Journal of Sleep Research最新文献_第2页

The future of paediatric sleep medicine: a blueprint for advancing the field.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-28 DOI: 10.1111/jsr.14482

Angelika A Schlarb, Sarah Blunden, Serge Brand, Olivero Bruni, Penny Corkum, Rosemary S C Horne, Osman S Ipsiroglu, Mirja Quante, Karen Spruyt, Judith Owens

{"title":"The future of paediatric sleep medicine: a blueprint for advancing the field.","authors":"Angelika A Schlarb, Sarah Blunden, Serge Brand, Olivero Bruni, Penny Corkum, Rosemary S C Horne, Osman S Ipsiroglu, Mirja Quante, Karen Spruyt, Judith Owens","doi":"10.1111/jsr.14482","DOIUrl":"https://doi.org/10.1111/jsr.14482","url":null,"abstract":"Paediatric sleep medicine has rapidly evolved and expanded over the past half century as it became increasingly recognised as a unique field related to but distinct from adult sleep medicine. In looking forward to the next years, the focus of the following discussion is two-fold: to summarise a brief history of the field, recent developments and current trends, and to present a blueprint for the future across various key domains. Using Bronfenbrenner's Ecological Systems Theory as a model for the interaction between the five interconnected ecosystems and sleep in children, we discuss a variety of topics relevant for the present state and future of paediatric sleep medicine. Such topics include the potential effects of climate change and war on children's sleep, the development of public policy initiatives-such as sleep education in schools and in communities, and global efforts to reduce the epidemic of insufficient sleep. Indeed, insufficient sleep contributes to a myriad of negative medical, mental health, functional, and safety consequences. We also focus on the development of paediatric sleep medicine-specific educational initiatives and training programmes, and we showcase professional organisations such as the International Paediatric Sleep Association that are dedicated to the global expansion of paediatric sleep medicine. Finally, we address the need for further interdisciplinary collaborations, identify critical research gaps and explore the potential role of artificial intelligence and other new technologies in paediatric sleep research, including standardisation of sleep measurements, and novel methods of monitoring sleep in children.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14482"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Obstructive Sleep Apnoea Mitigates Dampened Heart Rate Responses to Respiratory Events in Children With Down Syndrome.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-27 DOI: 10.1111/jsr.70053

Lisa M Walter, Marisha Shetty, Ahmad Bassam, Margot J Davey, Gillian M Nixon, Rosemary S C Horne

{"title":"Improving Obstructive Sleep Apnoea Mitigates Dampened Heart Rate Responses to Respiratory Events in Children With Down Syndrome.","authors":"Lisa M Walter, Marisha Shetty, Ahmad Bassam, Margot J Davey, Gillian M Nixon, Rosemary S C Horne","doi":"10.1111/jsr.70053","DOIUrl":"https://doi.org/10.1111/jsr.70053","url":null,"abstract":"Children with Down syndrome (DS) have a dampened heart rate (HR) response at obstructive respiratory event termination compared with typically developing children. Whether improving obstructive sleep apnoea (OSA) severity improves the HR response to both obstructive and central events remains unknown. Twenty-four children (3-19 years at baseline) were included. Children were grouped into improved (decrease in obstructive apnoea-hypopnoea index to ≤ 50% of baseline; n = 12; seven treated between studies) and unimproved (n = 12; two treated between studies) 2 years following baseline study. Beat-to-beat HR was averaged 10 s before (pre), during, and the peak after (post) each obstructive and central event during sleep, expressed as percentage change. A total of 1018 obstructive respiratory events were analysed during total sleep; 583 events were analysed at baseline and 435 at follow-up. A total of 330 central events were analysed during total sleep; 164 central events were at baseline and 166 were at follow-up. In the unimproved group, the % change in HR from during the event to post-event was smaller at follow-up for both obstructive (mean 16.8%, 95% CI [17.4%, 20.6%] vs. 22.3% [21.1%, 26.0%] and central events: 15.8% [13.6%, 17.9%] vs. 26.1% [22.4%, 29.9%]; p < 0.05 for both). % change remained unchanged between studies in the improved group. These results suggest that the dampened HR response to respiratory events seen in children with DS worsens over time when OSA does not improve, adding weight to the need for diagnosis and management of OSA in this population.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70053"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering Insomnia: Benchmarking Automated Sleep Staging Algorithms for Complex Sleep Disorders.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-27 DOI: 10.1111/jsr.70048

Umaer Hanif, Anis Aloulou, Flynn Crosbie, Paul Bouchequet, Mounir Chennaoui, Thomas Andrillon, Damien Leger

{"title":"Deciphering Insomnia: Benchmarking Automated Sleep Staging Algorithms for Complex Sleep Disorders.","authors":"Umaer Hanif, Anis Aloulou, Flynn Crosbie, Paul Bouchequet, Mounir Chennaoui, Thomas Andrillon, Damien Leger","doi":"10.1111/jsr.70048","DOIUrl":"https://doi.org/10.1111/jsr.70048","url":null,"abstract":"Polysomnography (PSG) is essential for diagnosing sleep disorders, but its manual interpretation is labor-intensive. Automated sleep staging algorithms are promising, yet their utility in complex sleep disorders such as insomnia remains uncertain. This study evaluates five of the most recognised sleep staging classifiers-U-Sleep, STAGES, GSSC, Luna and YASA-on PSG data from 904 patients with chronic insomnia. Performance was assessed using F1 scores, confusion matrices and predicted sleep metrics. The effect of demographics, sleepiness and PSG metrics on each classifier's performance was assessed using linear regression. Across all sleep stages, GSSC performed best (macro F1 score = 0.66), followed by U-Sleep (0.62), Luna (0.56), STAGES (0.54) and YASA (0.52). GSSC achieved the highest F1 scores in Wake (0.83), N1 (0.22), N2 (0.80), N3 (0.71) and REM (0.76), while U-Sleep matched its performance in N1 and REM and Luna in N3. STAGES performed poorest in N3 (0.39) and YASA in REM (0.35). Common misclassifications included N1 vs. Wake/N2 and N3 vs. N2, with REM misclassified as Wake/N1/N2 by STAGES, Luna and YASA. GSSC and U-Sleep exhibited minimal demographic bias, while STAGES and Luna had more. No performance difference was observed between chronic insomnia patients with and without abnormal PSG. Sleep metric accuracy was highest for U-Sleep (TST, R2 = 0.88), STAGES (SOL, R2 = 0.82) and GSSC (WASO, R2 = 0.82). These findings underscore the solid yet variable performance of the classifiers and highlight GSSC and U-Sleep as leading tools for sleep staging in patients with chronic insomnia.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70048"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Adult Obstructive Sleep Apnoea: Many Questions, Not Enough Answers!

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-24 DOI: 10.1111/jsr.70047

Maria Stanczyk, Walter T McNicholas, Dirk A Pevernagie, Renata L Riha, Silke Ryan

引用次数: 0

NREM Sleep Oscillations Are Associated With Anxiety and Negative Affect in Young Adults.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-24 DOI: 10.1111/jsr.70050

Hazal Arpaci, Nandita Banik, Pinar Kurdoglu Ersoy, Ciara Harrington, Aycan Kapucu, Bengi Baran

{"title":"NREM Sleep Oscillations Are Associated With Anxiety and Negative Affect in Young Adults.","authors":"Hazal Arpaci, Nandita Banik, Pinar Kurdoglu Ersoy, Ciara Harrington, Aycan Kapucu, Bengi Baran","doi":"10.1111/jsr.70050","DOIUrl":"https://doi.org/10.1111/jsr.70050","url":null,"abstract":"Non-rapid eye movement sleep (NREM) oscillations are critical for cognitive and affective processing. While several studies link anxiety and depression symptoms to sleep quality, a critical gap remains in elucidating the role of NREM physiology in sleep-dependent processing of affect and anxiety symptoms. The goals of the present study were to investigate sleep-dependent consolidation of emotional memory and the relations of NREM oscillations with state anxiety and affect upon awakening in a non-clinical sample enriched for trait anxiety. Forty-two participants were recruited from a larger cohort of college students based on self-reported high (> 2 SD cohort mean, n = 26) versus moderate-low levels of trait anxiety (< 2 SD cohort mean, n = 16) for a 2-h polysomnography monitored mid-day nap. Memory for negative and neutral picture stimuli was tested over this nap interval. Sleep spindles and slow oscillations (SOs) predicted post-nap state anxiety and negative affect. Importantly, these were independent relationships in opposing directions such that higher SO activity was associated with reduced negative affect and state anxiety, whereas spindle activity correlated with higher negative affect and anxiety. We observed significantly reduced SO activity in the high-anxiety group but no associations of anxiety with macro-features of sleep (sleep duration, latency, efficiency or stage distributions). There were no group differences in emotional memory, nor did sleep parameters correlate with memory performance. These findings reflect that NREM oscillations are uniquely sensitive to both trait and state level variability in anxiety and highlight their potential as a novel target to attenuate anxiety and negative affect.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70050"},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and False Memory Production: The Modulating Role of Immediate Testing and Type of Retrieval.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-21 DOI: 10.1111/jsr.70051

Francesca Conte, Serena Malloggi, Oreste de Rosa, Gianluca Ficca, Fiorenza Giganti, Nicola Cellini

{"title":"Sleep and False Memory Production: The Modulating Role of Immediate Testing and Type of Retrieval.","authors":"Francesca Conte, Serena Malloggi, Oreste de Rosa, Gianluca Ficca, Fiorenza Giganti, Nicola Cellini","doi":"10.1111/jsr.70051","DOIUrl":"https://doi.org/10.1111/jsr.70051","url":null,"abstract":"Data on the effect of sleep on false memories are mixed. Here we address two methodological issues which could explain these inconsistencies: the use of free recall vs. recognition tasks and the absence of immediate testing. In a mixed design, 8 word lists from the Deese-Roediger-McDermott task were administered to a Recall (n = 20) and a Recognition Group (n = 20) at 9 AM ('Wake' condition) or 9 PM ('Sleep' condition). Immediate Testing (IT) followed the presentation of 4 out of 8 lists. Delayed Testing was performed 12 h later. A week later, participants underwent the other condition with 8 different lists. In both groups: IT performance was similar between conditions; veridical recalls were facilitated by Sleep and by IT irrespectively of condition. False memories were enhanced in Sleep vs. Wake for non-tested lists only in the Recall Group. IT affected delayed false recognition regardless of the condition, whereas its effects on delayed recall differed between conditions: in Sleep, the false recall rate was similar between tested and non-tested lists, whereas in Wake, it was higher for tested than non-tested lists. Our results confirm that sleep enhances false recalls but not false recognitions when memory is tested directly after the retention interval. Moreover, immediate testing enhances veridical memory independently of condition, whereas its effect on false recall depends on the behavioural state in which retention occurs. Therefore, immediate testing could be usefully introduced in standard sleep-memory studies, while its use should be carefully evaluated in studies on sleep and false memories.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70051"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

About Digitalisation and AI, Data Protection, Data Exchange, Data Mining-Legal Constraints/Challenges Concerning Sleep Medicine.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-19 DOI: 10.1111/jsr.70044

Bernd Feige, Fee Benz, Raphael J Dressle, Dieter Riemann

引用次数: 0

The influence of sleep disruption on learning and memory in fish. 睡眠中断对鱼类学习和记忆的影响。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-19 DOI: 10.1111/jsr.70005

Will Sowersby, Taiga Kobayashi, Satoshi Awata, Shumpei Sogawa, Masanori Kohda

{"title":"The influence of sleep disruption on learning and memory in fish.","authors":"Will Sowersby, Taiga Kobayashi, Satoshi Awata, Shumpei Sogawa, Masanori Kohda","doi":"10.1111/jsr.70005","DOIUrl":"https://doi.org/10.1111/jsr.70005","url":null,"abstract":"Sleep is a ubiquitous process that has been conserved in animals. Yet, our understanding of the functions of sleep largely derives from a few species. Sleep is considered to play an important role in mental processes, including learning and memory consolidation, but how widespread this relationship is across taxa remains unclear. Here, we test the impact of sleep disruption on the ability of the cleaner fish (Labroides dimidiatus) to both learn and remember a novel cognitive task. Sleep was disrupted by exposing a subset of fish to light at set intervals during the night. We found a significant negative relationship between sleep disruption and the ability to learn a novel task. Specifically, we found that fish in the light-disturbed sleep treatment took significantly longer and made more incorrect decisions to find a food reward, compared with the undisturbed sleep treatment. All fish were then allowed a normal sleep schedule and retested several days later to assess their ability to remember the task. In contrast to the learning phase, we observed no significant differences between the two treatment groups in remembering the food reward several days later. Our results demonstrate a negative impact of sleep disruption on performance in a cognitive challenging task that appeared to have the strongest effect when fish were first exposed to the challenge. Importantly, we show that the association between sleep and mental processes, such as learning, may be widespread across vertebrate taxa and potentially have an early origin in the evolutionary history of vertebrate animals.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70005"},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70023

Wufang Zhou, Jialin Zhou, Qianyu Lu, Long Wang, Yutao Liang, Ye Xing, Zheng Zhang, Jinshan Yang, Wenxue Zhao, Xin Li, Guangsen Shi

{"title":"Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice.","authors":"Wufang Zhou, Jialin Zhou, Qianyu Lu, Long Wang, Yutao Liang, Ye Xing, Zheng Zhang, Jinshan Yang, Wenxue Zhao, Xin Li, Guangsen Shi","doi":"10.1111/jsr.70023","DOIUrl":"https://doi.org/10.1111/jsr.70023","url":null,"abstract":"The relationship between physical activity and sleep quality is a critical area of investigation, given the importance of both behaviours for health and disease. Despite the common use of running wheels to assess circadian rhythms and exercise, their impact on sleep has not been thoroughly explored. Here, we present a detailed analysis of how voluntary running affected sleep/wakefulness duration, architecture and electrophysiological characteristics in mice. Sequential electroencephalogram (EEG) assessments revealed that voluntary running elicits a progressive alteration in sleep/wake configurations, including a reduction in overall daily sleep time and an enhancement in sleep/wakefulness consolidation. These modifications exhibited a temporal association with the intensity of running activities. The observed changes in sleep/wakefulness duration and architecture partially persist even after the discontinuation of running. Spontaneous running also gradually changed the amplitude and/or frequency of EEG theta power not only during the running phase but also in rapid eye movement sleep (REMS). In vivo endoscopic calcium imaging in freely behaving mice revealed that running and REMS were accompanied by the activation of largely shared yet distinctive neuronal cohorts within the hippocampal CA1 region, concomitant with EEG theta oscillations during both behaviours. These findings highlight the dynamic nature of sleep/wakefulness regulation in response to voluntary exercise and suggest that physical activity played a pivotal role in modulating sleep need and the daily balance between sleep and wakefulness.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70023"},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Hypoglossal Nerve Stimulation on Upper Airway Structure and Function Using Moving Wall Computational Fluid Dynamics Simulations: A Pilot Study.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70040

Qiwei Xiao, Daniel Ignatiuk, Chamindu Gunatilaka, Keith McConnell, Christine Schuler, Ann Romaker, Stacey Ishman, Robert Fleck, Raouf Amin, Alister Bates

{"title":"Effects of Hypoglossal Nerve Stimulation on Upper Airway Structure and Function Using Moving Wall Computational Fluid Dynamics Simulations: A Pilot Study.","authors":"Qiwei Xiao, Daniel Ignatiuk, Chamindu Gunatilaka, Keith McConnell, Christine Schuler, Ann Romaker, Stacey Ishman, Robert Fleck, Raouf Amin, Alister Bates","doi":"10.1111/jsr.70040","DOIUrl":"https://doi.org/10.1111/jsr.70040","url":null,"abstract":"Hypoglossal nerve stimulation (HGNS) is an innovative alternative treatment option for obstructive sleep apnoea (OSA) in patients unable to tolerate continuous positive airway pressure. However, the success rate of HGNS is variable, but the reasons underlying variation in treatment efficacy are not well understood. In this pilot study of three male subjects, we propose an innovative, non-invasive method to quantify the structural and functional changes to the upper airway that occur with HGNS. We used four-dimensional computed tomography (4DCT) and computational fluid dynamics (CFD) simulations of respiratory airflow to quantify how HGNS changes: (1) airway cross-sectional area (CSA), (2) work done by muscles and air pressure in dilating and collapsing the airway and (3) airway resistance. Subjects underwent 4DCT under natural stage non-REM 2 (N2) sleep with and without HGNS. Each patient had concurrent electroencephalograms and airflow measurements. CFD simulations were performed based on anatomy and airway motion from 4DCT images and airflow data. HGNS was associated with an increase in neuromuscular work done in dilating the airway (up to 490%); airway CSA increased by up to 300%. Most motion with HGNS occurred in the oropharynx; changes in the nasopharynx and hypopharynx varied between subjects. Minute ventilation increased in all subjects (15%-36%). Airway resistance decreased across the three subjects (73%-97%). Quantifying the parameters measured in this study may help explain variable responses to HGNS as a treatment for OSA. These procedures may, in future, help predict non-responders to HGNS, isolate reasons for poor responses, or inform device titration.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70040"},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0