Journal of Sleep Research最新文献_第6页

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years. 过去30年中枢性嗜睡障碍的发病年龄和诊断延迟。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-15 DOI: 10.1111/jsr.70170

Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers

{"title":"Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years.","authors":"Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers","doi":"10.1111/jsr.70170","DOIUrl":"https://doi.org/10.1111/jsr.70170","url":null,"abstract":"Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre. Age at onset, age at diagnosis and diagnostic delays of patients with NT1, NT2 and IH were collected at the Reference Narcolepsy Centre, Montpellier-France. Age at onset for each disorder was categorised into three life periods (< 18, 18-25, > 25 years). Diagnostic delays were compared among disorders, taking into account sex, different life periods and time periods. NT1 was diagnosed in 415 patients (242 males), NT2 in 127 patients (68 males) and IH in 289 patients (75 males). Age at onset was not different between disorders (peak between 10 and 20 years in NT1, and 15-20 in IH and NT2). NT1 patients had the shortest diagnostic delays compared to NT2 and IH (median 4, 5 and 8 years respectively). Diagnostic delay is getting shorter in NT1 and IH over the last decades. In patients who started symptoms in childhood, diagnostic delays were the shortest in NT1 and the longest in IH. No sex difference in diagnostic delays was found in NT1 and NT2, but IH females had shorter delays than males. In conclusion, patients with NT1 and IH are diagnosed earlier nowadays compared to the 2000s. Increased public awareness and education efforts should be made to increase knowledge of the diseases and to early identify excessive daytime sleepiness.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70170"},"PeriodicalIF":3.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Odds Ratio Product as a Biological Marker of Phenotypes of Insomnia. 优势比乘积作为失眠表型的生物学标记。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-15 DOI: 10.1111/jsr.70169

Kari Lambing, Veronica Guadagni, Bethany Gerardy, Amy Bender, Magdy Younes, Célyne H Bastien

{"title":"Odds Ratio Product as a Biological Marker of Phenotypes of Insomnia.","authors":"Kari Lambing, Veronica Guadagni, Bethany Gerardy, Amy Bender, Magdy Younes, Célyne H Bastien","doi":"10.1111/jsr.70169","DOIUrl":"https://doi.org/10.1111/jsr.70169","url":null,"abstract":"The study investigated differences in objective markers of sleep depth and identified phenotypes of insomnia. Participants were screened with the Insomnia-Severity-Index and clinical interviews and assigned to control (n = 50) or insomnia (n = 69) groups. They completed three nights of in-laboratory overnight polysomnography. We measured the Odds Ratio Product (ORP), a continuous measure of sleep depth (0 = deep sleep, 2.5 = full wakefulness) and calculated: (a) ORP in stages Wake, NREM, REM, (b) percentage of TRT in deep sleep (ORP < 0.5) and full-wakefulness (ORP > 2.25), (c) number/hour of sleep of transient increases in ORP to wake levels (Wake Intrusion Index [WII]), (d) gamma power, (e) frequency of alpha intrusions, (f) speed of return to deep sleep after arousals (ORP-9). We used Latent Class Analysis to differentiate two insomnia groups with 'Objectively Normal' and 'Objectively Poor' metrics. The Objectively Poor group had higher ORPwake, ORPNREM, ORPREM, %TRT > 2.25, gamma power, alpha intrusion, WII and ORP-9 than good sleeper (GSC) and the Objectively Normal group, illustrating evidence of hyperarousal, while the Objectively Normal group was comparable to GSC. The Objectively Poor group had higher %awake and lower TST. Both insomnia groups reported worse sleep and underestimated TST relative to GSC, despite similar objective sleep metrics in the Objectively Normal group. Using novel objective sleep metrics, we identified a subgroup of insomnia with abnormalities consistent with hyperarousal and another with no difference from GSC. Future research should test if these groups benefit from different treatment pathways and thus improve outcomes and time to determine appropriate treatments.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70169"},"PeriodicalIF":3.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Sleep Loss on Retrospective Metacognitive Judgements Across Five Cognitive Tests. 睡眠缺失对五项认知测试中回溯性元认知判断的影响

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-14 DOI: 10.1111/jsr.70141

Tina Sundelin, Andreas Jemstedt, Alvin Gavel, Bennett L Schwartz, John Axelsson

{"title":"The Effect of Sleep Loss on Retrospective Metacognitive Judgements Across Five Cognitive Tests.","authors":"Tina Sundelin, Andreas Jemstedt, Alvin Gavel, Bennett L Schwartz, John Axelsson","doi":"10.1111/jsr.70141","DOIUrl":"https://doi.org/10.1111/jsr.70141","url":null,"abstract":"Sleep loss impairs many cognitive functions, ranging from simple attention to working memory. This study explores the extent to which people are aware of such impairments, their metacognitive accuracy, across different cognitive tests. Healthy participants (N = 182) were randomised to one night of total sleep deprivation or three nights of sufficient sleep. The next day they performed several cognitive tests, measuring simple attention, cognitive throughput, working memory, episodic memory and executive processing (using a Stroop task). After each test, participants rated how well they thought they performed. We operationalised metacognitive accuracy as the ability to correctly identify whether one performed above or below the median. We then used Bayesian methods to estimate the difference in this ability between the well-rested and sleep-deprived groups. The probability was 55% in the sleep-deprived group, and 59% in the rested group, suggesting some decrease in performance awareness during sleep loss. However, the probability that this difference in judgements is practically significant (i.e., exceeding 10 percentage points) is below 1%. Cognitive ability generally declines during sleep deprivation, and this was at least somewhat reflected in a decrease in how people rated their performance. The question remains whether and how people compensate for any sleep-loss induced cognitive impairments.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70141"},"PeriodicalIF":3.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and Rhythmic Profile After Pineal Gland Removal in Humans. 人类松果体切除后的睡眠和节律特征。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-13 DOI: 10.1111/jsr.70171

Renata de Andrade Prado Gobetti, Clarissa Bueno, Letícia M S F A Soster, Anna Carolina de Campos de Barros Luvizotto Monazzi, Fernanda Gaspar do Amaral, Andréa Maria Capellano, Nasjla Saba da Silva, José Cipolla-Neto

{"title":"Sleep and Rhythmic Profile After Pineal Gland Removal in Humans.","authors":"Renata de Andrade Prado Gobetti, Clarissa Bueno, Letícia M S F A Soster, Anna Carolina de Campos de Barros Luvizotto Monazzi, Fernanda Gaspar do Amaral, Andréa Maria Capellano, Nasjla Saba da Silva, José Cipolla-Neto","doi":"10.1111/jsr.70171","DOIUrl":"https://doi.org/10.1111/jsr.70171","url":null,"abstract":"Melatonin, a hormone produced by the pineal gland, is classically described as a central circadian modulator. However, the impact of its absence on circadian rhythmicity in humans remains poorly understood. Pinealectomised patients, in whom melatonin secretion is chronically suppressed, represent a valuable clinical model to investigate the physiological role of this hormone in sleep and temporal organisation. This study evaluated sleep quality and sleep disorders, as well as circadian rhythmicity, in 17 individuals who underwent surgical or radiotherapeutic treatment for pineal tumours and exhibited confirmed absence of circulating melatonin. Participants were assessed through structured clinical interviews, standardised sleep questionnaires, sleep diaries and actigraphy recording for a minimum of 15 consecutive days. Rhythmic analysis was performed for sleep/wakefulness and rest/activity data. Mild nocturnal sleep symptoms were reported, but diurnal complaints were frequent. Despite the chronic absence of melatonin, all subjects maintained a 24-h sleep/wake cycle, and none met criteria for circadian sleep/wake disorders. We conclude that melatonin demonstrated not to be crucial for the maintenance of the circadian sleep/wake cycle in individuals with chronic melatonin absence due to pineal gland removal and minor sleep complaints are present in this population. Other synchroniser mechanisms possibly involving non-photic entrainment might play an important role in the maintenance of the circadian rhythm.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70171"},"PeriodicalIF":3.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke. 睡眠、体力活动和久坐行为的替代与痴呆和中风的风险。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-12 DOI: 10.1111/jsr.70166

Sanne J W Hoepel, M Kamran Ikram, M Arfan Ikram, Trudy Voortman, Annemarie I Luik

{"title":"Substitutions of Sleep, Physical Activity, and Sedentary Behaviour and the Risk of Dementia and Stroke.","authors":"Sanne J W Hoepel, M Kamran Ikram, M Arfan Ikram, Trudy Voortman, Annemarie I Luik","doi":"10.1111/jsr.70166","DOIUrl":"https://doi.org/10.1111/jsr.70166","url":null,"abstract":"Sleep, sedentary behaviour, and physical activity (PA) are important for brain health. Spending more time in one behaviour always substitutes time in another, which may affect associations and should be considered in prevention strategies. We assessed how substitutions of sleep, sedentary behaviour, and PA are associated with incident dementia and stroke, using compositional analysis. Participants (mean age: 71.3 ± 9.26 years, 51.6% female) without prevalent dementia (N = 1899) or stroke (N = 1854) from the Rotterdam Study wore an accelerometer for ≥ 4 days to estimate the duration of sleep, sedentary behaviour, light PA, and moderate-to-vigorous PA. Participants were continuously followed up for dementia (median: 4.5 years) and stroke (median: 5.1 years). Compositional Cox regression with isotemporal substitution analysis was used to assess associations of 30-min pair-wise substitutions with dementia and stroke. In total, 50 (2.6%) participants were diagnosed with dementia and 75 (4.0%) with a first-time stroke. Spending more time in moderate-to-vigorous PA and less in other behaviours was associated with a lower risk of dementia (Hazard Ratio [HR] for 30 min less sedentary behaviour 0.36; 95% CI: 0.24-0.55) and so was more sleep and less sedentary behaviour (HR: 0.87; 0.79-0.97) or light PA (HR: 0.43; 0.27-0.68). Those with more light PA and less sedentary behaviour had a higher risk of dementia (HR: 1.78; 1.19-2.66). Only having more sleep and less sedentary behaviour was associated with having a stroke (HR: 1.14; 1.03-1.27). More time in sleep and moderate-to-vigorous PA, substituting particularly sedentary behaviour, may be a modifiable risk factor for dementia. No consistent effects for stroke were found, warranting future research.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70166"},"PeriodicalIF":3.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of the SONA Questionnaire: A Gender-Specific Screening Tool for Moderate-to-Severe Obstructive Sleep Apnoea. SONA问卷的开发和验证：中重度阻塞性睡眠呼吸暂停的性别筛选工具。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-09 DOI: 10.1111/jsr.70165

Ankur Joshi, Abhishek Goyal, Abhijit Pakhare

{"title":"Development and Validation of the SONA Questionnaire: A Gender-Specific Screening Tool for Moderate-to-Severe Obstructive Sleep Apnoea.","authors":"Ankur Joshi, Abhishek Goyal, Abhijit Pakhare","doi":"10.1111/jsr.70165","DOIUrl":"https://doi.org/10.1111/jsr.70165","url":null,"abstract":"Overnight polysomnography (PSG) poses logistical and financial challenges in resource-constrained settings for the diagnosis of OSA. This study aimed to develop a simple, effective screening tool for identifying individuals at risk for OSA. Data from 1015 healthy volunteers enrolled in the BLESS cohort were analysed, all of whom underwent Level I PSG. Optimal thresholds for selected demographic, anthropometric and clinical variables were determined using a bootstrapped matrix maximisation method, with apnoea-hypopnoea index (AHI) as the reference. The dataset was split into training (n = 732) and testing (n = 244) subsets, and four predictive models were developed. A scoring system, termed SONA, was derived from coefficients of the best-performing model. Its performance was compared to existing tools. The final model incorporated four variables (AIC = 699.21, BIC = 726.79, pseudo-R2 = 0.36): waist circumference (> 93 cm in males, > 85 cm in females) and neck circumference (> 37 cm in males, > 32 cm in females) assigned 3 points each; age (> 35 years in males, > 45 years in females) assigned 2 points; and presence of snoring assigned 3 points. The total score ranged from 0 to 11. Diagnostic cut-offs were identified at scores of 5 (i.e., any two variables affirmative) in community settings and 8 (i.e., any three variables affirmative) in hospital settings. At AHI cut-off of 15, the SONA score demonstrated superior discrimination (AUC = 0.83; p value < 0.001) compared to STOPBANG (0.72), NoSAS (0.77), GOAL (0.74) and the Berlin Questionnaire (0.70). The SONA score offers a simpler, more accurate alternative for OSA screening compared to existing tools and is well-suited for implementation in primary care and resource-limited settings.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70165"},"PeriodicalIF":3.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Clinical and Polysomnographic Features of Sleep Disturbances in Patients With Anti-IgLON5 Disease. 抗iglon5疾病患者睡眠障碍的临床和多导睡眠图特征综述

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-05 DOI: 10.1111/jsr.70159

You-Jiang Tan, Tushar Gosavi, Wai-Dic Foong

{"title":"A Review of the Clinical and Polysomnographic Features of Sleep Disturbances in Patients With Anti-IgLON5 Disease.","authors":"You-Jiang Tan, Tushar Gosavi, Wai-Dic Foong","doi":"10.1111/jsr.70159","DOIUrl":"https://doi.org/10.1111/jsr.70159","url":null,"abstract":"This scoping review aims to synthesise prevailing scientific evidence on the sleep-related manifestations of anti-IgLON5 disease to identify distinctive sleep and/or polysomnographic patterns which may facilitate diagnosis. A systematic search was conducted to identify studies from 2014 to 2023 which included patients with sleep disturbances and immunohistochemically-proven anti-IgLON5 disease. Eligible studies included clinical trials, observational studies, and case series that contained descriptions of their sleep disturbances and/or polysomnographic features. Data on their clinical features, polysomnographic findings, and non-sleep-related symptoms were extracted and analysed. 55 cases from eight reports were analysed. Median age at onset was 61.8 years, with a 2-year median delay to diagnosis. Sleep apnea (97.4%), parasomnia (61.5%), insomnia (41.0%), and daytime sleepiness (41.0%) were the most prevalent disturbances, of which two-thirds exhibited multiple sleep disorders within the same patient. Most patients had co-existing non-sleep-related features at the initial stages of evaluation, such as bulbar dysfunction (80%), dysautonomia (50.9%), and cognitive impairment (45.5%). Polysomnography (n = 26) mostly showed the non-specific features of reduced total sleep time, low sleep efficiency, increased arousal index, and elevated apnea-hypopnea index in affected patients. Diagnosis of anti-IgLON5 disease remains challenging. The diagnostic significance of undifferentiated non-rapid eye movement and poorly-structured N2 remains unproven. Polysomnographic anomalies were often non-specific, and their evolution as with disease progression was difficult to discern without longitudinal polysomnography data. Regardless, anti-IgLON5 disease should be strongly considered in patients with multiple sleep disorders and the above-mentioned polysomnographic abnormalities, especially when accompanied by neurological anomalies.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70159"},"PeriodicalIF":3.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

About the Other Side of Sleep Disorders: Improving Daytime Problems, Fatigue, Sleepiness, Cognitive Functioning and More 关于睡眠障碍的另一面：改善白天的问题，疲劳，嗜睡，认知功能等等。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-08-02 DOI: 10.1111/jsr.70164

Susanna Jernelöv, Kerstin Blom

{"title":"About the Other Side of Sleep Disorders: Improving Daytime Problems, Fatigue, Sleepiness, Cognitive Functioning and More","authors":"Susanna Jernelöv, Kerstin Blom","doi":"10.1111/jsr.70164","DOIUrl":"10.1111/jsr.70164","url":null,"abstract":"Daytime impairments—such as fatigue, emotional instability, and cognitive difficulties—are increasingly acknowledged as core features of insomnia, yet they remain underrepresented in both research and treatment strategies. While CBT-I remains the gold standard for treating nocturnal symptoms, its effects on daytime functioning, which are often the primary concern for patients, are less robust, inconsistently measured, and poorly understood. This narrative review highlights the need to elevate daytime symptoms from secondary outcomes to central targets in both research and clinical practice. Key gaps include the lack of standardised and conceptually clear outcome measures, limited personalisation of CBT-I protocols, and insufficient understanding of the mechanisms linking improved sleep to daytime recovery. Moreover, the ethical implications of emerging digital assessment tools must be addressed to ensure that technological innovation does not come at the cost of participant trust or autonomy. To move the field forward, future research should prioritise daytime functioning as a primary endpoint, adopt ethically grounded multimodal assessment strategies, and explore adaptive, symptom-specific treatment designs. Finally, insomnia should be recognised not only as a disorder in its own right but also as a transdiagnostic and potentially preventable contributor to broader mental health problems. Addressing these challenges may lead to more effective, personalised, and patient-centred care for individuals living with insomnia.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":"34 5","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsr.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal Associations of Physical Activity Volume, Intensity, and Timing With Sleep in Preschool-Aged Children. 学龄前儿童身体活动量、强度和时间与睡眠的时间关联。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-07-31 DOI: 10.1111/jsr.70162

Wendy Yajun Huang, Jie Feng, Cindy Hui-Ping Sit, John J Reilly, Asaduzzaman Khan

{"title":"Temporal Associations of Physical Activity Volume, Intensity, and Timing With Sleep in Preschool-Aged Children.","authors":"Wendy Yajun Huang, Jie Feng, Cindy Hui-Ping Sit, John J Reilly, Asaduzzaman Khan","doi":"10.1111/jsr.70162","DOIUrl":"https://doi.org/10.1111/jsr.70162","url":null,"abstract":"This study aimed to investigate the temporal relationships between accelerometer-derived physical activity metrics-specifically volume, intensity, and timing-with the preceding and subsequent nights' sleep in preschool-aged children. This analysis used the baseline data from a randomised controlled trial among 93 children (53 boys) aged 3-5.9 years who provided daily, repeated measures for at least four days. Open-source R package GGIR was used to generate daily measures of average acceleration, intensity gradient, timing of the most active 10 h (M10 start), sleep duration, sleep efficiency, and sleep midpoint. Linear mixed models were performed to examine temporal associations between waketime physical activity and the subsequent night's sleep, and between nocturnal sleep and physical activity the following day, at both within- and between-person levels. A higher intensity gradient compared to the personal average during the day predicted a lower sleep efficiency on the subsequent night (β = -10.71, 95% CI: -17.20, -4.21). At the between-person level, children with longer sleep duration (β = 0.87, 95% CI: 0.45, 1.29), a later sleep midpoint (β = 1.03, 95% CI: 0.79, 1.27), or lower sleep efficiency (-0.09, 95% CI: -0.14, -0.03) were more likely to have their active periods later in the following day. These findings suggest that the timing of physical activity and sleep midpoint showed consistent bidirectional associations at both within- and between-person levels. The findings suggest that incorporating lower intensity activities that are scheduled at appropriate times into daily routines may be crucial for better sleep for young children.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70162"},"PeriodicalIF":3.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep in Functional Motor Disorders: A Case-Control Polysomnographic Study. 功能性运动障碍患者的睡眠：一项病例对照多导睡眠图研究。

IF 3.9 3区医学

Journal of Sleep Research Pub Date : 2025-07-31 DOI: 10.1111/jsr.70163

Jiří Nepožitek, Simona Dostálová, Martin Jirásek, Gabriela Chaloupková, Zuzana Forejtová, Lucia Nováková, Veronika Rottová, Veronika Konvičná, Karel Šonka, Mark J Edwards, Tereza Serranová

{"title":"Sleep in Functional Motor Disorders: A Case-Control Polysomnographic Study.","authors":"Jiří Nepožitek, Simona Dostálová, Martin Jirásek, Gabriela Chaloupková, Zuzana Forejtová, Lucia Nováková, Veronika Rottová, Veronika Konvičná, Karel Šonka, Mark J Edwards, Tereza Serranová","doi":"10.1111/jsr.70163","DOIUrl":"https://doi.org/10.1111/jsr.70163","url":null,"abstract":"Sleep problems are frequent in functional motor disorders (FMDs). Surprisingly, objective correlates of impaired sleep and its relationship to other comorbidities have been understudied, and no polysomnographic study is available. We aimed to map the polysomnographic parameters in the context of self-reported sleep and mood symptoms and search for comorbid sleep disorders in FMD and healthy controls. Thirty-seven patients (mean age [SD], 48.2 [10.6] years) with clinically definite FMD and 37 controls (48.6 [11.2] years) underwent structured medical and sleep history assessment, neurological examination and polysomnography and completed questionnaires for sleep quality, sleepiness, depression and anxiety. In FMD, specific sleep disorders were identified in our cohort, with 32% having restless legs syndrome, 38% clinically significant obstructive sleep apnoea and 8% periodic limb movements in sleep. FMD patients reported worse sleep quality (p < 0.001), higher sleepiness (p < 0.001), depression (p < 0.001) and anxiety (p < 0.001), had longer REM sleep latency (p < 0.001), worse sleep efficiency (p = 0.012) and increased wake ratio (p = 0.013). Furthermore, longer sleep latency (p = 0.030) and decreased REM sleep ratio (p = 0.027) in FMD reached nominal significance before adjustment for multiple comparisons. In FMD, subjective sleep quality positively correlated with depression (ρ = 0.54; p < 0.002) and anxiety (ρ = 0.61; p < 0.001) and subjective sleepiness correlated with depression (ρ = 0.42; p = 0.010). Self-reported measures did not correlate with any polysomnographic parameters. Polysomnography detected sleep structure changes in FMD. Sleep abnormalities, including impairments in REM sleep, should be considered in the management of FMD. Future studies should further explore the role of REM sleep disturbances in the pathophysiology of FMD.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70163"},"PeriodicalIF":3.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0