Journal of Surgical Oncology最新文献_第2页

Challenges of Treating Merkel Cell Carcinoma in Brazil.

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-26 DOI: 10.1002/jso.28104

Matheus de Melo Lobo, João Pedreira Duprat Neto, Milton José de Barros E Silva, Rodrigo Ramella Munhoz, Andreia Cristina de Melo, Rodrigo Nascimento Pinheiro, James A DeCaprio

引用次数: 0

Circulating Tumor DNA as a Marker of Recurrence Risk in Stage III Colorectal Cancer: The α-CORRECT Study.

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-25 DOI: 10.1002/jso.27989

Brenda Diergaarde, Greg Young, David W Hall, Amin Mazloom, Gina L Costa, Soma Subramaniam, Melanie R Palomares, Jorge Garces, Frederick L Baehner, Robert E Schoen

{"title":"Circulating Tumor DNA as a Marker of Recurrence Risk in Stage III Colorectal Cancer: The α-CORRECT Study.","authors":"Brenda Diergaarde, Greg Young, David W Hall, Amin Mazloom, Gina L Costa, Soma Subramaniam, Melanie R Palomares, Jorge Garces, Frederick L Baehner, Robert E Schoen","doi":"10.1002/jso.27989","DOIUrl":"https://doi.org/10.1002/jso.27989","url":null,"abstract":"Background and objectives: Identification of colorectal cancer (CRC) patients at high risk of recurrence could be of substantial clinical use. We evaluated the association of ctDNA status, using a tumor-informed assay, with recurrence-free survival (RFS).Methods: Stage III CRC patients were enrolled between 2016 and 2020. Tumor tissue and serial (every 3 months for years 1-3, biannually for years 4-5) blood samples were collected. Utilizing whole-exome sequencing and selection of 50-200 variants for tumor informed assays, ctDNA status was determined using plasma cell-free DNA.Results: Of 137 patients enrolled, 124 with 1029 ctDNA results were included in the analyses. Median follow-up was 4.8 years. Plasma ctDNA status was strongly associated with risk of recurrence during the surveillance period (hazard ratio (HR) 49.6, 95% CI: 16.6-148.3; p < 0.0001), and at the postsurgical (HR 9.6, 95% CI: 3.2-29.5) and postdefinitive therapy timepoints (HR: 16.7, 95% CI: 6.9-40.3). The estimated 3-year RFS for ctDNA positive and ctDNA negative patients were, respectively, 54.5% and 96.1% after surgery, and 18.2% and 90.0% after definitive therapy. Multivariable analysis indicated ctDNA but not CEA was strongly prognostic for recurrence.Conclusions: Our tumor-informed ctDNA assay was strongly prognostic for recurrence in patients with stage III colorectal cancer at all timepoints.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Molecular Residual Disease Using ctDNA.

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-25 DOI: 10.1002/jso.28027

Stephen F Sener

引用次数: 0

Comment On: "Comparison of Reconstructive Techniques for Nonprimary Malignancies in the Proximal Humerus".

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-22 DOI: 10.1002/jso.28091

Changzong Deng, Jiahui Li

引用次数: 0

Comment on "Combined Autologous Breast Reconstruction and Gynecologic Procedures: Does Timing Affect Clinical and Patient-Reported Outcomes?"

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-22 DOI: 10.1002/jso.28100

Wei Liu, Yuwei Yang

引用次数: 0

Disparities in Access to Care in the Multimodal Treatment of Primary Nonmetastatic Liver Cancers and Their Impact on Patient Outcomes.

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-22 DOI: 10.1002/jso.28065

McKenzie Hargis, Denise Danos, Hannah R Malinosky, Aimée Galatas, Syndey McManus, Ann Byerley, Mohammad Al Efishat, John M Lyons, Kevin Sullivan, Omeed Moaven

{"title":"Disparities in Access to Care in the Multimodal Treatment of Primary Nonmetastatic Liver Cancers and Their Impact on Patient Outcomes.","authors":"McKenzie Hargis, Denise Danos, Hannah R Malinosky, Aimée Galatas, Syndey McManus, Ann Byerley, Mohammad Al Efishat, John M Lyons, Kevin Sullivan, Omeed Moaven","doi":"10.1002/jso.28065","DOIUrl":"https://doi.org/10.1002/jso.28065","url":null,"abstract":"Background: Liver cancer incidence and mortality have been shown to differ by race, ethnicity, and geography. This study aims to analyze disparities in the multimodal treatment of liver cancers in Louisiana.Methods: Cases of nonmetastatic liver cancer in Louisiana from 2010 to 2020 were obtained from the Louisiana Tumor Registry. Generalized linear mixed models were used to model the receipt of therapy.Results: A total of 2948 patients met inclusion criteria where 30.5% received no therapy. Multivariable models identified patients with increased odds of pursuing no treatment which include those 70 and older, no domestic partner, uninsured, high poverty, and rural residence (p < 0.05).Conclusions: Available therapeutic modalities are underutilized in Louisiana with a considerable number of patients receiving no treatment for liver cancer. Older age, no domestic partner, uninsured, rural residence, and high poverty are risk factors for not receiving treatment. Allocating resources to these patients is an important step in reversing inequities.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorectal Cancer Surgery at a Regional Cold Site Centre During the SARS-CoV-2 Pandemic: A Comparison With Prepandemic Practices. SARS-CoV-2大流行期间区域冷场中心的结直肠癌手术：与大流行前的做法比较

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-21 DOI: 10.1002/jso.28094

Mattias Soop, Kajsa Anderin, Erik Syk, Jonas Nygren, Josefin Segelman

{"title":"Colorectal Cancer Surgery at a Regional Cold Site Centre During the SARS-CoV-2 Pandemic: A Comparison With Prepandemic Practices.","authors":"Mattias Soop, Kajsa Anderin, Erik Syk, Jonas Nygren, Josefin Segelman","doi":"10.1002/jso.28094","DOIUrl":"https://doi.org/10.1002/jso.28094","url":null,"abstract":"Introduction: Stockholm, Sweden had among the highest excess mortality rates during the first wave of the SARS-CoV-2 pandemic. In March 2020, an entire hospital implemented an infection-free cold site infrastructure and scaled up imperative mainly colorectal cancer surgery, for the Stockholm health care region. The study evaluated the efficacy of the concept.Methods: Strict preadmission screening and prophylactic interventions were implemented. The outcomes of the cold site cohort (30th March-21st June 2020) were compared to a prepandemic control. Population-based data on colorectal cancer patients were collected from the Swedish Colorectal Cancer Registry.Results: There were 107 patients in the cold site cohort and 109 in the control cohort. None developed COVID-19 within 30 days postoperatively. The proportions of pelvic and laparoscopic surgery were similar. The cold site cohort had more potentially avoidable stomas (32/94 (34%) vs 19/91 (21%), p = 0.0442). In the region, the proportion of colorectal cancer resections at the cold site increased from prepandemic 12.9% (58 of 448) to 43.3% (94 of 217) (p < 0.001).Conclusion: A SARS-CoV-2-cold site can be kept infection-free by screening, allowing increased volumes of colorectal cancer surgery with outcomes comparable to prepandemic practice. The cold site model should be more widely adopted in future similar scenarios.Summary: This study reports on the implementation of an entire cold site hospital for imperative colorectal surgery, in particular colorectal cancer, during the SARS-CoV-2 pandemic. By comparing outcomes to prepandemic practices, we demonstrated that the cold site hospital was effective in preventing infection and safely increasing surgical volume many-fold.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host Index and Gallbladder Cancer: An Emerging Prognostic Biomarker. 宿主指数与胆囊癌：一种新兴的预后生物标志物。

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-20 DOI: 10.1002/jso.28097

Abhay K Kattepur, Muffadal Kazi, Shraddha Patkar, Mahesh Goel

{"title":"Host Index and Gallbladder Cancer: An Emerging Prognostic Biomarker.","authors":"Abhay K Kattepur, Muffadal Kazi, Shraddha Patkar, Mahesh Goel","doi":"10.1002/jso.28097","DOIUrl":"https://doi.org/10.1002/jso.28097","url":null,"abstract":"Background and objectives: There is emerging evidence that host related variables predict outcomes in various cancers. The Host index (H-index) incorporates various host-related, blood-derived biomarkers (immunological and nutritional parameters) as a single mathematical formula. The aim of this study was to evaluate outcomes using the H-index as a prognostic marker in gallbladder cancer (GBC) patients undergoing curative resection.Methods: Retrospective cohort study of surgically treated GBCs at a tertiary cancer centre from January 2010 to May 2023 was performed. Patients who had received neoadjuvant therapy, metastatic (M1) disease at time of surgical exploration and incidental GBCs were excluded. Baseline neutrophil, lymphocyte, monocyte and platelet counts, hemoglobin and albumin levels were recorded. H-index was computed and analysed.Results: 241 curatively resected GBC patients were included. The H-index was inversely associated with disease free survival (DFS), both on univariate (79.7 vs. 61.4% for H-index </= 1.3 and > 3.4 respectively; p = 0.046) and multivariate analysis (Hazard ratio [HR] for recurrence: 1.954 [95% C.I.: 1.366-2.796]; p = < 0.001). Using the maximally distributed rank statistics, a cut-off of 1.31 showed a significant difference in 3-year DFS (86.2 vs. 68.4% for H-index </= 1.31 vs. > 1.31 respectively; HR: 2.21 [95% CI: 1.16-4.21]; p = 0.013) but not overall survival (OS) (p = 0.269).Conclusion: A higher H-index predicted for worse DFS in curatively resected GBC patients. This shows host related variables do play a role in influencing outcomes in GBC. However, larger prospective studies are required to further strengthen this finding.Summary: Host-related, blood derived biomarkers can influence outcomes in various solid tumours. A higher baseline Host index (H-index) value which incorporates various blood-derived biomarkers, predicted for worse disease-free survival in curatively resected gallbladder cancers.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of Staging Laparoscopy for Patients With Gastric Cancer in Ukraine. 乌克兰胃癌分期腹腔镜检查的应用

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-19 DOI: 10.1002/jso.28095

Oleksii Dobrzhanskyi, Cameron E Gaskill, Darya Kizub, Yurii Kondratskyi, Andrii Horodetskyi, Nelya Melnitchouk, Mykyta Pepenin

{"title":"Utilization of Staging Laparoscopy for Patients With Gastric Cancer in Ukraine.","authors":"Oleksii Dobrzhanskyi, Cameron E Gaskill, Darya Kizub, Yurii Kondratskyi, Andrii Horodetskyi, Nelya Melnitchouk, Mykyta Pepenin","doi":"10.1002/jso.28095","DOIUrl":"https://doi.org/10.1002/jso.28095","url":null,"abstract":"Background: The use of advanced diagnostic methods, such as high-resolution CT or PET-CT scans, are limited in low and middle-income countries (LMICs). In gastric cancer, occult peritoneal disease may be present in up to 20% of cases, limiting the benefits of surgical resection. Accurate staging of gastric cancer is essential to ensure optimal patient management and prevent undue morbidity from unnecessary surgery. Our study evaluated the diagnostic accuracy and safety of staging laparoscopy (SL) versus computed tomography (CT) in detecting peritoneal metastases for gastric cancer in Ukraine.Methods: Patients who underwent SL between October 2017 and October 2022 were retrospectively reviewed. SL was performed for each newly diagnosed patient with gastric cancer without evidence of distant metastases, except when peritoneal carcinomatosis was in question. Pathological findings at SL were compared with initial CT reports, and analysis of the sensitivity and specificity for SL was performed.Results: Of 516 patients undergoing SL, 410 had no radiological considerations for distant metastases. Among them, radiographically occult peritoneal metastatic disease was found in 134 (32.7%). Overall SL sensitivity for peritoneal metastases was 90.6% (95% confidence interval [CI]: 85.8%-94.1%) and specificity 100.0% (95% CI: 98.8%-100.0%). Complications after SL occurred in 5 (1%) of patients. No mortality was associated with SL.Conclusion: SL is a safe and effective method to evaluate the presence of peritoneal disease in patients with gastric cancer. This method may be appropriate for LMICs, where availability of advanced imaging technologies is limited.","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Association of Preoperative Physical Fitness With Post-Esophagectomy Pneumonia in Older Patients With Locally Advanced Esophageal Cancer: An Exploratory Prospective Study". 对“老年局部晚期食管癌患者食管切除术后肺炎与术前体能的相关性：一项探索性前瞻性研究”的评论。

IF 2 3区医学

Journal of Surgical Oncology Pub Date : 2025-01-15 DOI: 10.1002/jso.28096

Wei Liu

引用次数: 0