Journal of Surgical Oncology最新文献

{"title":"A Methodological and Survival Comparison of NCDB and SEER Database for Colon Cancer Research.","authors":"Metincan Erkaya, Ekin Inal, Cigdem Benlice, Mehmet Ayhan Kuzu, Emre Gorgun","doi":"10.1002/jso.28141","DOIUrl":"https://doi.org/10.1002/jso.28141","url":null,"abstract":"<p><strong>Background: </strong>The National Cancer Database (NCDB) and Surveillance, Epidemiology, and End Results (SEER) database are widely used in colon cancer research, particularly for analyzing overall survival (OS) rates. However, differences in demographics, treatment patterns, and survival outcomes across colon cancer stages and locations between these databases remain incompletely understood. Addressing these disparities is crucial for researchers when selecting the most appropriate registry for survival analysis.</p><p><strong>Objectives: </strong>This study aims to systematically compare patient characteristics, oncologic outcomes, and OS rates between NCDB and SEER across various tumor locations and disease stages in colon cancer.</p><p><strong>Methods: </strong>We analyzed patients undergoing surgery for Stages I-IV primary colon cancer (2004-2019), comparing patient characteristics, oncologic outcomes, and OS rates across distinct tumor locations and cancer stages in NCDB and SEER. Our objective was to assess how differences in database structure and sampling methodologies influence reported survival outcomes.</p><p><strong>Results: </strong>The study included 777 827 patients (NCDB: 572 196; SEER: 205 631). Proximal colon cancers were more common in older and female patients in both databases, whereas distal colon cancers were more prevalent in younger patients. NCDB contained a slightly higher proportion of Caucasian patients, while SEER had a greater representation of Asian patients. Segmental resections were more frequent in SEER, with the highest weighted difference observed in sigmoid colon cancer (6.16%; 95% CI: 5.78%-6.54%). OS rates were generally comparable across databases, though minor variations were observed at different colonic locations and stages.</p><p><strong>Conclusion: </strong>Despite differences in sampling techniques and follow-up reporting, NCDB and SEER demonstrated remarkable consistency in survival trends across colon cancer stages and locations. Recognizing these database-specific variations is essential for researchers conducting population-based survival analyses and selecting the most suitable registry for their studies. WHAT DOES THIS PAPER ADD TO THE LITERATURE?: This study provides a comprehensive comparison of NCDB and SEER, highlighting how differences in sampling methodologies, follow-up reporting, and patient representation influence overall survival estimates in colon cancer. It clarifies why prior studies report conflicting survival trends and offers a methodological framework for researchers selecting the most appropriate database for their analysis.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Anemia and Iron Deficiency in Elective Gastrointestinal Cancer Surgery Patients.","authors":"Yiwen Chen, Jie Zhou, Mengjiao Hu, Fangfang Tao","doi":"10.1002/jso.28164","DOIUrl":"https://doi.org/10.1002/jso.28164","url":null,"abstract":"","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comment on \"Development and Validation of a Predictive Score for Preoperative Detection of Lymphovascular Invasion in Rectal Cancer\".","authors":"Sameh Hany Emile, Steven D Wexner","doi":"10.1002/jso.28133","DOIUrl":"https://doi.org/10.1002/jso.28133","url":null,"abstract":"","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brazilian Society of Surgical Oncology (SBCO) Guidelines for the Treatment of Exocrine Pancreatic Insufficiency in Cancer Patients.","authors":"Rodrigo Nascimento Pinheiro, Anelisa Kruschewsky Coutinho, Pedro Eder Portari Filho, Felipe Henning Gaia Duarte, Marcos Gonçalves Adriano Junior, Guilherme de Andrade Gagheggi Ravanini, Felipe José Fernández Coimbra, Flavio Daniel Saavedra Tomasich, Fernando Ernesto Cruz Felippe, Rafael Oliveira Albagli, Alexandre Menezes de Brito, Heládio Feitosa E Castro Neto, Alexandre Ferreira Oliveira","doi":"10.1002/jso.28162","DOIUrl":"https://doi.org/10.1002/jso.28162","url":null,"abstract":"<p><p>Exocrine pancreatic insufficiency (EPI) in oncology patients requires careful attention due to its clinical significance and frequent underdiagnosis. This narrative review and Guideline established by the Brazilian Society of Surgical Oncology suggest a practical approach to diagnosis and pancreatic enzyme replacement therapy (PERT). This promising approach can improve symptoms, nutritional status, and quality of life, potentially positively impacting survival in unresectable pancreatic cancer and postsurgical settings.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fragmentation of Multimodal Rectal Cancer Care: A Population-Level Retrospective Cohort Study.","authors":"Tyler McKechnie, Alessandro Ricci, Kelly Brennan, Vanessa Wiseman, Victoria Shi, Adom Bondzi-Simpson, Katrina Knight, Weidong Kong, Ameer Farooq, Sunil V Patel","doi":"10.1002/jso.28163","DOIUrl":"https://doi.org/10.1002/jso.28163","url":null,"abstract":"<p><strong>Background: </strong>Locally advanced rectal cancer is often treated with multimodal therapy. Patients may receive care at a single institution or across multiple institutions. We designed this population-level retrospective cohort to determine the association between fragmented care and timeliness of treatment and long-term oncologic outcomes.</p><p><strong>Methods: </strong>Patients with stage II/III rectal cancer who received at least two treatment modalities between 2010 and 2019 in Ontario, Canada were included. Fragmented care was defined as receiving at least one treatment modality at two or more institutions, while nonfragmented care was defined as receiving all treatments at a single institution. The primary outcome was timeliness of treatment as defined by Cancer Care Ontario Recommendations. Secondary outcomes included overall survival (OS).</p><p><strong>Results: </strong>Overall, 3381 patients received fragmented care and 2026 patients received nonfragmented care. Patients receiving nonfragmented care were more likely to undergo timely initiation of treatment (OR: 1.72, 95% CI: 1.50-1.97, p < 0.0001). This was driven by timely initiation of chemotherapy (OR: 1.32, 95% CI: 1.16-1.49, p < 0.0001). There was little to no difference in OS (HR: 1.11, 95% CI: 0.95-1.30, p = 0.19).</p><p><strong>Conclusion: </strong>Patients with stage II/III rectal cancer receiving multimodal therapy may experience less timely initiation of treatment if their cancer care is fragmented. This did not translate into differences in long-term oncologic outcomes.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The Surgical Management of Intracranial Metastasis Secondary to Follicular Cell-Derived Thyroid Carcinoma\".","authors":"Heyue Zhang, Jin Xu, Xudong Zhu","doi":"10.1002/jso.28131","DOIUrl":"https://doi.org/10.1002/jso.28131","url":null,"abstract":"","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"R0 Resection Rates in Minimally Invasive Versus Open Pelvic Exenteration for Colorectal Malignancies: A Systematic Review and Meta-Analysis.","authors":"Ernest Cheng, Juanita Chui, Mina Sarofim, Jasmine Mui, Amit Sarkar, Zachary Bunjo, Andrew Gilmore, Assad Zahid","doi":"10.1002/jso.28149","DOIUrl":"https://doi.org/10.1002/jso.28149","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pelvic exenteration is a curative option for select patients with locally invasive or recurrent colorectal cancer. Achieving clear margins (R0 resection) is critical for optimal oncological outcomes and quality of life. Minimally invasive surgery (MIS), including laparoscopic and robotic approaches, offers advantages in visualisation and precision, but its feasibility is debated given data limitations. This meta-analysis compares outcomes of MIS with open pelvic exenteration for colorectal cancer.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted with studies comparing MIS to open approaches for pelvic exenteration in colorectal cancer included. The primary outcome was R0 resection rate, with secondary outcomes encompassing operative, postoperative, and oncological results.</p><p><strong>Results: </strong>Seven retrospective studies were analysed, including a total of 564 patients. Meta-analysis showed no significant difference in R0 resection rates between MIS and open approaches (RR = 0.74, 95% CI: 0.36, 1.51, p = 0.41) with low heterogeneity (I² = 19%). MIS had similar lymph node harvest, operative time, and postoperative complications but demonstrated significantly reduced intraoperative blood loss, shorter length of stay, and improved 3-year overall and disease-free survival rates.</p><p><strong>Conclusions: </strong>MIS achieves comparable R0 resection rates to open surgery in pelvic exenteration for colorectal cancer, with advantages in recovery and survival outcomes. Current evidence is limited by retrospective studies with selection bias requiring future standardised prospective trials.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Evaluation of Postoperative Anastomotic Patency in Lymphaticovenular Anastomosis Using Photoacoustic Imaging\".","authors":"Ruohui Huang, Liqin Gu","doi":"10.1002/jso.28158","DOIUrl":"https://doi.org/10.1002/jso.28158","url":null,"abstract":"","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Opioid-Sparing Efficacy of Different Regional Blocks After Open Pancreatoduodenectomy.","authors":"Yan-Hua Guo, Dan-Feng Wang, Fu-Shan Xue","doi":"10.1002/jso.28126","DOIUrl":"https://doi.org/10.1002/jso.28126","url":null,"abstract":"","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment On \"Impact of Neoadjuvant Immunotherapy on Postoperative Complications After Surgery for Rectal Cancer\".","authors":"Haiquan Shi, Huan Zou, Hongchao Zhu, Zuyin Ge, Sheng Li, Sun Jianli","doi":"10.1002/jso.27964","DOIUrl":"https://doi.org/10.1002/jso.27964","url":null,"abstract":"","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}