Journal of Sleep Research最新文献_第3页

Orexin and Insomnia: Rethinking the Narrative.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70045

Jean-Arthur Micoulaud-Franchi, Christophe Gauld, Pierre Philip

引用次数: 0

Response to Martin-Olalla and Mira's Letter to the Editor 'Seasonal Daylight Saving Time in UK: A Long-Standing, Successful Record With Few Reasons to Alter'.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70022

Megan R Crawford, Eva C Winnebeck, Malcolm von Schantz, Maria Gardani, Michelle A Miller, Victoria Revell, Alanna Hare, Caroline L Horton, Simon Durrant, Joerg Steier

引用次数: 0

The Impact of Sleep Deprivation on Orthopaedic Surgeons: A Systematic Review.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70025

Colin Lipps, Michelle M Lawson, Natasha S McKibben, Jacqueline Brady, Zachary M Working

{"title":"The Impact of Sleep Deprivation on Orthopaedic Surgeons: A Systematic Review.","authors":"Colin Lipps, Michelle M Lawson, Natasha S McKibben, Jacqueline Brady, Zachary M Working","doi":"10.1111/jsr.70025","DOIUrl":"https://doi.org/10.1111/jsr.70025","url":null,"abstract":"Sleep deprivation is known to impact cognition, health and mood. Although the effect of sleep deprivation among medical and certain surgical specialties has been explored, there is a paucity of literature regarding sleep in orthopaedic surgeons. This systematic review attempts to provide a comprehensive overview of the current state of research on sleep in orthopaedic surgeons. Following the PRISMA guidelines for systematic reviews, we conducted a search of MEDLINE, Psychinfo and EMBASE to find all articles about sleep in orthopaedic surgeons. Inclusion criteria were non-review articles discussing sleep in orthopaedic surgery, English text, enrollment of attending or resident or fellow orthopaedic surgeons, reporting of sleep-related variables and publishing in a peer-reviewed journal. Out of 539 studies generated from our search, 10 were included in this review. The resulting study population included 232 residents, 10 fellows and 560 attendings. Average sleep was reported in nine articles; however, only two articles used objective measurements of sleep. Other reported outcomes varied widely, which included cognitive tests, reaction time, burnout/mood, self-reported sleepiness and arthroscopic skill. No articles reported on race, biochemical assays, call schedule, exercise, or utilised any intervention to improve sleep. Our systematic review concludes that not only is there a lack of research on sleep in orthopaedic surgeons, but that future research should include objective sleep measurements, including a greater breadth of outcome measures and potential interventions. Such studies will specifically target improvements in physician mental health and overall well-being, as well as promote durable patient safety.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70025"},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70032

Lisa M Walter, Dhruv Bhatnagar, Miles B H Ong, Eric Staykov, Dwayne L Mann, Margot J Davey, Gillian M Nixon, Rosemary S C Horne, Bradley A Edwards

{"title":"Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.","authors":"Lisa M Walter, Dhruv Bhatnagar, Miles B H Ong, Eric Staykov, Dwayne L Mann, Margot J Davey, Gillian M Nixon, Rosemary S C Horne, Bradley A Edwards","doi":"10.1111/jsr.70032","DOIUrl":"https://doi.org/10.1111/jsr.70032","url":null,"abstract":"Hypoxic burden (HB) is a measure incorporating frequency, depth and duration of respiratory event-related desaturations. While HB is associated with cardiovascular disease in adults with obstructive sleep apnea (OSA), it has not been assessed in typically developing (TD) children with OSA, nor in children with Down syndrome (DS), who have a higher incidence of OSA with more severe hypoxia. We assessed whether HB in these children was related to heart rate variability (HRV), an indicator of cardiovascular outcomes. Children (3-19 years, n = 44) with DS and TD children matched for OSA severity, age and sex underwent overnight polysomnography and were grouped into primary snoring (PS), Mild or Moderate/Severe (MS) OSA. HRV was analysed using power spectral analysis of the electrocardiograph. Regression analysis determined whether HB was predictive of HRV. Children with MS OSA in both groups had higher HB compared with children with PS (p < 0.001 for both) and Mild OSA (DS, p < 0.001; TD, p < 0.05). Children with DS and PS or Mild OSA had higher HB compared with TD children (PS p < 0.05; Mild OSA p < 0.001). There was no difference between the MS OSA groups. HB predicted dampened sympathetic and parasympathetic activity only in children with DS (R2 = 0.12, β = -10.6, SE = 4.6, p = 0.03). HB was higher in children with DS and PS or Mild OSA compared to TD children and predicted dampened autonomic function in children with DS. The potential contribution of the adverse effects of HB on autonomic function adds weight to the importance of identifying and treating OSA in children with DS.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70032"},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing Perceived Causal Networks in Sleep Medicine.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70035

Christophe Gauld, Tessa F Blanken, Lars Klintwall, Jean-Arthur Micoulaud-Franchi

引用次数: 0

Sleep and Aging. A Polysomnographic Follow-Up Study, Some 40 Years Later.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-18 DOI: 10.1111/jsr.70039

Peter Geisler, Renate Wehrle, Alexander Yassouridis, Alfred Ultsch, Thomas C Wetter, Hartmut Schulz

{"title":"Sleep and Aging. A Polysomnographic Follow-Up Study, Some 40 Years Later.","authors":"Peter Geisler, Renate Wehrle, Alexander Yassouridis, Alfred Ultsch, Thomas C Wetter, Hartmut Schulz","doi":"10.1111/jsr.70039","DOIUrl":"https://doi.org/10.1111/jsr.70039","url":null,"abstract":"The aim of the present study was to explore age-related sleep alterations in normal subjects whose sleep had been recorded for the first time 40.4 ± 4.8 years ago. For the follow-up polysomnography (3 nights) 15 participants (5 female, 10 male, age 56-74 years) were recruited. Recording conditions and sleep scoring were adapted to the previous study. In all older participants, the amount of slow-wave sleep and REM sleep was decreased, while stage 1 and wakefulness were increased. There was no significant change in stage 2 or in any of the additional REM sleep parameters (REM density, latency, number and duration of REM cycles). Sleep stage transition analysis showed a markedly reduced stability of SWS from young to older age. While none of the single sleep parameters showed intra-individual stability with age, a pattern analysis, which combined seven sleep parameters (sleep stages, total sleep time and REM density), showed that the concordance rate of the combined sleep parameters correlated significantly with the age at follow-up. The results of this longitudinal study over a period of about 40 years are largely consistent with those of cross-sectional studies. While the lack of significant correlation of the individual sleep parameters between the younger and older age groups did not allow for the identification of any of them as trait markers, the result of the pattern analysis, which combined a set of sleep parameters, indicates that the stability of the sleep structure decreases significantly in the age range between the late 50s and early 70s.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70039"},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Suvorexant on Fear Extinction Recall: A Double-Blind Randomised Controlled Pilot Trial in Healthy Individuals.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-15 DOI: 10.1111/jsr.70033

Maya T Schenker, Lilith Z Zeng, Joshua Lynskey, Matthew D Greaves, Shima Rouhi, Amanda Kay, Andrew Dawson, Therese Thornton, Christian L Nicholas, Kim L Felmingham, Amy S Jordan

{"title":"The Effect of Suvorexant on Fear Extinction Recall: A Double-Blind Randomised Controlled Pilot Trial in Healthy Individuals.","authors":"Maya T Schenker, Lilith Z Zeng, Joshua Lynskey, Matthew D Greaves, Shima Rouhi, Amanda Kay, Andrew Dawson, Therese Thornton, Christian L Nicholas, Kim L Felmingham, Amy S Jordan","doi":"10.1111/jsr.70033","DOIUrl":"https://doi.org/10.1111/jsr.70033","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a highly debilitating condition that develops after trauma exposure. Dysregulation in extinction memory consolidation (i.e., the ability to remember that trauma-related stimuli no longer signal danger) is proposed to underlie PTSD development. Disruptions in rapid eye movement (REM) sleep are thought to be the key contributor to this dysregulation, as REM sleep is suggested to play a vital role in the processing of emotional memories. While previous literature has investigated the role of natural REM sleep variations or REM sleep disruptions on extinction recall capacities, none have attempted to increase REM sleep to improve extinction recall. In this pilot, randomised controlled trial, we investigated the effect of 20 mg suvorexant to increase REM sleep, 20 mg temazepam to decrease REM sleep, and a placebo on extinction recall in 30 healthy adults (age: M = 26.93 years, SD = 7.54). Overall, no difference in REM percentage (p = 0.68, η2 = 0.0.03, small effect), nor in extinction recall (p = 0.58, η2 = 0.04, small effect) was observed between the drug conditions. However, increased REM percentage was associated with decreased conditioned fear response at recall, indicating better extinction recall (β = -0.71, p = 0.03, ηp 2 = 0.10; moderate effect) across the sample. These findings suggest that increasing REM sleep in populations with REM disruptions such as PTSD to optimal levels could improve extinction recall. This underscores the potential of enhancing REM sleep as a therapeutic target for improving PTSD outcomes, warranting further investigation of suvorexant in clinical populations where REM sleep deficits are prevalent.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70033"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Dynamic Lighting on Sleep Timing and Duration for Hospitalised Patients.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-13 DOI: 10.1111/jsr.70041

Andrew S Dunn, Barbara Rabin Fastman, Alan Weinberg, Lindsay Condrat, Allison Fraser, Rabia Khan, Marjorie P Zambrano Loor, Geetanjali Rajda, Octavio L Perez, Ayham Adawi, Korey Kam, Ankit Parekh, Andrew W Varga, Richard L Vincent

{"title":"The Impact of Dynamic Lighting on Sleep Timing and Duration for Hospitalised Patients.","authors":"Andrew S Dunn, Barbara Rabin Fastman, Alan Weinberg, Lindsay Condrat, Allison Fraser, Rabia Khan, Marjorie P Zambrano Loor, Geetanjali Rajda, Octavio L Perez, Ayham Adawi, Korey Kam, Ankit Parekh, Andrew W Varga, Richard L Vincent","doi":"10.1111/jsr.70041","DOIUrl":"10.1111/jsr.70041","url":null,"abstract":"Poor sleep is common in hospitalised patients due to multiple factors, including disruption of the circadian rhythm. Few studies have examined programmable artificial lighting systems in hospital patient rooms, and few have achieved meaningful improvement in sleep. We sought to determine how novel dynamic lighting affects sleep timing and duration compared to standard hospital lighting. Patients were admitted to rooms on a cardiology unit with customised intervention or standard lighting. The lighting system delivered blue-enriched light during the day, a melanopic stimulus twice daily and blue-depleted light in the evening. Sleep/wake probability was measured in 30-s epochs using mattress sensors to capture sleep timing and nocturnal sleep duration. Subjective sleep duration and alertness were assessed with sleep diaries and the Karolinska Sleepiness Scale (KSS), respectively. A total of 87 patients were enrolled. Subjects experiencing customised lighting demonstrated significantly advanced rest/wake activity phase by 160 min and overall greater sleep probability. Overnight sleep duration (11 p.m.-7 a.m.) was 66 min greater in the lighting condition (266 vs. 200 min, p < 0.05). Patients in the intervention group reported higher levels of alertness during the morning (KSS score 3.8 vs. 4.9, p = 0.01) and evening (5.4 vs. 7.1, p = 0.01). A lighting system programmed to entrain the circadian rhythm and provide a daytime melanopic stimulus on a hospital unit was associated with advanced circadian phase, increased nocturnal sleep duration and increased perceived morning and evening alertness. These results suggest that dynamic lighting systems have the potential to improve sleep for hospitalised patients.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70041"},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-13 DOI: 10.1111/jsr.70002

Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel

{"title":"A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia.","authors":"Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel","doi":"10.1111/jsr.70002","DOIUrl":"https://doi.org/10.1111/jsr.70002","url":null,"abstract":"This double-blind, placebo-controlled, two-way crossover trial evaluated the efficacy and safety of daridorexant in patients with chronic insomnia and comorbid nocturia. In total, 60 patients aged ≥55 years with insomnia complaints for ≥3 months, Insomnia Severity Index (ISI) ≥13 and ≥3 voids/night for ≥1 month were randomised (1:1) to daridorexant 50 mg/placebo for 4 weeks followed by crossover after a 14-21-day washout period. The primary endpoint was change from baseline to Week (W) 4 in self-reported total sleep time (sTST). Other endpoints included change in ISI score, sleep depth and quality (visual analogue scale scores), nocturnal voids (mean number, time to first) and daytime functioning (Insomnia Daytime Symptoms and Impacts Questionnaire score [IDSIQ]). At W4, daridorexant significantly increased sTST versus placebo (least-squares mean difference [LSMD] 20.9 min, 95% confidence interval [CI] 8.0-33.7; p = 0.002); significant improvements were also seen at W1-3. Compared with placebo, daridorexant significantly decreased (p < 0.001) ISI at both timepoints, W2 (LSMD -3.7, 95% CI -5.1 to -2.3) and W4 (LSMD -3.3, 95% CI -4.7 to -1.8) and significantly improved (p < 0.05) sleep depth (W1, 2, 3, 4), sleep quality (W1, 2, 3) and IDSIQ total score (W1, 3). Daridorexant versus placebo reduced the number of voids (LSMD [95% CI]: W1-0.6 [-0.9 to -0.3], p < 0.001; W4-0.3 [-0.7 to +0.1], p = 0.090) and increased median time to first void (difference to placebo, W1: +31 min, p = 0.0027; W4: +23 min, p = 0.2026). No adverse events of special interest (falls/urinary incontinence) were reported during daridorexant treatment. In conclusion, in patients with chronic insomnia and nocturia, daridorexant improves both conditions with a favourable safety profile.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70002"},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypnogram and Hypnodensity Analysis of REM Sleep Behaviour Disorder Using Both EEG and HRV-Based Sleep Staging Models.

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-12 DOI: 10.1111/jsr.70046

Jaap F van der Aar, Merel M van Gilst, Daan A van den Ende, Hans van Gorp, Peter Anderer, Angelique Pijpers, Pedro Fonseca, Elisabetta Peri, Sebastiaan Overeem

{"title":"Hypnogram and Hypnodensity Analysis of REM Sleep Behaviour Disorder Using Both EEG and HRV-Based Sleep Staging Models.","authors":"Jaap F van der Aar, Merel M van Gilst, Daan A van den Ende, Hans van Gorp, Peter Anderer, Angelique Pijpers, Pedro Fonseca, Elisabetta Peri, Sebastiaan Overeem","doi":"10.1111/jsr.70046","DOIUrl":"https://doi.org/10.1111/jsr.70046","url":null,"abstract":"Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is a primary sleep disorder strongly associated with Parkinson's disease. Assessing sleep structure in RBD is important for understanding the underlying pathophysiology and developing diagnostic methods. However, the performance of automated sleep stage classification (ASSC) models is considered suboptimal in RBD, for both models utilising neurological signals (\"ExG\": EEG, EOG, and chin EMG) and heart rate variability combined with body movements (HRVm). Here, we explore this underperformance through the categorical representation of sleep macrostructure (i.e., hypnogram) and a representation that leverages the underlying probability distribution of ASSCs (i.e., hypnodensity). By comparing the RBD population (n = 36) to a sex- and age-matched group of OSA patients chosen for their anticipated similarly decreased sleep stability, we confirm lower 4-stage classification performance in both ExG-based ASSC (RBD: κ = 0.74, OSA: κ = 0.80) and HRVm-based ASSC (RBD: κ = 0.50, OSA: κ = 0.63). Stages showing lower agreement in RBD, namely, N1 + N2 and REM sleep, exhibited elevated ambiguity in the hypnodensity, indicating more ambiguous classification distributions. Limited differences in bout durations between RBD and OSA suggested sleep instability is not necessarily driving lower agreement in RBD. However, stage transitions in OSA showed more abrupt changes in the underlying probability distribution, while RBD transitions had a more continuous profile, possibly complicating classification. Although both ExG-based and HRVm-based automated sleep staging in RBD remain challenging, hypnodensity analysis is informative for the characterisation of (RBD) sleep and can capture potential drivers of classification disagreement.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70046"},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0