Journal of Sleep Research最新文献

{"title":"Aberrant Resting-State Effective Connectivity Between the Insula and Other Regions of the Whole Brain in Children With Obstructive Sleep Apnea.","authors":"Tingting Ji, Xiaodan Li, Zhifei Xu, Jing Zhao, Guixiang Wang, Yanzhen Li, Xuexi Zhang, Qiaoyin Liu, Nian Sun, Lin Mei, Shengcai Wang, Xin Ni","doi":"10.1111/jsr.70015","DOIUrl":"https://doi.org/10.1111/jsr.70015","url":null,"abstract":"<p><p>To investigate the effective connectivity between the bilateral insulae and other regions of the whole brain in children with obstructive sleep apnea (OSA), and to reveal the relationships between these abnormal connections and cognitive dysfunction in this condition. Resting-state functional magnetic resonance imaging (rs-fMRI) data and clinical variables were collected from 55 children with OSA [5.0 (5.0, 8.0) years, 32 males, 28 pre-school children] and 25 healthy controls [6.0 (5.0, 9.0) years, 11 males, 9 pre-school children], matched for age, gender, and education. Rs-fMRI data were analysed to investigative group-difference in the effective connectivity between the bilateral insulae and other regions of the brain of children with OSA with those of controls. Spearman correlation analysis was conducted between these abnormal connections and clinical variables among children with OSA. Compared with controls, children with OSA showed abnormal clinical variables (i.e., increased OAHI, AHI, OAI, HI, ODI, time of SpO₂ < 90%, total AI, and respiratory-related AI, while decreased minimal SpO₂, FIQ, VIQ, and PIQ). Additionally, significant alterations were observed in the effective connectivity between the bilateral insulae and other regions of brain, such as frontal, parietal, occipital, and cerebellum and so forth. Furthermore, the mean values of the effective connectivity in children with OSA were significantly correlated with several sleep-related and neurocognitive parameters. There exist abnormal causal interactions between the bilateral insulae and other regions throughout the brain in OSA children, accompanied by impaired cognitive function, suggesting that the former may be a potential neural mechanism underlying the latter.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70015"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ikelos-Rating Scale: Validation of a Behavioural Severity Marker in REM Sleep Behaviour Disorder.","authors":"Sophia Stotz, Frederik Bes, Dieter Kunz","doi":"10.1111/jsr.70019","DOIUrl":"https://doi.org/10.1111/jsr.70019","url":null,"abstract":"<p><p>The Ikelos-Rating Scale (Ikelos-RS) is a new, expert-interviewed and bedpartner-reported severity marker assessing frequency and expression of isolated REM sleep behaviour disorder (iRBD), a precursor of clinical α-synucleinopathies. This study aimed to validate the Ikelos-RS in 180 patients with three-night PSG-confirmed iRBD (68.4 ± 8.3 years; 139 m). Inter-rater (n = 45) and test-retest reliabilities (n = 25; 174 Ikelos-RS) were evaluated. For construct validity, correlation analyses were performed with: (1) Clinical Global Impressions-Severity (CGI-S; n = 151), (2) REM sleep without atonia (RWA) within videometry (n = 20), (3) RWA at initial diagnosis (n = 131) and changes over time (n = 36), (4) dopamine transporter scintigraphy (DaT-SPECT) at baseline and changes over time (n = 75). RWA- and DaT-SPECT-analyses were conducted for the whole sample ('all') and after excluding confounders ('cleaned'). Correlation analyses indicated high inter-rater (r_s = 0.865, p < 0.001) and test-retest reliabilities (r_s = 0.900, p < 0.001). Construct validity was supported by associations of Ikelos-RS with (1) CGI-S (r_s = 0.845, p < 0.001), (2) RWA within videometric analysis (r_s = 0.592, p = 0.006) and at baseline ('all': r_s = 0.274, p = 0.002), (3) DaT-binding (z-scores) at baseline in right anterior putamen (AP) ('all': r_s = -0.319, p = 0.005) and changes over time, most pronounced in right anterior putamen (AP) ('all': r_s = -0.243, p = 0.035; 'cleaned': r_s = -0.374, p = 0.008) and left posterior putamen (PP) ('all': r_s = -0.259, p = 0.025; 'cleaned': r_s = -0.319, p = 0.024). Given its high reliability and construct validity, demonstrated by associations with the best available severity markers DaT-binding ratios and RWA, Ikelos-RS appears to represent a reliable, valid and easy-to-use tool for measuring the severity of iRBD. Thus, Ikelos-RS may prove beneficial in research. Its suitability as a screening tool in older at-risk populations needs to be proven in future studies.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70019"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of a personalized sleep improvement app in subclinical poor sleepers: A randomized controlled trial.","authors":"Oliver Munt, Michael Schredl, Elie Gottlieb, Susanne Fischer, Daniela Gautschi, Luke Gahan, Christoph Schoebel","doi":"10.1111/jsr.14445","DOIUrl":"https://doi.org/10.1111/jsr.14445","url":null,"abstract":"<p><p>The aim of this study was to determine the effects of a personalized smartphone application on subjective sleep quality, wellbeing and stress in participants with subclinical sleep problems. Healthy participants with subclinical threshold sleep issues that did not meet diagnostic criteria for insomnia were randomly assigned to use the app or be on a waiting list for app usage (control group). Subjective data on sleep quality (sleep quality component of Sleep Questionnaire B [primary endpoint] and the Pittsburgh Sleep Quality Index), feeling refreshed after the sleep component of Sleep Questionnaire B, Short Form-12 physical and mental components, and stress (Perceived Stress Scale) were compared between the app and control groups at baseline and after 6 and 12 weeks. Depending on their usage, app users were defined as \"frequent\", \"occasional\" or \"rare/never\" users. Two-hundred and six and 205 app users and 286 and 285 control participants completed the 6- and 12-week assessments, respectively. Sleep Questionnaire B scores improved in frequent (effect size 0.595; F = 13.7) and occasional users (0.653; F = 9.4) after 6 weeks; effects persisted at 12 weeks, and were similar for the Pittsburgh Sleep Quality Index. Feeling refreshed after the sleep component of Sleep Questionnaire B improved over time in all groups, with no significant difference between app users and controls. There were no changes in Short Form-12 physical component, Short Form-12 mental component, and Perceived Stress Scale scores. A personalized app positively affected subjective sleep quality in a population of users with subclinical threshold sleep issues, and could serve as a low-burden digital intervention to potentially prevent the exacerbation of sleep pathologies.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14445"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of training load and schedule on youth athletes' sleep.","authors":"Tanisha Tate, Spencer Roberts, Luana C Main, Lyndell Bruce","doi":"10.1111/jsr.70013","DOIUrl":"https://doi.org/10.1111/jsr.70013","url":null,"abstract":"<p><p>Sleep is important for youth athletes, supporting sport-related recovery and performance, as well as growth and development. Sleep may be influenced by training factors; therefore, this study aimed to characterise youth athletes' sleep, and examine associations between training load, schedule and frequency, and sleep. Twenty-six youth basketballers (age: 14.22 ± 0.74 years, 13 male, 13 female) from a high-performance sporting school were monitored for a period of 8 weeks. Sleep measures (via actigraphy and sleep diaries) were collected alongside training diaries (recording time, duration and perceived exertion). Youth athletes who finished training after 20:30 hours had significantly less total sleep time than when training finished before 20:30 hours. Higher daily total training duration was associated with decreased total sleep time. There is a potential contradiction with findings related to the number of sessions per day, as participants who completed two training sessions in a day had more sleep than those who completed one session per day; but this was not observed for athletes with three sessions per day. Participants had large intra-individual variations (mean intra-individual standard deviation) in bedtime (1.06 hr) and sleep time (0.84 hr). In conclusion: (1) late night training sessions appear to reduce total sleep time and should be avoided in youth athletes; (2) total daily training duration had a greater negative effect on sleep than session frequency; and (3) participants' large intra-individual variation in bedtime may reduce sleep quality and efficiency.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70013"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of manually scored multichannel frontal electroencephalography against polysomnography in a paediatric cohort.","authors":"Sigridur Sigurdardottir, Henna Pitkänen, Henri Korkalainen, Samu Kainulainen, Marta Serwatko, Kristin A Olafsdottir, Sigurveig Þ Sigurðardóttir, Michael Clausen, Pranavan Somaskandhan, Barbara G Stražišar, Timo Leppänen, Erna Sif Arnardottir","doi":"10.1111/jsr.70012","DOIUrl":"https://doi.org/10.1111/jsr.70012","url":null,"abstract":"<p><p>Polysomnography is the only internationally recognized method to diagnose paediatric obstructive sleep apnea, thus, simpler and more cost-effective diagnostic tools are urgently needed. This study aimed to validate the manual scoring of frontal self-applicable electroencephalography against polysomnography in a paediatric cohort. The polysomnography and the frontal electroencephalography were simultaneously recorded for 1 night (n = 102) in 10-13-year-old children. Scoring was performed according to the American Academy of Sleep Medicine rules, with minor adjustments to the frontal electroencephalography. Manual scorings of sleep stages were compared in an epoch-by-epoch manner using Cohen's kappa (κ) and confusion matrices using three different models: the three-stage (wake/non-rapid eye movement/rapid eye movement), the four-stage (wake/sleep stage 1 + sleep stage 2/deep sleep Stage 3/rapid eye movement) and the five-stage model (wake/sleep stage 1/sleep stage 2/deep sleep Stage 3/rapid eye movement). The inter-scorer agreements were assessed, and the intraclass correlation coefficient was used for common sleep variables: total sleep time, wake after sleep onset, sleep efficiency, sleep-onset latency and arousal index. Cohen's κ values for the three-stage, four-stage and five-stage models were 0.85, 0.73 and 0.70, respectively. The agreement for the sleep variables studied ranged from 0.87 to 0.99. The inter-rater agreement (n = 10) was κ = 0.78 for the polysomnography and κ = 0.70 for the frontal electroencephalography. Sleep staging from the frontal electroencephalography was comparable to that of a standard polysomnography in a paediatric cohort, and showed promising results in estimating sleep time and sleep architecture.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70012"},"PeriodicalIF":3.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and incidence of periodic limb movements during sleep in São Paulo, Brazil: results from the EPISONO cohort.","authors":"Vanessa Cavalcante-Silva, Priscila Kalil Morelhão, Gabriel Natan de Pires, Priscila Farias Tempaku, Vânia D'Almeida, Sergio Tufik, Monica L Andersen","doi":"10.1111/jsr.14475","DOIUrl":"https://doi.org/10.1111/jsr.14475","url":null,"abstract":"<p><p>Periodic limb movements in sleep (PLMS) are characterised by repetitive and involuntary movements of the limbs during sleep. When these movements exceed 15 events/h, they are considered clinically significant and can disrupt sleep quality and contribute to various health risks. The aim of this study was to investigate the prevalence, incidence, and remission of PLMS in a representative sample from São Paulo, Brazil. Data from the 2007 (and its 2015 follow-up) and 2018 editions of the São Paulo Epidemiologic Sleep Study (EPISONO) study were used. PLMS prevalence rates were determined for 2007 and 2018, while incidence and remission rates were evaluated between 2007 and 2015. In 2007, the prevalence of PLMS was 9.02% (95% confidence interval [CI] 7.28-10.76%), which increased to 15.60% (95% CI 13.04-18.17%) by 2018. The incidence of new PLMS cases from 2007 to 2015 was 6.54% (95% CI 4.60-8.4%), with a remission rate of 50.82% (95% CI 38.27-63.37%). Ageing significantly influenced the increase in both the prevalence and severity of PLMS over time. Individuals with African ancestry had lower odds of PLMS compared to those of Caucasian ancestry (odds ratio 0.25, 95% CI 0.10-0.60; p = 0.002). Our study revealed that the prevalence of PLMS in São Paulo, a city with a racially mixed population, was significantly lower than in population samples with Caucasian ancestry. The observed increase in PLMS prevalence over a decade was potentially linked to population ageing and lifestyle changes. These findings highlight the importance of ongoing research into the long-term health implications of PLMS and its role in sleep disorders.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14475"},"PeriodicalIF":3.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep neuroimaging: Review and future directions.","authors":"Mariana Pereira, Xinyuan Chen, Anastasiya Paltarzhytskaya, Yibran Pacheсo, Nils Muller, Leonore Bovy, Xu Lei, Wei Chen, Haoran Ren, Chen Song, Laura D Lewis, Thien Thanh Dang-Vu, Michael Czisch, Dante Picchioni, Jeff Duyn, Philippe Peigneux, Enzo Tagliazucchi, Martin Dresler","doi":"10.1111/jsr.14462","DOIUrl":"https://doi.org/10.1111/jsr.14462","url":null,"abstract":"<p><p>Sleep research has evolved considerably since the first sleep electroencephalography recordings in the 1930s and the discovery of well-distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used to describe the sleeping brain in much detail, since the 1990s neuroimaging techniques have been applied to uncover the brain organization and functional connectivity of human sleep with greater spatial resolution. The combination of electroencephalography with different neuroimaging modalities such as positron emission tomography, structural magnetic resonance imaging and functional magnetic resonance imaging imposes several challenges for sleep studies, for instance, the need to combine polysomnographic recordings to assess sleep stages accurately, difficulties maintaining and consolidating sleep in an unfamiliar and restricted environment, scanner-induced distortions with physiological artefacts that may contaminate polysomnography recordings, and the necessity to account for all physiological changes throughout the sleep cycles to ensure better data interpretability. Here, we review the field of sleep neuroimaging in healthy non-sleep-deprived populations, from early findings to more recent developments. Additionally, we discuss the challenges of applying concurrent electroencephalography and imaging techniques to sleep, which consequently have impacted the sample size and generalizability of studies, and possible future directions for the field.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14462"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Review: \"The Clinician's Guide to Cognitive and Behavioural Therapeutics (CBTx) for Insomnia-A Scientist-Practitioner Approach\".","authors":"Daniel Ruivo Marques","doi":"10.1111/jsr.70016","DOIUrl":"https://doi.org/10.1111/jsr.70016","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70016"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New developments in insomnia assessment and diagnosis: Self-reported questionnaires, clinical interviews, and ecological momentary assessment.","authors":"Silvia Cerolini, Jason G Ellis, Debora Meneo, Elisabetta Baldi, Chiara Baglioni","doi":"10.1111/jsr.70010","DOIUrl":"https://doi.org/10.1111/jsr.70010","url":null,"abstract":"<p><p>Accurate and timely assessment is essential for diagnostic and therapeutic purposes. Over the past few years, new developments in the assessment of insomnia disorder have been outlined. This review aims to summarise the available instruments in line with the updated scientific research and advances in clinical sleep research. A synthesis of new developments in the field from 2020 to 2024, focussing on self-reported questionnaires, clinical interviews, and ecological momentary assessment, are provided. After exploring novel advances and their interplay with evidence-based validated instruments, we will discuss limitations and future directions. What are we missing? What should be improved and ameliorated? What are the next steps for insomnia assessment and diagnosis regarding methodology, dissemination, and practice?</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70010"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting vocabulary learning during sleep at home using closed-loop targeted memory reactivation.","authors":"Federico Salfi, Aurora D'Atri, Benedetto Arnone, Domenico Corigliano, Giulia Amicucci, Lorenzo Viselli, Federica Naccarato, Fabiana Festucci, Daniela Tempesta, Michele Ferrara","doi":"10.1111/jsr.70000","DOIUrl":"https://doi.org/10.1111/jsr.70000","url":null,"abstract":"<p><p>Targeted memory reactivation represents an established technique for promoting sleep-dependent memory consolidation in laboratory studies. This investigation aimed to test the potentiality of a wearable electroencephalography-based closed-loop targeted memory reactivation system to boost vocabulary learning in home settings. In the evening, 24 adults (23.58 years ± 3.36 years, 19 females) were asked to learn the Italian translation of 40 pseudowords (test session). Subsequently, participants slept at their home wearing an electroencephalography headband (Dreem 2), and half of the pseudowords were acoustically re-presented (cued) following the real-time detection of slow waves. After the awakening, memory recall of the Italian translations was retested. The stimulation effect was evaluated by comparing the test-retest variations in memory accuracy between cued and uncued pseudowords. Moreover, we assessed the event-related potentials and spectral perturbations induced by the cued stimuli during sleep, comparing the electrophysiological correlates of correctly translated pseudowords with incorrectly translated ones at the retest session. Closed-loop targeted memory reactivation increased the translation accuracy for cued pseudowords (+8.6%), while no significant test-retest variation for uncued items was observed (-4.6%). Time-frequency analysis indicated a spectral power increase in the spindle frequency band coinciding with the second positive peak of the sound-elicited slow wave as the correlate of successful morning recall. This study extended the targeted memory reactivation effectiveness in enhancing vocabulary learning to an ecological home environment, providing further support to the role of spindle activity in the targeted memory reactivation effect. A wearable closed-loop targeted memory reactivation system could represent a memory-enhancement tool in real-world settings by promoting the hallmark sleep electroencephalographic rhythms of memory consolidation.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70000"},"PeriodicalIF":3.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}