Journal of Sleep Research最新文献

{"title":"Optimising lighting conditions to enhance seafarer adaptation to the '6-h on/6-h off' shift pattern: a balanced crossover study.","authors":"Chenyao Zhao, Nuoyi Li, Xiangwei Yi, Xiao Wang, Ying He, Haiping Shen, Yandan Lin","doi":"10.1111/jsr.14450","DOIUrl":"https://doi.org/10.1111/jsr.14450","url":null,"abstract":"<p><p>The '6-h on/6-h off' shift pattern could potentially disrupt the physiological rhythms and cognitive performance of seafarers, attributed to its shorter and more frequent shifts. Conversely, light exposure has been demonstrated to enhance cognitive abilities and synchronise physiological processes. Therefore, we studied the fatigue, cognition, sleep and rhythm of seafarers with different shifts to determine how light can benefit their performance. A total of 16 seafarers participated in a 2 × 2 crossover study, which involved two shift types (Morning-Evening and Day-Night) and two lighting conditions (static lighting and dynamic lighting). Sleepiness, cognition and fatigue were assessed every 2 h during '6-h on' period, using the Karolinska Sleepiness Scale, psychomotor vigilance task, critical flicker frequency and visual analogue scale for fatigue. Sleep was monitored during '6-h off' period, core body temperature was continuously tracked for rhythm throughout the shift protocol. For the Day-Night shift, the static mode with stable higher illuminance than dynamic lighting significantly reduced sleepiness (p = 0.01), objective fatigue (p = 0.001), subjective fatigue (fatigue level [p = 0.004] and visual fatigue [p = 0.001]) during the night period, while increasing sleep duration during the day (6:00 a.m. to 12:00 p.m.) and delaying the rhythm. For the Morning-Evening shift, dynamic lighting with lower illuminance significantly increased sleep duration during the night (12:00 a.m. to 6:00 a.m.) without causing a significant difference in performance. Overall, static lighting is more suitable for Day-Night shift seafarers due to lower sleepiness, fatigue and longer daytime sleep duration, while dynamic lighting is more suitable for Morning-Evening shift seafarers due to longer night-time sleep duration. Therefore, different lighting patterns should be adopted for seafarers during different shifts.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14450"},"PeriodicalIF":3.4,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better sleep hygiene is associated with better sleep health in mining shift workers in Australia.","authors":"Philipp Beranek, Ian C Dunican, Travis Cruickshank, Mitchell Turner","doi":"10.1111/jsr.14457","DOIUrl":"https://doi.org/10.1111/jsr.14457","url":null,"abstract":"<p><p>Australia's mine sites are largely situated in remote locations and operate around the clock. Many shift workers fly to site, where they work 12-hr shifts and sleep in camp accommodation before they return home for the period rostered off work. Mining shift workers experience poor sleep, yet limited research is available on contributing factors. This study investigated, for the first time, the relationship between the sleep health and sleep hygiene in this population. A survey was disseminated to shift workers in the mining industry, utilising a cross-sectional study design. The Sleep Health Index and Sleep Hygiene Index questionnaires were used to evaluate their sleep health and sleep hygiene, respectively. In total, 470 shift workers (mean age [years]: 39 ± 12, mean body mass index [kg m^-2]: 28 ± 5) were included, which involved 132 females. Average scores for the Sleep Health Index and Sleep Hygiene Index were 76 ± 15 and 30 ± 7, respectively. Better sleep health was observed in shift workers with better sleep hygiene (β = -0.52, SE = 0.09 [-0.71, -0.34], p < 0.001). Differences in Sleep Health Index scores were found for individual Sleep Hygiene Index items related to \"sleep regularity\", \"sleep environment\", \"mental health\" and \"time in bed extension\". However, no differences in Sleep Health Index scores were found for items related to \"caffeine, alcohol or nicotine consumption\" or \"exercise\" close to bedtime and \"bedtime activities\" (p > 0.05 for all). These findings demonstrate a relationship between sleep hygiene and sleep health; therefore, it may be possible to improve the sleep of shift workers by improving their sleep hygiene.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14457"},"PeriodicalIF":3.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary feasibility and efficacy of a brief behavioural treatment for insomnia after acquired brain injury: A case series.","authors":"Maria Gardani, Satu Baylan, Veronika Zouhar","doi":"10.1111/jsr.14441","DOIUrl":"https://doi.org/10.1111/jsr.14441","url":null,"abstract":"<p><p>Insomnia after acquired brain injury (ABI) is common and can negatively impact an individual's rehabilitation, recovery, and quality of life. The present study investigated the feasibility and preliminary efficacy of a Brief Behavioural Treatment for Insomnia (BBTI) in a community sample following ABI. Ten participants were recruited. Seven participants attended four weekly sessions of BBTI and kept a daily sleep diary. Participants completed a semi-structured sleep interview at baseline and self-report measures of sleep, anxiety, and depression pre- and post-treatment as well as a treatment acceptability questionnaire post-treatment. Follow-up data were collected at 1-, 2-, and 3-months post-treatment. Visual analyses of the data were performed on a case-by-case basis. Five of the seven participants (71%) no longer met the criteria for insomnia disorder on the Sleep Condition Indicator (SCI) post-treatment. Treatment effects on sleep outcomes were either maintained or augmented at follow-ups. BBTI was found to be well tolerated, as evidenced by the high overall retention rates (70%) and positive feedback on the treatment acceptability questionnaire. These results provide preliminary evidence of BBTI being both feasible to use and potentially efficacious in individuals with post-brain-injury insomnia. Larger-scale randomised controlled trials are needed to establish the effectiveness of BBTI following ABI.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14441"},"PeriodicalIF":3.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the important risk factors for excessive daytime sleepiness in a population-based cohort?","authors":"Jenny Theorell-Haglöw, Martin Ulander, John Brandberg, Martin Claesson, Karl A Franklin, Jan Hedner, Magnus Hultin, Fredrik Iredahl, Eva Lindberg, Mirjam Ljunggren, Andrei Malinovschi, Maria Mannila, Ida Pesonen, Anthony Prakash, Carin Sahlin, Magnus Sköld, Jonas Spaak, Hanan Tanash, Ding Zou, Ludger Grote","doi":"10.1111/jsr.14449","DOIUrl":"https://doi.org/10.1111/jsr.14449","url":null,"abstract":"<p><p>Excessive daytime sleepiness (EDS) is a common complaint in the general population and is associated with cardiovascular disease and increased mortality. We aimed to investigate whether sleep duration is related to excessive daytime sleepiness in the general population, both in itself and in combination with other factors. We performed a cross-sectional analysis in the population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort (n = 27,976; 14,436 females; aged 50-64 years) to assess how sleep-related factors along with anthropometric, lifestyle, socioeconomic factors as well as somatic disease and psychological distress, were related with EDS assessed by the Epworth sleepiness scale (ESS). Analyses were performed using logistic regression modelling with EDS defined by an ESS score of ≥11 as the main outcome. Both short and long sleep duration were related to EDS with increasing ORs for decreasing sleep duration (7 h vs. reference (8 h): OR 1.2, 95% CI 1.02-1.3 to ≤4 h: 1.9; 1.4-2.5). In addition to sleep-related factors such as insomnia (1.3; 1.2-1.4), poor sleep quality (1.2; 1.04-1.4), snoring (1.5; 1.4-1.6), and nocturnal gastro-oesophageal reflux (1.5; 1.21-1.8), psychological distress showed a strong association with EDS. This included sadness/depression (1.2; 1.1-1.3), stress (some stress: 1.4; 1.1-1.7 to constant stress over 5 years: 1.7; 1.3-2.2), and self-rated \"control in life\" (lowest quartile: 1.7; 1.6-2.0). Daytime sleepiness is multifactorial and associated with both sleep duration and sleep quality. Strong associations were also established with factors related to psychological distress. Further research may investigate interventions targeting both sleep and psychological health to reduce daytime sleepiness at the societal level.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14449"},"PeriodicalIF":3.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positional obstructive sleep apnea in children prescribed continuous positive airway pressure therapy for obstructive sleep-disordered breathing.","authors":"Ajay Kevat, Dhruv Alwadhi, Ai Xin Chew, Kartik Iyer, Jasneek Chawla, Sadasivam Suresh, Andrew Collaro","doi":"10.1111/jsr.14443","DOIUrl":"https://doi.org/10.1111/jsr.14443","url":null,"abstract":"<p><p>Positional obstructive sleep apnea, in which there is a ≥ 2:1 predominance of obstructive events in the supine position, is a sleep-disordered breathing phenotype with a targeted treatment in the form of positional device therapy. We sought to determine the prevalence of positional obstructive sleep apnea in a cohort of children prescribed continuous positive airway pressure therapy, ascertain risk factors for the condition, and determine the associated continuous positive airway pressure treatment adherence rate. A retrospective cohort study of all children > 2 years old from a single tertiary paediatric centre prescribed continuous positive airway pressure therapy over an 8-year period was conducted. Positional obstructive sleep apnea prevalence was established by analysing positional and respiratory event data from the participants' original diagnostic polysomnography. Continuous positive airway pressure therapy adherence was determined using data from machine download. Univariable and multivariable logistic regression modelling was used to determine participant demographic and clinical factors associated with positional obstruction. Positional obstructive sleep apnea (defined by Bignold's criteria modified for paediatric use) prevalence in the cohort of 237 analysed participants was 38%. Suboptimal continuous positive airway pressure adherence was noted in 30% of this group based on initial machine download, performed a median of 96 days post-treatment initiation. Higher age and lower obstructive apnea-hypopnea index were independent predictors of positional obstructive sleep apnea, whereas neurodevelopmental diagnosis, presence/absence of rapid eye movement-related obstructive sleep apnea, overweight/obesity status and history of adenoidectomy/adenotonsillectomy were not. For children, positional device therapy is a treatment option worthy of further consideration and research.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14443"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Morningness-Eveningness Scale for Children (MESC) with ambulatory circadian monitoring of temperature, light exposure and activity.","authors":"Yaiza Puig-Navarro, Juan F Díaz-Morales","doi":"10.1111/jsr.14444","DOIUrl":"https://doi.org/10.1111/jsr.14444","url":null,"abstract":"<p><p>The external validity of the Morningness-Eveningness Scale for Children was analysed via objective measures of skin temperature, light exposure and motor activity with the ambulatory circadian monitoring methodology. A total of 138 adolescents (57 boys and 81 girls) aged 12-13 years, who in addition to completing the Morningness-Eveningness Scale for Children to determine their circadian typology wore a wrist activity device (Kronowise 3.0; Kronohealth SL) during school days and a weekend, participated. Circadian parameters, such as mesor, amplitude and acrophase, were estimated for skin temperature, light exposure and motor activity, as were sleep parameters, such as risetime, bedtime and social jetlag. The results indicated that during the weekend E-type adolescents experienced later acrophases in temperature, light and activity than I-type and M-type adolescents did, whereas boys experienced earlier acrophases in temperature and activity. When school weekdays were compared with the weekend, there was a weekend delay in the acrophases of temperature (1:03), light exposure (2:03) and activity (3:15). The results obtained in this study provide external validity for applying the Morningness-Eveningness Scale for Children in the naturalistic context of high school while considering sex and type-of-day differences as important variables in chronopsychological studies.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14444"},"PeriodicalIF":3.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability of excessive daytime sleepiness and cataplexy according to seasonality: A study in central disorders of hypersomnolence.","authors":"Flavia Cirillo, Mariana Fernandes, Fabio Placidi, Francesca Izzi, Nicola Biagio Mercuri, Claudio Liguori","doi":"10.1111/jsr.14451","DOIUrl":"https://doi.org/10.1111/jsr.14451","url":null,"abstract":"<p><p>Seasonality of excessive daytime sleepiness has been proposed, yet no research has specifically investigated its impact on daytime sleepiness and cataplexy in central disorders of hypersomnolence. This study examined seasonal variations in daytime sleepiness and cataplexy in narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia. Patients included in the study were on stable pharmacological treatment, and participated in sleep medicine interviews to assess diurnal sleepiness and daytime napping and completed the Epworth Sleepiness Scale to assess excessive daytime sleepiness (Epworth Sleepiness Scale ≥ 10). Patients with narcolepsy type 1 also maintained a cataplexy diary. Evaluations were conducted in autumn, winter, spring and summer. The study included 29 patients with narcolepsy type 1, 16 patients with narcolepsy type 2 and 10 patients with idiopathic hypersomnia. Patients with narcolepsy type 1 and narcolepsy type 2 showed higher Epworth Sleepiness Scale scores in summer compared with other seasons, while patients with idiopathic hypersomnia showed no changes in excessive daytime sleepiness across the four seasons. Epworth Sleepiness Scale scores were higher in idiopathic hypersomnia patients compared to narcolepsy type 1 and narcolepsy type 2 patients in spring, autumn, and winter; conversely, in summer there were no differences in Epworth Sleepiness Scale scores among the three groups. No significant differences in Epworth Sleepiness Scale scores were noted between patients with narcolepsy type 1 and narcolepsy type 2 throughout the year. Furthermore, no seasonal effect on cataplexy frequency was found in patients with narcolepsy type 1. This study demonstrates that seasonality may influence daytime sleepiness in patients with narcolepsy type 1 and narcolepsy type 2 but not in patients with idiopathic hypersomnia, while cataplexy symptoms remain unaffected by seasonal changes. The underlying mechanisms linking excessive daytime sleepiness to seasonality have yet to be explored, though social factors and vacation time may contribute to increased excessive daytime sleepiness in narcolepsy.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14451"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actigraphy-based assessment of circadian rhythmicity and sleep in patients with Usher syndrome type 2a: A case-control study.","authors":"Jessie M Hendricks, Juriaan R Metz, H Myrthe Boss, Rob W J Collin, Erik de Vrieze, Erwin van Wijk","doi":"10.1111/jsr.14456","DOIUrl":"https://doi.org/10.1111/jsr.14456","url":null,"abstract":"<p><p>This study aimed to improve our understanding of sleep problems as a comorbidity of hereditary deaf-blindness due to Usher syndrome type 2a. Fifteen patients with Usher syndrome type 2a with a conclusive genetic diagnosis and 15 unaffected controls participated in comprehensive sleep and activity assessments for 2 weeks, using the MotionWatch 8 actigraph and consensus sleep diary. Various sleep parameters including sleep opportunity window, sleep latency, sleep efficiency, and self-reported sleep quality were analysed. Non-parametric circadian rhythm analysis was performed to evaluate circadian rhythmicity. Additionally, regression analyses were conducted to study potential correlations between sleep parameters and patients' demographics and disease progression. Patients with Usher syndrome type 2a exhibited significantly longer sleep latency and lower self-reported sleep and rest quality compared with controls. Additionally, day-to-day variability of sleep efficiency and sleep latency were significantly higher in the patient population. Non-parametric circadian rhythm analysis revealed no significant differences in circadian rhythmicity. Regression analyses indicated that having Usher syndrome type 2a was a significant predictor of poor sleep outcomes. No clear correlations were found between the level of visual impairment and sleep parameters, suggesting that the negative effects of Usher syndrome type 2a on sleep manifest independently of the progressive visual impairment. These findings suggest that, while circadian sleep-wake rhythm remain intact, patients with Usher syndrome type 2a suffer from sleep disturbances that likely arise from factors beyond their progressive blindness. With sleep problems being a major risk factor for physical and mental health problems, we advocate that sleep problems should be recognized as a hallmark symptom of Usher syndrome type 2a, warranting in-depth research for potential targeted therapeutic interventions.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14456"},"PeriodicalIF":3.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders in patients with obsessive-compulsive disorder: A systematic review of the literature.","authors":"Therese Santiago, Isabel Simbre, Lourdes M DelRosso","doi":"10.1111/jsr.14446","DOIUrl":"https://doi.org/10.1111/jsr.14446","url":null,"abstract":"<p><p>Patients with obsessive-compulsive disorder are presumed to be at higher risk of sleep disorders due to the potential interference that persistent thoughts and compulsions may exert on sleep. Although there are studies on sleep findings in patients with obsessive-compulsive disorder, there are few systematic reviews on the presence of sleep disorders in patients with obsessive-compulsive disorder for adults and children. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed to perform a comprehensive search of PubMed and Web of Science using the MeSH terms \"obsessive-compulsive disorder\" and \"sleep wake disorders\". The exclusion criteria included publications not in English, studies performed on non-humans, abstracts, reviews, and meta-analyses. After applying the exclusion criteria, 17 studies qualified for inclusion in this systematic review. Nine studies were written about children and eight on adults. In the adult studies, sleep questionnaires, actigraphy and dim light melatonin onset showed delayed circadian rhythm in those with obsessive-compulsive disorder. Several studies showed an increased prevalence of insomnia in adult patients with obsessive-compulsive disorder. Overall, these studies showed sleep-onset and maintenance insomnia, and poor sleep quality. In the paediatric studies, sleep questionnaires revealed that paediatric patients with obsessive-compulsive disorder have increased sleep-related problems, including poor sleep quality, difficulty initiating and maintaining sleep, nightmares and sleepwalking. Two studies using actigraphy demonstrated a decreased total sleep time, increased wake after sleep onset and increased duration of awakening. Studies also showed an improvement in sleep symptoms with cognitive behavioural therapy. The systematic review has shown increased sleep-related problems and poor sleep quality both in adult and paediatric patients with obsessive-compulsive disorder. All patients with obsessive-compulsive disorder should therefore be screened for sleep-related problems to help in the overall outcome of treatment plans.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14446"},"PeriodicalIF":3.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement.","authors":"Marco Sforza, Charles M Morin, Thien Thanh Dang-Vu, Florence B Pomares, Aurore A Perrault, Jean-Philippe Gouin, Jitka Bušková, Karolina Janků, Alexandros Vgontzas, Julio Fernandez-Mendoza, Celyne H Bastien, Dieter Riemann, Chiara Baglioni, Giacomo Carollo, Francesca Casoni, Marco Zucconi, Vincenza Castronovo, Andrea Galbiati, Luigi Ferini-Strambi","doi":"10.1111/jsr.14452","DOIUrl":"https://doi.org/10.1111/jsr.14452","url":null,"abstract":"<p><p>Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understanding of insomnia and its treatment. To date, no study has examined the relationship between K-complexes (KC) and CBT-I, despite the known homeostatic and protective function of this relevant sleep brainwave. This retrospective multicentre study aims to explore the relationship between electroencephalographic (EEG) indices and CBT-I, with a particular focus on evaluating an index of sleep homeostasis identified by KC. This research is designed to assess the predictive value of this index for treatment outcomes and to examine its variations before and after intervention. Ninety eight patients with ID underwent a 6-8 week in-person CBT-I programme, with pre-and post-treatment evaluation conducted using polysomnography (PSG) and the Insomnia Severity Index (ISI). The main outcome was determined by calculating the slope of the linear equation indexing the KC density (number of KC/minutes of N2) in each non-artifacted NREM stage 2 epoch throughout the night (KCSlope). Furthermore, the sample was categorised into Responders (ISIdecrease ≥8) and non-Responders (ISIdecrease <8). The results indicate that the KC Slope is effective not only to predict treatment response (one-way ANOVA, F = 7.831 p = 0.007; Responders = -2.954*10^-5 ± 3.346*10^-5, non-Responders = -5.583*10^-5 ± 5.305*10^-5; adjusted for PSG wake after sleep onset at the baseline), but also to detect a statistically significant improvement in sleep pressure following CBT-I (Wilcoxon signed-rank test W = 3074.000 p = 0.022; KCSlope pre-treatment = -4.054*10^-5 ± 4.446*10^-5, KCSlope post-treatment = -4.797*10^-5 ± 5.710*10^-5). These findings suggest that CBT-I increases sleep pressure in patients with chronic insomnia, highlighting a novel and relevant biomarker in this context.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e14452"},"PeriodicalIF":3.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}