Journal of Sleep Research最新文献

{"title":"Diagnostic Accuracy of the Screening Questionnaires for Obstructive Sleep Apnoea in Pregnancy: A Meta-Analysis and Updated Systematic Review.","authors":"Marco La Verde, Esposito Renata, Maria Maddalena Marrapodi, Luigi Della Corte, Mario Fordellone, Hande Uzunçıbuk, Vincenzo Ronsivalle, Gabriele Cervino, Giuseppe Minervini","doi":"10.1111/jsr.70197","DOIUrl":"10.1111/jsr.70197","url":null,"abstract":"<p><p>This systematic review and meta-analysis evaluate the diagnostic performance of obstructive sleep apnoea (OSA) screening tools in pregnant populations and the efficacy of common sleep questionnaires. A comprehensive search was conducted from the beginning to March 2024 using MEDLINE, Scopus, Cochrane CENTRAL, and Google Scholar, adhering to PRISMA guidelines. Studies were included if they adopted OSA screening questionnaires in pregnant women and compared results with overnight polysomnography. Keywords included terms related to pregnancy and OSA (e.g., Berlin questionnaire, ESS, PSQI, PSG, Watch-PAT). Sensitivity, specificity, diagnostic odds ratios (DOR), and likelihood ratios (LR) were calculated for each study. Tests for equality of sensitivity and specificity were conducted to evaluate variability. Eight studies involving 10,043 pregnant women were included. Reported OSA prevalence ranging from 12% to 72.3%. The Berlin questionnaire demonstrated significant heterogeneity in both sensitivity (χ² = 23.54, df = 6, p = 0.0006) and specificity (χ² = 33.74, df = 6, p = 7.56e-06), with a strong positive correlation between sensitivity and false positive rate (max. correlation coefficient = 0.994; 95% CI 0.092-0.994). The ESS showed similar variability (sensitivity: χ² = 10.55, df = 4, p = 0.0321; specificity: χ² = 74.18, df = 4, p = 2.97e-15), also revealing a positive correlation between sensitivity and false positives. Traditional screening tools such as the Berlin questionnaire and ESS exhibit poor diagnostic accuracy for OSA during pregnancy. These findings highlight the need for pregnancy-specific screening instruments and further research into OSA risk factors unique to this population.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70197"},"PeriodicalIF":3.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When CBT-I Falls Short: Why Solution-Focused Therapy Deserves Attention in Insomnia Research.","authors":"Matteo Carpi, Erica Marie Szkody","doi":"10.1111/jsr.70216","DOIUrl":"https://doi.org/10.1111/jsr.70216","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70216"},"PeriodicalIF":3.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG and Computational Aspects of How Ageing Affects Sleep Slow Waves.","authors":"Karim El Kanbi, Núria Tort-Colet, Karim Benchenane, Alain Destexhe","doi":"10.1111/jsr.70214","DOIUrl":"https://doi.org/10.1111/jsr.70214","url":null,"abstract":"<p><p>Ageing is known to affect sleep slow waves, but the underlying mechanisms are unknown. Here we aim to precisely quantify the effect of aeging on the shape and dynamics of sleep slow waves in a large cohort of human subjects, and to explore possible underlying mechanisms using a computational model. We analyzed EEG sleep recordings from 2377 healthy individuals aged 19 to 85, collected over multiple nights in their natural environments using the DREEM headband. The fine-structure analysis of slow waves was conducted to assess changes in frequency, amplitude, and variability with age. Additionally, we developed a computational model to investigate possible underlying mechanisms. The study reveals that with aeging, sleep slow waves show a significant reduction in frequency, increase in variability, and decrease in amplitude. Older individuals also experience more sleep fragmentation. REM sleep changes are less consistent, with some findings of minor decreases and others showing no significant changes. The computational model supports these observations by replicating the age-related changes in slow waves from a decrease in excitatory drive, suggesting that ageing affects excitatory interactions at large scales. In conclusion, by examining individuals free from sleep disorders and controlled lab environments, this study provides a detailed characterisation of age-related changes in sleep slow waves and proposes a potential mechanism involving alterations in cortical network connectivity.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70214"},"PeriodicalIF":3.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Functional Network Connectivity Patterns Distinguish Neurobiological Substrates of Narcolepsy Type 1 and Idiopathic Hypersomnia: Potential Biomarkers From Resting-State fMRI.","authors":"Wang Mengmeng, Zhang Haodong, Fan Chongyang, Dong Xiaosong, Han Fang, Karen Spruyt, Xiao Fulong","doi":"10.1111/jsr.70209","DOIUrl":"https://doi.org/10.1111/jsr.70209","url":null,"abstract":"<p><p>This study aimed to explore dynamic functional network connectivity (dFNC) differences between narcolepsy type 1 (NT1), idiopathic hypersomnia (IH), and healthy controls (HCs), and evaluate the potential of dFNC as a neurobiological marker for differentiating these hypersomnolent disorders. We recruited 50 drug-naive NT1 patients, 31 IH patients, and 50 HCs. Resting-state fMRI data were acquired, and intrinsic connectivity networks (ICNs) were identified using group independent component analysis (ICA), yielding 10 networks (e.g., visual network [VIN], auditory network [AUN], sensorimotor network [SMN], default mode network [DMN]). dFNC was analysed via sliding-window and k-means clustering to identify recurring functional connectivity states, and temporal properties (fractional windows, mean dwell time [MDT]) were compared across groups. Machine learning models (support vector machine, random forest [RF], logistic regression) were constructed using state-specific functional connectivity (FC) features to distinguish NT1 and IH. Five distinct FNC states were identified. State II (39% of windows, sparse connectivity with strengthened DMN/SMN/VIN coupling) was more prevalent in NT1 (47.68% ± 34.5%) than in IH (37.07% ± 28.73%) or HCs (31.32% ± 23.67%). Conversely, State I (33% of windows, sparse ICN connectivity) was less frequent in NT1 (13.24% ± 22.04%) versus IH (39.14% ± 35.92%) and HCs (49.28% ± 30.42%). NT1 also showed longer MDT in State II and shorter MDT in State I compared to IH and HCs (p < 0.05, ANOVA with post hoc tests FDR corrected). FC features in State I and II (notably AUN-VIN and SMN-VIN) effectively distinguished NT1 and IH, with the RF model achieving an AUC of 0.9 in State II. These findings reveal distinct dFNC patterns in NT1 and IH, reflecting divergent perturbations in sleep-wake regulatory circuits, particularly involving VIN, which may underpin their neurobiological heterogeneity. dFNC holds promise as a biomarker for differentiating these disorders, with VIN-centered connectivity emerging as a key discriminative feature.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70209"},"PeriodicalIF":3.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Efficacy of Sodium Glucose Cotransporter-2 Inhibitors in Management of Obstructive Sleep Apnea; a Systematic Review and Meta-Analysis.","authors":"Sana Murtaza, Rohab Sohail, Bisma Akram, Sameen Tahira, Maham Zaman, Syed Nazeer Mehmood","doi":"10.1111/jsr.70196","DOIUrl":"https://doi.org/10.1111/jsr.70196","url":null,"abstract":"<p><p>While Zepbound (Tirzepetide) is the only FDA-approved drug for obstructive sleep apnea (OSA), pharmacological options remain limited. Emerging data suggest sodium glucose co-transporter (SGLT-2) inhibitors may offer a novel therapeutic benefit in this population. Our meta-analysis aims to evaluate their efficacy based on current evidence. PubMed and Google Scholar were searched from inception to September 2024 for Randomised Controlled Trials (RCTs) and observational studies comparing SGLT-2 inhibitors to placebo in patients with OSA using continuous positive airway pressure (CPAP). After careful screening, 4 studies involving 686 patients were analysed using the random-effects model in RevMan 5.4.1, and mean differences (MD) were calculated. The addition of an SGLT-2 inhibitor showed a statistically significant reduction in the apnea-hypopnea index (AHI) [MD = -5.52 (95% CI: -9.72 to -1.32) (p = 0.01)], oxygen desaturation index [MD = -3.16 (95% CI: -5.33 to -0.99) (p = 0.004)], and Body Mass Index (BMI) [MD = -1.29 (95% CI: -2.20 to -0.39) (p = 0.005)]. However, they failed to show any significant improvement in daytime sleepiness [MD = -2.28 (95% CI: -4.92 to 0.37) (p = 0.90)] and Haemoglobin A1c [MD = 0.25 (95% CI: -0.32 to 0.82) (p = 0.88)]. Similarly, SGLT-2 inhibitors failed to depict any significant improvement in blood pressure or serum lipid levels. SGLT-2 inhibitors, along with significantly reducing AHI, also offer added cardiometabolic benefits in OSA patients. These findings support their role as a promising adjunct or alternative to existing therapeutic options. Further studies are warranted to define their place in OSA management.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70196"},"PeriodicalIF":3.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic Burden in Children With Sleep-Disordered Breathing: Determinants and Correlates.","authors":"Plamen Bokov, Benjamin Dudoignon, Christophe Delclaux","doi":"10.1111/jsr.70211","DOIUrl":"https://doi.org/10.1111/jsr.70211","url":null,"abstract":"<p><p>Hypoxic burden (HB) is an emerging metric for quantifying intermittent hypoxia associated with sleep apnea, offering potential advantages over traditional measures such as the apnea-hypopnea index (AHI). This study evaluated the distribution and clinical significance of non-respiratory event-specific HB in children and adolescents with habitual snoring, exploring its relationship with sleepiness and other clinical parameters. The data were gathered from 512 children referred for suspected sleep-disordered breathing (SDB), focusing on 380 subjects with available HB data. HB was calculated as the total area under oxygen saturation (SpO₂) curves for events with ≥ 3% oxygen desaturation, with a median value of 1.7% min/h [IQR: 0.6% min/h-4.6% min/h]. Children with moderate-to-severe obstructive sleep apnea syndrome (OSAS) exhibited significantly higher HB than those with mild OSAS or primary snoring (7.5% min/h, 2.7% min/h, and 1.1% min/h, respectively). HB was notably linked to the AHI (rho_s = 0.61), the oxygen desaturation index (rho_s = 0.73), and minimum SpO₂ (rho_s = -0.70). Furthermore, increased HB was observed in obese children and those with tonsillar hypertrophy, underscoring their synergistic impact. These effects were reflected in desaturation depth rather than their duration. In children with primary snoring, HB showed a significant association with parent-reported sleepiness. Specifically, there was a 39% increase in the odds ratio for a modified Epworth sleepiness scale score exceeding 10 for each standard deviation increase in HB (p = 0.040). These findings suggest HB as an independent marker of SDB severity, with potential implications for understanding cognitive deficits linked to SDB in children.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70211"},"PeriodicalIF":3.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine and Restless Legs Syndrome: A Meta-Analysis.","authors":"Florindo d'Onofrio, Maria Cropano, Giada Panzino, Mariachiara Gaita, Giulio Cicarelli, Piero Barbanti, Gerardo Casucci, Simona Raimo, Antonio Costanzo","doi":"10.1111/jsr.70202","DOIUrl":"https://doi.org/10.1111/jsr.70202","url":null,"abstract":"<p><p>Restless legs syndrome is a sensorimotor disorder of sleep/wake regulation that frequently coexists with migraine, affecting patients' quality of life. This study aimed to estimate the prevalence of restless legs syndrome in individuals with migraine and to explore the associated clinical, demographic and behavioural aspects. A systematic review and meta-analysis of the existing literature was conducted. Articles were included if they provided data on individuals with migraine, with or without restless legs syndrome and these proportions were used to estimate the prevalence of restless legs syndrome in migraine. A total of 30 studies were included in the meta-analysis. The overall pooled prevalence of restless legs syndrome among individuals with migraine was 20% (95% confidence interval [CI] = 17%-23%). The pooled prevalence of restless legs syndrome was affected by migraine duration (higher prevalence with longer duration), disability (higher prevalence with greater migraine-related disability) and age (higher prevalence in older individuals). A significant association was found between restless legs syndrome, migraine with aura and chronic migraine. No significant sex-related differences were observed. Among behavioural factors, depression, pain and poor sleep quality were significantly associated with restless legs syndrome. These findings suggest that restless legs syndrome is a common comorbidity in migraine with aura and chronic migraine, with a higher prevalence than that reported in the general population. Moreover, specific demographic, clinical and behavioural characteristics may help identify individuals at higher risk. Further studies are needed to clarify the underlying pathophysiological mechanisms and to identify potential therapeutic targets.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70202"},"PeriodicalIF":3.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Bruxism as a Protective Factor in the Mild and Moderate Obstructive Sleep Apnea: A Polysomnographic Study.","authors":"Jakub Przegrałek, Dorian Nowacki, Piotr Niemiec, Mieszko Więckiewicz, Anna Wojakowska, Katarzyna Madziarska, Helena Martynowicz","doi":"10.1111/jsr.70206","DOIUrl":"https://doi.org/10.1111/jsr.70206","url":null,"abstract":"<p><p>The protective properties of sleep bruxism (SB) for obstructive sleep apnea (OSA) are often suggested in the literature. The main objective of the present study is to assess the alleged protective effects of SB on the duration of respiratory events and blood saturation in OSA patients. The study involved data from 241 subjects with mild and moderate OSA who underwent polysomnography, which was evaluated according to American Academy of Sleep Medicine guidelines. Two cut-off points for SB diagnosis were established-bruxism episodes index (BEI) = 2 and BEI = 4. Out of the 241 patients, 66 subjects did not have SB (BEI < 2), while 175 were bruxers (BEI ≥ 2) and 97 of them had severe bruxism (BEI ≥ 4). SB patients had a significantly increased duration of hypopnea and apnea + hypopnea in both BEI ≥ 2 (25.88 vs. 23.28, p = 0.001 and 24.04 vs. 21.97, p = 0.004, respectively) and BEI ≥ 4 (26.17 vs. 24.49, p = 0.038 and 24.30 vs. 22.92, p = 0.040, respectively) groups. The oxygen desaturation index (47.64 vs. 51.10, p = 0.004) was decreased in BEI ≥ 2 subjects. Snore % was decreased in the BEI ≥ 4 group (21.22 vs. 26.43, p = 0.039). Average pulse was lower in the BEI ≥ 2 group (60.58 vs. 64.30, p = 0.0009). These results contradict the hypothesis that SB episodes shorten the apnea-hypopnea events in OSA patients. Protective SB properties might be limited to milder airway obstruction or might diminish over time. The relationship between SB and OSA is complex and needs further extensive research.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70206"},"PeriodicalIF":3.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus.","authors":"María Cerdà Moncadas, Oleksandr Serednytskyy, Ainhoa Álvarez Ruiz De Larrinaga, Laura Cànaves-Gómez, Andrés Sánchez Barón, Mercedes Codina Marcet, Mónica De La Peña Bravo, Amanda Iglesias Coma, Daniel Morell-Garcia, José Antonio Peña Zarza, María Paloma Giménez Carrero, María Concepción Piñas Cebrian, Susana García Fernández, Francisco García-Río, Alberto Alonso-Fernández","doi":"10.1111/jsr.70204","DOIUrl":"https://doi.org/10.1111/jsr.70204","url":null,"abstract":"<p><p>The prevalence of obstructive sleep apnea (OSA) increases during pregnancy and is associated with gestational diabetes mellitus (GDM), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several OSA criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with GDM. In this prospective study, polysomnography was performed on 89 women with GDM. Insulin resistance indices (HOMA-IR/QUICKI) were calculated, and biomarkers (insulin-like growth factor-1 (IGF-1), resistin, soluble endoglobulin, galectin-3, and free fatty acids) were analysed from women and some cord blood samples using enzyme-linked immunosorbent assay. Whereas OSA did not significantly affect overall perinatal outcomes, specific OSA features-including REM-OSA, supine-position OSA, and an oxygen desaturation index (ODI) ≥ 1 h^-1-were linked to adverse effects on neonatal birthweight and length. Moreover, apnea duration was an independent predictor of birthweight, while insulin resistance was more impaired in women with OSA and showed an inverse relationship with sleep and REM time, respectively. IGF-1 was elevated and demonstrated a significant predictive value for OSA, as indicated by the AUC-ROC curve. In summary, although OSA did not adversely affect overall perinatal outcomes in women with GDM, specific OSA characteristics were associated with adverse neonatal growth metrics. Insulin resistance was higher in women with OSA, and IGF-1 may serve as a potential biomarker for OSA in this population. Further prospective studies with attention to REM-stage, supine-position OSA, apnea duration, and hypoxic burden are needed to elucidate the complex interactions between OSA, GDM, and fetal outcomes.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70204"},"PeriodicalIF":3.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In the End: Associations Between Sleep Disturbance and Functional Impairment in Fibromyalgia-A Path Analysis Study.","authors":"Kristoffer Bothelius, Eva Kosek, Markus Jansson-Fröjmark","doi":"10.1111/jsr.70199","DOIUrl":"https://doi.org/10.1111/jsr.70199","url":null,"abstract":"<p><p>Fibromyalgia is a chronic pain condition characterised by widespread pain, sleep disturbances and mood disorders, often leading to significant functional impairment. Although sleep problems are recognised as important contributors to fibromyalgia symptoms, the mechanisms linking sleep disturbances, psychological factors and functional impairment remain insufficiently understood. This study investigated the direct and indirect relationships among sleep disturbances, pain catastrophising, depression, bodily pain and functional impairment using path analysis. Data were drawn from 253 women diagnosed with fibromyalgia. Poor sleep quality was directly associated with elevated levels of pain catastrophising and depression, and both psychological factors were, in turn, significantly related to greater functional impairment. Together, these variables accounted for 32.5% of the variance in functional impairment. No significant indirect effects were observed between sleep disturbances and functional impairment through bodily pain, and pain severity was not significantly associated with functional outcomes. These findings underscore the critical role of poor sleep quality in functional impairment among individuals with fibromyalgia. Implementing interventions that target and improve sleep may, in turn, alleviate related psychological distress, reduce disability and enhance quality of life in this population.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70199"},"PeriodicalIF":3.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}