Association Between Mesorectal Grade and Oncologic Outcomes in Rectal Cancer: A Systematic Review and Meta-Analysis.

IF 1.9 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-07-11 DOI:10.1002/jso.70038

Peter Rogers, Justin Dourado, Sameh Hany Emile, Anjelli Wignakumar, Zachary Delgado, Pauline Aeschbacher, Zoe Garoufalia, Victor Strassmann, Steven D Wexner

引用次数: 0

Abstract

We aimed to clarify the impact of TME grading on recurrence and survival. PubMed and Scopus were searched. The main outcome measures were local and distant recurrence and overall survival. Ten studies (2002-2023) were analyzed. Patients with incomplete TME exhibited lower overall survival (HR 0.75, p = 0.044) and higher local (RR 3.09, p = 0.001) and distant (RR 1.44, p = 0.005) recurrence rates compared to complete/near-complete TME. Complete and near-complete TME had similar risk of local recurrence, distant metastasis, and overall survival. This meta-analysis supports the crucial role of TME in rectal cancer outcomes.

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直肠癌肠系膜分级与肿瘤预后的关系：一项系统综述和荟萃分析。

我们的目的是阐明TME分级对复发和生存的影响。检索PubMed和Scopus。主要观察指标为局部和远处复发及总生存期。10项研究（2002-2023）进行了分析。与完全/接近完全TME相比，不完全TME患者的总生存率较低（HR 0.75, p = 0.044），局部（RR 3.09, p = 0.001）和远处（RR 1.44, p = 0.005）复发率较高。完全和接近完全TME具有相似的局部复发、远处转移和总生存风险。这项荟萃分析支持TME在直肠癌预后中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.