Journal of Sleep Research最新文献

{"title":"Neurobehavioural Associations of Recurrent Short Sleep in School-Aged Children.","authors":"Tiffany Belinda Koa, Yanran Hu, June Chi-Yan Lo","doi":"10.1111/jsr.70466","DOIUrl":"https://doi.org/10.1111/jsr.70466","url":null,"abstract":"<p><p>Recurrent cycles of weekday short sleep and weekend sleep extension have been shown to result in more prominent neurobehavioural impairments during subsequent weeks of sleep restriction in adolescents and young adults. Whether the same would be observed in school-aged children is unclear. In this micro-longitudinal observational cohort study, 79 children (6-12 years old, 34 males) were tracked for 16 days at home. Sleep was measured using actigraphy. Neurobehavioural functions-processing speed, working memory, vigilance, subjective sleepiness and affect-were assessed daily through a smartphone application. Forty participants had a daily average time-in-bed of less than 9 h on weekdays but at least 9 h on weekends (short sleep group), while 39 participants had at least 9 h on both weekdays and weekends (well-rested group). There were no significant group × day interactions for any neurobehavioural measure (p > 0.61), but the short sleep group reported overall higher levels of subjective sleepiness (mean Karolinska Sleepiness Scale score [SE]: 4.51 [0.21] vs. 3.77 [0.21], p = 0.01) and lower positive affect (score on the 10-item Positive and Negative Affect Schedule for Children: 12.84 [0.64] vs. 15.15 [0.65], p = 0.01) than the well-rested group. Within the short sleep group, none of the neurobehavioural measures showed observable weekday-weekend differences or compounding impairments during the second cycle of weekday short sleep. Unlike in adolescents and young adults, recurrent cycles of short sleep on weekdays and sleep extension on weekends may not be associated with compounding neurobehavioural impairments in school-aged children.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70466"},"PeriodicalIF":4.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic Burden Is an Important Determinant of Height in Nonobese Children With Sleep-Disordered Breathing.","authors":"Plamen Bokov, Benjamin Dudoignon, Christophe Delclaux","doi":"10.1111/jsr.70477","DOIUrl":"https://doi.org/10.1111/jsr.70477","url":null,"abstract":"<p><p>The relationship between linear growth and obstructive sleep-disordered breathing (SDB) has not been extensively studied. Hypoxic burden (HB) is a new metric that may better capture end-organ damage in paediatric SDB compared to the traditional apnea-hypopnea index (AHI). This observational cross-sectional study examined the association between HB and linear growth in nonobese children aged 3-9 years with SDB. HB was assessed as the area under the peripheral oxygen desaturation curve, alongside standard polysomnography indices. A cohort of 164 children without comorbidities except for asthma was evaluated for suspected SDB, with demographic and anthropometric data collected. The mean ± standard deviation height z score was -0.05 ± 1.09, and the median [25th; 75th percentile] HB was 1.4 [0.4; 3.5] %min/h. Forty children (24%) had an obstructive AHI greater than 5/h. HB and frequent snoring (≥ 3 nights/week) were significantly and negatively associated with height z score (standardized β = -0.21, p = 0.036 and -0.37, p = 0.043, respectively), whereas AHI did not predict linear growth outcomes. In multivariate analyses, HB remained independently associated with lower height z score and accounted for 7.5% of its variance, compared with 12.7% for ethnicity and 6.4% for body mass index z score. The oxygen desaturation index was also a significant predictor, but it explained less variance in height z score than HB. These findings suggest that intermittent hypoxia may contribute to impaired linear growth in children with SDB, although its contribution is modest and other determinants of growth remain important.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70477"},"PeriodicalIF":4.6,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Charon Knocks at the Sleep Laboratory: Are European Heatwaves an Underrecognized Methodological Challenge for Sleep Research?","authors":"Giulia Amicucci, Diego Centonze, Claudio Liguori","doi":"10.1111/jsr.70465","DOIUrl":"https://doi.org/10.1111/jsr.70465","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70465"},"PeriodicalIF":4.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotypic Traits of Hypopnea-Predominant OSA: The Role of Hypopnea Criteria.","authors":"Shinn-Jye Liang, Liang-Wen Hang, Chun-Sen Huang, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Wan-Ju Cheng","doi":"10.1111/jsr.70472","DOIUrl":"https://doi.org/10.1111/jsr.70472","url":null,"abstract":"<p><p>Hypopnea-predominant OSA (HypoOSA) represents a distinct phenotype compared to apnea-predominant OSA. Nevertheless, hypopnea has been defined using varying criteria, leading to differences in the estimation of AHI. This study investigated the endotypic traits of HypoOSA, as defined by ≥ 4% desaturation (4% OD) and ≥ 3% desaturation or arousal (3% ODA) criteria for hypopnea and how AHI and endotypic traits differ by criteria. We prospectively enrolled 765 adult patients with moderate-to-severe OSA from a single sleep centre. Endotypic traits were obtained from in-laboratory polysomnographic studies. Respiratory events were scored twice using 3% ODA and 4% OD criteria. Endotypic traits characterizing HypoOSA, defined as AHI comprising < 50% apneas, were identified and compared to apnea-predominant OSA. Within-subject differences in endotypic traits between the hypopnea criteria were analysed. We observed that 4% OD and 3% ODA identified 40.3% and 57.0% patients as HypoOSA, respectively. Compared to apnea-predominant OSA, HypoOSA was characterized by a lower arousal threshold, higher compensation and less collapsible upper airway, regardless of hypopnea criteria used. Compared with the 4% OD criterion, the 3% ODA criterion for hypopnea increased AHI by 33%, whereas the proportion of time with SpO₂ < 90% and endotypic traits showed less variation. Patients with low consistency in AHI estimates between the two criteria showed lower AHI and favourable upper airway pathology compared to the high consistency group. In conclusion, HypoOSA is characterized by lower arousal threshold and favourable upper airway patency. Different hypopnea criteria resulted in variation in AHI, particularly among patients with lower AHI, whereas hypoxic burden and endotypic traits remained relatively stable.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70472"},"PeriodicalIF":4.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographical Patterns of Slow Wave Activity in Sleep Talking: An Exploratory Polysomnographic Investigation.","authors":"Elisa Pellegrini, Milena Camaioni, Anastasia Mangiaruga, Daniel Pumo, Valentina Alfonsi, Ludovica Annarumma, Serena Scarpelli, Claudio Sanguineti, Anna Castelnovo, Luigi De Gennaro, Armando D'Agostino, Maurizio Gorgoni","doi":"10.1111/jsr.70474","DOIUrl":"10.1111/jsr.70474","url":null,"abstract":"<p><p>Sleep talking (ST) is a parasomnia characterized by the utterance of unaware linguistic activations during sleep. Electrophysiological evidence is scarce, and it remains unclear whether local electroencephalographic (EEG) alterations characterize the sleep of STs outside of parasomnia episodes. Findings from NREM parasomnias suggest that local slow-wave activity (SWA) abnormalities may characterize a full night's sleep beyond behavioural manifestations. Accordingly, this study investigates SWA topography and the spatial distribution of the single SWA bins across sleep stages in a group of 12 young STs compared to 10 healthy controls (HCs) matched for sex and age, who underwent overnight laboratory polysomnographic recordings. The relationship between SWA pattern and parasomnia frequency was explored, and the overnight decline in SWA was examined to assess the potential impact of homeostatic processes. Our findings point to a peculiar SWA pattern characterized by a substantially stable central increase across sleep stages and a frontopolar decrease primarily in N2 sleep, suggesting a local and frequency-specific (≥ 1 Hz) SWA regulation in STs that may interact with homeostatic processes. These results provide new insights into the sleep electrophysiology of STs and shed light on trait-like regional alterations in SWA that may facilitate parasomnia events. Our findings align with the concept of local sleep, which posits that distinct cortical regions may simultaneously exhibit diverse functional states. In this view, different parasomnias may be characterized by specific SWA topographical patterns reflecting the peculiar behaviours enacted during sleep.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70474"},"PeriodicalIF":4.6,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant Responsiveness to Sleep Deprivation Is Not a Fixed Phenotypic Trait.","authors":"Michael S Pollock, Hans P A Van Dongen","doi":"10.1111/jsr.70359","DOIUrl":"10.1111/jsr.70359","url":null,"abstract":"<p><p>Sleep deprivation (SD) has long been known to produce a rapid antidepressant effect in approximately half of depressed patients, yet the underlying mechanisms and consistency of this response remain poorly understood. This study investigated whether the antidepressant response to SD reflects a stable, trait-like characteristic by analysing previously collected data from 76 depressed patients exposed repeatedly to SD over multiple separate sessions. Using intraclass correlation coefficient (ICC) analysis, we quantified the proportion of variance in SD responsiveness attributable to stable interindividual differences. Results revealed a low ICC value characterized as slight (< 0.2), indicating that most of the variance in the dataset was associated with variability within individuals across sessions. This finding challenges the assumption that SD responsiveness is a fixed phenotypic trait and instead supports a state-dependent model in which responsiveness fluctuates over time. This has important implications for clinical practice and research, indicating that the antidepressant response to SD is not reliably predictable from prior sessions and may be influenced by transient neurobiological states. Future work should focus on identifying dynamic biomarkers that can predict the potential for antidepressant responses in real time, possibly optimising the timing of SD interventions and shedding new light on the neurobiology of depression.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70359"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Variability in Slow-Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity.","authors":"Antoine Salmeron, Pierre A Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d'Ortho, Julia Maruani","doi":"10.1111/jsr.70332","DOIUrl":"10.1111/jsr.70332","url":null,"abstract":"<p><p>Slow-wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture-proportion, duration, and latency-identifies clinically distinct profiles in major depressive episode (MDE). Ninety-seven adults with MDE underwent overnight polysomnography. N3 metrics (latency, duration, % of total sleep period (TSP), % of total sleep time (TST)) were analysed both dimensionally (correlations with clinical measures) and categorically (reduced, normal, or increased N3). Backward stepwise logistic regression identified variables distinguishing N3 categories, and sensitivity analyses assessed psychotropic medication effects. Shorter N3 latency correlated with poorer subjective sleep quality and greater anxiety and depressive severity. Extremes of N3 (%TSP) carried clinical burden: increased N3% associated with earlier hospitalisation, younger age at first suicide attempt, and higher daytime sleepiness; reduced N3% related to more hospitalisations and depressive episodes. Categorical contrasts showed increased N3 duration linked to higher anxiety and depressive symptom severity, reduced N3 (%TST) predicted more hospitalisations, while increased N3 (%TST) aligned with greater seasonality and morning chronotype. Men exhibited higher %N3 TST than women; bipolar depression had lower N3 than unipolar depression. A five-factor model (episode count, chronotype, seasonality, age, sex) distinguished increased %N3 TST from normal levels (AUC = 0.863; sensitivity = 0.957; specificity = 0.714), explaining 30.8% of variance. Medication analyses revealed no major effects. N3 sleep is not a uniform biomarker in depression. Its proportion and duration delineate distinct, clinically meaningful profiles. Sleep-based stratification may guide precision care.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70332"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and Sleep Profiles in Insomnia, OSA and COMISA: A Comparative Study in Portugal and Spain.","authors":"Margarida Carvalho, Eva Almeida, Pedro Amorim, Marta Drummond, Adrián Martín-Montero, Gonzalo C Gutiérrez-Tobal, Tomás Ruiz-Albi, Julio De Frutos, Pedro Pereira Rodrigues, Daniela Ferreira-Santos","doi":"10.1111/jsr.70367","DOIUrl":"10.1111/jsr.70367","url":null,"abstract":"<p><p>Insomnia and obstructive sleep apnea (OSA) are common sleep disorders that often co-occur as comorbid insomnia and sleep apnea (COMISA), worsening health outcomes. This study characterized and compared the physiological and sleep profiles of insomnia, OSA and COMISA in population-based datasets from Portugal (n = 147) and Spain (n = 264), excluding patients with cardiovascular disease. Classification followed clinical guidelines, and analyses included polysomnography and heart rate variability (HRV) data. Conventional HRV metrics in the time and frequency domains, along with condition-specific frequency bands (BWMS, BWOSA, BWCOMISA, BWRes) were compared alongside demographic and clinical variables. The Portuguese and Spanish datasets differed significantly in gender distribution, daytime sleepiness, sleep efficiency and apnea-hypopnea index (AHI), with Spanish patients showing a higher severity of AHI and a predominantly male composition. COMISA patients were older, had higher BMI, and showed a hypopnea-dominant respiratory profile in both datasets. Classical HRV indices did not differ significantly between groups, although trends suggested decreased parasympathetic activity in OSA. Condition-specific bands were largely non-discriminative in Portugal, while BWOSA emerged as a significant marker of respiratory burden in Spain. When the populations were analysed jointly, age and obesity remained significant risk factors and COMISA maintained its hypopnea-dominant profile. The combined dataset revealed significant differences in several HRV features. OSA and COMISA patients exhibited a higher cardiovascular burden and autonomic imbalance (lower HF, higher LF/HF and LFn), while condition-specific bands all showed discriminatory power across groups. BWOSA may represent a useful spectral biomarker for OSA, although population and methodological factors strongly influence discriminative power.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70367"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nightly Sleep Disruption Predicts Next-Day PTSD Symptoms: A Pilot Ecological Momentary Assessment Study in Sexual Assault Survivors With and Without PTSD.","authors":"Rebecca C Cox, Bunmi O Olatunji","doi":"10.1111/jsr.70361","DOIUrl":"10.1111/jsr.70361","url":null,"abstract":"<p><p>Sleep disruption is a hallmark feature of posttraumatic stress disorder (PTSD). Studies using ecological momentary assessment suggest sleep disruption predicts next-day PTSD symptoms, though evidence for the reverse effect is inconsistent. We examined bidirectional associations between subjective sleep and PTSD symptom severity in a pilot sample of sexual assault survivors with and without PTSD (N = 35). Participants completed a sleep diary each morning and self-report measures of PTSD symptom severity and negative affect 3 times/day for 1 week. Multilevel models revealed that shorter sleep duration and longer sleep onset latency significantly predicted higher PTSD symptoms the following day, controlling for prior PTSD symptoms and negative affect (p's < 0.05). In contrast, tests of reverse models revealed no significant associations between daytime PTSD symptoms and subsequent sleep disruption on any sleep outcome (p's > 0.05). These findings suggest night-to-night disruptions in sleep may signal risk for increased PTSD symptoms. Implications for targeting sleep to treat PTSD symptoms are discussed.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70361"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure Trajectories and Cardiovascular Risk in Obstructive Sleep Apnea: A Dual-Cohort Analysis.","authors":"Jianhong Liao, Yunhan Shi, Bowen Zhang, Mengshuang Lv, Yanru Li, Demin Han","doi":"10.1111/jsr.70366","DOIUrl":"10.1111/jsr.70366","url":null,"abstract":"<p><p>This study primarily examined longitudinal systolic blood pressure trajectories in untreated obstructive sleep apnea (OSA) and their association with cardiovascular risk. A complementary analysis in the independent trial evaluated longitudinal blood pressure change after CPAP treatment. Data were obtained from the observational Sleep Heart Health Study (SHHS) and the interventional Apnea Positive Pressure Long-term Efficacy Study (APPLES). Participants with OSA who were not receiving antihypertensive treatment were included. Group-based trajectory modelling was used to identify SBP patterns over time, cardiovascular risk was assessed using Kaplan-Meier and Cox proportional hazards analyses, and CPAP-related SBP changes were evaluated using linear mixed-effects models. During a 10-year follow-up of 624 untreated patients with OSA, three SBP trajectories were identified: stable (87.0%), falling (5.9%), and rising (7.1%). Compared with the stable trajectory, the rising SBP group had a significantly higher risk of cardiovascular events (adjusted hazard ratio [HR] 2.84, 95% confidence interval [CI] 2.13-3.78; p < 0.001). CPAP therapy was associated with a reduced risk of cardiovascular events (adjusted HR 0.62, 95% CI 0.45-0.84; p = 0.002). Supplementary adherence analyses suggested more sustained SBP reduction with higher nightly CPAP use, and restricted cubic spline analysis indicated a steeper decline above 5.59 h/night. These findings suggest that rising SBP trajectories identify patients with OSA at highest cardiovascular risk, while CPAP use was associated with lower cardiovascular event risk in the observational SHHS comparison and modest SBP reduction in the complementary APPLES analysis. Trial Registration: SHHS (NCT00005275) and APPLES (NCT00051363).</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70366"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}