Christian M Horvath, Hristina Drangova, Jakub Stefela, Carolin Schäfer, Frederic Zubler
{"title":"Refuting a Temporal Correlation: Interictal Epileptic Discharges Do Not Preferentially Occur During Respiratory Events in Patients With Sleep-Related Breathing Disorder and Epilepsy.","authors":"Christian M Horvath, Hristina Drangova, Jakub Stefela, Carolin Schäfer, Frederic Zubler","doi":"10.1111/jsr.70021","DOIUrl":"https://doi.org/10.1111/jsr.70021","url":null,"abstract":"<p><p>The bidirectional interaction between sleep and epilepsy is well known. In particular, it has been established that sleep apnea can worsen epilepsy, whereas sleep apnea (SA) treatment has a beneficial effect on seizure control. However, the exact mechanisms whereby SA promotes epileptic seizures are unknown. We set out to examine whether interictal epileptic discharges (IED), one of the hallmarks of epilepsy, occur predominantly during respiratory events (RE, apnea or hypopnea) or desaturations in patients with obstructive SA (OSA) and epilepsy. Adult patients (> 18) who underwent a video-polysomnography at the Bern University Hospital between 2012 and 2020 with an apnea-hypopnea-index (AHI) ≥ 10/h and IED were included in this retrospective study. IED density (per hour) was computed during and outside RE and oxygen desaturations (3%) using the AASM criteria and an extended definition. A total of 27 patients (9 females) met the inclusion criteria. The median age was 49 years and the median AHI was 17.4/h. There was no statistically significant difference in IED density in phases of sleep with RE compared to sleep without (median 3.6 [IQR 0.2-8.0] vs. 6.3 [3.7-19.7], p = 0.055). In the extended definition of RE, IED density was significantly lower during RE: 2.6 [0.3-6.6] versus 6.7 [3.9-20.5], p = 0.017. Desaturations were similarly associated with lower IED density in both analyses: 2.2 [0-7.4] versus 6.4 [3.4-18.4], p = 0.009 and 2.6 [0-6.7] versus 6.8 [3.4-18.5], p = 0.012. Our study shows that the influence of OSA on epileptic activity is probably indirect and does not result solely from immediate hypoxemia.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70021"},"PeriodicalIF":3.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stuck in time: The slow march of circadian medicine and how to speed it up.","authors":"Christian Cajochen, Sara Montagnese","doi":"10.1111/jsr.70011","DOIUrl":"https://doi.org/10.1111/jsr.70011","url":null,"abstract":"<p><p>While there is considerable enthusiasm for the translational and clinical applications of chronobiology, their actual implementation is not progressing as rapidly as might be expected. Here we discuss the possibility that this may relate to a combination of conceptual, methodological, evidentiary and training challenges. These are compounded by the remaining, profound cultural differences between basic and applied chronobiologists. We argue that all these issues can be overcome by cross-faculty teaching, time, patience and goodwill, together with a set of more formal actions, such as the establishment of a collaborative framework for evidence generation, the engagement of relevant stakeholders and public health campaigns based on already available evidence. We hope that chronobiology, and in particular the transformative power of circadian medicine, will change health outcomes, increase safety and improve quality of life for patients worldwide. Now is the time to bring \"internal time\" into medicine.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70011"},"PeriodicalIF":3.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Actigraphy against 32-hour polysomnography in patients with suspected idiopathic hypersomnia.","authors":"Tugdual Adam, Jérôme Tanty, Lucie Barateau, Yves Dauvilliers","doi":"10.1111/jsr.70007","DOIUrl":"https://doi.org/10.1111/jsr.70007","url":null,"abstract":"<p><p>Actigraphy, a tool known for investigating sleep-wake patterns at home, lacks scientific validation in hypersomnolent subjects. We aim to validate an actigraphy-based sleep-wake prediction algorithm against 32-h continuous polysomnography in patients with suspected idiopathic hypersomnia, and to compare its performance to predict sleep-wake parameters assessed by polysomnography with those of a commercially available algorithm. Two hundred and six hypersomnolent subjects were included prospectively in a Reference Centre for Hypersomnias, and underwent a 32-h bedrest protocol, wearing wrist-actigraphy, to diagnose idiopathic hypersomnia. Among them, 126 patients (91 females, 30.6 ± 15.5 years, 101 idiopathic hypersomnia, 25 non-specified hypersomnia) with synchronised actigraphy and polysomnography were analysed. Age, sex, and Epworth Sleepiness Scale scores were collected. We trained various supervised algorithms and selected a recurrent neural network (S2S sequence-to-sequence long short-term memory network) for comparison with Actiwatch Software (AS) on sleep-wake variables and prediction errors during daytime and nighttime. S2S outperformed AS across all relevant metrics, and Bland-Altman analysis showed disagreement between the two algorithms. S2S had a lower absolute error than AS. AS mainly overestimated sleep, an overestimation that was substantially reduced with S2S, overall as well as during day and night. Performance was not correlated with age, sex, or subjective sleepiness, but objective sleepiness and longer sleep time on the bedrest were associated with sleep underestimation. Our S2S algorithm using deep learning performed better to predict sleep-wake parameters than AS and other commonly used algorithms. The next objective is to leverage this algorithm to study sleep-wake patterns in patients with hypersomnolence at home.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70007"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rasmus Møller Buus, Silvia Genovese, Kira Vibe Jespersen
{"title":"The art of sleep: examining sleep strategies in the general population with a focus on the use of music for sleep.","authors":"Rasmus Møller Buus, Silvia Genovese, Kira Vibe Jespersen","doi":"10.1111/jsr.70006","DOIUrl":"https://doi.org/10.1111/jsr.70006","url":null,"abstract":"<p><p>Insomnia is highly prevalent and associated with serious health issues. Despite the negative impact of poor sleep on mind and body, most people do not seek treatment. This study aimed to examine the strategies used to improve sleep in the general population with a particular focus on music. A survey was distributed via Facebook advertisements to Danish adults aged ≥18 years. Among 3667 responders, a representative subsample of 1195 participants was randomly selected based on age and sex. Data analysis involved chi-square tests and logistic regression with adjustments for age, sex, education, and insomnia status. The results showed that nearly all participants utilised strategies to aid their sleep, with the most common strategies being 'following a routine' (73%), 'reducing caffeine in the afternoon/evening' (65%) and 'lowering the temperature in the bedroom' (62%). Individuals with insomnia utilised significantly more strategies (average 8.4 strategies) compared to those without insomnia (average 6.6 strategies). Among all participants, 20% reported using music for sleep at least 1-2 times/month, whereas 11% used music for sleep weekly, and 4.5% used music almost daily. Music users tended to be younger, and they were also more likely to have insomnia. By evaluating 24 different sleep strategies, this study shows that people do several things to promote sleep in their daily lives. These findings enhance our understanding of sleep behaviour, providing an important fundament for targeting future public health interventions to reduce the use of sleep disruptive strategies and promote strategies known to improve sleep health.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70006"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valentin Bilgeri, Philipp Spitaler, Patrick Rockenschaub, Fabian Lehner, Bernhard Erich Pfeifer, Peter Willeit, Fabian Barbieri, Ambra Stefani, Birgit Högl, Herbert Formayer, Axel Bauer, Wolfgang Dichtl
{"title":"Weather-Associated Variations of Device-Detected Severe Sleep Apnea in Cardiac Pacemaker Patients.","authors":"Valentin Bilgeri, Philipp Spitaler, Patrick Rockenschaub, Fabian Lehner, Bernhard Erich Pfeifer, Peter Willeit, Fabian Barbieri, Ambra Stefani, Birgit Högl, Herbert Formayer, Axel Bauer, Wolfgang Dichtl","doi":"10.1111/jsr.70024","DOIUrl":"https://doi.org/10.1111/jsr.70024","url":null,"abstract":"<p><p>Using continuous thoracic impedance measurements, sleep apnea can be long-time monitored via an electronic device sensor. In the ACaSA trial, 233 patients implanted with a cardiac pacemaker (MicroPort CRM, Clamart, France) were prospectively observed between March 2022 and July 2024. For each night of follow-up, the burden of device-detected sleep apnea (DDSA) was measured via transthoracic impedance, defined by a respiratory disturbance index (RDI) ≥ 20 events per sleeping hour. Local meteorological data including maximum ambient diurnal temperature, humidity, precipitation and air pressure change were extracted from the national weather system and linked to the individual patient's place of residence. The association between these weather conditions and RDI in the following night was estimated using a generalised linear mixed effects model. Overall, 74,031 patient-nights of 210 individuals (median age 75.7 years [IQR 69.9-81.3], 77 [36.7%] female) with a median follow up of 593 nights (IQR 348-755) were analysed. In a multivariate regression analysis, ambient maximum diurnal temperature was independently associated with presence of DDSA. Following days with a maximum of 30°C, the odds of experiencing severe DDSA increased by 1.34 (95% CI: 1.17-1.54, p < 0.001) compared to days with only 10°C. Higher relative humidity increased the odds for suffering from severe DDSA as well (OR 1.19 [1.07-1.33] in 90% relative humidity vs. 65% humidity; p = 0.007). These associations of ambient maximum diurnal temperature and relative humidity with severe DDSA the following night need further investigations, in particular in view of upcoming global climate changes.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70024"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of sleep medication-induced parasomnias using the Japanese Adverse Drug Event Report database.","authors":"Shotaro Kobayashi, Koji Shinozaki, Hiroyuki Nagano, Ayaka Miyamori, Taichi Muramatsu, Akifumi Kushiyama","doi":"10.1111/jsr.70009","DOIUrl":"https://doi.org/10.1111/jsr.70009","url":null,"abstract":"<p><p>The association between sleep medication and parasomnia remains unclear. However, some sleep medications may also cause parasomnia. Therefore, we examined the association between sleep medication use and parasomnia. We performed an analysis using cases registered in the Japanese Adverse Drug Event Report Database from April 2004 to March 2022. We calculated the unadjusted reporting odds ratio (ROR) and adjusted it to consider confounding factors. The ROR for each sleep medication was significant: benzodiazepines (ROR 3.55, 95% confidence interval [CI] 2.39-5.27), non-benzodiazepines (ROR 14.21, 95% CI 10.41-19.39), melatonin receptor agonists (ROR 6.79, 95% CI 2.79-16.51), orexin receptor antagonists (ROR 18. 40, 95% CI 10.66-31.75). The adjusted RORs for non-benzodiazepines (9.75, 95% CI 6.71-14.2) and orexin receptor antagonists (8.65, 95% CI 4.56-16.4) were significant for sleep medications. These findings indicate that non-benzodiazepines and orexin receptor antagonists may cause parasomnias. Significant signals were detected, even when confounding factors were considered.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70009"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bárbara Araújo Conway, Marwin Machay Indio do Brasil do Carmo, Helder Sergio Lira Soares Filho, Andrea Cecília Toscanini, Rosa Hasan, Marcela Mansur Alves, Renatha El Rafihi-Ferreira
{"title":"Personality traits and insomnia: direct and anxiety-mediated associations.","authors":"Bárbara Araújo Conway, Marwin Machay Indio do Brasil do Carmo, Helder Sergio Lira Soares Filho, Andrea Cecília Toscanini, Rosa Hasan, Marcela Mansur Alves, Renatha El Rafihi-Ferreira","doi":"10.1111/jsr.70003","DOIUrl":"https://doi.org/10.1111/jsr.70003","url":null,"abstract":"<p><p>Insomnia is the one of the most prevalent sleep disorders in the adult population. Studies have shown that personality traits, particularly neuroticism, act as factors that predispose to and potentially perpetuate insomnia; however, there is still no consensus in the literature regarding these relationships considering their mechanisms. A total of 595 participants answered the Insomnia Severity Index, Revised Neuroticism-Extroversion-Openness (NEO) Five-Factor Inventory, Hospital Anxiety and Depression Scale, questions of the Diagnostic and Statistical Manual of Mental Disorders (fifth edition), and a sociodemographic questionnaire. Descriptive analysis, correlations and stepwise linear regression were used to assess the associations between the five personality traits and insomnia severity. Mediation and moderation analyses were performed to evaluate the mechanisms underlying the association between insomnia severity and neuroticism. There was a direct negative association between insomnia severity and openness to experience and an indirect positive association between insomnia severity and neuroticism. Anxiety was identified as a mediator and depression as a moderator of the association between insomnia severity and neuroticism. The neuroticism and openness to experience personality traits are significant predictors of insomnia severity. Openness to experience appears to be a protective factor against insomnia. Longitudinal studies are needed to confirm our findings. These results may contribute to the development of new psychological and behavioural protocols for the treatment of insomnia.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70003"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Daylight Savings Time—A Position Statement of the British Sleep Society and More!","authors":"Dieter Riemann","doi":"10.1111/jsr.70020","DOIUrl":"10.1111/jsr.70020","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"34 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva M van Heese, Jari K Gool, Gert Jan Lammers, Ysbrand D van der Werf, Matthias J P van Osch, Rolf Fronczek, Lydiane Hirschler
{"title":"MRI-based surrogates of brain clearance in narcolepsy type 1.","authors":"Eva M van Heese, Jari K Gool, Gert Jan Lammers, Ysbrand D van der Werf, Matthias J P van Osch, Rolf Fronczek, Lydiane Hirschler","doi":"10.1111/jsr.14479","DOIUrl":"https://doi.org/10.1111/jsr.14479","url":null,"abstract":"<p><p>Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI-based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy. We processed diffusion-weighted and functional resting-state images to extract two surrogates: Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS index), and dBOLD-CSF coupling. Both measures were analysed in 12 drug-free, awake people with narcolepsy type 1 and 11 age- and sex-matched controls, as well as in relation to clinical features. We also assessed the correlation between the DTI-ALPS index and dBOLD-CSF coupling. The DTI-ALPS index and dBOLD-CSF coupling amplitude did not show significant differences between narcolepsy and controls, nor significant relations with the severity of excessive daytime sleepiness. We found a significant correlation between dBOLD-CSF coupling and sleep efficiency, as well as a significant correlation between the DTI-ALPS index and dBOLD-CSF coupling. The hypothesis of altered brain clearance in narcolepsy type 1 is not supported by evidence from the current study. The two surrogates correlated with each other, suggesting that both offer different perspectives from the same underlying physiology. Yet, the suitability of the surrogates as brain clearance markers remains debatable. Whereas DTI is not exclusively sensitive to perivascular fluid, dBOLD-CSF coupling is reflecting large-scale CSF motion. Future work should explore other surrogate markers, preferably during sleep, to better understand the possible role of altered brain clearance in narcolepsy type 1 symptomatology.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14479"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leanna M McWood, Stephen A Erath, Ben Hinnant, Mona El-Sheikh
{"title":"Predicting weekday and weekend sleep: Interactions between peers and mothers.","authors":"Leanna M McWood, Stephen A Erath, Ben Hinnant, Mona El-Sheikh","doi":"10.1111/jsr.70014","DOIUrl":"https://doi.org/10.1111/jsr.70014","url":null,"abstract":"<p><p>Adolescents often experience insufficient, inconsistent and poor-quality sleep. Deviant peer affiliation may promote insufficient or inconsistent sleep schedules, and could be an important factor in understanding adolescents' sleep. Furthermore, parenting behaviours have been shown to impact sleep in youth. We examined relations between deviant peer affiliation and sleep in adolescents, and assessed the role of maternal management of peer relationships as a moderator of these associations. A sample of 131 adolescents (M<sub>age</sub> = 15.75 years, SD = 9.5 months; 70% white, 30% black; 54% female) reported their deviant peer affiliation, and mothers reported their directive and non-directive management of peer relationships. Adolescents wore actigraphs for 1 week to assess sleep hours, efficiency, onset and latency, which were used to calculate weekend (Friday-Saturday) and weekday (Sunday-Thursday) sleep parameters. Using latent difference score models, results indicated that deviant peer affiliation was associated with shorter and less efficient sleep during the weekend. Moderation effects suggested that deviant peer affiliation related to fewer sleep hours, later sleep onset and longer sleep latency during the weekend for adolescents with higher levels of non-directive maternal management. Furthermore, the greatest difference between weekend and weekday sleep onset was found for youth with both higher levels of deviant peer affiliation and higher levels of non-directive maternal management of peer relationships. Results of this study provide evidence that deviant peer relationships may be particularly influential for weekend sleep, and that more active maternal management of peer relationships can protect against poor sleep.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70014"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}