Journal of Sleep Research最新文献

{"title":"Eyes-Closed Resting-State fMRI After Sleep Deprivation: A Vigilance-Sensitive Window.","authors":"Mariana Toricelli, Sergio Tufik, Monica Levy Andersen","doi":"10.1111/jsr.70360","DOIUrl":"10.1111/jsr.70360","url":null,"abstract":"","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70360"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive Sleep Apnea and Cognitive Impairment: Implications for Surgical Outcomes.","authors":"Yasmin Alhamdah, Ellene Yan, Paras Kapoor, Aparna Saripella, Nina Butris, David He, Leif Erik Lovblom, Sazzadul Islam, Jean Wong, Frances Chung","doi":"10.1111/jsr.70390","DOIUrl":"10.1111/jsr.70390","url":null,"abstract":"<p><p>The influence of coexisting obstructive sleep apnea (OSA) and cognitive impairment (CI) on perioperative outcomes is unclear, despite its potential clinical significance. We aimed to compare clinical outcomes between surgical patients with OSA or high risk OSA (OSA/HR-OSA) who have CI and those without CI. We assessed 655 surgical patients aged ≥ 65 years. All participants completed the STOP or STOP-Bang questionnaires to assess for risk of OSA and were classified as OSA/HR-OSA or No-OSA/LR-OSA. To assess for probable CI, participants completed the in-person or telephone Montreal Cognitive Assessment (MoCA) and were classified as CI or No-CI. Among 655 participants, 377 (57.6%) had OSA/HR-OSA and 216 (33.0%) had CI. Twenty-one percent (137/655) presented with coexisting OSA/HR-OSA and CI. More participants in the OSA/HR-OSA group had CI compared to the No-OSA/LR-OSA group (36.3% vs. 28.4%, p = 0.041). After adjustment, each additional year of education was associated with a 12% decrease in the odds of CI among participants with OSA/HR-OSA (p < 0.001). Participants with coexisting OSA/HR-OSA and CI had about 2-fold higher odds for all-cause complications (OR: 2.01, 95% CI: 1.29, 3.13, p = 0.002) and 80% higher adverse composite outcomes (OR: 1.79, 95% CI: 1.16, 2.79, p = 0.009) at 30 days postoperatively than those with OSA/HR-OSA and No-CI, after adjustment for covariates. In conclusion, coexisting OSA/HR-OSA and CI was common at 21% and associated with increased 30-day all-cause complications and composite outcomes. These findings emphasise the need for enhanced preoperative screening and multidisciplinary strategies to identify and manage such vulnerable patients.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70390"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lights On or Off? The Efficacy of Light Therapy as Add-On to Cognitive Behavioural Therapy for Insomnia-A Pilot Study.","authors":"Sarah R Schmid, Christine Blume, Johanna Ell, Nikolas Konzen, Matthias Apweiler, Bernd Feige, Bernd L Fiebich, Julian E Schiel, Katharina Domschke, Kai Spiegelhalder","doi":"10.1111/jsr.70357","DOIUrl":"10.1111/jsr.70357","url":null,"abstract":"<p><p>Cognitive behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study investigates the therapeutic potential of light therapy as an add-on to CBT-I. Insomnia severity and questionnaire-related secondary outcomes were assessed at baseline, post-treatment and follow-up. Sleep diary-related variables and the cortisol awakening response were assessed at pre- and post-treatment. Linear mixed models were calculated for each outcome variable. The study included 42 patients with insomnia disorder. Reduction in insomnia severity did not significantly differ between groups from baseline to post-treatment (β = 0.35, SE = 1.31, p = 0.792). Regarding exploratory secondary outcomes, daytime sleepiness was significantly more reduced from baseline to follow-up in the CBT-I + light therapy group than in the CBT-I + placebo light group (β = -1.05, SE = 0.43, p = 0.020). There was no significant condition × time point interaction effect for any of the other secondary outcomes. The findings show no significant add-on effect of light therapy on insomnia severity. However, light therapy had a significant effect on daytime sleepiness that became evident only at the follow-up. Given that daytime functioning is of high clinical relevance for patients with insomnia disorder, daytime sleepiness should be further evaluated as treatment target and may be addressed with light therapy. TRIAL REGISTRATION: ClinicalTrials.gov identifier: DRKS00029640.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70357"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Symptoms in a Swiss Population-Based Cohort: Prevalence, Clinical Correlates and Polysomnographic Alterations.","authors":"Isabel Ericson, Geoffroy Solelhac, Théo Imler, Kari Lambing, Magdy Younes, Pedro Marques-Vidal, Peter Vollenweider, Marie-Pierre Françoise Strippoli, Martin Preisig, Raphaël Heinzer, Nicola A Marchi","doi":"10.1111/jsr.70376","DOIUrl":"10.1111/jsr.70376","url":null,"abstract":"<p><p>This study assessed the prevalence, clinical correlates and polysomnographic features of insomnia symptoms in a population-based cohort (HypnoLaus, Lausanne, Switzerland). Data were obtained from 3947 participants (mean age 57.5 ± 10.5 years; range 40-82; 52.0% female). Insomnia symptoms were defined as difficulty initiating or maintaining sleep ≥ 3 nights/week during the past month or regular hypnotic use. Independent correlates of insomnia symptoms were examined using logistic regression. In the subset of 1718 participants who underwent polysomnography (performed 1.1 ± 0.9 years after insomnia symptom assessment), associations between insomnia symptoms and sleep variables were examined using linear regression models adjusted for age, sex, depression, anxiety and psychotropic use. Insomnia symptoms affected 32.0% of participants, and 4.2% of the total sample reported regular hypnotic use. Independent correlates included older age, female sex, lower education, dyslipidaemia, lower likelihood of current smoking, excessive alcohol consumption, depression, anxiety, psychotropic use and daytime sleepiness. Compared with those without symptoms, participants with insomnia showed shorter total sleep time, longer sleep onset latency, longer wake after sleep onset and lower sleep efficiency (all small effect sizes). Sleep microstructure analysis showed higher odds ratio product (ORP) values (in wake, NREM, and N2, and ORP-9), higher normalised EEG power, higher beta power and higher gamma power (all small effect sizes). Insomnia symptoms are highly prevalent in this population-based cohort and are linked to multiple sociodemographic and clinical factors. Polysomnographic findings indicate modest sleep macrostructural differences, whereas microstructural alterations, although subtle in magnitude, appeared more consistently associated with insomnia symptoms.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70376"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Dynamics During Respiratory Arousal From Sleep Assessed by Oximeter-Based Vascular Stiffness Measures.","authors":"Christian Strassberger, Ding Zou, Jan Hedner, Ludger Grote","doi":"10.1111/jsr.70343","DOIUrl":"10.1111/jsr.70343","url":null,"abstract":"<p><p>Cortical arousals significantly impact obstructive sleep apnoea (OSA) pathophysiology and cardiovascular consequences, often mediated by sympathetic activation. While pulse oximetry (PPG) provides an accessible reflection of autonomic responses such as changes in pulse rate (PR) and pulse wave amplitude (PWA), the dynamic influence on other vascular indices remains less explored. We investigated dynamic changes in PPG-derived pulse propagation time (PPT), a metric reflecting modulation in vascular stiffness. It is hypothesised that PPT beat-to-beat responses to arousals are specific and independent from other pulse wave parameters. Polysomnography data from 87 patients were analysed (mean age 54 ± 12 years, 26% female, mean BMI 27.7 ± 3.6 kg/m², mean Apnea-Hypopnea Index 33 ± 23 events/h; total 18,275 respiratory events). The mean percentage change (shortening, vascular stiffening) of the PPT following respiratory events was significantly greater when accompanied by an EEG arousal in both apnoeas (-21.1% vs. -17.9%, p < 0.001) and hypopneas (-19.4% vs. -17.0%, p < 0.001). In a multivariate logistic mixed-effect model, ∆PPT emerged as an independent predictor of EEG arousal presence (p < 0.001, scaled odds ratio: 1.14; 95% CI: 1.09-1.20), accounting for event type, anthropometrics and changes in PWA, PR, SpO₂. Dynamic, short-term changes in PPG-derived PPT are significantly associated with cortical arousals following respiratory events in OSA patients. This parameter provides independent predictive information beyond established PPG metrics, likely reflecting rapid, arousal-induced alterations in vascular tone. These findings highlight a novel PPG-based marker that could quantify the vascular stress in OSA.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70343"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Prodromal Parkinson's Disease-Like Features in Long COVID With Dream-Enactment Behaviours.","authors":"Siyi Gong, Yaping Liu, Bei Huang, Ngan Yin Chan, Eemil Partinen, Christian Benedict, Bjørn Bjorvatn, Ilona Merikanto, Luigi De Gennaro, Yves Dauvilliers, Brigitte Holzinger, Juliana Yordanova, Maria Korman, Cátia Reis, Anne-Marie Landtblom, Sergio Mota-Rolim, Michael R Nadorff, Frances Chung, Yuichi Inoue, Harald Hrubos-Strøm, Kentaro Matsui, Courtney J Bolstad, Pei Xue, Colin A Espie, Charles M Morin, Thomas Penzel, Giuseppe Plazzi, Markku Partinen, Yun Kwok Wing","doi":"10.1111/jsr.70371","DOIUrl":"10.1111/jsr.70371","url":null,"abstract":"<p><p>Emerging evidence links COVID-19 to the predisposition of Parkinson's disease (PD). However, the relationship between long COVID and prodromal PD-like features remains unclear, particularly in long COVID participants with dream-enactment behaviours (DEBs) that may be suggestive of possible REM sleep behaviour disorder. This study aimed to quantify the burden of prodromal PD-like features in long COVID. This online survey (May-Nov 2021) across 16 countries/regions included 11,261 participants. Data on demographics, COVID-19 diagnosis, long COVID symptoms, sleep features and other typical prodromal PD-like features were collected. The likelihood ratio (LR) of prodromal PD was calculated as a proxy for each participant's overall burden of prodromal PD-like features, based on the 2019 Movement Disorder Society research criteria. Participants with long COVID (n = 1155) exhibited more symptoms suggestive of prodromal PD-like features, including DEBs, olfactory dysfunctions, constipation, excessive daytime sleepiness, postural dizziness, depression with/without anxiety, urinary dysfunctions, cognitive impairment and a higher LR of prodromal PD when compared to non-COVID-19 participants and COVID-19 recoverees. Long COVID was associated with a 73% higher burden of potential prodromal PD-like features (adjusted odds ratio [aOR] = 1.73, 95% confidence interval [CI] = 1.57-1.90). Among those with long COVID, emergence or exacerbation of post-infection DEBs further increased this burden by 38% (aOR = 1.38, 95% CI = 1.19-1.60). Our study suggested that long COVID is associated with an increased burden of prodromal PD-like features, which appears to be further enhanced with DEBs.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70371"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actigraphy Meets AI: A Digital Biomarker for Parkinson's Disease and Isolated REM Sleep Behaviour Disorder.","authors":"Leonor Lopes, Jan D Warncke, Irina Filchenko, Kuangyu Shi, Claudio L A Bassetti, Carolin Schäfer","doi":"10.1111/jsr.70396","DOIUrl":"10.1111/jsr.70396","url":null,"abstract":"<p><p>Isolated rapid eye movement (REM) sleep behaviour disorder (RBD) is an early stage of alpha-synucleinopathies, such as Parkinson's disease (PD). Actigraphy is a promising tool for assessing rest-activity patterns, however its diagnostic or predictive value in these disorders is understudied. This study evaluated AI-based models applied to actigraphy data to improve the detection of PD and RBD, additionally exploring their capability to capture early neurodegenerative patterns in isolated RBD. We trained and evaluated machine learning models with extracted actigraphy features, a convolutional neural network and a pre-trained transformer model-PAT-on two classification tasks: (1) distinguishing patients with PD from non-neurodegenerative controls and (2) distinguishing patients with PD and RBD (PD-RBD) from those without (PD-noRBD). We tested the best-performing model on patients with isolated RBD. PD-RBD showed significantly altered actigraphy features compared to PD-noRBD and controls. In PD versus control classification, the PAT model performed best (AUC = 0.937, sensitivity = 80.5%, specificity = 92.9%) followed by the neural network (AUC = 0.863) and machine learning (AUC = 0.840). In the PD-RBD versus PD-noRBD classification task, the PAT model again outperformed the other models (AUC = 0.956, sensitivity = 84.4% and specificity = 92.9%). For both tasks, the scores of isolated RBD patients fell between those of the comparison groups. AI-based actigraphy models can distinguish PD patients from controls and identify subtypes with high sensitivity and specificity. This shows their potential as non-invasive, scalable diagnostic tools and their relevance for identifying prodromal motor features, with future applications in predicting isolated RBD progression to PD. Validation in longitudinal cohorts remains necessary.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70396"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Resting State Quantitative EEG and Daytime Sleepiness Complaints in Parkinson's Disease.","authors":"Thaïna Rosinvil, Ronald B Postuma, Jean-Marc Lina, Jacques Montplaisir, Jean-François Gagnon, Julie Carrier","doi":"10.1111/jsr.70408","DOIUrl":"10.1111/jsr.70408","url":null,"abstract":"<p><p>Although many studies have reported the presence of daytime sleepiness in Parkinson's disease (PD), either a weak or no association has been found between self-reported and current objective measures of daytime sleepiness in this population. Changes in resting state quantitative electroencephalography (qEEG) have been associated with increased subjective sleepiness induced by sleep deprivation in young and older adults. The aim of this study was to investigate the relationship between resting state qEEG and self-reported daytime sleepiness in adults with PD. Sixty-two participants with PD underwent polysomnographic recording and clinical assessment. Daytime sleepiness severity was measured with the Epworth Sleepiness Scale (ESS). Resting state EEG was recorded 30 min after awakening. Spectral power and functional connectivity analyses (weighted-phase lag index, amplitude-amplitude coupling) were performed on artefact-free resting state EEG in 2 Hz mini bands from 0.5 to 12 Hz. Partial correlations and a hierarchical regression were used to evaluate the relationship between the qEEG metrics and ESS scores. Lower phase synchronisation in the low alpha band (8-10 Hz) within the occipital cortex was the best EEG predictor of higher daytime sleepiness severity in PD. Our results are in line with some findings of previous studies conducted in healthy young participants that reported lower alpha connectivity after sleep deprivation, suggesting disrupted arousal networks may contribute to daytime sleepiness in PD. Lower alpha phase synchronisation within the occipital cortex could serve as a proxy for daytime sleepiness in PD.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70408"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness.","authors":"Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C Nisbet, Margot J Davey, Gillian M Nixon, Lisa M Walter, Rosemary S C Horne","doi":"10.1111/jsr.70415","DOIUrl":"10.1111/jsr.70415","url":null,"abstract":"<p><p>Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro-architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and subjectively sleepy children with a non-diagnostic multiple sleep latency test, and individually age- and sex-matched controls. Twenty eight children with narcolepsy, 11 with IH and 26 with subjective sleepiness (aged 6-19 years) were included. Spindle activity was characterised as spindle density (number of spindles/min) and intensity (density × average duration) of central (C4) and frontal (F4) EEG electrodes for Slow and Fast spindles and combined (Slow&Fast) across the sleep period and also when separated into NREM sleep periods (NREMP) across the night. C4 Slow and Fast and F4 Slow spindle duration was longer in children with narcolepsy compared to their controls (p < 0.05 for all comparisons) and to those with subjective sleepiness (p < 0.05). In the children with narcolepsy and subjective sleepiness C4 spindle intensity was greater (p < 0.05 for both groups) compared to controls. C4 spindle density and intensity were lower at the beginning compared to the end of the night in the children with narcolepsy and subjective sleepiness (p < 0.05 for both groups). There were no relationships between spindle activity and parental reports of daytime sleepiness. Spindle characteristics differed between children with narcolepsy compared to controls and to children with undiagnosed subjective sleepiness. Our findings may aid in distinguishing between groups of children referred for assessment of excessive daytime sleepiness.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70415"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Tibetan Ancestry on Respiratory Control and Central Sleep Apnea in Hypoxia.","authors":"Grégory Heiniger, Lise Piquilloud, Geoffroy Solelhac, Théo Imler, Adrien Waeber, Brian Bradley, Gianpaolo Lecciso, Francis Degache, Alban Lovis, Karma Lambercy, Bengt Kayser, Scott Sands, Andrew Wellman, Raphael Heinzer","doi":"10.1111/jsr.70346","DOIUrl":"10.1111/jsr.70346","url":null,"abstract":"<p><p>The onset of altitude-induced central sleep apnea (CSA) varies among individuals and may be influenced by genetic factors affecting respiratory control. Tibetans, who have undergone high-altitude adaptation over generations, may exhibit physiologic traits that protect against CSA. This study investigated the impact of Tibetan ancestry on respiratory control and hypoxia-induced CSA. Nine healthy unacclimatized Tibetans living in Switzerland for at least 5 years and 20 Caucasians (all males; median[IQR] age: 28 [27-32] vs. 24 [23.5-26] years; median[IQR] BMI: 23.8 [23.1-28] vs. 22.1[21.2-23.1]kg/m²) underwent two full polysomnographies, one at low altitude and one in a hypoxic chamber simulating 3500 m. The apnea-hypopnea index (AHI) and the percentage of sleep spent in periodic breathing (PB) were calculated. A hyperoxic hypercapnic ventilatory response (HCVR) test and hypoxic ventilatory response tests at rest (HVRr) and during exercise (HVRe) were performed. Parameters were compared between groups using non-parametric tests. At simulated altitude, Tibetans exhibited a significantly lower AHI (51.2 [12.7-72.1]/h vs. 107.0 [36.7-140.3]/h; p = 0.0231) and spent less sleep time in PB (27.6 [2.6-44.5]% vs. 58.8 [14.0-89.0]%; p = 0.0334) compared to Caucasians. HCVR did not differ significantly between groups (Tibetans: 1.983 [1.349-2.224] L/min/mmHg; Caucasians: 2.227 [1.698-3.071] L/min/mmHg; p = 0.2167). Tibetans showed a significantly lower HVRr (Tibetans: 0.001 [-0.211-0.074] L/min/%/kg; Caucasians: 0.384 [0.160-0.637] L/min/%/kg; p = 0.0112) and a blunted HVRe (Tibetans: 0.311 [0.225-0.789] L/min/%/kg; Caucasians: 0.806 [0.518-1.196] L/min/%/kg; p = 0.0448). These results indicate that Tibetan ancestry is associated with a partial protection from hypoxia-induced central sleep apnea, likely related to a blunted hypoxic ventilatory response. These findings suggest that inherited differences in ventilatory control may modulate breathing stability during sleep at high altitude.</p>","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70346"},"PeriodicalIF":4.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}