Trisha Lal, Weichuan Dong, Siran M. Koroukian, Natalie N. Chakraborty, Luke D. Rothermel, Richard S. Hoehn
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引用次数: 0
Abstract
Background and Objectives
Melanoma is one of the fastest-growing cancers in the United States, with nearly 100% 5-year survival for early-stage disease compared to 35% for late-stage disease. Regional studies suggest that areas with increased early-stage melanoma diagnoses may not experience a reduction in late-stage cases, raising questions about the effectiveness of early detection. We hypothesize that higher socioeconomic status (SES) will correlate with increased early-stage melanoma without a decrease in late-stage disease, with geographic variation across US regions.
Methods
This cross-sectional study used SEER data to analyze 829 391 non-Hispanic White patients diagnosed with melanoma between 2004 and 2021, including 725 077 with early-stage (in situ/localized) and 104 314 with late-stage (regional/distant) disease. Regression models evaluated associations between county-level stage-specific melanoma incidence and population characteristics, including SES, ultraviolet exposure, agricultural employment, and rural-urban status.
Results
Higher SES counties had higher early-stage melanoma incidence without a reduction in late-stage incidence. Counties in the West and South had increased odds of early-stage melanoma, while rural counties exhibited lower melanoma incidence across stages. Agricultural employment and ultraviolet exposure were not consistently associated with melanoma incidence.
Conclusion
Findings suggest early- and late-stage melanoma may represent distinct diseases. Screening may aid in early detection, but its impact on reducing late-stage disease and mortality remains uncertain.
期刊介绍:
The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.