Journal of Surgical Oncology最新文献

Correction to "Implementation of a Multidisciplinary Enhanced Recovery After Surgery (ERAS) Program for Cytoreductive Surgery (CRS) With Hyperthermic Intraperitoneal Chemotherapy (HIPEC)". 更正“细胞减少手术（CRS）与腹腔内高温化疗（HIPEC）的多学科增强术后恢复（ERAS）计划的实施”。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-25 DOI: 10.1002/jso.70114

引用次数: 0

A Seer-Based Analysis of Survival Predictors in Stage I Colorectal Adenocarcinomas. 基于先知的I期结直肠癌生存预测因素分析。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-21 DOI: 10.1002/jso.70111

Sameh Hany Emile, Nir Horesh, Zoe Garoufalia, Marcus Oosenbrug, Marylise Boutros, Steven D Wexner

{"title":"A Seer-Based Analysis of Survival Predictors in Stage I Colorectal Adenocarcinomas.","authors":"Sameh Hany Emile, Nir Horesh, Zoe Garoufalia, Marcus Oosenbrug, Marylise Boutros, Steven D Wexner","doi":"10.1002/jso.70111","DOIUrl":"https://doi.org/10.1002/jso.70111","url":null,"abstract":"Background: We assessed predictors of overall (OS) and cancer-specific survival (CSS) in stage I colorectal cancer (CRC).Methods: Retrospective analysis of patients with stage I colon or rectal adenocarcinomas from the SEER database (2010-2020) Survival was assessed using Kaplan-Meier statistics and multivariable Cox regression analyses. The primary outcomes were 5-year OS and CSS.Results: 40,001 patients (51.3% male; mean age: 65.1 ± 12.6 years) were included. Colon and rectal cancers accounted for 75.8% and 24.2%, respectively. Five-year OS and CSS were 83.1% (95% CI: 82.6-83.5%) and 93.2% (95% CI: 92.9-93.5%), respectively. Factors independently associated with worse OS were age (HR: 1.07; p < 0.001), male sex (HR:1.48; p < 0.001), Black race (HR: 1.25; p < 0.001), single, divorced, or widowed status (HR: 1.49, 1.46, and 1.43; p < 0.001), tumor size (HR: 1.001; p = 0.008), poorly differentiated carcinomas (HR: 1.32; p < 0.001), undifferentiated carcinomas (HR:1.44; p = 0.026), perineural invasion (HR: 1.84; p < 0.001), elevated CEA levels (HR: 1.68; p < 0.001), and systemic therapy (neoadjuvant: HR: 1.3; p = 0.032, adjuvant: HR: 2.2; p < 0.001, both: HR: 1.97; p < 0.001). Factors independently associated with worse CSS were age (HR: 1.05; p < 0.001), male sex (HR: 1.32; p < 0.001), Black race (HR: 1.43; p < 0.001), marital status (HR: 1.44, 1.28, and 1.68; p < 0.001), tumor size (HR: 1.003; p < 0.001), poorly differentiated carcinomas (HR: 1.77; p < 0.001), perineural invasion (HR: 2.29; p < 0.001), elevated CEA levels (HR: 2.24; p < 0.001), and systemic therapy (neoadjuvant: HR: 2.53; p = 0.032, adjuvant: HR: 4.22; p < 0.001, both: HR: 3.83; p < 0.001).Conclusions: Although patients with stage I CRC had excellent survival, single, older, Black, male patients with large, high-grade tumors associated with perineural invasion and elevated CEA levels had a higher mortality risk.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete Cytoreduction of Colorectal Liver Metastases: Evolving Systemic Therapy and Liver Transplantation. 结肠直肠癌肝转移的完全细胞减少：不断发展的全身治疗和肝移植。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-16 DOI: 10.1002/jso.70112

Viet Le, Jan Franko, Yuman Fong

引用次数: 0

The Melanoma Divide: Hispanic Health Disparities From Peru to the United States. 黑色素瘤的鸿沟：从秘鲁到美国的西班牙裔健康差异。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-14 DOI: 10.1002/jso.70110

Gabriel De la Cruz Ku, Gonzalo Ziegler-Rodriguez, Anshumi Desai, Luis Piedra Delgado, Jessica Farzan, Jiddu Guart, Michael Mallouh, Camila Franco, Sheila Diaz-Mora, Sandro Casavilca-Zambrano, Jose Cotrina-Concha, Mecker G Möller

{"title":"The Melanoma Divide: Hispanic Health Disparities From Peru to the United States.","authors":"Gabriel De la Cruz Ku, Gonzalo Ziegler-Rodriguez, Anshumi Desai, Luis Piedra Delgado, Jessica Farzan, Jiddu Guart, Michael Mallouh, Camila Franco, Sheila Diaz-Mora, Sandro Casavilca-Zambrano, Jose Cotrina-Concha, Mecker G Möller","doi":"10.1002/jso.70110","DOIUrl":"https://doi.org/10.1002/jso.70110","url":null,"abstract":"Introduction: Melanoma is a heterogeneous malignancy, the incidence of which has increased by 20% in the Hispanic population over the past two decades. We aimed to compare the clinical, pathological, and outcome-related characteristics of Hispanic patients with melanoma in Peru (HPP) versus the United States (HPUS).Methods: Two retrospective cohorts were evaluated: HPP diagnosed with melanoma at a tertiary institution in Lima-Peru and HPUS with melanoma registered in the Surveillance, Epidemiology, and End Results Program during the period 2010-2019.Results: A total of 1136 HPP and 5302 HPUS were included. HPP patients were older (61.17 vs. 56.63 years, p < 0.001), more likely to be male (51.5% vs. 39.6%, p < 0.001), and resided in nonmetropolitan areas (49.6% vs. 3.5%, p < 0.001). HPP had a higher prevalence of primary lesions in the lower extremities (75.5% vs. 36.9%, p < 0.001) and ulceration (65.3% vs. 21.3%, p < 0.001). Histologically, HPP most commonly presented with acral lentiginous melanoma (38.1%), while HPUS had a more superficial spreading type (30.8%, p < 0.001). HPP showed greater Breslow depth (mean: 7.66 vs. 1.51 mm, p < 0.001) and mitotic activity and were diagnosed at more advanced stages: stage III (36.5% vs. 15.0%, p < 0.001). With a median follow-up of 74 months, HPP exhibited worse 5-year overall survival (OS) rates across all stages versus HPUS.Conclusions: HPP with melanoma exhibit more aggressive pathological features than their HPUS counterparts and are diagnosed at more advanced stages, resulting in poorer OS rates across all stages, and being HPP is a prognostic factor of a worse OS. These findings emphasize the need for further research to deepen our understanding of the molecular factors influencing this diverse biological presentation in Hispanic populations.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excision Depth and Prognosis in T1-T3 Plantar Melanoma: Is Complete Excision of Plantar Fat Pad Necessary? T1-T3足底黑色素瘤的切除深度和预后：足底脂肪垫完全切除是必要的吗？

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-13 DOI: 10.1002/jso.70108

Kyeong-Tae Lee, Sungjin Kim, Goo-Hyun Mun

{"title":"Excision Depth and Prognosis in T1-T3 Plantar Melanoma: Is Complete Excision of Plantar Fat Pad Necessary?","authors":"Kyeong-Tae Lee, Sungjin Kim, Goo-Hyun Mun","doi":"10.1002/jso.70108","DOIUrl":"https://doi.org/10.1002/jso.70108","url":null,"abstract":"Background: While peripheral excision margins in cutaneous melanoma are well established, the optimal excision depth remains unclear. In plantar melanoma, the fat pad plays a key functional role, raising concerns about whether full excision is necessary for thin and intermediate-thickness lesions. This study evaluated the association between excision depth and oncologic outcomes in T1-T3 plantar melanoma.Methods: Patients with primary T1-T3 plantar melanoma who underwent wide excision between 2008 and 2022 were reviewed. They were grouped by excision depth: intra-adiposal (partial fat pad preservation) and suprafascial (complete removal). Oncologic and functional outcomes, assessed via the Foot Function Index (FFI), were compared.Results: Ninety-four patients (40 intra-adiposal, 54 suprafascial) were analyzed (median follow-up, 43 months). Tumor-free margins were achieved in all cases. Baseline characteristics were similar, except for lesion location. Recurrence rates were comparable, and excision depth was not significantly associated with recurrence-free survival. FFI scores from 26 patients (13 per group) tended to be better in the intra-adiposal group, though not statistically significant.Conclusions: In thin to intermediate-thickness plantar melanoma, intra-adiposal excision may be oncologically safe if tumor-free margins are achieved, potentially offering functional benefits without compromising oncologic outcomes.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study. 子宫内膜癌前哨淋巴结定位失败的预测因素：一项回顾性多中心研究。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-11 DOI: 10.1002/jso.70106

Cristina Taliento, Gennaro Scutiero, Giuseppe Cucinella, Vito Chiantera, Giovanni Pontrelli, Marko Klaric, Dragan Belci, Martin Steinkasserer, Stefano Restaino, Ruby Martinello, Orsola Brasile, Martina Arcieri, Sara Pregnolato, Giulia Pellecchia, Giulia Soraci, Rosa Taratufolo, Carmelia Milano, Marcello Desgro, Francesca Davià, Mariano Catello Di Donna, Dino Becic, Sara Notaro, Giuseppe Vizzielli, Pantaleo Greco

{"title":"Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study.","authors":"Cristina Taliento, Gennaro Scutiero, Giuseppe Cucinella, Vito Chiantera, Giovanni Pontrelli, Marko Klaric, Dragan Belci, Martin Steinkasserer, Stefano Restaino, Ruby Martinello, Orsola Brasile, Martina Arcieri, Sara Pregnolato, Giulia Pellecchia, Giulia Soraci, Rosa Taratufolo, Carmelia Milano, Marcello Desgro, Francesca Davià, Mariano Catello Di Donna, Dino Becic, Sara Notaro, Giuseppe Vizzielli, Pantaleo Greco","doi":"10.1002/jso.70106","DOIUrl":"https://doi.org/10.1002/jso.70106","url":null,"abstract":"Background and objectives: This study aims to evaluate the predictive factors associated with failed sentinel lymph node (SLN) mapping in a large, retrospective cohort of patients with early-stage endometrial cancer (EC).Methods: We retrospectively evaluated a series of EC patients who underwent laparoscopic SLN mapping with intracervical indocyanine green (ICG) injection in five referred oncological centers from January 2019 to March 2024. We compared the clinical and pathological features of bilateral and failed SLN mapping, which was defined as either unilateral mapping or no SLN mapping. Logistic regression was used to identify predictors of failure.Results: Among 623 analyzed patients, 437 (70.14%) had a successful bilateral procedure. On univariate analysis, age (p = 0.03), non-endometrioid histology (p = 0.02) and previous vaginal delivery (p = 0.015) were significant associated with failed SLN mapping. On multivariable analysis, only increasing age (OR 1.03; 95% CI, 1.01-1.04, p = 0.03) and non-endometrioid histology (OR 1.81; 95% CI, 1.01-3.19) were independently associated with unsuccessful procedure. No significant differences were observed for BMI, enlarged lymph nodes, intraoperative lysis of adhesion, LVSI, grade 3, and FIGO stage.Conclusions: Increasing age and non-endometrioid histology are independent predictors of bilateral SLN mapping failure in EC patients undergoing SLN mapping with cervical ICG injection.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid Biopsy in Metastatic Breast Cancer: Adoption Lags Despite Growing Evidence. 转移性乳腺癌的液体活检：尽管证据越来越多，但采用滞后。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-10 DOI: 10.1002/jso.70107

Kadri Altundag

引用次数: 0

Protocols, Complications, and Outcomes of Pressurized Intraperitoneal Aerosol Chemotherapy for Patients With Peritoneal Metastasis: A Systematic Review of the Literature. 腹膜转移患者的加压气雾化疗方案、并发症和结果：文献系统综述。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-10 DOI: 10.1002/jso.70109

Ian S Reynolds, William P Duggan, Nicholas P McKenna, Amit Merchea, Jürgen Mulsow

{"title":"Protocols, Complications, and Outcomes of Pressurized Intraperitoneal Aerosol Chemotherapy for Patients With Peritoneal Metastasis: A Systematic Review of the Literature.","authors":"Ian S Reynolds, William P Duggan, Nicholas P McKenna, Amit Merchea, Jürgen Mulsow","doi":"10.1002/jso.70109","DOIUrl":"https://doi.org/10.1002/jso.70109","url":null,"abstract":"Background: The use of pressurized intraperitoneal aerosol chemotherapy (PIPAC) is becoming more frequent for patients with unresectable peritoneal metastases. This systematic review explores the indications, protocols, feasibility, safety, oncological outcomes, patient reported outcomes and quality of life outcomes for patients being treated with PIPAC.Methods: A review of PubMed, Embase and the Cochrane Library was undertaken to identify studies pertaining to patients undergoing treatment with PIPAC. Clinicopathological characteristics, treatment protocols, safety data, treatment response data and outcome data were extracted from relevant studies and included in the analysis.Results: Data from 1980 patients undergoing 4454 PIPAC procedures for peritoneal metastases from a range of primary cancers was extracted. The treatment protocols identified were relatively homogenous across all studies. Grade 3/4 complications, grade 3/4 toxicity and procedure related mortality occurred infrequently. At least partial histological response was seen in 61.8% of patients. Overall survival for studies presenting data for mixed primary tumors ranged from 8 to 25 months. Quality of life and function were relatively stable throughout treatment.Conclusions: PIPAC is a safe and feasible treatment option for patients with peritoneal metastases. Ongoing studies are required to evaluate how it compares to best option standard of care chemotherapy.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Anesthesia in Surgical Oncology: Insights From the Literature and Clinical Considerations. 麻醉在外科肿瘤中的作用：来自文献和临床考虑的见解。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-08 DOI: 10.1002/jso.70105

Roberta Oliveira de Almeida, Eduardo Soares Rodrigues, Maria Thereza Palmieri Barbosa, Fabrício Tavares Mendonça, Ana Cristina Pinho Mendes Pereira, Catia Sousa Govêia, Larissa Goveia Moreira, Bruno Luís de Castro Araujo, Mauro Pereira de Azevedo, Alexandre Ferreira Oliveira, Rodrigo Nascimento Pinheiro

引用次数: 0

Marginal Resection Is Appropriate for Radical Surgery for Solitary Fibrous Tumours of the Pelvis: A High Volume Pelvic Exenteration Centre Experience. 边缘切除是骨盆孤立性纤维性肿瘤根治性手术的合适选择：大容量盆腔切除中心的经验。

IF 1.9 3区医学

Journal of Surgical Oncology Pub Date : 2025-10-02 DOI: 10.1002/jso.70103

Evonne Z Younan, Kilian G M Brown, David J Coker, Lylee Ye, Kirk K S Austin, Peter J Lee, Chris Byrne, Michael J Solomon

{"title":"Marginal Resection Is Appropriate for Radical Surgery for Solitary Fibrous Tumours of the Pelvis: A High Volume Pelvic Exenteration Centre Experience.","authors":"Evonne Z Younan, Kilian G M Brown, David J Coker, Lylee Ye, Kirk K S Austin, Peter J Lee, Chris Byrne, Michael J Solomon","doi":"10.1002/jso.70103","DOIUrl":"https://doi.org/10.1002/jso.70103","url":null,"abstract":"Solitary fibrous tumours (SFTs) are rare soft-tissue neoplasms with variable metastatic potential and a tendency to exhibit more aggressive behaviour in the pelvis. This study evaluated the outcomes of pelvic SFT resections using a marginal resection approach at a specialist sarcoma and pelvic oncology centre. Eighteen patients underwent resection of pelvic SFTs between 1994 and 2025. Fifteen (83%) cases required resection of adjacent pelvic structures, of which three (17%) patients underwent total pelvic exenteration to achieve complete resection or to facilitate surgical access. Clear (R0) margins were achieved in 69% of cases, although most were ≤ 1 mm (IQR: 0.30-4.75). Major complications occurred in two patients (11%), and there was no inpatient or 30-day mortality. After a median follow-up of 42 months, 14 of 15 surviving patients were disease-free and only 2 patients experienced recurrence. These findings suggest that pelvic SFTs may be safely resected with low recurrence using a marginal resection approach.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0