Journal of Surgical Oncology最新文献

{"title":"Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis","authors":"Alice Zhu,&nbsp;Chloe Wong,&nbsp;Neill K. J. Adhikari,&nbsp;Ka Yan Ip,&nbsp;Alyson Mahar,&nbsp;Amy T. Hsu,&nbsp;Julie Hallet,&nbsp;Natalie Coburn","doi":"10.1002/jso.70303","DOIUrl":"10.1002/jso.70303","url":null,"abstract":"<p>Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We conducted a systematic review and meta-analysis of studies that developed, validated, or updated clinical prognostic tools to predict survival in adults with primary GIST, identifying 47 eligible studies (38 development and 9 validation studies). Meta-analyses were performed to assess performance in external validation cohorts. The MSKCC nomogram was most frequently validated, with a pooled C-statistic of 0.78 for recurrence-free survival.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"359-382"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jso.70303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“It Depends on the Situation”: Variability in How Surgical Oncologists Elicit and Integrate Patient Values","authors":"Jacquelyn E. F. Speer,&nbsp;Avery C. Bechthold,&nbsp;Olivia Monton,&nbsp;Anna Newcomb,&nbsp;J. Nicholas Odom,&nbsp;Kimberly E. Kopecky","doi":"10.1002/jso.70312","DOIUrl":"10.1002/jso.70312","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Understanding what matters most to patients is central to person-centered care, particularly in surgical oncology, where decisions often involve significant tradeoffs. We explored how surgeons elicit, integrate, document, and support patient values in cancer-related decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This qualitative descriptive study involved semi-structured interviews with surgical oncologists (June–September 2025). Participants were purposively sampled from a prior international survey to ensure variation in demographics. Interviews were recorded, transcribed, and analyzed using thematic analysis. Participant characteristics were summarized descriptively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fourteen surgeons participated. Most were male (71%), White (86%), and early-career (43%), practicing primarily in gastrointestinal or hepatobiliary surgery (each 43%) at academic centers (57%) in the U.S. South or Midwest (each 36%). Surgeons described various approaches to eliciting values, including inferring values from contextual clues and clarifying tradeoffs between survival and quality-of-life. Values elicitation was largely situational, occurring in high-risk or preference-sensitive contexts. When values conflicted with recommendations, surgeons adapted plans within oncologic safety. Documentation varied and was shaped by relevance, medicolegal concerns, and workflow. Barriers included time limitations, emotional distress, family dynamics, and limited training.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Values elicitation was inconsistent and situational rather than routine. More structured, earlier approaches and system-level support may better align surgical decisions with patient values.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"458-465"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jso.70312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How I Do It: The Life and Work of a Rubber Band in Robotic Liver Parenchymal Transection","authors":"Yifan Wang,&nbsp;Caroline J. Simon,&nbsp;Yee Lee Cheah","doi":"10.1002/jso.70311","DOIUrl":"10.1002/jso.70311","url":null,"abstract":"<div>\u0000 \u0000 <p>Liver retraction is critical for safe and efficient robotic liver transection. Conventional methods often require additional instruments, tacking sutures or continuous bedside assistance. This “How I Do It” article presents our double rubber band technique, which enables stable, hands-free retraction during robotic liver transection. We provide a video demonstration of our standard retraction technique for hemihepatectomy and describe adaptations for complex resections.</p>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"455-457"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distance to Care, Regional Context, and Survival in Early-Onset Colorectal Cancer","authors":"Sara Myers,&nbsp;Elizabeth S. Davis,&nbsp;Sing Chau Ng,&nbsp;Teviah Sachs,&nbsp;Jennifer S. Davids,&nbsp;Kelly M. Kenzik","doi":"10.1002/jso.70307","DOIUrl":"10.1002/jso.70307","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite an overall decrease in colorectal cancer (CRC) mortality in recent decades, incidence and mortality of CRC among individuals younger than 50 (early onset CRC; EOCRC) has increased. Individual and population-level exposures contribute to EOCRC, but it is not clear how rurality and traveling for care impact survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using the National Cancer Database (NCDB, 2010–2022), we (1) characterized and compared the EOCRC population to the average-onset (AOCRC) population, and (2) analyzed individual and population-level sociodemographic and clinical factors associated with 5-year survival. We used accelerated failure-time models; hazard ratios (HR) and 95% confidence intervals (CI) are reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 404,440 individuals with CRC (15.7% EOCRC), more EOCRC patients were non-white (32.2% vs. 24.6%; <i>p</i> &lt; 0.001), had rectal cancer (43% vs. 34%; <i>p</i> &lt; 0.001), and presented at later stages compared to AOCRC patients. EOCRC patients traveled farther for care overall, and rural EOCRC patients with rectal cancer traveled farthest of any group (median 41.7 miles). In adjusted EOCRC survival models, compared to urban patients traveling for care, survival was worse for urban patients who did not travel (HR 1.09, 95% CI 1.05–1.12) and rural patients regardless of travel (rural, traveled: HR 1.12, 95% CI 1.07–1.18; rural, no travel: HR 1.16, 95% CI 1.09–1.22).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>EOCRC individuals living in urban areas experienced improved survival when traveling farther for care, though their rural counterparts did not necessarily gain the same survival benefit by traveling. Using exposures and health behaviors to guide screening beyond age-based guidelines could improve early detection and survival.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"403-412"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Paradigms of Cancer Require New Language: A Qualitative Study Exploring Language for Non-Curative Non-Palliative Cancer Surgery","authors":"Bonnie O. Wong,&nbsp;Orly N. Farber,&nbsp;Amanda J. Reich,&nbsp;Zara R. Cooper,&nbsp;Jennifer W. Mack,&nbsp;Thomas E. Clancy,&nbsp;Chandrajit P. Raut,&nbsp;Elizabeth J. Lilley","doi":"10.1002/jso.70306","DOIUrl":"10.1002/jso.70306","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Methods</h3>\u0000 \u0000 <p>Cancer interventions are traditionally described as either “curative” or “palliative,” but evolving cancer biology and new treatments have transformed some cancers into chronic diseases where surgery plays a non-curative, disease-targeted role. We conducted semi-structured interviews with cancer surgeons via purposive snowball sampling, exploring two hypothetical scenarios and discussing “disease-control” surgery as a category of neither palliative nor curative surgical intent. Interviews were thematically analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighteen surgeons from 16 US institutions described how evolving cancer treatment paradigms challenge existing language for surgical intent. “Disease-control” surgery captured new adjuvant surgical roles including debulking to improve systemic therapy efficacy, resection of treatment-resistant disease, and “resetting the clock” for indolent tumors. Surgical goals are increasingly defined by individual patients' broader multidisciplinary treatment trajectory.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Traditional “curative” versus “palliative” categories inadequately describe contemporary cancer surgery. New frameworks aligned with current understandings of cancer biology and new treatment modalities may facilitate clearer communication about surgical goals and enable developing appropriate research outcome measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>These findings highlight a need for standardized surgical intent terminology. Broader validation through multidisciplinary stakeholder engagement is needed to refine and implement this proposed framework.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"413-421"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis of Resection Sequence in Synchronous Colorectal Liver Metastasis: Primary vs. Liver First","authors":"Sofoklis Mavrantonis,&nbsp;Omar Abou El-Wafa,&nbsp;Sascha Vaghiri,&nbsp;Dimitrios Prassas","doi":"10.1002/jso.70309","DOIUrl":"10.1002/jso.70309","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This present systematic review and meta-analysis aims to compare overall survival (OS), disease-free survival (DFS), morbidity and mortality outcomes in patients undergoing colorectal first (CRf) versus liver first (Lf) resections with synchronous colorectal liver metastases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>A literature search was performed in PubMed, Cochrane Central trials register, and Google Scholar databases. This was conducted in line with current PRISMA guidelines. 95% confidence intervals were calculated for the primary endpoints and odds ratios for secondary endpoints. The Cochrane <i>Q</i> test and the measurement of inconsistency test were used to assess the degree of heterogeneity among the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifteen studies were included with a total of 8611 patients from 2010 to 2025. A statistically significant survival benefit was seen in the overall 1-year survival of the CRf group compared to the Lf group, with no significant difference in 3- and 5-year follow-up. In addition, a statistically significant benefit in 1-, 3-, and 5- year DFS rates was seen in the CRf group when compared to the Lf group. No significant difference was seen in major morbidity and 90-day mortality, and failure to proceed to the second resection stage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DFS was significantly increased in the CRf group compared to the Lf group, with no difference in secondary outcomes. One-year OS was also found to be higher in the CRf group; however, this finding likely reflects the heterogeneity of the included studies and perioperative course after hepatic resections. To our knowledge, this is the first meta-analysis to demonstrate such a significant difference of one strategy over the other. However, caution should be used in the interpretation of these results due to the lack of available randomized control trials.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"444-454"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jso.70309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazilian Society of Surgical Oncology Analysis in Cost-Effectiveness of Population-Based BRCA Testing for Ovarian Cancer in the Public Health System","authors":"Alexandre Ferreira Oliveira,&nbsp;Antonio Abílio Pereira de Santa Rosa,&nbsp;Audrey Tieko Tsunoda,&nbsp;Bruno Roberto Braga Azevedo,&nbsp;Erika Martins de Carvalho,&nbsp;Glauco Baiocchi,&nbsp;Jorge Soares Lyra,&nbsp;Paulo Henrique de Sousa Fernandes,&nbsp;Renato Morato Zanatto,&nbsp;Reitan Ribeiro,&nbsp;René Aloisio da Costa Vieira,&nbsp;Rodrigo Conrado de Lorena Medeiros,&nbsp;Rodrigo Nascimento Pinheiro,&nbsp;Rosilene Jara Reis,&nbsp;Vandré Cabral Gomes Carneiro,&nbsp;Viviane Rezende e Oliveira","doi":"10.1002/jso.70302","DOIUrl":"10.1002/jso.70302","url":null,"abstract":"<div>\u0000 \u0000 <p>Although ovarian cancer is the most lethal among gynecological cancers, access to massive BRCA testing is still limited. Its cost-effectiveness is still a topic of discussion in several countries. In Brazil, olaparib was recently incorporated into the public health system, access to BRCA testing is still limited. In this article, we aim to review the cost-effectiveness of offering BRCA testing to the at-risk population. A working group composed of 14 specialists in surgical oncology and cancer genetics was established to discuss the cost-effectiveness of population-based BRCA testing for ovarian cancer. The project was divided into five main areas, each with subtopics assigned among the 14 participants. They were: the existing clinical testing guidelines, the current healthcare infrastructure in the Brazilian public health system, cost-effectiveness analysis, challenges in implementing prophylactic surgeries, and family counseling and risk communication. A comprehensive literature review was conducted, followed by a series of meetings among the article's contributors to reach consensus on unresolved issues. These discussions aimed to build recommendations based on the best available scientific evidence. Using as a basis the current structure already existing within the Brazilian public health service (SUS [Sistema Único de Saude]), and based on the testing of the at-risk population chosen by our experts, we estimated savings. The net savings for a population of 100 000 women would range from BRL 7030.30 (US$1255.41) to BRL 1853.92 (US$331.05). And these costs could have an even greater impact when public service PARP inhibitors are incorporated. The working group of the Brazilian Society of Surgical Oncology understands that large-scale BRCA testing is cost-effective, especially when risk-reducing surgery is implemented. Other measures are important, such as training teams of non-specialists to recognize the population at risk, in addition to creating an entire line of care for patients with ovarian cancer in the SUS.</p></div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"337-348"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology and Pathophysiology of 10 Different Types of Peritoneal Metastases","authors":"Paul H. Sugarbaker,&nbsp;John J. Liang","doi":"10.1002/jso.70301","DOIUrl":"10.1002/jso.70301","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Predictions concerning the natural history of peritoneal surface malignancy may be available from the study of the sites of cancer progression on the peritoneal surface. As a first step to identify useful clinical and histopathological correlations the multiple morphologic types of peritoneal metastases must be identified and a meaningful nomenclature associated with each type.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The morphological types were selected from their appearance on peritoneal surfaces. Both open and laparoscopic observations and photographs were utilized. The pathophysiology that was responsible for the lesion's appearance was an important consideration in separating the numerous shapes and sizes into specific morphologic types.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>As an initial step peritoneal lesions were separated into raised types and flat types. Line drawings of each of the 10 morphologic types were constructed and a single illustrative photograph associated with each morphologic type. A description of the pathophysiology of each type was contained within the text.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ten morphologic types of peritoneal surface malignancies were selected, illustrated and provided with a definitive nomenclature. The pathophysiology of each type was presented. These morphologic types are considered the starting place for further study of morphology in the prediction of outcome of peritoneal metastases treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"349-358"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncologic Outcomes After Liver Transplantation for Unresectable Colorectal Liver Metastases: A Systematic Review and Meta-Analysis of Proportions","authors":"Bernardo Fontel Pompeu,&nbsp;Lorrany Ramos Aguiar,&nbsp;Giuliana Daneluci Melillo,&nbsp;Laryssa Santana Nakabayashi,&nbsp;Gabriel Leal Barone,&nbsp;Lucas Monteiro Delgado,&nbsp;Claudia Theis,&nbsp;Leonardo de Melo Del Grande,&nbsp;Sérgio Mazzola Poli de Figueiredo,&nbsp;Fernanda Bellotti Formiga,&nbsp;Alexsander Kuroiwa Bressan","doi":"10.1002/jso.70310","DOIUrl":"10.1002/jso.70310","url":null,"abstract":"<div>\u0000 \u0000 <p>Liver transplantation has emerged as a therapeutic option for highly selected patients with unresectable colorectal liver metastases (CRLM). This review evaluated oncologic and perioperative outcomes in 92 patients who underwent transplantation. One- and 3-year overall survival (OS) were 96.32% and 73.07%, respectively. Disease-free survival (DFS) was lower, with high rates of recurrence. Major complications occurred in 39.36%, and 90-day mortality was 1.03%. Further randomized studies are needed to better define the role of liver transplantation and optimize patient selection criteria</p></div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"422-433"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehabilitation Prior to Colorectal Cancer Surgery: Impact and Implementation","authors":"Elize W. Lockhorst,&nbsp;Theresia A. M. Backhuijs,&nbsp;Teun M. E. Kerkhoff,&nbsp;Robert R. J. Coebergh van den Braak,&nbsp;Ninos Ayez,&nbsp;Cornelis Verhoef,&nbsp;Paul D. Gobardhan,&nbsp;Jennifer M. J. Schreinemakers","doi":"10.1002/jso.70305","DOIUrl":"10.1002/jso.70305","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>Multimodal prehabilitation aims to improve surgical outcomes and preoperative fitness in patients undergoing surgery for colorectal cancer (CRC). This study evaluated implementation of a standardised prehabilitation programme for elective CRC surgery, assess its impact, and identify pitfalls and challenges during implementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective single-centre study, all CRC patients scheduled for resection between January 2022 and April 2024 were included. Since May 2023, standardised multimodal prehabilitation was introduced. Before, patients received physiotherapy and a dietician if indicated, although this was not routinely offered. Patients were divided into a prehabilitation and non-prehabilitation group. Clinical data, prehabilitation details, and physiotherapy results were collected from patient charts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 401 patients, 198 (49%) underwent prehabilitation. Participation increased after standardisation (40% vs. 59%, <i>p</i> &lt; 0.001). Strength and physical fitness improved significantly (leg press 100 vs. 135 kg; steep ramp 160 vs. 213 W; <i>p</i> &lt; 0.001). Patients in the non-standardised programme experienced a significantly longer postoperative hospital stay than those in standardised programme (4 vs. 3 days, <i>p</i> = 0.010). Despite more comorbidities in prehabilitated patients, complication rates were similar between patients without and with prehabilitation (28% vs. 24%, <i>p</i> = 0.45).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Standardised prehabilitation appears beneficial and safe, improving participation, referral justification and outcomes, particularly in high-risk colorectal cancer patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"134 3","pages":"434-443"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jso.70305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}