Journal of Sleep Research最新文献

{"title":"EEG Brain Rhythms During Resting-State Wakefulness and Sleep in Elderly Expert Meditators.","authors":"Pierre Champetier, Anaïs Hamel, Claire André, Valentin Ourry, Tristan Lacroix, Stéphane Rehel, Léa Chauveau, Sacha Haudry, Françoise Bertran, Vincent de la Sayette, Denis Vivien, Gaël Chételat, Antoine Lutz, Géraldine Rauchs","doi":"10.1111/jsr.70161","DOIUrl":"https://doi.org/10.1111/jsr.70161","url":null,"abstract":"<p><p>Meditation practice has been shown to impact resting-state EEG activity in expert meditators, but its benefits on sleep, which is particularly affected with age, are poorly understood. Our aim was to better understand the effects of long-term meditation practice on resting-state EEG and sleep in older adults. Twenty-seven elderly expert meditators (mean age ± SD: 70.7 ± 5.0 years) were compared to meditation-naive controls (69.3 ± 3.8 years) for sleep questionnaires (n = 135), polysomnography (n = 47) and resting-state EEG (n = 73). Sleep microstructure (slow waves and spindles) and EEG features (power, Kolmogorov complexity and permutation entropy (PE)) during resting-state, NREM, and REM sleep were compared between groups. Correlations were tested between the metrics that differed between the two groups and the level of meditation expertise within the meditator group. At rest, expert meditators exhibited lower delta power and higher delta PE than controls. Self-reported sleep quality did not differ between groups, but expert meditators slept longer, had reduced %N1, and higher %N2. During NREM sleep, they exhibited reduced delta power, increased alpha power, and greater theta PE. During REM sleep, they tended to show greater theta power. Finally, the composite score of meditation expertise was negatively associated with %N1, and tended to be positively associated with %N2 and REM sleep theta power. Overall, these results suggest that expert meditators showed more preserved brain activity at rest and sleep architecture, and exhibited EEG features suggesting higher cognitive states during NREM sleep. Clinical Trial Information: Name: Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training (Age-Well). Registration: EudraCT: 2016-002441-36; IDRCB: 2016-A01767-44; ClinicalTrials.gov Identifier: NCT02977819. (https://clinicaltrials.gov/ct2/show/NCT02977819?term=Age-Well&draw=2&rank=1).</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70161"},"PeriodicalIF":3.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Liraglutide on Intermittent Hypoxia-Induced Metabolic Dysfunction: From Bench to Bedside.","authors":"Cliona O'Donnell, Ailbhe King, Guillaume Vial, Emily O'Neill, Shane Crilly, Jonathan D Dodd, David J Murphy, Elise Belaidi, Jean-Louis Pepin, Claire Arnaud, Donal O'Shea, Silke Ryan","doi":"10.1111/jsr.70152","DOIUrl":"https://doi.org/10.1111/jsr.70152","url":null,"abstract":"<p><p>Intermittent hypoxia (IH)-mediated adipose tissue inflammation with M1 macrophage polarisation plays a key role in the pathogenesis of metabolic diseases in obstructive sleep apnoea (OSA). Effective treatment strategies are so far lacking. Here, we hypothesised that a glucagon-like peptide (GLP)-1 (Liraglutide)-based weight loss regimen improves IH-induced metabolic perturbations. To test the hypothesis, we employed a comprehensive translational approach consisting of an innovative IH system for cell cultures, a murine IH model of diet-induced obese mice and a proof-of-concept randomised-controlled study in OSA (NCT04186494). Liraglutide significantly attenuated IH-mediated pro-inflammatory polarisation of bone marrow-derived murine macrophages in cell culture. However, this did not translate into improved IH-induced insulin resistance in C57Bl/6 mice fed on a high-fat diet despite significant weight loss. In OSA subjects without diabetes (n = 30, 50 ± 7 years, 80% males, apnoea-hypopnoea index [AHI] 50 ± 19/h, body mass index [BMI] 35.0 ± 3 kg/m²), Liraglutide in contrast to CPAP over 24 weeks led to improvement in insulin sensitivity (mean difference 1.91 ± 1.46 vs. -1.02 ± 2.75, p = 0.03) in correlation with reduction in anthropometric measures and visceral adipose tissue volume. However, in conjunction with its limited effect on OSA parameters, the combination of Liraglutide with CPAP therapy appeared superior to Liraglutide alone for improvement of other glycaemic parameters such as fasting glucose, glucose tolerance, or HbA1c. In summary, while Liraglutide is effective in mediating weight loss, a lack of improvement in IH-triggered metabolic dysfunction does not support its role as monotherapy for metabolic diseases in OSA.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70152"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticotropin-Releasing Hormone (CRH) in Murine Narcolepsy: What Do Genetic and Immune Models Tell Us?","authors":"J Zhou, S Melzi, A L Morel, B Georges, T E Scammell, G J Lammers, R Fronczek, C Peyron","doi":"10.1111/jsr.70151","DOIUrl":"https://doi.org/10.1111/jsr.70151","url":null,"abstract":"<p><p>Narcolepsy type 1 is a chronic sleep disorder of putative autoimmune aetiology, primarily caused by the loss of orexin-producing neurons in the hypothalamus. An additional 88% reduction in corticotropin-releasing hormone-immunoreactive neurons of the paraventricular nucleus has been recently observed in post-mortem brains of individuals with narcolepsy type 1. It is, however, unknown whether this reduction is specific to the paraventricular nucleus or involves other brain regions expressing corticotropin-releasing hormone, such as the amygdala, which plays a central role in mood regulation, stress response and cataplexy. This study examined whether orexin neuron loss and/or hypothalamic neuroinflammation would affect the expression of corticotropin-releasing hormone and other neuropeptides, including melanin-concentrating hormone and histidine decarboxylase as a proof of concept. We used quantitative polymerase chain reaction to measure messenger RNA levels in three mice models of narcolepsy type 1: mice lacking orexin due to genetic disruption, mice with toxin-induced orexin neuron ablation and mice with autoimmune-mediated orexin neuron loss accompanied by hypothalamic neuroinflammation. We found no change in corticotropin-releasing hormone expression in both the hypothalamus and amygdala across all models, regardless of the timeline or mechanism of orexin loss. Similarly, the expression of melanin-concentrating hormone and histidine decarboxylase was unaffected. These findings suggest that the absence of orexin signalling alone is not sufficient to alter corticotropin-releasing hormone expression. Alternative mechanisms may account for the observation made in human narcolepsy type 1 post-mortem samples. Future human studies are warranted to identify the underlying processes and determine whether similar changes occur in other brain regions.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70151"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Trajectories of Insomnia Severity and Quality of Life Among Adults in Opioid Use Disorder Treatment: A Longitudinal Study With Parallel Process Latent Growth Curve Modelling.","authors":"Ariel Hoadley, Anju Felix, Salome Hailu, Jennifer D Ellis, Justin C Strickland, Jill A Rabinowitz, David Wolinsky, Martin Hochheimer, J Gregory Hobelmann, Andrew S Huhn","doi":"10.1111/jsr.70160","DOIUrl":"https://doi.org/10.1111/jsr.70160","url":null,"abstract":"<p><p>Sleep health is related to quality of life (QOL) in the general population, yet less is known about the trajectories of sleep and QOL during opioid use disorder (OUD) treatment. This study examined the joint trajectories of insomnia severity and QOL during the first 4 weeks of OUD treatment and tested predictors of the growth trajectories. Adults (N = 1607) in supervised withdrawal or residential OUD treatment completed surveys weekly for 4 weeks. Kruskal-Wallis tests and correlations examined differences in insomnia and QOL at intake by sociodemographic and clinical characteristics. An unconditional parallel process growth model examined the joint trajectories of sleep and QOL, and time-invariant covariates were added to a conditional growth model. In the unconditional growth model, insomnia and QOL were inversely related at intake (p < 0.001). Greater insomnia at intake was associated with more pronounced increases in QOL (p = 0.020), but QOL at intake did not predict changes in insomnia. Increases in insomnia severity were associated with worsening of QOL (p < 0.001). Patients who were younger (p = 0.020) and unemployed (p = 0.048) had greater improvements in insomnia, and patients who were younger (p = 0.001) and started treatment in a supervised withdrawal setting (p = 0.002) had greater improvements in QOL. Sleep quality and QOL are modifiable, so understanding their joint trajectories during OUD treatment can help improve quality of care and recovery. Targeting sleep disturbances early in treatment may support overall well-being and improve recovery outcomes.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70160"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of a High Heat Conductivity Mattress Topper on Sleep During Heat Night.","authors":"Florane Pasquier, Jonathan Monin, Pierre-Emmanuel Tardo-Dino, Pascal Van Beers, Michael Quiquempoix, Mathias Guillard, Claire Deshayes, Vincent Beauchamps, Keyne Charlot, Laurent Bosquet, Mounir Chennaoui, Mathieu Nedelec, Fabien Sauvet","doi":"10.1111/jsr.70137","DOIUrl":"https://doi.org/10.1111/jsr.70137","url":null,"abstract":"<p><p>Environmental high temperatures can strongly affect sleep. Our aim was to assess the protective effect of a High Heat Conductivity Mattress topper (HHCM) on sleep duration and quality during one night's exposure to heat. HHCM efficacy was studied in a randomised double-blind crossover design in fifteen healthy young active subjects by overnight polysomnography in a temperature-controlled sleep laboratory, during 4 nights: 2 nights at 22°C (HHCM and Control Mattress, CM) and 2 nights at 32°C (HHCM and CM). Core body temperature (CBT), skin, room and mattress toppers surface temperatures were continuously recorded. We observed interactions between temperature and mattress conditions. At 22°C, we did not show any beneficial effect of HHCM compared to CM on sleep duration, but a longer N3 sleep stage duration (p = 0.03) and higher slow oscillation spectral density (p = 0.03). Heat night exposure (32°C) induced a decrease in total sleep time (TST) (-24.8 ± 7.1 min, p = 0.02), rapid eye movement (REM) duration (p = 0.03), sleep efficiency (p = 0.04), delta power spectral density (p = 0.03) and an increase of wake after sleep onset (p = 0.03) and transition between stages rate (p = 0.02). At 32°C, in comparison to CM, HHCM induced higher TST (+21.4 ± 16.1 min, p = 0.04), sleep efficiency (p = 0.04), REM duration (p = 0.03), and lower awakening duration (p = 0.03). These effects were associated with lower skin temperature and CBT. In conclusion, HHCM improves sleep quality and has a protective effect on CBT and sleep patterns during heat exposure in active healthy subjects. It could be a countermeasure for promoting sleep in particular during heat waves.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70137"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yawning as Therapy? The Potential of the Conditioned Yawn Reflex as a Novel Treatment for Insomnia Disorder","authors":"Colin A. Espie","doi":"10.1111/jsr.70142","DOIUrl":"10.1111/jsr.70142","url":null,"abstract":"<p>In 1986, Provine, the pioneer of yawning research wrote that ‘Yawning may have the dubious distinction of being the least understood, common human behaviour’ (p. 120); and so yawning remains some 40 years later, as something of a biological and social curiosity. However, this article examines contemporary scientific understanding of this age-old conundrum, proposing not only that yawning is a universal component of sleep's normal stimulus control paradigm, but that the conditioned yawn reflex might be harnessed to treat insomnia disorder. The core features of yawning as a ubiquitous, involuntary, periodic and conditionable behaviour; its associated actions on arousal, biofeedback and selective attention, as well as thermoregulation and airway patency; and its potential to signal and promote sleep engagement, lead to the proposition that the conditioned yawn reflex as therapy (CYRaT) is a feasible and potentially effective novel therapeutic for sleep-onset and sleep-maintenance insomnia disorder. Much research is required to test this hypothesis, but the article describes preliminary protocols for the administration and testing of CYRaT that might be utilised for this purpose.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"34 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDC25A Alleviates Obstructive Sleep Apnea-Hypopnea Syndrome With Hypertension and Inhibits Ferroptosis.","authors":"Xin Yang, Chunsheng Wang, Deng Ouyang, Haofeng Xu, Zhile Wu, HuiLing Ye, Ping Yan","doi":"10.1111/jsr.70155","DOIUrl":"https://doi.org/10.1111/jsr.70155","url":null,"abstract":"<p><p>Obstructive sleep apnea-hypopnea syndrome (OSAHS) is significantly correlated with hypertension. This investigation aimed to explore the effect of ferroptosis on OSAHS-hypertension. Ferroptosis-associated genes were screened based on the GSE205050 dataset and FerrDb database. An OSAHS-hypertension model was established by exposing Sprague Dawley rats to chronic intermittent hypoxia for 8 weeks, and human umbilical vein endothelial cells (HUVECs) were exposed to intermittent hypoxia in vitro. CDC25A was overexpressed using recombinant adeno-associated virus in vivo and plasmid transfection in vitro. Ferroptosis markers, oxidative stress indicators, blood pressure, abdominal aortic tissue histopathology, and endothelial cell viability/apoptosis were then assessed. Six ferroptosis-associated hub genes were identified, including CDC25A, EZH2, PARP1, HELLS, FANCD2, and RRM2, all of which were lowly expressed. In the rat model of OSAHS-hypertension, overexpression of CDC25A significantly reduced systolic and diastolic blood pressure as well as vascular wall thickness, while increasing α-SMA expression. Biochemical analyses showed that CDC25A decreased malondialdehyde (MDA) and Fe²⁺ levels while increasing glutathione (GSH), superoxide dismutase (SOD), and ferroptosis-associated proteins (FTH1, SLC7A11, GPX4). CDC25A overexpression in HUVECs ameliorated hypoxia-induced endothelial dysfunction by inhibiting ferroptosis and apoptosis and promoting cell survival; however, these protective effects were significantly abrogated by co-treatment with erastin. CDC25A inhibits OSAHS-hypertension progression and modulates ferroptosis-related pathways. This study identifies ferroptosis as a potential therapeutic target in OSAHS-associated hypertension, with CDC25A acting as a key regulatory factor.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70155"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Wake-Up Call for Adolescents: Uncovering the Relationship Between Sleep and Circadian Factors on Executive Functioning and Risk-Taking Behaviours in Adolescents.","authors":"Isabella D Wright, Kathleen Erekson Rugh, Sarah Kamhout, Mary Broadbent, Nicholas York, Kara McRae Duraccio","doi":"10.1111/jsr.70154","DOIUrl":"https://doi.org/10.1111/jsr.70154","url":null,"abstract":"<p><p>Poor sleep may heighten adolescent risk-taking and impair executive functioning (EF). Circadian misalignment (CM)-the gap between internal circadian timing and 24-h behavioural cycles-might also impact EF and risk-taking. However, the link between circadian factors and EF/risk-taking remains underexplored. This study investigates the relationships between sleep duration, circadian timing, morningness/eveningness preference and CM with adolescent EF and risk-taking behaviour. Participants (N = 52), aged 14-18, provided demographic information and completed the Morningness/Eveningness Questionnaire and Pubertal Development Scale. They wore Actiwatches for 11 days and attended a dim-light melatonin onset (DLMO) appointment, completing the Youth Risk Behavior Survey and Behavior Rating Inventory of Executive Function. Independent samples t-tests compared EF and risk-taking across four sleep health aspects: circadian timing (DLMO), morningness/eveningness preference, CM, and sleep duration. Evening preference significantly predicted higher risk-taking (g = 0.991), worsened EF (g = 0.75) and reduced metacognition and behavioural regulation (g's > 0.60). Inadequate sleep duration trended towards predicting reduced EF and inhibition (g's > 0.55). DLMO and CM were not associated with EF or risk-taking (Hedge's g < 0.5). Eveningness preference and lower sleep duration may increase risky behaviour and worsen EF in adolescents. Future research should explore whether increasing sleep duration and advancing sleep schedule preferences reduce risky behaviour and improve cognitive function.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70154"},"PeriodicalIF":3.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion Regulation and Executive Functions in Insomnia Disorder Comorbid With Mood and Sedative-Hypnotic Use Disorders: Findings From a Naturalistic Longitudinal Study Employing Daridorexant in the Management of Chronic Insomnia.","authors":"Laura Palagini, Gaspare Alfi, Giulia Aquino, Giovanna Grenno, Leonardo Anastasio, Eric Annuzzi, Gianluca Cerofolini, Andrea Coccoglioniti, Matteo Gambini, Alessio Gullotta, Matteo Pioltino, Paula Prodani, Donatella Marazziti, Mario Miniati, Angelo Gemignani","doi":"10.1111/jsr.70158","DOIUrl":"https://doi.org/10.1111/jsr.70158","url":null,"abstract":"<p><p>Insomnia disorder has a considerable effect on mental health, making its effective management crucial in clinical practice. An observational study was conducted on consecutive outpatients with insomnia disorder (DSM-5-TR criteria) attending the Insomnia Clinic of the Psychiatric Unit of the University Hospital of Pisa (Italy). Patients were treated according to insomnia guidelines with DORA Daridorexant. Evaluations were performed at baseline (T0), 1 month (T1) and 3 months (T2). Data collected included clinical assessments of insomnia severity (Insomnia Severity Index [ISI]), depressive and mixed symptoms (Beck Depression Inventory II [BDI-II], Young Mania Rating Scale [YMRS]) and emotional dysregulation (Difficulties in Emotion Regulation Scale [DERS], Frontal Assessment Battery [FAB]). Concurrent pharmacological treatments were collected. The study included 90 patients (mean age 53 ± 13.6 years, n° = 43 females). A significant proportion (63.3%) was comorbid with unipolar or bipolar depression and sedative-hypnotic use disorders. Repeated measures ANOVA analyses revealed a significant improvement for the ISI, DERS and FAB over time, with F-values of 24.23, 15.56 and 21.74 (p < 0.001). Additionally, BDI-II and YMRS scores showed significant decreases during the same period, with F-values of 10.24, 10.33 and 70.00 (p < 0.001). Multiple regression analyses indicated that improvements in depressive symptoms were best predicted by improvement in DERS and ISI, while mixed symptoms were predicted by ISI and FAB improvements. With the caution of a naturalistic design, this study may show that by treating insomnia comorbid to other mental disorders, it may be possible to improve not only insomnia symptoms but also emotion regulation and executive functions.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70158"},"PeriodicalIF":3.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Medicine—What's in a Name?","authors":"Dirk A. Pevernagie,&nbsp;Erna Sif Arnardottir,&nbsp;Oliviero Bruni,&nbsp;Sarah Hartley,&nbsp;Gert Jan Lammers,&nbsp;Tiina Paunio,&nbsp;Dieter Riemann,&nbsp;Renata L. Riha","doi":"10.1111/jsr.70150","DOIUrl":"10.1111/jsr.70150","url":null,"abstract":"<p>Sleep medicine has matured into a recognised medical discipline, characterised by defined diagnostic concepts, evidence-based treatments, and significant progress in understanding sleep physiology and disorders. Sleep and its disturbances impact virtually every aspect of health and well-being. The major categories of sleep disorders include insomnia, neurological and psychiatric sleep disorders, sleep-disordered breathing, and paediatric sleep disorders. Breakthroughs in biomedical research have deepened clinical expertise across each of these domains. Although sleep medicine has historically developed from various specialties, the current approach emphasises interdisciplinary collaboration. Today, diagnostic and therapeutic pathways are well established, supported by professional standards outlined in nosological classifications, clinical guidelines, and structured frameworks of competencies and skills. Despite the universal importance of sleep and the high prevalence of sleep disorders, the field continues to face systemic challenges—most notably limited access to care, inadequate funding for clinical services, and insufficient investment in research. The central challenge is to balance the integration of new opportunities with the resolution of persistent uncertainties. However, advances in technology and the emergence of precision medicine offer promising prospects for progress. Sleep medicine stands at a crossroads. Its future will depend on rearticulating its mission and vision, addressing structural shortcomings, embracing innovation, and affirming its essential role in promoting public health.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"34 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}