathology for T-stage and N-stage was 55% and 65%, respectively. Kappa statistic found higher agreement between MRI and final histopathology for T-staging (κ = 0.33) versus N-staging (κ = 0.18). MRI correctly assessed 91% of T1 tumors, 43% of T2 tumors, 65% of T3 tumors, and 80% of T4 tumors. MRI accuracy was higher for N-negative tumors (74.1%) than for N-positive tumors (44.4%).Conclusion: MRI is moderately accurate at staging T1, T3, and T4 rectal tumors but caution when staging tumors as T2 is advised. Greater accuracy for staging N-negative versus N-positive tumors is indicated.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment On: "Reliability of Artificial Intelligence Chatbot Responses to Frequently Asked Questions in Breast Surgical Oncology". 评论："人工智能聊天机器人回答乳腺肿瘤外科常见问题的可靠性"。

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2024-09-05 DOI: 10.1002/jso.27895

Hua Zhao, Kun Xu, Yuejun Zhou

引用次数: 0