Socioeconomic Influences on Melanoma Incidence Patterns by Stage in the US

IF 1.9 3区 医学 Q3 ONCOLOGY
Trisha Lal, Weichuan Dong, Siran M. Koroukian, Natalie N. Chakraborty, Luke D. Rothermel, Richard S. Hoehn
{"title":"Socioeconomic Influences on Melanoma Incidence Patterns by Stage in the US","authors":"Trisha Lal,&nbsp;Weichuan Dong,&nbsp;Siran M. Koroukian,&nbsp;Natalie N. Chakraborty,&nbsp;Luke D. Rothermel,&nbsp;Richard S. Hoehn","doi":"10.1002/jso.70036","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Objectives</h3>\n \n <p>Melanoma is one of the fastest-growing cancers in the United States, with nearly 100% 5-year survival for early-stage disease compared to 35% for late-stage disease. Regional studies suggest that areas with increased early-stage melanoma diagnoses may not experience a reduction in late-stage cases, raising questions about the effectiveness of early detection. We hypothesize that higher socioeconomic status (SES) will correlate with increased early-stage melanoma without a decrease in late-stage disease, with geographic variation across US regions.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This cross-sectional study used SEER data to analyze 829 391 non-Hispanic White patients diagnosed with melanoma between 2004 and 2021, including 725 077 with early-stage (in situ/localized) and 104 314 with late-stage (regional/distant) disease. Regression models evaluated associations between county-level stage-specific melanoma incidence and population characteristics, including SES, ultraviolet exposure, agricultural employment, and rural-urban status.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Higher SES counties had higher early-stage melanoma incidence without a reduction in late-stage incidence. Counties in the West and South had increased odds of early-stage melanoma, while rural counties exhibited lower melanoma incidence across stages. Agricultural employment and ultraviolet exposure were not consistently associated with melanoma incidence.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Findings suggest early- and late-stage melanoma may represent distinct diseases. Screening may aid in early detection, but its impact on reducing late-stage disease and mortality remains uncertain.</p>\n </section>\n </div>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":"132 3","pages":"465-472"},"PeriodicalIF":1.9000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jso.70036","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jso.70036","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and Objectives

Melanoma is one of the fastest-growing cancers in the United States, with nearly 100% 5-year survival for early-stage disease compared to 35% for late-stage disease. Regional studies suggest that areas with increased early-stage melanoma diagnoses may not experience a reduction in late-stage cases, raising questions about the effectiveness of early detection. We hypothesize that higher socioeconomic status (SES) will correlate with increased early-stage melanoma without a decrease in late-stage disease, with geographic variation across US regions.

Methods

This cross-sectional study used SEER data to analyze 829 391 non-Hispanic White patients diagnosed with melanoma between 2004 and 2021, including 725 077 with early-stage (in situ/localized) and 104 314 with late-stage (regional/distant) disease. Regression models evaluated associations between county-level stage-specific melanoma incidence and population characteristics, including SES, ultraviolet exposure, agricultural employment, and rural-urban status.

Results

Higher SES counties had higher early-stage melanoma incidence without a reduction in late-stage incidence. Counties in the West and South had increased odds of early-stage melanoma, while rural counties exhibited lower melanoma incidence across stages. Agricultural employment and ultraviolet exposure were not consistently associated with melanoma incidence.

Conclusion

Findings suggest early- and late-stage melanoma may represent distinct diseases. Screening may aid in early detection, but its impact on reducing late-stage disease and mortality remains uncertain.

Abstract Image

Abstract Image

美国社会经济对黑色素瘤分期发病模式的影响
背景和目的:黑色素瘤是美国增长最快的癌症之一,早期疾病的5年生存率接近100%,而晚期疾病的5年生存率为35%。区域性研究表明,早期黑色素瘤诊断增加的地区,晚期病例可能不会减少,这引发了对早期发现有效性的质疑。我们假设,较高的社会经济地位(SES)与早期黑色素瘤的增加有关,而与晚期疾病的减少有关,但在美国各地区存在地理差异。方法:本横断面研究使用SEER数据分析了2004年至2021年间诊断为黑色素瘤的829391例非西班牙裔白人患者,其中725077例为早期(原位/局部),1040314例为晚期(局部/远处)疾病。回归模型评估了县级特定阶段黑色素瘤发病率与人口特征之间的关系,包括社会经济地位、紫外线照射、农业就业和城乡状况。结果:高SES县有较高的早期黑色素瘤发病率,但没有降低晚期发病率。西部和南部的县患早期黑色素瘤的几率增加,而农村县在各个阶段的黑色素瘤发病率都较低。农业就业和紫外线照射与黑色素瘤发病率并不一致。结论:研究结果提示早期和晚期黑色素瘤可能代表不同的疾病。筛查可能有助于早期发现,但其对减少晚期疾病和死亡率的影响仍不确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.70
自引率
4.00%
发文量
367
审稿时长
2 months
期刊介绍: The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信