Journal of Sleep Research最新文献

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Structural Imaging Measures of Cortical and Basal Ganglia Morphology in Insomnia. 失眠症患者皮层和基底神经节形态的结构成像测量。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-05-07 DOI: 10.1111/jsr.70086
Delaina B Cimmino, Jolynn Jones, Daniel J Buysse, Daniel Asay, Holly Winiarski, Ben Graul, Kennedy Madrid, Sierra Jarvis, Samuel Johnson, Julia Cornwell, Chase Junge, Helmet T Karim, Daniel B Kay, Derin Cobia
{"title":"Structural Imaging Measures of Cortical and Basal Ganglia Morphology in Insomnia.","authors":"Delaina B Cimmino, Jolynn Jones, Daniel J Buysse, Daniel Asay, Holly Winiarski, Ben Graul, Kennedy Madrid, Sierra Jarvis, Samuel Johnson, Julia Cornwell, Chase Junge, Helmet T Karim, Daniel B Kay, Derin Cobia","doi":"10.1111/jsr.70086","DOIUrl":"https://doi.org/10.1111/jsr.70086","url":null,"abstract":"<p><p>While insomnia disorder is associated with changes in the brain, results vary across studies and levels of severity; no consistent morphometric pattern has yet emerged. Prior large-scale genetic work has implicated specific cortical and subcortical regions in the pathophysiology of insomnia. The aim of the current study is to utilise surface-based morphometry tools to examine these specific regions, thereby offering new insights into the disorder from a genetically informed perspective. This study leveraged archival neuroimaging data from the University of Pittsburgh, analysing 58 individuals with DSM-IV-TR primary insomnia and 67 good sleepers. Using T1-weighted structural MRI scans, harmonised shape analysis protocols were applied for bilateral caudate, putamen and globus pallidus. In addition, cerebellar volumes, as well as anterior cingulate and rostral middle frontal cortical thickness measures were obtained. Linear models were then constructed to assess group differences in all regions, then correlation coefficients between brain values and scores from the Pittsburgh Sleep Quality Index (PSQI) from all participants were calculated. Results revealed individuals with insomnia exhibited significantly greater cortical thinning in anterior cingulate cortex, and inward shape deformation in the head of the right caudate compared to good sleepers. These findings reveal focal neurobiological abnormalities in insomnia that are in line with regions implicated in previous genetic work. The results may hold important implications for future research identifying biomarkers and mechanisms that contribute to the onset and course of insomnia in these areas.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70086"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moderate to Severe Obstructive Sleep Apnea Is a Risk Factor for Severe COVID-19-A Nationwide Cohort Study. 中度至重度阻塞性睡眠呼吸暂停是严重covid -19的危险因素-一项全国性队列研究
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-05-05 DOI: 10.1111/jsr.70082
Mirjam Ljunggren, Andreas Palm, Magnus Ekström, Josefin Sundh, Ludger Grote, Huiqi Li, Fredrik Nyberg, Össur Ingi Emilsson
{"title":"Moderate to Severe Obstructive Sleep Apnea Is a Risk Factor for Severe COVID-19-A Nationwide Cohort Study.","authors":"Mirjam Ljunggren, Andreas Palm, Magnus Ekström, Josefin Sundh, Ludger Grote, Huiqi Li, Fredrik Nyberg, Össur Ingi Emilsson","doi":"10.1111/jsr.70082","DOIUrl":"https://doi.org/10.1111/jsr.70082","url":null,"abstract":"<p><p>The impact of obstructive sleep apnea (OSA) and positive airway pressure (PAP) treatment on COVID-19 severity is unclear. In this population-based, nationwide study using multi-register data, we aimed to assess if OSA is a risk factor for COVID-19 severity and how adherence to PAP treatment and clinical characteristics affect the risk. Swedish residents with COVID-19 infection January 2020-May 2022 were included. An exposed group of OSA (starting PAP treatment 2015-2019) was identified. COVID-19 severity outcome was defined as mild (non-hospitalised), severe (hospitalised) or critical (intensive care or death). Covariates included comorbidities and sociodemographics. Conditional odds ratios (COR) with 95% confidence intervals (95% CI) were estimated using multinomial logistic regression. Among 8,894,162 individuals in Sweden, 1,932,081 (21.7%) had registered COVID-19 January 2020-May 2022. OSA was identified in 11,407 (0.6%) and was associated with an increased risk of severe (COR 1.34; 95% CI 1.25-1.43) and critical (1.25; 1.11-1.42) COVID-19 after adjustment for age, sex, education and comorbidities. Stratified by PAP adherence, age and COVID-19 wave, OSA was a risk factor for more severe COVID-19 in PAP-adherent and non-adherent individuals, in people aged 40-60 but not > 60 years and not after June 2021. OSA severity, assessed with the oxygen desaturation index (ODI), was independently associated with COVID-19 severity, with the highest risks for severe (1.23; 1.01-1.52) and critical (1.76; 1.17-2.63) COVID-19 observed in ODI ≥ 30 (vs. ODI < 15). We conclude that patients with moderate to severe OSA have an increased risk of severe COVID-19, also when PAP-treated, with an independent dose-response relationship between the severity of intermittent hypoxia and COVID-19 severity.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70082"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orexin Restoration in Narcolepsy: Breakthroughs in Cellular Therapy. 嗜眠症的食欲素恢复:细胞治疗的突破。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-05-05 DOI: 10.1111/jsr.70083
Emmanuel Ortega-Robles, Magdalena Guerra-Crespo, Shahd Ezzeldin, Estefanía Santana-Román, Artur Pałasz, Mohamed Salama, Oscar Arias-Carrión
{"title":"Orexin Restoration in Narcolepsy: Breakthroughs in Cellular Therapy.","authors":"Emmanuel Ortega-Robles, Magdalena Guerra-Crespo, Shahd Ezzeldin, Estefanía Santana-Román, Artur Pałasz, Mohamed Salama, Oscar Arias-Carrión","doi":"10.1111/jsr.70083","DOIUrl":"https://doi.org/10.1111/jsr.70083","url":null,"abstract":"<p><p>Narcolepsy is a chronic neurodegenerative disorder defined by the selective loss of orexin-producing neurons in the lateral hypothalamus, leading to excessive daytime sleepiness and cataplexy. While pharmacological therapies have evolved to mitigate symptoms, they fail to address the core pathology-orexin deficiency. This narrative review examines the potential of orexin cell transplantation as an innovative therapeutic approach to restore orexin signalling and treat the root cause of narcolepsy. We begin by examining the clinical features, pathophysiology, and diagnostic criteria of narcolepsy, focusing on the essential role of orexins in regulating the sleep-wake cycle and the neurobiological mechanisms underlying cataplexy. The review then explores experimental therapeutic approaches, including hypothalamic tissue grafts, gene therapy, and immortalised orexin-expressing cell lines, highlighting their potential to address the orexin deficit in narcolepsy. While preclinical studies show that transplanted orexin cells can integrate into host neural networks, enhance sleep stability, and decrease the frequency of cataplexy in animal models, several challenges remain. Immortalised orexin cell lines offer a scalable and consistent option for transplantation therapies. However, immune rejection, long-term cell survival, and complete functional integration persist. These translational hurdles must be addressed to bring these therapies to clinical practice. This review underscores the need for continued research to overcome these barriers and optimise cell-based therapies for narcolepsy.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70083"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy of Non-Pharmacological Interventions for Sleep Disorders in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis. 非药物干预对多发性硬化症患者睡眠障碍的疗效:系统回顾和荟萃分析。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-05-05 DOI: 10.1111/jsr.70084
Asiye Tuba Ozdogar, Alon Kalron
{"title":"The Efficacy of Non-Pharmacological Interventions for Sleep Disorders in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis.","authors":"Asiye Tuba Ozdogar, Alon Kalron","doi":"10.1111/jsr.70084","DOIUrl":"https://doi.org/10.1111/jsr.70084","url":null,"abstract":"<p><p>Sleep disorders significantly impact the quality of life in people with multiple sclerosis (pwMS), affecting up to 60% of this population. These disorders, including insomnia, sleep apnea, restless legs syndrome, narcolepsy, and REM sleep behaviour disorders, result from both the direct neurological impacts of MS and secondary factors, such as pain and medication side effects. Non-pharmacological interventions offer potential benefits without the adverse effects associated with medications. This systematic review and meta-analysis aimed to evaluate the efficacy of non-pharmacological interventions in improving sleep disorders in pwMS, address inconsistencies in individual studies, and provide estimates of the magnitude of improvement. The review followed PRISMA guidelines and included randomised controlled trials, even if pilot studies, that examined non-pharmacological interventions for sleep disorders in pwMS. The literature search was completed in April 2024 in PubMed, Embase, and Web of Science databases. Data were extracted on study design, participant characteristics, intervention details, and outcomes. Quality was assessed using the PEDro scale, and a random-effects meta-analysis was conducted. The primary outcome was the assessment of sleep quality. Nine studies met the inclusion criteria, encompassing various non-pharmacological interventions such as cognitive-behavioural therapy, mindfulness, aerobic exercise, and occupational therapy. Non-pharmacological interventions may effectively improve sleep disorders in pwMS, while also providing additional benefits for overall psychological well-being and quality of life. Future research should focus on long-term effects, underlying mechanisms, and standardising intervention protocols to enhance comparability and generalisability. The major limitation of the meta-analysis is the high heterogeneity among eligible studies.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70084"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visual Training Induced Temporo-Occipital Fast Sleep Spindle Clustering in Humans Revealed by Full-Night HD-EEG Recordings. 整夜高清脑电图记录揭示视觉训练诱导人类颞枕快速睡眠纺锤体聚类。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-05-01 DOI: 10.1111/jsr.70068
Patrícia Gerván, Gábor Bocskai, Andrea Berencsi, Ferenc Gombos, Ilona Kovács
{"title":"Visual Training Induced Temporo-Occipital Fast Sleep Spindle Clustering in Humans Revealed by Full-Night HD-EEG Recordings.","authors":"Patrícia Gerván, Gábor Bocskai, Andrea Berencsi, Ferenc Gombos, Ilona Kovács","doi":"10.1111/jsr.70068","DOIUrl":"https://doi.org/10.1111/jsr.70068","url":null,"abstract":"<p><p>This study investigates the impact of extensive visual procedural training on the temporal organisation of sleep spindles in healthy young adults. We selected 39 participants aged 16-20 and employed high-density electroencephalography to assess spindle characteristics during two full nights of sleep, with daytime practising in a contour integration task in between the two nights. We utilised linear mixed models (LMM) to comprehensively analyse the effects of age and training on basic, clustering- and rhythmicity-related spindle parameters. Our findings indicate no significant age effects in this age range, and no significant change between the two nights with respect to slow spindles. Fast spindles demonstrated a significant increase in density after training, and we observed significant changes in spindle clustering and rhythmicity parameters as well. Local spindle density, train density, the number of spindles within trains, the ratio of clustered spindles, and spindle duration in trains have increased, and inter-train interval decreased by the second night within the task-related temporo-occipital regions. These results might be interpreted in the context of sleep-dependent memory consolidation or potentially by homeostatic-related processes following extensive training. Moreover, here we illustrate that spindle reorganisation occurs not only in motor tasks but also in visual learning. The absence of age-related differences indicates that the reorganisation of spindles following training is a similar process in late adolescence and young adulthood. Our study emphasises the importance of spindle dynamics in procedural learning and suggests promising possibilities for future research into the neurophysiological basis of memory consolidation.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70068"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of Neural Compensatory Response by Duration of Sleep Deprivation in a Cognitive Flexibility Task. 认知灵活性任务中睡眠剥夺时间对神经代偿反应的调节作用。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-05-01 DOI: 10.1111/jsr.70081
Yue Zhang, Haofei Miao, Chao Wang, Bin Wu, Xiaoping Chen, Lizhong Chi
{"title":"Modulation of Neural Compensatory Response by Duration of Sleep Deprivation in a Cognitive Flexibility Task.","authors":"Yue Zhang, Haofei Miao, Chao Wang, Bin Wu, Xiaoping Chen, Lizhong Chi","doi":"10.1111/jsr.70081","DOIUrl":"https://doi.org/10.1111/jsr.70081","url":null,"abstract":"<p><p>The neural compensation mechanism involves maintaining cognitive performance during sleep deprivation (SD) by triggering alternative neural activations. While cognitive task complexity modulates post-SD neural activation, the role of SD duration remains uncertain. Thirty-three healthy college students (16 male and 17 female) completed a 36-h SD protocol, performing a switching task at baseline (pre-SD), after 24 h of SD (SD-24), and after 36 h of SD (SD-36). Resting-state EEG signals were recorded for 5 min at each SD stage and analysed using Standardised Low-Resolution Electromagnetic Tomography. Behavioural results showed that task performance declined after SD-24 compared to pre-SD, but recovered toward baseline levels after SD-36. Additionally, cognitive flexibility was lower after SD-24 and SD-36 than pre-SD, with no significant difference observed between SD-24 and SD-36. EEG results indicated decreased activation of the orbitofrontal and superior frontal gyrus after SD-24 and SD-36 compared to pre-SD, but increased activation of the superior parietal lobe after SD-36 compared to SD-24. The results of this study suggest that compensatory mechanisms depend on SD duration, indicating that effective neural compensation requires sustained wakefulness to activate fully.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70081"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association Between Circadian Disruption in Core Body Temperature Rhythm and Post-Chemotherapy Sleep Disturbances in Breast Cancer Survivors. 乳腺癌幸存者核心体温节律的昼夜节律中断与化疗后睡眠障碍之间的关系。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-04-29 DOI: 10.1111/jsr.70080
Joon Sung Shin, Sanghyup Jung, Geun Hui Won, Sun Hyung Lee, Jaehyun Kim, Saim Jung, Chan-Woo Yeom, Kwang-Min Lee, Kyung-Lak Son, Jang-Il Kim, Sook Young Jeon, Han-Byoel Lee, Bong-Jin Hahm
{"title":"The Association Between Circadian Disruption in Core Body Temperature Rhythm and Post-Chemotherapy Sleep Disturbances in Breast Cancer Survivors.","authors":"Joon Sung Shin, Sanghyup Jung, Geun Hui Won, Sun Hyung Lee, Jaehyun Kim, Saim Jung, Chan-Woo Yeom, Kwang-Min Lee, Kyung-Lak Son, Jang-Il Kim, Sook Young Jeon, Han-Byoel Lee, Bong-Jin Hahm","doi":"10.1111/jsr.70080","DOIUrl":"https://doi.org/10.1111/jsr.70080","url":null,"abstract":"<p><p>Sleep disturbance is a common symptom experienced by approximately 70% of breast cancer survivors and persists after the conclusion of chemotherapy. This study aimed to quantify the circadian disruption of the core body temperature (CBT) rhythm and its correlation with sleep disturbance following chemotherapy. In a sample of 25 breast cancer survivors, CBT was measured using an ingestible thermometer pill to calculate the relative amplitude (RA) prior to chemotherapy. The Pittsburgh Sleep Quality Index (PSQI) was employed to assess global sleep quality at three time points: prior to the commencement of chemotherapy, at 1 month (T1) and 9 months (T2) following the conclusion of chemotherapy. Subjective and objective sleep latency (SL<sub>s</sub> and SL<sub>o</sub>) were measured using the PSQI and actigraphy, respectively. The lower RA group exhibited higher intradaily variability of CBT and a higher average temperature of the lowest 5-h period in comparison to the higher RA group. The lower RA group exhibited lower global sleep quality than the higher RA group at both time points (T1 and T2). SL<sub>s</sub> in the lower RA group were significantly longer compared to the higher RA group at both time points. Furthermore, the discrepancy in SL (∆SL<sub>s</sub>-SL<sub>o</sub>) demonstrated a notable between-group difference at both time points. The findings of this study suggest that breast cancer survivors with pronounced circadian disruption of the CBT rhythm prior to chemotherapy are more prone to sleep disturbances following chemotherapy. Additionally, prolonged SL<sub>s</sub> may be a contributing factor to their poor sleep quality. Trial Registration: clinicaltrials.gov: NCT04364347.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70080"},"PeriodicalIF":3.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of Polysomnography-Derived Sleep Disturbance in People Living With Multiple Sclerosis Compared to Matched Controls From the General Population. 多发性硬化症患者多导睡眠图引发的睡眠障碍与普通人群匹配对照的比较研究
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-04-28 DOI: 10.1111/jsr.70075
Amy C Reynolds, Emma Thomas, Yohannes Adama Melaku, Hanna A Hensen, Arun V Krishnan, Simon C Gandevia, Stephen R Lord, Peter R Eastwood, Danny J Eckert
{"title":"A Comparative Study of Polysomnography-Derived Sleep Disturbance in People Living With Multiple Sclerosis Compared to Matched Controls From the General Population.","authors":"Amy C Reynolds, Emma Thomas, Yohannes Adama Melaku, Hanna A Hensen, Arun V Krishnan, Simon C Gandevia, Stephen R Lord, Peter R Eastwood, Danny J Eckert","doi":"10.1111/jsr.70075","DOIUrl":"https://doi.org/10.1111/jsr.70075","url":null,"abstract":"<p><p>Sleep structure and sleep disorders were compared between people with multiple sclerosis (MS; n = 39) and age, sex, and BMI-matched members of the general population (n = 39) using overnight polysomnography (PSG). Compared to population controls, people with MS had a higher prevalence of periodic limb movement disorder (PLMD; 59% vs. 18%, p < 0.001) and PLM-related arousals (PLMI: 21.1 vs. 0.8, p < 0.001); as well as longer sleep duration (402.9 [59.8] vs. 370.4 [54.0] min, p = 0.014), longer median sleep latency (12.4 min) and a reduced proportion of total sleep time in stage N1 sleep (8.5% vs. 14.8%, p < 0.001) and more time in N2 sleep (54.4% vs. 48.0%, p < 0.001). Sleep architecture appeared to differ for people with MS, even in the context of no recent exacerbations or relapse. Managing periodic leg movements during sleep may help improve sleep quality in people with MS.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70075"},"PeriodicalIF":3.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intensive Sleep Retraining and Total Sleep Deprivation for Treating Chronic Insomnia: A Randomised Controlled Trial. 强化睡眠再训练和完全睡眠剥夺治疗慢性失眠:一项随机对照试验。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-04-28 DOI: 10.1111/jsr.70043
J Le Bouthillier, H Ivers, C M Morin
{"title":"Intensive Sleep Retraining and Total Sleep Deprivation for Treating Chronic Insomnia: A Randomised Controlled Trial.","authors":"J Le Bouthillier, H Ivers, C M Morin","doi":"10.1111/jsr.70043","DOIUrl":"https://doi.org/10.1111/jsr.70043","url":null,"abstract":"<p><p>The aim of the study was to compare the efficacy of intensive sleep retraining (ISR) and total sleep deprivation (TSD) against a no-treatment control condition for treating chronic insomnia and examine two potential mechanisms: the resolution of conditioned insomnia and the increase in homeostatic sleep drive produced by sleep deprivation. Thirty-four adults with chronic sleep onset insomnia (with or without sleep maintenance difficulties) were randomised to ISR, TSD, or a control condition. The ISR condition consisted of a 38.5-h period of sleep deprivation, the last 21 h of which included 42 sleep onset trials; the TSD condition consisted of an equivalent 38.5-h sleep deprivation period without any sleep onset trials, and the control condition consisted of one night of habitual sleep in the laboratory. Significant decreases in insomnia severity were observed from pre- to post-treatment in both ISR and TSD, but not in the control condition. A significant reduction in sleep onset latency was observed during the same period for the ISR condition, but not for the TSD or control conditions, with no clinically meaningful change in anxiety or depressive symptoms. Significant decreases in fatigue were also observed for both ISR and TSD conditions during the same period. These results were generally significant at 3 months after treatment. Sleep improvements produced by ISR, and to a lesser extent by TSD, suggest that both the resolution of conditioned insomnia and the increase in homeostatic sleep drive represent important mechanisms responsible for the efficacy of ISR.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70043"},"PeriodicalIF":3.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Closer Look at Paediatric Sleep: Sleep Health and Sleep Behavioural Disorders in Children and Adolescents. 儿童睡眠:儿童和青少年的睡眠健康和睡眠行为障碍。
IF 3.4 3区 医学
Journal of Sleep Research Pub Date : 2025-04-28 DOI: 10.1111/jsr.70078
Debora Meneo, Dimitri Gavriloff, Silvia Cerolini, Elisabetta Baldi, Angelika Schlarb, Lino Nobili, Chiara Baglioni
{"title":"A Closer Look at Paediatric Sleep: Sleep Health and Sleep Behavioural Disorders in Children and Adolescents.","authors":"Debora Meneo, Dimitri Gavriloff, Silvia Cerolini, Elisabetta Baldi, Angelika Schlarb, Lino Nobili, Chiara Baglioni","doi":"10.1111/jsr.70078","DOIUrl":"https://doi.org/10.1111/jsr.70078","url":null,"abstract":"<p><p>Adequate sleep is crucial for healthy development, contributing significantly to physical and mental well-being. While research on paediatric sleep is expanding, there remain several open questions. This narrative review provides an overview of our current knowledge on paediatric sleep health and identifies literature gaps, considering factors such as age, gender, cultural differences, and the interplay between sleep, physical activity, nutrition, and mental health. It also considers sleep health in the more specific group of children with neurodevelopmental disorders. By viewing paediatric sleep health as a multidimensional construct, this review discusses age-specific issues, including the different factors affecting satisfaction, daytime alertness, sleep timing, efficiency and duration, and sleep-related behaviours. While gender differences in sleep health become apparent after puberty, few studies have addressed sex differences in children or different parental attitudes toward sleep in boys and girls. Cultural differences in sleep duration, timing, and setting are reported from infancy through adolescence; however, the cultural influence on sleep health, particularly during adolescence, remains unclear. This is crucial when considering the effects of screen time, smartphone use, and social media exposure on sleep. Further research is required to understand how sleep, nutrition, and physical health interact throughout the developmental span. Additionally, this review underscores the protective nature of sleep for adolescent mental health and for the management of emotional and behavioural problems in children with neurodevelopmental disorders. The review identifies critical areas for future research to enhance our understanding of paediatric sleep health and develop more effective and tailored interventions and preventive programmes.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70078"},"PeriodicalIF":3.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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