Journal of Sleep Research最新文献_第2页

The Future of Insomnia Research-There's Still Work to Be Done. 失眠研究的未来——仍有工作要做。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-09 DOI: 10.1111/jsr.70091

Raphael J Dressle, Kai Spiegelhalder, Julian E Schiel, Fee Benz, Anna Johann, Bernd Feige, Susanna Jernelöv, Michael Perlis, Dieter Riemann

{"title":"The Future of Insomnia Research-There's Still Work to Be Done.","authors":"Raphael J Dressle, Kai Spiegelhalder, Julian E Schiel, Fee Benz, Anna Johann, Bernd Feige, Susanna Jernelöv, Michael Perlis, Dieter Riemann","doi":"10.1111/jsr.70091","DOIUrl":"https://doi.org/10.1111/jsr.70091","url":null,"abstract":"Insomnia Disorder (ID) is a highly debilitating disorder affecting up to 10% of the general population. In recent years, the number of studies in this area has increased rapidly, resulting in a wealth of accumulated knowledge. ID is generally regarded as a hyperarousal disorder affecting cognitive, emotional, cortical and physiological domains. Nevertheless, there is still a significant lack of knowledge about the pathophysiology of ID. For example, the existence of insomnia subtypes is discussed, albeit no uniform definition has yet been found. Significant progress has been made in understanding the neurobiology of insomnia, which points to a dysfunction in emotion regulation. However, neuroimaging studies frequently have small sample sizes and allow only for limited causal conclusions. The assessment of sleep has been significantly influenced by the increasing availability of methods for ambulatory sleep measurement. While these methods enable sleep to be measured more cost-effectively than polysomnography, many devices lack sufficient empirical evidence of validity. In terms of insomnia treatment, cognitive behavioural therapy for insomnia (CBT-I) has been shown to be highly effective. However, the underlying mechanisms of CBT-I remain partially unclear, and the optimal sequence for applying the individual components, as well as the effectiveness of CBT-I in cases of comorbidity, remain open questions. Furthermore, many widely applied pharmacological treatment approaches are used off-label with only a limited empirical evidence base. This narrative review aims to summarise the current state of research on ID and attempts to outline a selection of the important future challenges in insomnia research.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70091"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of a Transdiagnostic Sleep and Circadian Intervention for Outpatients With Sleep Problems and Depression, Attention Deficit Disorder, or Bipolar Disorder: A Randomised Controlled Trial. 跨诊断睡眠和昼夜节律干预对患有睡眠问题和抑郁症、注意力缺陷障碍或双相情感障碍的门诊患者的疗效：一项随机对照试验

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-09 DOI: 10.1111/jsr.70088

Mette Kragh, Henny Dyrberg, Sanne Toft Kristiansen, Maria Speed, Pernille Pedersen, Klaus Martiny

{"title":"Efficacy of a Transdiagnostic Sleep and Circadian Intervention for Outpatients With Sleep Problems and Depression, Attention Deficit Disorder, or Bipolar Disorder: A Randomised Controlled Trial.","authors":"Mette Kragh, Henny Dyrberg, Sanne Toft Kristiansen, Maria Speed, Pernille Pedersen, Klaus Martiny","doi":"10.1111/jsr.70088","DOIUrl":"https://doi.org/10.1111/jsr.70088","url":null,"abstract":"This study aimed to investigate the efficacy of a Danish adaption of a transdiagnostic sleep and circadian intervention, combining cognitive behavioural therapy for insomnia with chronotherapy. A randomised controlled trial enrolling 88 outpatients with depression, attention deficit disorder, or bipolar disorder suffering from insomnia or circadian rhythm disorders was conducted. Patients with insomnia and/or circadian rhythm disorders were randomised to either an intervention group receiving six individual sessions of a transdiagnostic sleep and circadian intervention or a control group receiving sleep hygiene education at a single session. Primary outcome was sleep quality and insomnia severity. Secondary outcomes were well-being, personal recovery, work ability, perceived overall health, sleep efficiency, sleep onset latency, wake after sleep onset, nocturnal awakenings, and sleep medication consumption. Data were collected via validated questionnaires, actigraphy, and sleep diaries, with assessments at baseline, week 2, and 6; actigraphy and sleep diaries were recorded continuously over the 6-week period. The intervention group statistically significantly improved sleep quality (p < 0.001), reduced insomnia severity (p < 0.001), and increased well-being (p = 0.002), personal recovery (p = 0.037), work ability (p < 0.001), and perceived overall health (p = 0.004) from baseline to week 6 compared to the control group. Actigraphy and sleep diary analyses revealed no statistically significant differences between the groups. In conclusion, the transdiagnostic sleep and circadian intervention was effective for both patients with insomnia and circadian rhythm disorders comorbid with depression, attention deficit disorder, or bipolar disorder. It resulted in improved sleep quality, a reduction in insomnia, and enhanced well-being, personal recovery, work ability, and overall health perception.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70088"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep, Shocks and SNUS: A Case Report on Nicotine-Induced Hypnic Jerks. 睡眠、休克和SNUS：尼古丁诱发的睡眠痉挛病例报告。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-07 DOI: 10.1111/jsr.70077

E Houter, Marjolein A J Van Looij, K M Kasius

{"title":"Sleep, Shocks and SNUS: A Case Report on Nicotine-Induced Hypnic Jerks.","authors":"E Houter, Marjolein A J Van Looij, K M Kasius","doi":"10.1111/jsr.70077","DOIUrl":"https://doi.org/10.1111/jsr.70077","url":null,"abstract":"SNUS is a smokeless tobacco that is placed under the (upper) lip, Although the adverse effects of nicotine have been extensively described, its impact on sleep remains relatively unknown. We describe a case of hypnic jerks caused by SNUS. Hypnic jerks are short, sudden, and spontaneous muscle contractions occurring at sleep onset that may increase due to stimulants, such as SNUS. We describe a 32-year-old male patient with disturbed sleep for 5 years. The patient experienced shock-like episodes when falling asleep since he had been using SNUS. A polysomnography demonstrated an increase in muscle activity on the EMG- and the leg channel during transition from light sleep to wake, as well as an increase in heart rate. A diagnosis of hypnic jerks was made. The patient was advised to quit using SNUS. After discontinuing SNUS use, the patient fully recovered. This case report is the first to describe hypnic jerks caused by SNUS. The hypnic jerks were confirmed by polysomnography. It is also the first to describe the negative effects of SNUS on sleep. Meticulous history taking, addressing the patient's drug use, including stimulants such as SNUS/nicotine, may help prevent unnecessary testing.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70077"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Patterns Alterations in Professional Tennis Players. 职业网球运动员睡眠模式的改变

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-07 DOI: 10.1111/jsr.70085

Donatella Marazziti, Angelo Gemignani, Elisabetta Parra, Riccardo Gurrieri, Gaspare Alfì, Giulia Aquino, Mario Miniati, Laura Palagini

{"title":"Sleep Patterns Alterations in Professional Tennis Players.","authors":"Donatella Marazziti, Angelo Gemignani, Elisabetta Parra, Riccardo Gurrieri, Gaspare Alfì, Giulia Aquino, Mario Miniati, Laura Palagini","doi":"10.1111/jsr.70085","DOIUrl":"https://doi.org/10.1111/jsr.70085","url":null,"abstract":"Sleep is a fundamental physiological process for maintaining physical health, cognitive function and overall wellbeing. For athletes, its restorative properties are essential for optimal recovery and performance. Emerging evidence highlights the intricate relationship between circadian rhythms, recovery processes and sport-specific performance outcomes. This study aimed to investigate the sleep quality and characteristics of professional tennis players, and how sleep patterns and circadian rhythms might influence athletic performance and wellbeing. Twenty professional tennis players (10 men, 10 women; mean age: 27.6 ± 6.06 years) were recruited through the Italian Tennis Federation during competitions in Tallinn, Estonia and Tirrenia, Italy. Sleep quality and disturbances were assessed using validated questionnaires, including the Pittsburgh sleep quality index, insomnia severity index, morningness-eveningness questionnaire and Ford insomnia response to stress test. Descriptive and t-test analyses were performed. Poor sleep quality was prevalent among professional tennis players, with gender differences suggesting worse outcomes for women. Despite the absence of clinical insomnia, subjective dissatisfaction and high stress-related sleep reactivity may negatively impact recovery and performance. The predominance of morning chronotypes aligns with structured training schedules, highlighting the potential benefits of aligning sleep strategies with circadian preferences. Professional tennis players face significant challenges related to sleep quality and stress-induced disturbances, emphasising the need for targeted interventions. Tailored approaches focusing on sleep hygiene, stress management, and chronotype-aligned schedules may enhance recovery, performance and wellbeing. Future longitudinal studies are needed to explore the dynamic relationships between sleep, performance and circadian alignment.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70085"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Imaging Measures of Cortical and Basal Ganglia Morphology in Insomnia. 失眠症患者皮层和基底神经节形态的结构成像测量。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-07 DOI: 10.1111/jsr.70086

Delaina B Cimmino, Jolynn Jones, Daniel J Buysse, Daniel Asay, Holly Winiarski, Ben Graul, Kennedy Madrid, Sierra Jarvis, Samuel Johnson, Julia Cornwell, Chase Junge, Helmet T Karim, Daniel B Kay, Derin Cobia

{"title":"Structural Imaging Measures of Cortical and Basal Ganglia Morphology in Insomnia.","authors":"Delaina B Cimmino, Jolynn Jones, Daniel J Buysse, Daniel Asay, Holly Winiarski, Ben Graul, Kennedy Madrid, Sierra Jarvis, Samuel Johnson, Julia Cornwell, Chase Junge, Helmet T Karim, Daniel B Kay, Derin Cobia","doi":"10.1111/jsr.70086","DOIUrl":"https://doi.org/10.1111/jsr.70086","url":null,"abstract":"While insomnia disorder is associated with changes in the brain, results vary across studies and levels of severity; no consistent morphometric pattern has yet emerged. Prior large-scale genetic work has implicated specific cortical and subcortical regions in the pathophysiology of insomnia. The aim of the current study is to utilise surface-based morphometry tools to examine these specific regions, thereby offering new insights into the disorder from a genetically informed perspective. This study leveraged archival neuroimaging data from the University of Pittsburgh, analysing 58 individuals with DSM-IV-TR primary insomnia and 67 good sleepers. Using T1-weighted structural MRI scans, harmonised shape analysis protocols were applied for bilateral caudate, putamen and globus pallidus. In addition, cerebellar volumes, as well as anterior cingulate and rostral middle frontal cortical thickness measures were obtained. Linear models were then constructed to assess group differences in all regions, then correlation coefficients between brain values and scores from the Pittsburgh Sleep Quality Index (PSQI) from all participants were calculated. Results revealed individuals with insomnia exhibited significantly greater cortical thinning in anterior cingulate cortex, and inward shape deformation in the head of the right caudate compared to good sleepers. These findings reveal focal neurobiological abnormalities in insomnia that are in line with regions implicated in previous genetic work. The results may hold important implications for future research identifying biomarkers and mechanisms that contribute to the onset and course of insomnia in these areas.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70086"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate to Severe Obstructive Sleep Apnea Is a Risk Factor for Severe COVID-19-A Nationwide Cohort Study. 中度至重度阻塞性睡眠呼吸暂停是严重covid -19的危险因素-一项全国性队列研究

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-05 DOI: 10.1111/jsr.70082

Mirjam Ljunggren, Andreas Palm, Magnus Ekström, Josefin Sundh, Ludger Grote, Huiqi Li, Fredrik Nyberg, Össur Ingi Emilsson

{"title":"Moderate to Severe Obstructive Sleep Apnea Is a Risk Factor for Severe COVID-19-A Nationwide Cohort Study.","authors":"Mirjam Ljunggren, Andreas Palm, Magnus Ekström, Josefin Sundh, Ludger Grote, Huiqi Li, Fredrik Nyberg, Össur Ingi Emilsson","doi":"10.1111/jsr.70082","DOIUrl":"https://doi.org/10.1111/jsr.70082","url":null,"abstract":"The impact of obstructive sleep apnea (OSA) and positive airway pressure (PAP) treatment on COVID-19 severity is unclear. In this population-based, nationwide study using multi-register data, we aimed to assess if OSA is a risk factor for COVID-19 severity and how adherence to PAP treatment and clinical characteristics affect the risk. Swedish residents with COVID-19 infection January 2020-May 2022 were included. An exposed group of OSA (starting PAP treatment 2015-2019) was identified. COVID-19 severity outcome was defined as mild (non-hospitalised), severe (hospitalised) or critical (intensive care or death). Covariates included comorbidities and sociodemographics. Conditional odds ratios (COR) with 95% confidence intervals (95% CI) were estimated using multinomial logistic regression. Among 8,894,162 individuals in Sweden, 1,932,081 (21.7%) had registered COVID-19 January 2020-May 2022. OSA was identified in 11,407 (0.6%) and was associated with an increased risk of severe (COR 1.34; 95% CI 1.25-1.43) and critical (1.25; 1.11-1.42) COVID-19 after adjustment for age, sex, education and comorbidities. Stratified by PAP adherence, age and COVID-19 wave, OSA was a risk factor for more severe COVID-19 in PAP-adherent and non-adherent individuals, in people aged 40-60 but not > 60 years and not after June 2021. OSA severity, assessed with the oxygen desaturation index (ODI), was independently associated with COVID-19 severity, with the highest risks for severe (1.23; 1.01-1.52) and critical (1.76; 1.17-2.63) COVID-19 observed in ODI ≥ 30 (vs. ODI < 15). We conclude that patients with moderate to severe OSA have an increased risk of severe COVID-19, also when PAP-treated, with an independent dose-response relationship between the severity of intermittent hypoxia and COVID-19 severity.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70082"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orexin Restoration in Narcolepsy: Breakthroughs in Cellular Therapy. 嗜眠症的食欲素恢复：细胞治疗的突破。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-05 DOI: 10.1111/jsr.70083

Emmanuel Ortega-Robles, Magdalena Guerra-Crespo, Shahd Ezzeldin, Estefanía Santana-Román, Artur Pałasz, Mohamed Salama, Oscar Arias-Carrión

{"title":"Orexin Restoration in Narcolepsy: Breakthroughs in Cellular Therapy.","authors":"Emmanuel Ortega-Robles, Magdalena Guerra-Crespo, Shahd Ezzeldin, Estefanía Santana-Román, Artur Pałasz, Mohamed Salama, Oscar Arias-Carrión","doi":"10.1111/jsr.70083","DOIUrl":"https://doi.org/10.1111/jsr.70083","url":null,"abstract":"Narcolepsy is a chronic neurodegenerative disorder defined by the selective loss of orexin-producing neurons in the lateral hypothalamus, leading to excessive daytime sleepiness and cataplexy. While pharmacological therapies have evolved to mitigate symptoms, they fail to address the core pathology-orexin deficiency. This narrative review examines the potential of orexin cell transplantation as an innovative therapeutic approach to restore orexin signalling and treat the root cause of narcolepsy. We begin by examining the clinical features, pathophysiology, and diagnostic criteria of narcolepsy, focusing on the essential role of orexins in regulating the sleep-wake cycle and the neurobiological mechanisms underlying cataplexy. The review then explores experimental therapeutic approaches, including hypothalamic tissue grafts, gene therapy, and immortalised orexin-expressing cell lines, highlighting their potential to address the orexin deficit in narcolepsy. While preclinical studies show that transplanted orexin cells can integrate into host neural networks, enhance sleep stability, and decrease the frequency of cataplexy in animal models, several challenges remain. Immortalised orexin cell lines offer a scalable and consistent option for transplantation therapies. However, immune rejection, long-term cell survival, and complete functional integration persist. These translational hurdles must be addressed to bring these therapies to clinical practice. This review underscores the need for continued research to overcome these barriers and optimise cell-based therapies for narcolepsy.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70083"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of Non-Pharmacological Interventions for Sleep Disorders in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis. 非药物干预对多发性硬化症患者睡眠障碍的疗效：系统回顾和荟萃分析。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-05 DOI: 10.1111/jsr.70084

Asiye Tuba Ozdogar, Alon Kalron

{"title":"The Efficacy of Non-Pharmacological Interventions for Sleep Disorders in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis.","authors":"Asiye Tuba Ozdogar, Alon Kalron","doi":"10.1111/jsr.70084","DOIUrl":"https://doi.org/10.1111/jsr.70084","url":null,"abstract":"Sleep disorders significantly impact the quality of life in people with multiple sclerosis (pwMS), affecting up to 60% of this population. These disorders, including insomnia, sleep apnea, restless legs syndrome, narcolepsy, and REM sleep behaviour disorders, result from both the direct neurological impacts of MS and secondary factors, such as pain and medication side effects. Non-pharmacological interventions offer potential benefits without the adverse effects associated with medications. This systematic review and meta-analysis aimed to evaluate the efficacy of non-pharmacological interventions in improving sleep disorders in pwMS, address inconsistencies in individual studies, and provide estimates of the magnitude of improvement. The review followed PRISMA guidelines and included randomised controlled trials, even if pilot studies, that examined non-pharmacological interventions for sleep disorders in pwMS. The literature search was completed in April 2024 in PubMed, Embase, and Web of Science databases. Data were extracted on study design, participant characteristics, intervention details, and outcomes. Quality was assessed using the PEDro scale, and a random-effects meta-analysis was conducted. The primary outcome was the assessment of sleep quality. Nine studies met the inclusion criteria, encompassing various non-pharmacological interventions such as cognitive-behavioural therapy, mindfulness, aerobic exercise, and occupational therapy. Non-pharmacological interventions may effectively improve sleep disorders in pwMS, while also providing additional benefits for overall psychological well-being and quality of life. Future research should focus on long-term effects, underlying mechanisms, and standardising intervention protocols to enhance comparability and generalisability. The major limitation of the meta-analysis is the high heterogeneity among eligible studies.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70084"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Training Induced Temporo-Occipital Fast Sleep Spindle Clustering in Humans Revealed by Full-Night HD-EEG Recordings. 整夜高清脑电图记录揭示视觉训练诱导人类颞枕快速睡眠纺锤体聚类。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-01 DOI: 10.1111/jsr.70068

Patrícia Gerván, Gábor Bocskai, Andrea Berencsi, Ferenc Gombos, Ilona Kovács

{"title":"Visual Training Induced Temporo-Occipital Fast Sleep Spindle Clustering in Humans Revealed by Full-Night HD-EEG Recordings.","authors":"Patrícia Gerván, Gábor Bocskai, Andrea Berencsi, Ferenc Gombos, Ilona Kovács","doi":"10.1111/jsr.70068","DOIUrl":"https://doi.org/10.1111/jsr.70068","url":null,"abstract":"This study investigates the impact of extensive visual procedural training on the temporal organisation of sleep spindles in healthy young adults. We selected 39 participants aged 16-20 and employed high-density electroencephalography to assess spindle characteristics during two full nights of sleep, with daytime practising in a contour integration task in between the two nights. We utilised linear mixed models (LMM) to comprehensively analyse the effects of age and training on basic, clustering- and rhythmicity-related spindle parameters. Our findings indicate no significant age effects in this age range, and no significant change between the two nights with respect to slow spindles. Fast spindles demonstrated a significant increase in density after training, and we observed significant changes in spindle clustering and rhythmicity parameters as well. Local spindle density, train density, the number of spindles within trains, the ratio of clustered spindles, and spindle duration in trains have increased, and inter-train interval decreased by the second night within the task-related temporo-occipital regions. These results might be interpreted in the context of sleep-dependent memory consolidation or potentially by homeostatic-related processes following extensive training. Moreover, here we illustrate that spindle reorganisation occurs not only in motor tasks but also in visual learning. The absence of age-related differences indicates that the reorganisation of spindles following training is a similar process in late adolescence and young adulthood. Our study emphasises the importance of spindle dynamics in procedural learning and suggests promising possibilities for future research into the neurophysiological basis of memory consolidation.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70068"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Neural Compensatory Response by Duration of Sleep Deprivation in a Cognitive Flexibility Task. 认知灵活性任务中睡眠剥夺时间对神经代偿反应的调节作用。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-05-01 DOI: 10.1111/jsr.70081

Yue Zhang, Haofei Miao, Chao Wang, Bin Wu, Xiaoping Chen, Lizhong Chi

{"title":"Modulation of Neural Compensatory Response by Duration of Sleep Deprivation in a Cognitive Flexibility Task.","authors":"Yue Zhang, Haofei Miao, Chao Wang, Bin Wu, Xiaoping Chen, Lizhong Chi","doi":"10.1111/jsr.70081","DOIUrl":"https://doi.org/10.1111/jsr.70081","url":null,"abstract":"The neural compensation mechanism involves maintaining cognitive performance during sleep deprivation (SD) by triggering alternative neural activations. While cognitive task complexity modulates post-SD neural activation, the role of SD duration remains uncertain. Thirty-three healthy college students (16 male and 17 female) completed a 36-h SD protocol, performing a switching task at baseline (pre-SD), after 24 h of SD (SD-24), and after 36 h of SD (SD-36). Resting-state EEG signals were recorded for 5 min at each SD stage and analysed using Standardised Low-Resolution Electromagnetic Tomography. Behavioural results showed that task performance declined after SD-24 compared to pre-SD, but recovered toward baseline levels after SD-36. Additionally, cognitive flexibility was lower after SD-24 and SD-36 than pre-SD, with no significant difference observed between SD-24 and SD-36. EEG results indicated decreased activation of the orbitofrontal and superior frontal gyrus after SD-24 and SD-36 compared to pre-SD, but increased activation of the superior parietal lobe after SD-36 compared to SD-24. The results of this study suggest that compensatory mechanisms depend on SD duration, indicating that effective neural compensation requires sustained wakefulness to activate fully.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70081"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0