Journal of Sleep Research最新文献

{"title":"When the Solution May Be Worse Than the Problem: A Caution Against Permanent Daylight Saving Time, on Behalf of the Italian Academy of Sleep Medicine.","authors":"A Romigi, S Garbarino, L Ferini Strambi, C Lombardi, L Nobili","doi":"10.1111/jsr.70347","DOIUrl":"https://doi.org/10.1111/jsr.70347","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70347"},"PeriodicalIF":3.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Tibetan Ancestry on Respiratory Control and Central Sleep Apnea in Hypoxia.","authors":"Grégory Heiniger, Lise Piquilloud, Geoffroy Solelhac, Théo Imler, Adrien Waeber, Brian Bradley, Gianpaolo Lecciso, Francis Degache, Alban Lovis, Karma Lambercy, Bengt Kayser, Scott Sands, Andrew Wellman, Raphael Heinzer","doi":"10.1111/jsr.70346","DOIUrl":"https://doi.org/10.1111/jsr.70346","url":null,"abstract":"<p><p>The onset of altitude-induced central sleep apnea (CSA) varies among individuals and may be influenced by genetic factors affecting respiratory control. Tibetans, who have undergone high-altitude adaptation over generations, may exhibit physiologic traits that protect against CSA. This study investigated the impact of Tibetan ancestry on respiratory control and hypoxia-induced CSA. Nine healthy unacclimatized Tibetans living in Switzerland for at least 5 years and 20 Caucasians (all males; median[IQR] age: 28 [27-32] vs. 24 [23.5-26] years; median[IQR] BMI: 23.8 [23.1-28] vs. 22.1[21.2-23.1]kg/m²) underwent two full polysomnographies, one at low altitude and one in a hypoxic chamber simulating 3500 m. The apnea-hypopnea index (AHI) and the percentage of sleep spent in periodic breathing (PB) were calculated. A hyperoxic hypercapnic ventilatory response (HCVR) test and hypoxic ventilatory response tests at rest (HVRr) and during exercise (HVRe) were performed. Parameters were compared between groups using non-parametric tests. At simulated altitude, Tibetans exhibited a significantly lower AHI (51.2 [12.7-72.1]/h vs. 107.0 [36.7-140.3]/h; p = 0.0231) and spent less sleep time in PB (27.6 [2.6-44.5]% vs. 58.8 [14.0-89.0]%; p = 0.0334) compared to Caucasians. HCVR did not differ significantly between groups (Tibetans: 1.983 [1.349-2.224] L/min/mmHg; Caucasians: 2.227 [1.698-3.071] L/min/mmHg; p = 0.2167). Tibetans showed a significantly lower HVRr (Tibetans: 0.001 [-0.211-0.074] L/min/%/kg; Caucasians: 0.384 [0.160-0.637] L/min/%/kg; p = 0.0112) and a blunted HVRe (Tibetans: 0.311 [0.225-0.789] L/min/%/kg; Caucasians: 0.806 [0.518-1.196] L/min/%/kg; p = 0.0448). These results indicate that Tibetan ancestry is associated with a partial protection from hypoxia-induced central sleep apnea, likely related to a blunted hypoxic ventilatory response. These findings suggest that inherited differences in ventilatory control may modulate breathing stability during sleep at high altitude.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70346"},"PeriodicalIF":3.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Jetlag Emerges in Preadolescent Children Despite Adequate Sleep Duration: Evidence for Child-Mother Circadian Misalignment Associations.","authors":"Maria Korman, Vadim Tkachev, Lital Mahlof, Liat Hen-Herbst","doi":"10.1111/jsr.70345","DOIUrl":"https://doi.org/10.1111/jsr.70345","url":null,"abstract":"<p><p>Social jetlag, the misalignment between behaviourally expressed circadian timing and social schedules, has been extensively studied in adults but remains poorly characterized in preadolescent children. This cross-sectional survey examined sleep-wake patterns in 972 Israeli children (mean age: 5.8 ± 1.6 years, range: 4-10) and their mothers (mean age: 37.1 ± 5.7 years, range: 22-49), who reported sleep behaviours using adapted Munich Chronotype Questionnaire items and an item about evening screen exposure between 16:00 and sleep onset. Children's mean sleep duration was 10.45 h, with 57.1% showing 30 min or less variation between free and school days. Surprisingly, children exhibited higher social jetlag than their mothers (64.9 ± 47.7 vs. 46.6 ± 52.9 min, p < 0.001), increasing from 54.5 min at age 4 to 107.1 min at age 10. Positive correlations existed between mother-child chronotypes (ρ = 0.224, p < 0.001) and social jetlag (ρ = 0.222, p < 0.001). Evening screen exposure averaged 84 ± 66 min and correlated with age (ρ = 0.240, p < 0.001). Later chronotype was the strongest predictor of child social jetlag; higher body mass index was associated with greater social jetlag, whereas older age, secular lifestyle, longer sleep, more consistent sleep duration and screen exposure were associated with lower social jetlag. Maternal social jetlag independently predicted greater child social jetlag. Young children experience substantial social jetlag, challenging assumptions about sleep timing regularity in preadolescence. Adequate sleep duration coexisting with high social jetlag, a marker linked to adverse metabolic and behavioural outcomes, suggests paediatric guidelines may need to incorporate weekly sleep timing consistency. Child-mother sleep interconnections highlight the necessity of exploring family-based interventions beyond focus on sleep quantity.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70345"},"PeriodicalIF":3.9,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two-Hit Stress Model.","authors":"John Axelsson, Mats Lekander, Camilla I Svensson, Nils Simon, Alexandra Kuliszkiewicz, Julie Lasselin, Leonie J T Balter","doi":"10.1111/jsr.70335","DOIUrl":"https://doi.org/10.1111/jsr.70335","url":null,"abstract":"<p><p>Sleep loss and low-grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two-hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night); sleep-restriction (two nights, 4 h in bed/night); and an immune challenge (~24 h post COVID-19 vaccination) combined with either sleep saturation (n = 26) or restriction (n = 30). Motivation for everyday behaviours and sleepiness were rated, and blood samples were collected. Both sleep restriction and vaccination increased motivation for sleep-related behaviours and reduced motivation for physical and social activity, with sleep restriction having broader effects. These changes were associated with inflammation and sleepiness. Vaccination increased thirst, while sleep restriction reduced it, but neither affected hunger or food preferences. Sleep restriction amplified the inflammatory response to vaccination. For motivation, the stressors combined caused larger changes than either alone for some outcomes, without amplifying one another. These findings support that different stressors reallocate motivation towards rest and sleep-supporting behaviours over physical and social activity, likely to drive behaviours that support homeostasis after allostatic challenges. As these stressors often co-occur, this adaptive response can meaningfully shape daily functioning. Future work may determine when this functional response becomes maladaptive.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70335"},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Branch on a Deep-Rooted Tree.","authors":"Ivana Rosenzweig, William Wisden","doi":"10.1111/jsr.70342","DOIUrl":"https://doi.org/10.1111/jsr.70342","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70342"},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Dynamics During Respiratory Arousal From Sleep Assessed by Oximeter-Based Vascular Stiffness Measures.","authors":"Christian Strassberger, Ding Zou, Jan Hedner, Ludger Grote","doi":"10.1111/jsr.70343","DOIUrl":"https://doi.org/10.1111/jsr.70343","url":null,"abstract":"<p><p>Cortical arousals significantly impact obstructive sleep apnoea (OSA) pathophysiology and cardiovascular consequences, often mediated by sympathetic activation. While pulse oximetry (PPG) provides an accessible reflection of autonomic responses such as changes in pulse rate (PR) and pulse wave amplitude (PWA), the dynamic influence on other vascular indices remains less explored. We investigated dynamic changes in PPG-derived pulse propagation time (PPT), a metric reflecting modulation in vascular stiffness. It is hypothesised that PPT beat-to-beat responses to arousals are specific and independent from other pulse wave parameters. Polysomnography data from 87 patients were analysed (mean age 54 ± 12 years, 26% female, mean BMI 27.7 ± 3.6 kg/m², mean Apnea-Hypopnea Index 33 ± 23 events/h; total 18,275 respiratory events). The mean percentage change (shortening, vascular stiffening) of the PPT following respiratory events was significantly greater when accompanied by an EEG arousal in both apnoeas (-21.1% vs. -17.9%, p < 0.001) and hypopneas (-19.4% vs. -17.0%, p < 0.001). In a multivariate logistic mixed-effect model, ∆PPT emerged as an independent predictor of EEG arousal presence (p < 0.001, scaled odds ratio: 1.14; 95% CI: 1.09-1.20), accounting for event type, anthropometrics and changes in PWA, PR, SpO₂. Dynamic, short-term changes in PPG-derived PPT are significantly associated with cortical arousals following respiratory events in OSA patients. This parameter provides independent predictive information beyond established PPG metrics, likely reflecting rapid, arousal-induced alterations in vascular tone. These findings highlight a novel PPG-based marker that could quantify the vascular stress in OSA.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70343"},"PeriodicalIF":3.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription of Psychotropic Drugs for Chronic Insomnia in Primary Care.","authors":"Jesús Escribá-Alepuz, Lidia Herrero-Huertas, María García-Gil, Estefanía Estévez-López, Francisco Javier Puertas, Manuel de Entrambasaguas","doi":"10.1111/jsr.70334","DOIUrl":"https://doi.org/10.1111/jsr.70334","url":null,"abstract":"<p><p>Insomnia is the most prevalent sleep disorder in adults, representing a major public health problem. Healthcare management in a specific area first requires analysing its current practices and issues. We conducted a retrospective observational study of over 100,000 patients from two large primary care databases in the public healthcare Department of Sagunto (Valencia, Spain), from 2009 to 2017. Cases of insomnia were defined by ICD-10 codes, and prescriptions of hypnotics were collected. The data analysis was performed on epidemiological aspects, comorbidity, diagnosis and treatment of insomnia. A significant increase in the incidence of insomnia occurred, rising from 58.9 per 1000 inhabitants (95% CI: 57.7-60.0) in 2009 to 91.4 per 1000 inhabitants (95% CI: 90.0-92.9) in 2017. A total of 12,404 prescriptions for hypnotics and sedatives were issued, including 39.8% for indications other than insomnia. Lorazepam was the most frequently prescribed hypnotic-sedative (36%), followed by zolpidem (21.1%); 54% of insomnia cases revealed more prescription units than medical consultations, suggesting automatic renewals. Excessive prescription of hypnotic drugs for insomnia, along with a lack of follow-up, were identified as significant issues.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70334"},"PeriodicalIF":3.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Risk Stratification of Atrial Fibrillation Detected After Ischemic Stroke and TIA: The Role of Apnoea-Hypopnoea Index and Hypoxic Burden-A Study From the Bern Sleep-Stroke Registry.","authors":"Xiaoli Yang, Julian Lippert, Irina Filchenko, Christian M Horvath, Sebastien Baillieul, Corrado Bernasconi, Stefan A Bauer-Gambelli, Anne-Kathrin Brill, David J Seiffge, Elias Auer, Tobias Reichlin, Urs Fischer, Marcel Arnold, Markus H Schmidt, Claudio L A Bassetti","doi":"10.1111/jsr.70338","DOIUrl":"https://doi.org/10.1111/jsr.70338","url":null,"abstract":"<p><p>Sleep-disordered breathing is an independent risk factor for stroke and atrial fibrillation. Accurate assessment of atrial fibrillation in stroke patients with sleep-disordered breathing is crucial for secondary prevention. This study aimed to determine whether combining apnoea-hypopnoea index and hypoxic burden improves risk stratification for atrial fibrillation detected after ischemic stroke. About 911 patients with ischemic stroke underwent respiratory polygraphy within 3 days after an event. Hypoxic burden was defined as the cumulative area under the oxygen desaturation curve of respiratory events. Atrial fibrillation was monitored with up to three 7-day electrocardiogram recordings within 6 months. Patients were stratified by apnoea-hypopnoea index (≥ 15 vs. < 15 events/h) and by hypoxic burden (above vs. below the median, 35% min h^-1). Logistic regression adjusted for age, sex, and cardiovascular risk factors assessed associations between apnoea-hypopnoea index/hypoxic burden categories and atrial fibrillation. Among 911 patients (mean age 66 ± 14 years, 62% male), atrial fibrillation was detected in 145 (16%) patients. Patients with both apnoea-hypopnoea index ≥ 15 and high hypoxic burden had nearly double the odds of atrial fibrillation compared to those with low apnoea-hypopnoea index and low hypoxic burden (adjusted odds ratio 1.97, 95% CI 1.25-3.12). In contrast, neither elevated apnoea-hypopnoea index nor high hypoxic burden alone demonstrated a statistically significant association. Elevated apnoea-hypopnoea index combined with high hypoxic burden identifies stroke patients at higher risk of atrial fibrillation. Integrating these metrics into post-stroke evaluation may improve personalized management and secondary prevention of recurrent cardiovascular or cerebrovascular events.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70338"},"PeriodicalIF":3.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pharyngeal Resistance Index-A Promising Diagnostic Tool in OSA.","authors":"Nils Lucca Kern, Alexander Pugachev, Tobias Ebker, Tim Lukas Elter, Jan Oliver Voß, Axel Bumann, Max Heiland, Simon Bigus","doi":"10.1111/jsr.70341","DOIUrl":"10.1111/jsr.70341","url":null,"abstract":"<p><p>This study investigates the newly developed pharyngeal resistance index derived from computational fluid dynamics analysis of the upper airway in patients with obstructive sleep apnea. The aim was to evaluate this index as a diagnostic and severity assessment tool by comparing it with the apnea-hypopnea index before and after maxillomandibular advancement surgery. A retrospective single-center study was conducted at the Department of Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, including 16 patients with obstructive sleep apnea who underwent maxillomandibular advancement between November 2019 and June 2023. Each patient received polysomnography and cone beam computed tomography preoperatively and at least three months postoperatively following a standardised protocol. The apnea-hypopnea index and pharyngeal resistance index were statistically compared. The mean apnea-hypopnea index decreased from 23.42 (SD = 22.53) preoperatively to 4.32 (SD = 5.0) postoperatively, a mean reduction of 81.55%. Mean pharyngeal resistance index decreased from 0.96 (SD = 0.81) preoperatively to 0.17 (SD = 0.22) postoperatively, representing an 82.29% reduction. Wilcoxon signed-rank tests confirmed significant postoperative improvements for both indices (p < 0.01). Spearman analysis revealed no significant correlation between both indices, either preoperatively (ρ = 0.130, p = 0.633) or postoperatively (ρ = 0.159, p = 0.556). Class-based comparison demonstrated improved agreement postoperatively, with most discrepancies limited to within ±1 class. Although no direct correlation was found, the pharyngeal resistance index demonstrated significant postoperative improvement and enhanced class-level agreement with the apnea-hypopnea index, supporting its future role as a supplementary diagnostic and predictive tool in obstructive sleep apnea management.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70341"},"PeriodicalIF":3.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Variability in Slow-Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity.","authors":"Antoine Salmeron, Pierre A Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d'Ortho, Julia Maruani","doi":"10.1111/jsr.70332","DOIUrl":"https://doi.org/10.1111/jsr.70332","url":null,"abstract":"<p><p>Slow-wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture-proportion, duration, and latency-identifies clinically distinct profiles in major depressive episode (MDE). Ninety-seven adults with MDE underwent overnight polysomnography. N3 metrics (latency, duration, % of total sleep period (TSP), % of total sleep time (TST)) were analysed both dimensionally (correlations with clinical measures) and categorically (reduced, normal, or increased N3). Backward stepwise logistic regression identified variables distinguishing N3 categories, and sensitivity analyses assessed psychotropic medication effects. Shorter N3 latency correlated with poorer subjective sleep quality and greater anxiety and depressive severity. Extremes of N3 (%TSP) carried clinical burden: increased N3% associated with earlier hospitalisation, younger age at first suicide attempt, and higher daytime sleepiness; reduced N3% related to more hospitalisations and depressive episodes. Categorical contrasts showed increased N3 duration linked to higher anxiety and depressive symptom severity, reduced N3 (%TST) predicted more hospitalisations, while increased N3 (%TST) aligned with greater seasonality and morning chronotype. Men exhibited higher %N3 TST than women; bipolar depression had lower N3 than unipolar depression. A five-factor model (episode count, chronotype, seasonality, age, sex) distinguished increased %N3 TST from normal levels (AUC = 0.863; sensitivity = 0.957; specificity = 0.714), explaining 30.8% of variance. Medication analyses revealed no major effects. N3 sleep is not a uniform biomarker in depression. Its proportion and duration delineate distinct, clinically meaningful profiles. Sleep-based stratification may guide precision care.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70332"},"PeriodicalIF":3.9,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}