Journal of Sleep Research最新文献_第10页

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-24 DOI: 10.1111/jsr.70315

Isla Tsz Kwan Hui, Tommy Ho-Fung Chung, Sing-Hang Cheung, Nazanin Biabani, Panagis Drakatos, Romola S Bucks, Sharon L Naismith, David O'Regan, Veena Kumari, Dieter Riemann, Toby Wise, Shirley Xin Li, Ivana Rosenzweig

{"title":"Sleep-Related Attentional Bias in Insomnia: A Drift Diffusion Model Approach.","authors":"Isla Tsz Kwan Hui, Tommy Ho-Fung Chung, Sing-Hang Cheung, Nazanin Biabani, Panagis Drakatos, Romola S Bucks, Sharon L Naismith, David O'Regan, Veena Kumari, Dieter Riemann, Toby Wise, Shirley Xin Li, Ivana Rosenzweig","doi":"10.1111/jsr.70315","DOIUrl":"https://doi.org/10.1111/jsr.70315","url":null,"abstract":"Cognitive models propose that insomnia is maintained in part by selective attention to sleep-related information, yet reaction-time indices alone offer limited mechanistic specificity. We investigated sleep-related attentional bias in adolescents and young adults with insomnia disorder (n = 201; aged 15-24 years; DSM-5) using a sleep-related dot-probe task with sleep-related and neutral Cantonese Chinese word pairs. Trial-level responses were analysed with Hierarchical Drift Diffusion Modelling (HDDM) to estimate drift rate (v), the speed of evidence accumulation for probe response choices and to examine moderation by anxiety symptoms. Drift rates were higher on congruent than incongruent trials (q = 0.036), indicating faster evidence accumulation when the probe appeared in the location of sleep-related words, consistent with sleep-related attentional bias indexed indirectly via probe responses. Higher anxiety was associated with faster drift rates across both trial types (q = 0.023 and q = 0.024), consistent with generalised hyperarousal rather than selective enhancement of sleep-related bias. The congruency × anxiety interaction was not significant (95% HDI [-0.10, 0.31]). These findings provide computational evidence consistent with sleep-related attentional bias in young people with insomnia and suggest that comorbid anxiety is associated with broadly increased evidence accumulation rather than cue-specific amplification.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70315"},"PeriodicalIF":3.9,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Night-To-Night Variability in Sleep Apnea Is Associated With Persistence and Burden of Device-Detected Atrial Fibrillation. 睡眠呼吸暂停的夜间变异性与设备检测心房颤动的持续性和负担有关。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-23 DOI: 10.1111/jsr.70313

Philipp Spitaler, Valentin Bilgeri, Patrick Rockenschaub, Fabian Barbieri, Birkan Tugrul, Agne Adukauskaite, Markus Stühlinger, Bernhard Erich Pfeifer, Peter Willeit, Axel Bauer, Wolfgang Dichtl

{"title":"Night-To-Night Variability in Sleep Apnea Is Associated With Persistence and Burden of Device-Detected Atrial Fibrillation.","authors":"Philipp Spitaler, Valentin Bilgeri, Patrick Rockenschaub, Fabian Barbieri, Birkan Tugrul, Agne Adukauskaite, Markus Stühlinger, Bernhard Erich Pfeifer, Peter Willeit, Axel Bauer, Wolfgang Dichtl","doi":"10.1111/jsr.70313","DOIUrl":"https://doi.org/10.1111/jsr.70313","url":null,"abstract":"Using pacemaker-derived thoracic impedance monitoring, sleep apnea severity and its night-to-night variability can be continuously tracked in patients with implanted cardiac devices. In the prospective ACaSA study, 171 pacemaker patients without permanent atrial fibrillation at baseline were followed for a median of 539 days. During an initial 28-night run-in period free of atrial fibrillation, baseline night-to-night variability of the respiratory disturbance index (RDI) was quantified as the coefficient of variation. Patients were subsequently monitored for the onset of persistent device-detected atrial fibrillation (DDAF, ≥ 7 days) and cumulative DDAF burden. Median RDI variability was 38.7% (IQR 29.9%-47.6%), and 35 patients (20.5%) had high variability (≥ 50%). Over follow-up, 17 patients (9.9%) developed persistent DDAF. Each 10% increase in RDI variability was associated with a significantly higher risk of persistent DDAF (adjusted HR 1.89, 95% CI 1.26-2.84; p = 0.002). Patients with high variability also carried a greater cumulative DDAF burden compared to those with low variability (9.6% vs. 1.9%, p = 0.016). These results suggest that the dynamic instability of sleep apnea, reflected by night-to-night variability, is associated with DDAF persistence and burden. Continuous long-term monitoring through pacemaker systems offers a novel approach for risk stratification and may open opportunities for more personalised management strategies.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70313"},"PeriodicalIF":3.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending Sleep Improves Sleep and Stress Measures With Limited Microbiome Shift. 延长睡眠时间可以改善睡眠和压力措施，限制微生物群的变化。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-23 DOI: 10.1111/jsr.70321

Jaime L Tartar, Arjena Valls, Maya Totev, Maximiliano Barbosa Mendoza, Jose V Lopez, Robert P Smith

{"title":"Extending Sleep Improves Sleep and Stress Measures With Limited Microbiome Shift.","authors":"Jaime L Tartar, Arjena Valls, Maya Totev, Maximiliano Barbosa Mendoza, Jose V Lopez, Robert P Smith","doi":"10.1111/jsr.70321","DOIUrl":"https://doi.org/10.1111/jsr.70321","url":null,"abstract":"Poor sleep quality and duration are associated with adverse health. However, these can be remediated by experimental sleep extension. While the physiological mechanisms underlying the benefits of experimental sleep extension are unknown, recent evidence has highlighted the role of the gut microbiome in sleep physiology, potentially via the gut microbiome and inflammatory pathways. This pilot study examined whether extending sleep for 2 weeks would improve sleep, reduce stress and inflammation, and alter gut microbiome composition. Healthy female adults underwent a 2-week baseline assessment, followed by a 2-week sleep extension intervention. Pre- and post-intervention assessments included actigraphy, subjective sleep quality, perceived stress, salivary cortisol, interleukin-6 (IL-6), and gut microbiome profiling. Sleep extension increased total sleep time and time in bed without compromising sleep efficiency. Participants reported reductions in perceived stress and improved sleep quality, with large effect sizes. Skeletal muscle mass increased significantly, though no statistically significant changes were observed in cortisol or IL-6. While microbial diversity remained unchanged, linear discriminant analysis effect size analysis revealed a significant increase in the relative abundance of Peptostreptococcus, a genus implicated in producing indoleacrylic acid, a tryptophan-derived metabolite with anti-inflammatory and gut barrier-enhancing properties. Our findings suggest that increases in sleep duration can yield psychological, physiological, and microbiome-related benefits, supporting sleep extension as an intervention to improve stress-related health outcomes.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70321"},"PeriodicalIF":3.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Across the Pandemic in Norwegian University and College Students: A National Repeated Cross-Sectional Analysis (2010-2023). 挪威大学和大学生在流行病中的睡眠：一项全国重复横断面分析（2010-2023）。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-19 DOI: 10.1111/jsr.70312

Børge Sivertsen, Allison G Harvey, Øystein Vedaa, Ståle Pallesen, Mari Hysing

{"title":"Sleep Across the Pandemic in Norwegian University and College Students: A National Repeated Cross-Sectional Analysis (2010-2023).","authors":"Børge Sivertsen, Allison G Harvey, Øystein Vedaa, Ståle Pallesen, Mari Hysing","doi":"10.1111/jsr.70312","DOIUrl":"10.1111/jsr.70312","url":null,"abstract":"Sleep problems are increasingly common among students in higher education, but long-term trajectories before, during and after the COVID-19 pandemic remain poorly described. We analysed population-level surveillance data from the Students' Health and Wellbeing Study conducted in Norway in 2010, 2014, 2018, 2021, 2022 and 2023, including nearly 200,000 participants. Difficulties initiating or maintaining sleep were assessed in all waves using a consistent survey item. In the 2018, 2021 and 2022 surveys, participants also reported bedtime, risetime, sleep onset latency, wake after sleep onset and total sleep duration. DSM-5-based insomnia disorder symptoms were identified using criteria based on symptom frequency, duration and daytime impairment. The prevalence of difficulties initiating or maintaining sleep increased steadily from 2010 to 2023, rising from 23.8% to 38.3% among women and from 20.3% to 32.2% among men. Symptom prevalence was higher in every survey wave compared with 2010, with the steepest increase occurring during the pandemic. Insomnia disorder symptoms increased markedly from 2018 to 2021 and declined only modestly in 2022. Sleep onset latency and wake after sleep onset increased during the pandemic, resulting in reduced sleep efficiency, whereas mean sleep duration remained stable at approximately seven and a half hours. Bedtime and risetime were delayed during the pandemic, with partial reversion in 2022. In conclusion, worsening sleep among students appears to represent a sustained trend rather than a transient pandemic-related disruption. These findings provide population-level surveillance of long-term sleep trends and underscore the need for systematic support for student sleep health within higher education.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70312"},"PeriodicalIF":3.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REM Sleep Correlates of Trait Anxiety in Non-Clinical Adults: The Role of Sex and Age. 非临床成人快速眼动睡眠与特质焦虑相关：性别和年龄的作用。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-19 DOI: 10.1111/jsr.70318

Mar Mediano, Enrique G Fernández-Abascal, Sabela Fondevila Estévez

{"title":"REM Sleep Correlates of Trait Anxiety in Non-Clinical Adults: The Role of Sex and Age.","authors":"Mar Mediano, Enrique G Fernández-Abascal, Sabela Fondevila Estévez","doi":"10.1111/jsr.70318","DOIUrl":"https://doi.org/10.1111/jsr.70318","url":null,"abstract":"This study examined associations between trait anxiety and relative sleep-stage proportions, with a focus on REM sleep, and explored differences across sex and age groups. A total of 128 non-clinical adults (75 women, 53 men; age range 18-82 years, M = 35.5, SD = 18.4) were recruited from a university setting. Sleep stages were recorded using Fitbit Charge 5 devices, and a complementary verification substudy (n = 6) was conducted to confirm whether the observed correspondence between wearable-derived and polysomnographic estimates replicated trends in validation studies. Higher trait anxiety (STAI-T) correlated positively with REM sleep proportion (r = 0.34, p < 0.005) and negatively with light sleep (r = -0.20, p = 0.02), while deep sleep was unrelated (p = 0.49). Women exhibited higher STAI-T scores (t(126) = 3.86, p < 0.005) and greater REM proportions (t(126) = 2.65, p = 0.01) than men. Participants aged ≥ 50 years showed lower anxiety (t(126) = 3.79, p < 0.005) and reduced REM sleep (t(126) = 4.27, p < 0.005) than younger adults. Multivariate analyses revealed differences between sex-age groups in anxiety measures and sleep architecture (p < 0.005). Additionally, sleep-related anxiety (DSEA-S) was higher in men from the ≥ 50 group, while stable across age groups in women. Overall, these results indicate that REM sleep and trait anxiety are linked in healthy adults and that patterns of anxiety and sleep vary according to sex and age group. Findings support the ecological validity of wearables for assessing sleep architecture.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70318"},"PeriodicalIF":3.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Natural History of Insomnia: Sleep Opportunity Extension Following a Poor Night of Sleep Is Not Related to the Transition From Acute to Chronic Insomnia. 失眠的自然历史：睡眠不足后的睡眠时间延长与从急性失眠到慢性失眠的转变无关。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-18 DOI: 10.1111/jsr.70304

Julia T Boyle, Knashawn H Morales, Ivan Vargas, Alexandria Muench, Donn A Posner, Michael A Grandner, Mark Seewald, Hannah Scott, Jason Ellis, Michael Perlis

{"title":"The Natural History of Insomnia: Sleep Opportunity Extension Following a Poor Night of Sleep Is Not Related to the Transition From Acute to Chronic Insomnia.","authors":"Julia T Boyle, Knashawn H Morales, Ivan Vargas, Alexandria Muench, Donn A Posner, Michael A Grandner, Mark Seewald, Hannah Scott, Jason Ellis, Michael Perlis","doi":"10.1111/jsr.70304","DOIUrl":"https://doi.org/10.1111/jsr.70304","url":null,"abstract":"The behavioural tendency to expand sleep opportunity to compensate for prior sleep loss is referred to as 'sleep extension.' It is believed that sleep extension (here referred to as 'sleep opportunity extension' [SOE]) is the primary perpetuating factor explaining the transition from acute to chronic insomnia. Recently, this proposition was prospectively evaluated by assessing how sleep opportunity varied, week-by-week, relative to the incidence of acute and chronic insomnia. Significant differences in sleep opportunity before and after onset of acute insomnia were not detected. In the present analysis, a more granular evaluation was undertaken to assess whether SOE occurs on the nights and/or weekends following poor sleep. The data set (n = 1243) was modelled by group (good sleepers and participants with acute insomnia) for SOE occurring on the nights and weekends following poor nights of sleep (i.e., ≥ 30 min of sleep latency and/or nocturnal wakefulness and/or early morning awakenings) for the post-acute insomnia interval. A linear mixed effects model was used to account for up to one year of night-to-night sleep per participant. During the weekdays, sleep opportunity following a poor night of sleep was not found to increase (overall or by group) (< 5 min). During the weekends, all groups tended to decrease their sleep opportunity. This counterintuitive finding casts further doubt on the proposition that SOE is responsible for the transition between acute insomnia and chronic insomnia. This finding does not, however, change the relevance of addressing the mismatch between sleep opportunity and ability as part of behavioural treatment.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70304"},"PeriodicalIF":3.9,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent Presentation of Memory-Related Odours and Sounds Nullified Sleep Reactivation Benefits. 同时呈现与记忆相关的气味和声音会抵消睡眠再激活的好处。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-17 DOI: 10.1111/jsr.70314

Gayathri Subramanian, Christina Zelano, Ken A Paller, Eitan Schechtman

{"title":"Concurrent Presentation of Memory-Related Odours and Sounds Nullified Sleep Reactivation Benefits.","authors":"Gayathri Subramanian, Christina Zelano, Ken A Paller, Eitan Schechtman","doi":"10.1111/jsr.70314","DOIUrl":"10.1111/jsr.70314","url":null,"abstract":"Reactivation of recently acquired memories during sleep supports their longevity. Reactivation can be altered during sleep using odours or sounds through a technique termed targeted memory reactivation (TMR). Here, we attempted to selectively weaken memories by reactivating them together with forgetting instructions. We delivered sounds to reactivate spatial memories and concurrent odours to reactivate instructions. Participants learned about the instructions in a Directed-Forgetting task performed with a list of to-be-remembered and to-be-forgotten words. One odour was linked with instructions to forget, one with instructions to remember, and a third was not assigned any meaning. During a nap, sounds previously linked with object-location learning were simultaneously presented with these odours. Spatial recall was tested after sleep. Sound cues produced a selective recall benefit for weakly encoded memories. However, memory results did not support the prediction that forgetting could be instilled by the concurrent Forget odour. An encoding-strength-dependent benefit was largest when sounds were presented together with the odour that lacked assigned meaning, whereas the other two odours both disrupted sound-induced memory reactivation. These two odours were linked with instructions and with multiple learning episodes in the Directed-Forgetting task. Accordingly, we infer that reactivation evoked by the Remember and Forget odour cues interfered with the reactivation of spatial memories. Odours also induced a prolonged decline in sigma EEG power (12-16 Hz) that continued at least 10 s after odour offset. Overall, these findings highlight the complexity of memory consolidation during sleep when multiple memories and multiple cues are involved.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70314"},"PeriodicalIF":3.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Sleep Disturbances Treatment in Patients With Fibromyalgia: A Scoping Review. 睡眠障碍治疗对纤维肌痛患者的影响：一项范围综述。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-16 DOI: 10.1111/jsr.70296

Milena Araújo Dos Santos, Milena Camargo da Luz, Severino Correia do Prado Neto, Souza Amanda de Almeida, Antonio Felipe Lopes Cavalcante, Lara Arcipreti Boel Souza

{"title":"Impact of Sleep Disturbances Treatment in Patients With Fibromyalgia: A Scoping Review.","authors":"Milena Araújo Dos Santos, Milena Camargo da Luz, Severino Correia do Prado Neto, Souza Amanda de Almeida, Antonio Felipe Lopes Cavalcante, Lara Arcipreti Boel Souza","doi":"10.1111/jsr.70296","DOIUrl":"https://doi.org/10.1111/jsr.70296","url":null,"abstract":"Fibromyalgia (FM) is a chronic clinical syndrome characterised by widespread musculoskeletal pain, fatigue and sleep disturbances, with non-restorative sleep being a central symptom that severely exacerbates the condition. Although management is multidisciplinary, the role of interventions specifically directed at sleep as a primary pathway to improve core FM symptoms requires systematisation. The objective of this scoping review was to map the therapeutic approaches, both pharmacological and non-pharmacological, that address sleep disturbances in FM patients, identifying their characteristics, outcomes and evidence gaps. The review was conducted in accordance with the JBI and PRISMA-ScR guidelines. The search, restricted to articles published between 2020 and 2024, was performed in the PubMed, SciELO and ScienceDirect databases, utilising descriptors such as 'fibromyalgia', 'sleep disorders' and 'therapeutics'. Nine studies met the inclusion criteria (six non-pharmacological, three pharmacological). Non-pharmacological interventions (including diet, manual therapies, and biofeedback) showed mixed results, often without a significant impact on primary sleep outcomes. Repetitive Transcranial Magnetic Stimulation (rTMS) and the drug Suvorexant stood out as the most promising strategies, demonstrating statistically significant improvement in both sleep quality (objective and subjective measures) and core FM symptoms. The field of study is characterised by high heterogeneity in interventions and outcomes, underscoring the need for high-quality Randomised Controlled Trials that utilise objective sleep measures as primary outcomes to provide robust evidence. The mapping provided by this review guides future research in optimising sleep treatment, a critical factor in managing FM and improving patients' quality of life.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70296"},"PeriodicalIF":3.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabinol for Acute Treatment of Insomnia Disorder in a Randomized Placebo-Controlled Crossover Trial. 大麻酚在一项随机安慰剂对照交叉试验中的急性失眠治疗。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-16 DOI: 10.1111/jsr.70284

Isobel G Lavender, Nathaniel S Marshall, Danielle McCartney, Garry Cho, Chris Irwin, Anastasia Suraev, Rebecca Gordon, Jonathon C Arnold, Angela L D'Rozario, Christopher J Gordon, Bandana Saini, Sheila Sivam, Yizhong Zheng, Ronald R Grunstein, Brendon J Yee, Iain S McGregor, Camilla M Hoyos

{"title":"Cannabinol for Acute Treatment of Insomnia Disorder in a Randomized Placebo-Controlled Crossover Trial.","authors":"Isobel G Lavender, Nathaniel S Marshall, Danielle McCartney, Garry Cho, Chris Irwin, Anastasia Suraev, Rebecca Gordon, Jonathon C Arnold, Angela L D'Rozario, Christopher J Gordon, Bandana Saini, Sheila Sivam, Yizhong Zheng, Ronald R Grunstein, Brendon J Yee, Iain S McGregor, Camilla M Hoyos","doi":"10.1111/jsr.70284","DOIUrl":"https://doi.org/10.1111/jsr.70284","url":null,"abstract":"Insomnia disorder is harmful and requires novel treatments. Cannabinol, an oxidative by-product of Δ9-tetrahydrocannabinol, is claimed to be a hypnotic, but its effects on objective sleep and insomnia remain unknown. This randomized, double-blind, placebo-controlled, three-arm, single-night crossover trial evaluated the acute efficacy and safety of cannabinol for insomnia disorder. Twenty adults (aged 25-65) with physician-diagnosed insomnia disorder (meeting DSM-5 and ICSD-3 criteria; Insomnia Severity Index ≥ 15) were enrolled at the Woolcock Institute of Medical Research (Sydney, Australia) between August 2022 and September 2023. Participants received a single 2 mL oral dose of 30 mg (1.5%) or 300 mg (15%) cannabinol, or matched placebo (2-week washout). All participants (17 female and 3 males; mean ± SD age 42 ± 13 years) completed the protocol and were statistically analysed. The primary outcome was wake after sleep onset (WASO) minutes, measured by overnight polysomnography. Cannabinol did not significantly change WASO (300 mg: -6.3 min [95% CI: -18.2, +5.5], p = 0.29, dz = -0.22; 30 mg: -4.0 min [-15.9, +7.9], p = 0.50, dz = 0.11). However, 300 mg cannabinol increased non-rapid eye movement-2 sleep (p = 0.03, dz = 0.54), subjective sleep quality (p = 0.005, dz = 0.56); and reduced sleep onset latency (p = 0.004, dz = -0.74) and electroencephalographic arousal indices (p = 0.02, dz = -0.65). There were 247 mild-to-moderate adverse events across arms. Larger, longer trials are warranted. ClinicalTrials.gov Identifier: NCT05344170.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70284"},"PeriodicalIF":3.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placebo Effect of Sham Acupuncture for Primary Insomnia: A Meta-Analysis of Randomised Controlled Trials. 假针灸治疗原发性失眠的安慰剂效应：一项随机对照试验的荟萃分析。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2026-02-15 DOI: 10.1111/jsr.70280

Bo Jiang, Yi-Nan Wang, Jun Zhang, Hong-Ru Li, Pei-Wen Xue, Juan Li, Rong-Jiang Jin

{"title":"Placebo Effect of Sham Acupuncture for Primary Insomnia: A Meta-Analysis of Randomised Controlled Trials.","authors":"Bo Jiang, Yi-Nan Wang, Jun Zhang, Hong-Ru Li, Pei-Wen Xue, Juan Li, Rong-Jiang Jin","doi":"10.1111/jsr.70280","DOIUrl":"https://doi.org/10.1111/jsr.70280","url":null,"abstract":"To provide updated evidence from randomised controlled trials (RCTs) on the placebo effect size and influencing factors of sham acupuncture for primary insomnia. A systematic literature review and meta-analysis were conducted in accordance with the PRISMA guidelines. Databases such as PubMed, Cochrane, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database and Chinese Biological Medicine Database were searched, focusing on sham acupuncture and primary insomnia. RCTs would be included if they compared the clinical efficacy of sham acupuncture before and after the intervention in patients with primary insomnia. The risk of bias of the included studies was evaluated using the Cochrane risk-of-bias tool (version 2.0). A total of 4348 studies were retrieved, and 36 eligible randomised controlled trials were included. The overall risk of bias in 13 studies were considered as high risk, 7 studies were categorised as some concerns and 16 studies were considered as low risk. The results of the meta-analysis showed that sham acupuncture significantly reduced Pittsburgh Sleep Quality Index (PSQI) [weighted mean difference (WMD) = 1.38, (95% confidence interval (CI) = 0.90, 1.86), p < 0.05] and Insomnia Severity Index (ISI) [WMD = 2.58, (95% CI = 1.46-3.69), p < 0.05]. There was no significant change in polysomnography and actigraphy. Sham acupuncture had a certain placebo effect in clinical trials of primary insomnia. The placebo effect varied from different types of sham acupuncture.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70280"},"PeriodicalIF":3.9,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0