Journal of Sleep Research最新文献_第8页

The Effect of Suvorexant on Fear Extinction Recall: A Double-Blind Randomised Controlled Pilot Trial in Healthy Individuals. 抗抑郁药对恐惧消退记忆的影响：一项健康个体双盲随机对照试验

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-15 DOI: 10.1111/jsr.70033

Maya T Schenker, Lilith Z Zeng, Joshua Lynskey, Matthew D Greaves, Shima Rouhi, Amanda Kay, Andrew Dawson, Therese Thornton, Christian L Nicholas, Kim L Felmingham, Amy S Jordan

{"title":"The Effect of Suvorexant on Fear Extinction Recall: A Double-Blind Randomised Controlled Pilot Trial in Healthy Individuals.","authors":"Maya T Schenker, Lilith Z Zeng, Joshua Lynskey, Matthew D Greaves, Shima Rouhi, Amanda Kay, Andrew Dawson, Therese Thornton, Christian L Nicholas, Kim L Felmingham, Amy S Jordan","doi":"10.1111/jsr.70033","DOIUrl":"https://doi.org/10.1111/jsr.70033","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a highly debilitating condition that develops after trauma exposure. Dysregulation in extinction memory consolidation (i.e., the ability to remember that trauma-related stimuli no longer signal danger) is proposed to underlie PTSD development. Disruptions in rapid eye movement (REM) sleep are thought to be the key contributor to this dysregulation, as REM sleep is suggested to play a vital role in the processing of emotional memories. While previous literature has investigated the role of natural REM sleep variations or REM sleep disruptions on extinction recall capacities, none have attempted to increase REM sleep to improve extinction recall. In this pilot, randomised controlled trial, we investigated the effect of 20 mg suvorexant to increase REM sleep, 20 mg temazepam to decrease REM sleep, and a placebo on extinction recall in 30 healthy adults (age: M = 26.93 years, SD = 7.54). Overall, no difference in REM percentage (p = 0.68, η2 = 0.0.03, small effect), nor in extinction recall (p = 0.58, η2 = 0.04, small effect) was observed between the drug conditions. However, increased REM percentage was associated with decreased conditioned fear response at recall, indicating better extinction recall (β = -0.71, p = 0.03, ηp 2 = 0.10; moderate effect) across the sample. These findings suggest that increasing REM sleep in populations with REM disruptions such as PTSD to optimal levels could improve extinction recall. This underscores the potential of enhancing REM sleep as a therapeutic target for improving PTSD outcomes, warranting further investigation of suvorexant in clinical populations where REM sleep deficits are prevalent.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70033"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Dynamic Lighting on Sleep Timing and Duration for Hospitalised Patients. 动态照明对住院病人睡眠时间和持续时间的影响。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-13 DOI: 10.1111/jsr.70041

Andrew S Dunn, Barbara Rabin Fastman, Alan Weinberg, Lindsay Condrat, Allison Fraser, Rabia Khan, Marjorie P Zambrano Loor, Geetanjali Rajda, Octavio L Perez, Ayham Adawi, Korey Kam, Ankit Parekh, Andrew W Varga, Richard L Vincent

{"title":"The Impact of Dynamic Lighting on Sleep Timing and Duration for Hospitalised Patients.","authors":"Andrew S Dunn, Barbara Rabin Fastman, Alan Weinberg, Lindsay Condrat, Allison Fraser, Rabia Khan, Marjorie P Zambrano Loor, Geetanjali Rajda, Octavio L Perez, Ayham Adawi, Korey Kam, Ankit Parekh, Andrew W Varga, Richard L Vincent","doi":"10.1111/jsr.70041","DOIUrl":"10.1111/jsr.70041","url":null,"abstract":"Poor sleep is common in hospitalised patients due to multiple factors, including disruption of the circadian rhythm. Few studies have examined programmable artificial lighting systems in hospital patient rooms, and few have achieved meaningful improvement in sleep. We sought to determine how novel dynamic lighting affects sleep timing and duration compared to standard hospital lighting. Patients were admitted to rooms on a cardiology unit with customised intervention or standard lighting. The lighting system delivered blue-enriched light during the day, a melanopic stimulus twice daily and blue-depleted light in the evening. Sleep/wake probability was measured in 30-s epochs using mattress sensors to capture sleep timing and nocturnal sleep duration. Subjective sleep duration and alertness were assessed with sleep diaries and the Karolinska Sleepiness Scale (KSS), respectively. A total of 87 patients were enrolled. Subjects experiencing customised lighting demonstrated significantly advanced rest/wake activity phase by 160 min and overall greater sleep probability. Overnight sleep duration (11 p.m.-7 a.m.) was 66 min greater in the lighting condition (266 vs. 200 min, p < 0.05). Patients in the intervention group reported higher levels of alertness during the morning (KSS score 3.8 vs. 4.9, p = 0.01) and evening (5.4 vs. 7.1, p = 0.01). A lighting system programmed to entrain the circadian rhythm and provide a daytime melanopic stimulus on a hospital unit was associated with advanced circadian phase, increased nocturnal sleep duration and increased perceived morning and evening alertness. These results suggest that dynamic lighting systems have the potential to improve sleep for hospitalised patients.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70041"},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia. daridorexant治疗慢性失眠和夜尿症的随机交叉试验。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-13 DOI: 10.1111/jsr.70002

Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel

{"title":"A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia.","authors":"Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel","doi":"10.1111/jsr.70002","DOIUrl":"https://doi.org/10.1111/jsr.70002","url":null,"abstract":"This double-blind, placebo-controlled, two-way crossover trial evaluated the efficacy and safety of daridorexant in patients with chronic insomnia and comorbid nocturia. In total, 60 patients aged ≥55 years with insomnia complaints for ≥3 months, Insomnia Severity Index (ISI) ≥13 and ≥3 voids/night for ≥1 month were randomised (1:1) to daridorexant 50 mg/placebo for 4 weeks followed by crossover after a 14-21-day washout period. The primary endpoint was change from baseline to Week (W) 4 in self-reported total sleep time (sTST). Other endpoints included change in ISI score, sleep depth and quality (visual analogue scale scores), nocturnal voids (mean number, time to first) and daytime functioning (Insomnia Daytime Symptoms and Impacts Questionnaire score [IDSIQ]). At W4, daridorexant significantly increased sTST versus placebo (least-squares mean difference [LSMD] 20.9 min, 95% confidence interval [CI] 8.0-33.7; p = 0.002); significant improvements were also seen at W1-3. Compared with placebo, daridorexant significantly decreased (p < 0.001) ISI at both timepoints, W2 (LSMD -3.7, 95% CI -5.1 to -2.3) and W4 (LSMD -3.3, 95% CI -4.7 to -1.8) and significantly improved (p < 0.05) sleep depth (W1, 2, 3, 4), sleep quality (W1, 2, 3) and IDSIQ total score (W1, 3). Daridorexant versus placebo reduced the number of voids (LSMD [95% CI]: W1-0.6 [-0.9 to -0.3], p < 0.001; W4-0.3 [-0.7 to +0.1], p = 0.090) and increased median time to first void (difference to placebo, W1: +31 min, p = 0.0027; W4: +23 min, p = 0.2026). No adverse events of special interest (falls/urinary incontinence) were reported during daridorexant treatment. In conclusion, in patients with chronic insomnia and nocturia, daridorexant improves both conditions with a favourable safety profile.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70002"},"PeriodicalIF":3.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypnogram and Hypnodensity Analysis of REM Sleep Behaviour Disorder Using Both EEG and HRV-Based Sleep Staging Models. 基于EEG和hrv的睡眠分期模型对REM睡眠行为障碍的催眠图和催眠密度分析。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-12 DOI: 10.1111/jsr.70046

Jaap F van der Aar, Merel M van Gilst, Daan A van den Ende, Hans van Gorp, Peter Anderer, Angelique Pijpers, Pedro Fonseca, Elisabetta Peri, Sebastiaan Overeem

{"title":"Hypnogram and Hypnodensity Analysis of REM Sleep Behaviour Disorder Using Both EEG and HRV-Based Sleep Staging Models.","authors":"Jaap F van der Aar, Merel M van Gilst, Daan A van den Ende, Hans van Gorp, Peter Anderer, Angelique Pijpers, Pedro Fonseca, Elisabetta Peri, Sebastiaan Overeem","doi":"10.1111/jsr.70046","DOIUrl":"https://doi.org/10.1111/jsr.70046","url":null,"abstract":"Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is a primary sleep disorder strongly associated with Parkinson's disease. Assessing sleep structure in RBD is important for understanding the underlying pathophysiology and developing diagnostic methods. However, the performance of automated sleep stage classification (ASSC) models is considered suboptimal in RBD, for both models utilising neurological signals (\"ExG\": EEG, EOG, and chin EMG) and heart rate variability combined with body movements (HRVm). Here, we explore this underperformance through the categorical representation of sleep macrostructure (i.e., hypnogram) and a representation that leverages the underlying probability distribution of ASSCs (i.e., hypnodensity). By comparing the RBD population (n = 36) to a sex- and age-matched group of OSA patients chosen for their anticipated similarly decreased sleep stability, we confirm lower 4-stage classification performance in both ExG-based ASSC (RBD: κ = 0.74, OSA: κ = 0.80) and HRVm-based ASSC (RBD: κ = 0.50, OSA: κ = 0.63). Stages showing lower agreement in RBD, namely, N1 + N2 and REM sleep, exhibited elevated ambiguity in the hypnodensity, indicating more ambiguous classification distributions. Limited differences in bout durations between RBD and OSA suggested sleep instability is not necessarily driving lower agreement in RBD. However, stage transitions in OSA showed more abrupt changes in the underlying probability distribution, while RBD transitions had a more continuous profile, possibly complicating classification. Although both ExG-based and HRVm-based automated sleep staging in RBD remain challenging, hypnodensity analysis is informative for the characterisation of (RBD) sleep and can capture potential drivers of classification disagreement.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70046"},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Health and White Matter Integrity in the UK Biobank. 英国生物银行的睡眠健康和白质完整性。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-12 DOI: 10.1111/jsr.70034

Roxana Petri, Florian Holub, Julian E Schiel, Bernd Feige, Martin K Rutter, Sandra Tamm, Dieter Riemann, Simon D Kyle, Kai Spiegelhalder

{"title":"Sleep Health and White Matter Integrity in the UK Biobank.","authors":"Roxana Petri, Florian Holub, Julian E Schiel, Bernd Feige, Martin K Rutter, Sandra Tamm, Dieter Riemann, Simon D Kyle, Kai Spiegelhalder","doi":"10.1111/jsr.70034","DOIUrl":"https://doi.org/10.1111/jsr.70034","url":null,"abstract":"Many people experience impaired sleep health, yet knowledge about its neurobiological correlates is limited. As previous studies have found associations between white matter integrity and several sleep traits, white matter integrity could be causally implicated in poor sleep health. However, these studies were often limited by small sample sizes. In this study, we examine associations between multiple indices of white matter integrity and sleep health in 29,114 UK Biobank participants. Late chronotype, daytime sleepiness, insomnia symptoms and, most extensively, long sleep duration were independently associated with diffusion MRI markers of reduced white matter integrity. Previous findings showing an association between insomnia symptoms and decreased fractional anisotropy (FA) in the anterior internal capsule could not be replicated. To our knowledge, the current analysis is the first study to find an association between long sleep duration and impaired microstructural white matter integrity. Previous assumptions concerning the role of white matter integrity for insomnia are challenged.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70034"},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of RBDtector: An Open-Source Automated Software for Scoring REM Sleep Without Atonia. rbdetector的验证：一种开源的自动快速眼动睡眠评分软件。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-12 DOI: 10.1111/jsr.70037

Stephen Joza, Amélie Pelletier, Jean-François Gagnon, Jacques Y Montplaisir, David Bertram, Kasia Bozek, Ronald B Postuma, Michael Sommerauer

{"title":"Validation of RBDtector: An Open-Source Automated Software for Scoring REM Sleep Without Atonia.","authors":"Stephen Joza, Amélie Pelletier, Jean-François Gagnon, Jacques Y Montplaisir, David Bertram, Kasia Bozek, Ronald B Postuma, Michael Sommerauer","doi":"10.1111/jsr.70037","DOIUrl":"https://doi.org/10.1111/jsr.70037","url":null,"abstract":"Accurate quantification of REM sleep without atonia (RSWA) is essential in the diagnosis of idiopathic/isolated REM sleep behaviour disorder (iRBD). This study aims to validate RBDtector, a free and open-source tool for automated RSWA quantification using the Sleep Innsbruck Barcelona (SINBAR) scoring method, by comparing its performance against human visual scoring in a large independent cohort of subjects with iRBD and healthy controls. Muscle activity from 118 iRBD participants and 37 healthy controls that underwent polysomnography was analysed by RBDtector and compared with human visual scoring. Diagnostic performance was evaluated using receiver operating characteristic curves, and optimal cut-offs for iRBD screening and diagnosis were determined. The results of RSWA quantification were applied to survival analyses of time to phenoconversion. RBDtector showed excellent agreement with human visual scoring, particularly in 'any' RSWA activity (Pearson's correlation = 0.89, R2 = 0.79, p < 0.001). RBDtector identified iRBD subjects with 95.6% sensitivity and 95.5% specificity by using a cutoff of 33.0% for combined 'any' RSWA activity in the submentalis and flexor digitorum superficialis muscles, with each muscle in isolation providing comparable results. In iRBD patients, each 10% increase in submentalis 'any' activity was associated with a 23% increase in the risk of phenoconversion (HR = 1.23, 95% CI [1.06, 1.44], p = 0.008), while no associations were observed with increased activity in the flexor digitorum superficialis or tibialis anterior. RBDtector provides accurate, automated RSWA quantification comparable to human visual scoring, offering a reliable and efficient method to support the diagnosis of iRBD and identify iRBD at a higher risk of phenoconversion.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70037"},"PeriodicalIF":3.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slow Wave Sleep and Emotion Regulation in Adolescents With Depressive Symptoms: An Experimental Pilot Study. 青少年抑郁症状的慢波睡眠与情绪调节：一项实验性先导研究。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-11 DOI: 10.1111/jsr.70038

João Paulo Lima Santos, Mahi Pachgade, Adriane M Soehner

{"title":"Slow Wave Sleep and Emotion Regulation in Adolescents With Depressive Symptoms: An Experimental Pilot Study.","authors":"João Paulo Lima Santos, Mahi Pachgade, Adriane M Soehner","doi":"10.1111/jsr.70038","DOIUrl":"https://doi.org/10.1111/jsr.70038","url":null,"abstract":"Emotion regulation deficits are a hallmark of adolescent depression, and sleep greatly impacts emotion regulation. Initial data indicate acute mood benefits of slow-wave sleep deprivation (SWSD) in depressed adults, but it is unclear whether this may occur through improvement in emotion regulation. In addition, this has not been tested experimentally in adolescent depression. In this pilot study, we tested the effect of SWSD on emotion regulation in adolescents with elevated depressive symptoms. Fifteen adolescents (mean age [SD] = 17.47 [1.55] years, 12 female) completed three consecutive nights of polysomnographic sleep recording: Baseline, SWSD, and Recovery. Auditory stimulation (sounds of varying pitch, duration, and volume) suppressed slow-wave sleep (SWS) during SWSD. After Baseline and SWSD nights, the Emotional Go/No-Go task was administered the next day as a behavioural assessment of cognitive control, emotion discrimination, and emotion regulation outcomes. False Discovery Rate was used to account for multiple comparison correction. We found that, at Baseline, longer SWS duration was associated with poorer emotion discrimination (β = -0.44, p = 0.012, Q = 0.036). There was no association between other sleep stages and emotion regulation. While Emotional Go/No-Go outcomes did not significantly differ between Baseline and SWSD nights, greater attenuation in SWS significantly correlated with improvement in cognitive control (β = 0.61, p = 0.021, Q = 0.038), emotion discrimination (β = -0.44, p = 0.025, Q = 0.038), and emotion regulation (β = 0.62, p = 0.049, Q = 0.049) between nights. Findings from this pilot study tie elevated SWS to impaired emotion regulation in adolescents with depressive symptoms and suggest that targeted deprivation of SWS may improve emotion regulation in depressed adolescents with elevated SWS.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70038"},"PeriodicalIF":3.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological Data Analysis Based Characteristics of Electroencephalogram Signals in Children With Sleep Apnea. 基于拓扑数据分析的睡眠呼吸暂停患儿脑电图信号特征。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-11 DOI: 10.1111/jsr.70017

Aarti Sathyanarayana, Shashank Manjunath, Jose A Perea

{"title":"Topological Data Analysis Based Characteristics of Electroencephalogram Signals in Children With Sleep Apnea.","authors":"Aarti Sathyanarayana, Shashank Manjunath, Jose A Perea","doi":"10.1111/jsr.70017","DOIUrl":"https://doi.org/10.1111/jsr.70017","url":null,"abstract":"This study aims to identify differences in the functional neural connectivity of the brain of paediatric patients with obstructive sleep apnea. Using EEG signals from 3673 paediatric patients, we grouped subjects into OSA or control groups based on sleep oxygen desaturation levels and apnea-hypopnea index (AHI), and applied topological data analysis (TDA) techniques. We evaluated our approach through statistical testing of TDA-based EEG features, which indicate fundamental differences in the functional neural connectivity of subjects with sleep apnea as compared to controls. There were statistically significant differences ( <math> <semantics><mrow><mi>p</mi> <mo><</mo> <mn>0.05</mn></mrow> <annotation>$$ p<0.05 $$</annotation></semantics> </math> ) between EEG signals taken during apnea and hypopnea events as compared to those taken from healthy controls. No significance was found between the latent EEG signals within the same groups. We observed significant differences between EEG signals collected during oxygen desaturation as compared to the EEG signals of the controls. We additionally identified significant differences between the latent EEG signals (i.e., no oxygen desaturation event occurring) of subjects as compared with the EEGs from controls. Lastly, significant differences were additionally found in the awake before sleep portion of the polysomnograms when grouping subjects based on minimum oxygen saturation experienced during sleep. TDA techniques allow us to identify statistically significant differences between the EEG signals of subjects with OSA and healthy controls, including during awake periods. Our results provide novel insights on the effects of OSA on the central nervous system, and insights into potential novel methods for identification of sleep apnea.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70017"},"PeriodicalIF":3.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post-traumatic stress disorder: an early potential window into autonomic dysfunction? 患有快速眼动睡眠行为障碍、创伤性脑损伤和创伤后应激障碍的退伍军人睡眠期间心率变异性损害：自主神经功能障碍的早期潜在窗口？

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-10 DOI: 10.1111/jsr.70004

Hannah A Cunningham, Laura Dovek, Natasha Recoder, Mohini D Bryant-Ekstrand, Brittany R Ligman, Juan Piantino, Miranda M Lim, Jonathan E Elliott

{"title":"Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post-traumatic stress disorder: an early potential window into autonomic dysfunction?","authors":"Hannah A Cunningham, Laura Dovek, Natasha Recoder, Mohini D Bryant-Ekstrand, Brittany R Ligman, Juan Piantino, Miranda M Lim, Jonathan E Elliott","doi":"10.1111/jsr.70004","DOIUrl":"10.1111/jsr.70004","url":null,"abstract":"Individuals with comorbid rapid eye movement (REM) sleep behaviour disorder (RBD) and neurotrauma (NT; defined by traumatic brain injury and post-traumatic stress disorder) have an earlier age of RBD symptom onset, increased RBD-related symptom severity and more neurological features indicative of prodromal synucleinopathy compared to RBD only. An early sign of neurodegenerative condition is autonomic dysfunction, which we sought to evaluate by examining heart rate variability during sleep. Participants with overnight polysomnography were recruited from the Veterans Affairs Portland Health Care System. Veterans without NT or RBD (controls, n = 19), with RBD only (RBD, n = 14), and with RBD and NT (RBD+NT, n = 19) were evaluated. Eligible 5-min non-REM (NREM) and REM epochs without apneas/hypopneas, microarousals, and ectopic beats were analysed for frequency and time domain (e.g., low-frequency [LF] power; high-frequency [HF] power; root mean square of successive R-R intervals [RMSSD]; percentage of R-R intervals that vary ≥50 ms [pNN50]) heart rate variability outcomes. Heart rate did not significantly differ between groups in any sleep stage. Time domain and frequency domain variables (e.g., LF power, HF power, RMSSD, and pNN50) were significantly reduced in the RBD+NT group compared to the controls and RBD-only group during NREM sleep. There were no group differences detected during REM sleep. These data suggest significant reductions in heart rate variability during NREM sleep in RBD+NT participants, suggesting greater autonomic dysfunction compared to controls or RBD alone. Heart rate variability during sleep may be an early, promising biomarker, yielding mechanistic insight for diagnosis and prognosis of early neurodegeneration in this vulnerable population.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70004"},"PeriodicalIF":3.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared Determinants of Poor Sleep, Obesity and Adiposity in Adolescents Aged 8-18-Years: A Systematic Review. 8-18岁青少年睡眠不足、肥胖和肥胖的共同决定因素：一项系统综述。

IF 3.4 3区医学

Journal of Sleep Research Pub Date : 2025-03-10 DOI: 10.1111/jsr.70029

Emma Louise Gale, Joanne Elizabeth Cecil, Andrew James Williams

{"title":"Shared Determinants of Poor Sleep, Obesity and Adiposity in Adolescents Aged 8-18-Years: A Systematic Review.","authors":"Emma Louise Gale, Joanne Elizabeth Cecil, Andrew James Williams","doi":"10.1111/jsr.70029","DOIUrl":"https://doi.org/10.1111/jsr.70029","url":null,"abstract":"Relationships between multiple sleep outcomes, obesity and adiposity across childhood and adolescence have been previously reported. Health-promoting interventions to improve sleep and reduce adolescent obesity could target shared determinants of sleep and obesity. The aim of this systematic review was to systematically identify and examine research that investigated the shared determinants of poor sleep and increased adiposity or obesity in adolescents. A systematic literature search covering publications up to April 2024 was conducted across 10 bibliographic databases. Search terms included objective and subjective sleep/circadian rhythm measurements, objective adiposity measurements and adolescents aged 8-18 years. Eighty studies were included in the final review. Determinants were categorised into three different domains: socioenvironmental determinants, behavioural determinants and health determinants. Shared determinants of poor sleep and increased adiposity or obesity in adolescents aged 8-18 years included: socioenvironmental determinants (gender, ethnicity, pubertal status, academic attainment), behavioural determinants (timing of moderate-to-vigorous physical activity (MVPA), unhealthy diet choices and timing of consumption and screen time and videogaming quantity and timing) and health determinants (wellbeing). These findings suggest that sleep hygiene and the modifiable shared behavioural determinants should be targeted in health-promoting interventions, and statistical analyses should be adjusted for socioenvironmental determinants and wellbeing.","PeriodicalId":17057,"journal":{"name":"Journal of Sleep Research","volume":" ","pages":"e70029"},"PeriodicalIF":3.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0