Journal of Sleep Research最新文献

{"title":"Why Co-Production Should Be Standard Practice in Sleep Research","authors":"Emma L. Gale, Maria Gardani, Aja L. Murray, Lorna Caddick, Raahat Manrai, Heather C. Whalley","doi":"10.1111/jsr.70462","DOIUrl":"10.1111/jsr.70462","url":null,"abstract":"<p>Sleep research is changing. Alongside advances in digital health, personalised medicine, and behavioural science, there is growing recognition that people with lived experience of sleep and circadian disruption, together with caregivers, clinicians, educators and community partners, should play a more active role in shaping the research intended to benefit them. Co-production, where researchers work collaboratively with people with lived experience and other relevant stakeholders throughout the research process, offers an important opportunity to strengthen both the relevance and impact of sleep science. Lived experience partners bring unique expertise that can identify gaps in existing knowledge, shape research priorities and questions around what matters most to those directly affected by sleep problems, challenge assumptions underpinning study designs and measures, highlight barriers to recruitment and intervention delivery, and inform the interpretation and dissemination of findings.</p><p>Although patient and public involvement is increasingly encouraged across healthcare research, co-production has not yet become standard practice in sleep research (Gale et al. <span>2025</span>). In this respect it lags behind other disciplines where it has progressed more significantly, such as mental health and public health (Brotherdale et al. <span>2024</span>). Sleep research, by contrast, has yet to fully engage with co-production as a methodological approach. This delay limits the relevance, impact, and equity of sleep research (Vargas et al. <span>2022</span>). We argue that co-production should not be an optional enhancement but fundamental to how we design, conduct, and translate sleep research.</p><p>Co-production should include all those affected by the research, for example, patients, caregivers, clinicians, educators, and community members of the research population of interest (Albert et al. <span>2023</span>). Unlike brief consultation or tokenistic involvement, co-production requires sustained engagement across the research lifecycle, from conceptualisation, design and proposal development through to grant and ethical approval, implementation, analysis, and dissemination (Smith et al. <span>2023</span>). It relies on shared decision-making, shared power, mutual respect, and a commitment to producing knowledge that is both scientifically rigorous and socially meaningful (Pettican et al. <span>2023</span>).</p><p>The relationship between researcher and community partners is central to a high quality co-production. A co-production study functions more as a relational dyad sustained by trust, rapport and reciprocity. The quality of a co-produced study depends heavily on the strength of this relationship: stakeholders are more likely to share honest insights, challenge researcher assumptions and remain engaged across research lifespan. It is then that they feel heard, valued and safe (Mulvale et al. <span>2021</span>).</p><p>A scoping review","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two-Hit Stress Model","authors":"John Axelsson,&nbsp;Mats Lekander,&nbsp;Camilla I. Svensson,&nbsp;Nils Simon,&nbsp;Alexandra Kuliszkiewicz,&nbsp;Julie Lasselin,&nbsp;Leonie J. T. Balter","doi":"10.1111/jsr.70335","DOIUrl":"10.1111/jsr.70335","url":null,"abstract":"<p>Sleep loss and low-grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two-hit experimental model. Participants (<i>N</i> = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night); sleep-restriction (two nights, 4 h in bed/night); and an immune challenge (~24 h post COVID-19 vaccination) combined with either sleep saturation (<i>n</i> = 26) or restriction (<i>n</i> = 30). Motivation for everyday behaviours and sleepiness were rated, and blood samples were collected. Both sleep restriction and vaccination increased motivation for sleep-related behaviours and reduced motivation for physical and social activity, with sleep restriction having broader effects. These changes were associated with inflammation and sleepiness. Vaccination increased thirst, while sleep restriction reduced it, but neither affected hunger or food preferences. Sleep restriction amplified the inflammatory response to vaccination. For motivation, the stressors combined caused larger changes than either alone for some outcomes, without amplifying one another. These findings support that different stressors reallocate motivation towards rest and sleep-supporting behaviours over physical and social activity, likely to drive behaviours that support homeostasis after allostatic challenges. As these stressors often co-occur, this adaptive response can meaningfully shape daily functioning. Future work may determine when this functional response becomes maladaptive.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Sleep Quality and Oxidative Stress in Postoperative Cardiovascular Patients—A Pilot Study","authors":"K. Krawczyk,&nbsp;D. Riemann,&nbsp;E. Schleicher,&nbsp;A. Günther,&nbsp;A. Ayekoi,&nbsp;M. Czerny,&nbsp;J. S. Pooth,&nbsp;T. Böhmerle,&nbsp;B. Feige,&nbsp;J. Sahlmann,&nbsp;F. Beyersdorf","doi":"10.1111/jsr.70383","DOIUrl":"10.1111/jsr.70383","url":null,"abstract":"<p>Oxidative stress contributes to numerous physiological and pathological processes, and sleep behaviour as well as circadian rhythms may influence reactive oxygen species (ROS) concentrations in humans. This prospective pilot study quantified postoperative venous ROS concentrations in patients undergoing cardiovascular surgery and explored associations with subjective and objective sleep parameters, circadian patterns and patient characteristics. Fifteen patients undergoing cardiovascular surgery at the University Medical Center Freiburg were monitored during the first 48 postoperative hours. Serial venous blood samples were analysed for ROS concentrations using electron spin resonance. Sleep was assessed using validated questionnaires, including the Insomnia Severity Index, Pittsburgh Sleep Quality Index and Schlaffragebogen-A (SF-A), as well as actigraphy. Additional clinical data were recorded. Venous ROS concentrations showed substantial inter-individual variability but no significant circadian pattern. Mean postoperative ROS concentrations were not significantly associated with ISI scores, PSQI global score, SF-A parameters or objective actigraphic sleep measures. Among PSQI subdomains, however, higher ROS concentrations were significantly associated with reduced sleep efficiency (<i>r</i> = −0.74, <i>p</i> = 0.002) and longer nocturnal wake time (<i>r</i> = 0.62, <i>p</i> = 0.01), while shorter sleep duration showed a trend-level association (<i>r</i> = −0.49, <i>p</i> = 0.07). These findings demonstrate the feasibility of electron spin resonance-based venous ROS quantification in postoperative cardiac surgery patients. Specific subjective sleep parameters, particularly reduced sleep efficiency and increased nocturnal wake time, may be associated with higher postoperative ROS concentrations. Larger studies are warranted to confirm these exploratory findings.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Midday Nap and Night-Time Sleep on Offline Consolidation of Action Sequences Learning","authors":"Liang He,&nbsp;Zhuo Ma,&nbsp;Siwei Xie,&nbsp;Dong Wang,&nbsp;Xiaobin Ding","doi":"10.1111/jsr.70384","DOIUrl":"10.1111/jsr.70384","url":null,"abstract":"<div>\u0000 \u0000 <p>Offline consolidation refers to performance changes that occur after initial learning in the absence of further practice. Although sleep has often been associated with offline consolidation of sequence learning, it remains unclear whether different types of sleep contribute differently when compared with wakefulness and whether such effects depend on sequence characteristics. To address this issue, the present study employed a modified sequence reaction time task to examine offline changes in learned action sequences. Participants were assigned to one of four groups: night-time sleep, midday nap, daytime wake, or midday wake. Two sequence conditions differing in sequence length (short vs. long) were included to assess whether offline effects vary as a function of sequence length. We found that for long sequences, the night-time sleep group showed a larger offline consolidation effect than the midday nap group. In contrast, no reliable group differences were observed for short sequences. For both sequence conditions, the sleep groups differed from their respective wake control groups. Overall, these findings indicate that offline changes in action sequence learning are modulated by sequence length and differ across sleep–wake conditions.</p>\u0000 </div>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia","authors":"Nyissa A. Walsh,&nbsp;Emma-Maria Phillips,&nbsp;Arsenio Páez,&nbsp;Nathan E. Cross,&nbsp;Thien Thanh Dang-Vu,&nbsp;Aurore A. Perrault","doi":"10.1111/jsr.70388","DOIUrl":"10.1111/jsr.70388","url":null,"abstract":"<p>Mounting evidence shows sex-based differences in sleep experiences and outcomes, including the prevalence of insomnia disorder. However, the impact of biological sex on brain oscillations during sleep remains poorly understood, especially in the context of insomnia disorder. This is a notable gap, given that neurophysiological aspects of sleep are associated with brain health and overall sleep quality. We systematically reviewed and meta-analysed data from studies reporting spindle and slow wave activity in adults with and without insomnia disorder. We conducted systematic searches in PubMed, Embase, Scopus, and PsycInfo. Risk of bias was evaluated using the Newcastle Ottawa and the PEDro scales. Forty-three studies met our inclusion criteria, with thirteen studies of normal sleepers (<i>N</i> = 668) reporting sufficient data for random-effects meta-analyses. Compared with males, female normal sleepers had higher spindle density, sigma and delta power. Most studies recruited individuals with primary insomnia, and data pooling for insomnia and mixed groups was not possible due to insufficient statistical reporting. Moreover, group-by-sex interactions were limited, inconsistent, and varied across studies and sample characteristics. Further research is needed to explore sex-specific differences in sleep microarchitecture and their role in normal sleep and the manifestation of insomnia disorder.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-Related and Chronobiology Traits and Health-Related Phenotypes: A Phenome-Wide Mendelian Randomisation Study","authors":"Marta H. Hernandez,&nbsp;Camille Lassale,&nbsp;Anna Camps-Vilaró,&nbsp;Alba Fernández-Sanlés,&nbsp;Sara Polo-Alonso,&nbsp;Marta Huertas,&nbsp;Javier Hernando-Redondo,&nbsp;Eleonora Fornara,&nbsp;Elena Carrillo-Álvarez,&nbsp;María Fernanda Zerón-Rugerio,&nbsp;Maria Izquierdo-Pulido,&nbsp;Maria Gil-Vives,&nbsp;Cristina Fornaguera,&nbsp;Álvaro Hernáez","doi":"10.1111/jsr.70411","DOIUrl":"10.1111/jsr.70411","url":null,"abstract":"<div>\u0000 \u0000 <p>Sleep-related and chronotype traits have been shown to impact health in observational studies. To identify whether these associations are potentially causal, we conducted phenome-wide Mendelian randomisation analyses of short sleep, insomnia symptoms, total sleep duration, long sleep, snoring, daytime sleepiness and morning chronotype with a broad range of health-related phenotypes. We assessed the association between the genetic predisposition to these traits and the occurrence of 702 health-related phenotypes, using summary statistics of the largest genome-wide association studies in European individuals. Results that were significant (multiple comparisons: False Discovery Rate) and valid (robust genetic instruments, unaffected by horizontal pleiotropy) were validated using data from the second largest European genome-wide association study. Genetically determined short sleep was associated with increased risks of attention-deficit/hyperactivity disorder and neuroticism, musculoskeletal conditions, asthma and gastroesophageal reflux and lower educational attainment. Genetically determined insomnia symptoms showed associations with increased risk of coronary artery disease, major depression and osteoarticular disease. Genetically determined long sleep was linked to higher risk of iron deficiency anaemia and lower bone mineral density. Genetic predisposition to snoring was associated with more falls, greater body mass and higher low-grade inflammation. Genetically determined morning chronotype was related to higher vitamin D levels and lower risk of irritable bowel syndrome. No associations were found for daytime sleepiness. Overall, these findings indicate that genetically determined short sleep duration and insomnia symptoms are associated with mental and neurological problems, cardiovascular disease and musculoskeletal disorders, suggesting a potentially preventive, causal role of healthy sleeping patterns on chronic disease.</p>\u0000 </div>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sleep Duration Manipulation on Brain-Derived Neurotrophic Factor in Adolescents at Risk for Type 2 Diabetes: A Randomized Crossover Study","authors":"Caroline Dutil,&nbsp;Irina Podinic,&nbsp;Jeremy J. Walsh,&nbsp;Gary S. Goldfield,&nbsp;Jean-Philippe Chaput","doi":"10.1111/jsr.70375","DOIUrl":"10.1111/jsr.70375","url":null,"abstract":"<div>\u0000 \u0000 <p>This study examined the effect of sleep duration manipulation on serum brain-derived neurotrophic factor (BDNF) levels in adolescents at risk for type 2 diabetes (T2D). A randomized (1:1), sex-stratified, crossover study design was used to experimentally manipulate sleep duration using actigraphy. Time in bed was increased (IN) and decreased (DE) by 1.5 h per night for 1 week each, with conditions separated by a 1-week washout period of habitual sleep. Sleep manipulations were based on participants' mean baseline sleep duration obtained during 1 week of habitual (HB) sleep. Following each sleep condition, fasted blood samples were collected for the analysis of serum BDNF. Adolescent participants (<i>n</i> = 36, 52.8% female, mean age = 15.1 ± 1.3 years) with severe obesity (&gt; 99th BMI percentile) successfully increased and decreased their sleep duration by +1:02 h/night and −1:19 h/night, respectively, based on a week of HB sleep duration (mean = 7:31 h/night). Increasing sleep duration resulted in a significant (~14%) decrease in serum BDNF compared to the HB and DE weeks, while no significant differences were observed between the HB and DE weeks. This study provides the first experimental evidence that sleep duration influences serum BDNF levels in adolescents at risk for type 2 diabetes. Lower BDNF levels following sleep extension, alongside previously reported improvements in insulin sensitivity, may reflect reduced physiological stress or compensatory neurotrophic signalling, although the underlying mechanisms remain unclear. In contrast, higher BDNF levels during habitual and restricted sleep likely reflect adaptive responses to insufficient sleep rather than improved metabolic function.</p>\u0000 <p>\u0000 <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03754036</p>\u0000 </div>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks Associated With Benzodiazepine Long-Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta-Analysis","authors":"Dieter Riemann,&nbsp;Chiara Baglioni,&nbsp;Christoph Nissen,&nbsp;Agathe Nevière,&nbsp;Omar Irfan,&nbsp;Pauline Le Nouveau,&nbsp;Chrysoula Leontiou,&nbsp;Damien Léger","doi":"10.1111/jsr.70352","DOIUrl":"10.1111/jsr.70352","url":null,"abstract":"<p>This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day. Although benzodiazepine medications are often prescribed to treat insomnia, using them longer than 4 weeks raises concerns about dependence, negative side effects, and long-term health risks for patients. This review included 27 studies published between 1987 and 2023, focusing on adults with insomnia symptoms lasting at least 3 months. The main outcomes examined were sleep quality, safety issues such as risk of falls, mental health concerns including depression and anxiety, and overall quality of life. Five outcomes were deemed suitable for meta-analysis: severity of insomnia, sleep quality, incidence of falls, depression, and anxiety. The results showed that people taking benzodiazepine medications had more severe insomnia than healthy sleepers, but less severe than those who were not taking any medication. The risk of falls was similar between those using benzodiazepine medications and those who were not. However, people using these medications experienced significantly higher levels of depression and anxiety compared to healthy sleepers. This review highlights a lack of studies on the long-term use of benzodiazepine medications, but suggests that extended use may worsen sleep quality, mental health, and quality of life. The findings support guidelines recommending limited use and prioritizing behavioural therapy and alternative safer pharmacotherapies for insomnia.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue Light Exposure During Sleep in Type 1 Diabetes: Impacts on Glycemic Control and Psychosocial Health","authors":"Seok Jin Hong,&nbsp;Sarida Pratuangtham,&nbsp;Pamela Martyn-Nemeth,&nbsp;Alana D. Steffen,&nbsp;Chang Gi Park,&nbsp;Sirimon Reutrakul","doi":"10.1111/jsr.70380","DOIUrl":"10.1111/jsr.70380","url":null,"abstract":"<p>Light exposure at night is linked to increased risk for obesity and insulin resistance in the general population. While sleep health is recognized as a key component of diabetes management, there has been less emphasis on nighttime light exposure. This study aimed to investigate the effects of blue and white light exposure immediately prior to (1 h) and during sleep (LEDS) on glycemic control and psychosocial wellbeing in adults with type 1 diabetes (T1D). Using baseline data from a randomized controlled trial testing a sleep intervention (NCT 04506151), we analysed the following data from 170 adults with T1D: light exposure pattern and sleep from one week of wrist-worn actigraphy, glucose levels from one week of continuous glucose monitoring (CGM), and A1C and self-reported psychosocial measures. Generalized linear models, adjusting for covariates, were employed to examine the relationship between log-transformed light variables and glycemic/psychosocial outcomes. The results revealed that greater blue LEDS was significantly associated with higher glucose levels from CGM including less % time spent in glucose range 70–180 mg/dL (B = −7.30; <i>p</i> = 0.022) and greater % time spent above glucose range 180 mg/dL (B = 6.95; <i>p</i> = 0.041), along with greater depressive (B = 4.41; <i>p</i> = 0.016) and anxiety symptoms (B = 2.25; <i>p</i> = 0.008), and worse diabetes quality of life (B = −5.81; <i>p</i> = 0.031). Light exposure one hour prior to sleep was related to increased fatigue. In conclusion, increased blue LEDS is linked to hyperglycemia and worse psychosocial outcomes in T1D. Thus, blue LEDS warrants further investigation as a modifiable risk factor.</p><p>\u0000 <b>Trial Registration:</b> NCT 04506151, www.clinicaltrial.gov\u0000 </p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13403194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive Sleep Apnea and Glycemic Variability in People With Diabetes: A Systematic Review and Meta-Analysis","authors":"Jinjin Yuan,&nbsp;Yueying Wang,&nbsp;Pei Chen,&nbsp;Jinle Wang,&nbsp;Yunping Mu,&nbsp;Cynthia Fritschi,&nbsp;Yuli Hu,&nbsp;Yingdan Chen,&nbsp;Sirimon Reutrakul,&nbsp;Bingqian Zhu","doi":"10.1111/jsr.70370","DOIUrl":"10.1111/jsr.70370","url":null,"abstract":"<div>\u0000 \u0000 <p>Obstructive sleep apnea (OSA) is common among people with diabetes, but its association with glycemic variability (GV), an important indicator for glycemic control, remains unknown. This review synthesised and quantified the association between OSA and GV in people with diabetes. The review was registered in PROSPERO (CRD42022331493). Seven databases were searched from inception to March 2023 and updated in September 2025. Meta-analyses were performed to pool findings from interventional studies on continuous positive airway pressure (CPAP) treatment of OSA using a random-effects model. Studies that could not be pooled were narratively synthesised. Fourteen studies were included: nine interventional and five cross-sectional studies. Only one study included people with type 1 diabetes (T1D). In single-arm studies, CPAP treatment was associated with a significant reduction in nocturnal standard deviation (SD) (mean difference = −0.37, 95% CI [−0.58, −0.15], <i>p</i> = 0.001, <i>I</i>\u0000 ² = 82.19%) and a marginally significant reduction in nocturnal mean amplitude of glycemic excursions (MAGE) (mean difference = −0.23, 95% CI [−0.46, 0.00], <i>p</i> = 0.050, <i>I</i>\u0000 ² = 79.11%). In contrast, the pooled estimates for 24 h SD and MAGE were nonsignificant either from single-arm or controlled studies. Findings from studies examining mean of daily difference, mean of nocturnal glucose difference, and BG_diff showed significant reductions after CPAP, while coefficient of variation findings were inconsistent. Cross-sectional studies also revealed possible associations between OSA severity and GV. In conclusion, current findings suggest the potential impact of OSA on glucose metabolism in type 2 diabetes. More RCTs and studies in T1D are needed.</p>\u0000 </div>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"35 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}