Journal of Pharmacy and Pharmacology最新文献_第4页

Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats. PPAR-γ/Nrf2和AGE/RAGE信号转导的调节有助于蛹素对糖尿病大鼠心肌缺血/再灌注后心肌损伤的保护作用。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-09 DOI: 10.1093/jpp/rgae140

Neha Rani, Dharamvir Singh Arya

{"title":"Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats.","authors":"Neha Rani, Dharamvir Singh Arya","doi":"10.1093/jpp/rgae140","DOIUrl":"10.1093/jpp/rgae140","url":null,"abstract":"Objective: Advanced glycation end products/receptor for AGEs (AGE/RAGE) signaling has a well-established role in the etiology of diabetic-related cardiovascular disorders. The purpose of the study was to elucidate the role of chrysin, a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, against ischemia/reperfusion (IR) injury in diabetic rats and its functional interaction with the AGE/RAGE signaling pathway.Methods: A single intraperitoneal injection of streptozotocin (STZ, 70 mg/kg) was administered to rats for induction of diabetes. Rats having blood glucose levels more than 300 mg/dl following a 72 hr STZ injection were classified as diabetic. PPAR-γ antagonist GW9662 (1 mg/kg, i.p.), chrysin (60 mg/kg, p.o.), or both were administered to diabetic rats for 4 weeks. On the 29th day, rats were given ischemia for 45 min and then reperfusion for 1 hr to induce myocardial infarction (MI).Key findings: Pretreatment with chrysin significantly improved hemodynamic status, ventricular functions, and cardiac injury markers in diabetic myocardium. Increased PPAR-γ/Nrf2 and decreased RAGE protein expressions were linked to this improvement. Chrysin pretreatment resulted in the upregulation of endogenous antioxidants and reduced TBARS levels. Moreover, chrysin significantly decreased inflammation and apoptosis in diabetic myocardium.Conclusion: PPAR-γ/Nrf2 co-activation by chrysin ameliorated IR-induced MI in diabetic rats, possibly via modulating AGE/RAGE signaling.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"794-804"},"PeriodicalIF":2.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The state and trends of cinnamaldehyde research over the past three decades: a bibliometric and visualized analysis. 过去三十年肉桂醛研究的现状和趋势：文献计量学和可视化分析。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-09 DOI: 10.1093/jpp/rgaf019

Huize Zhang, Longfei Si, Chenhao Liu, Yi Liu

{"title":"The state and trends of cinnamaldehyde research over the past three decades: a bibliometric and visualized analysis.","authors":"Huize Zhang, Longfei Si, Chenhao Liu, Yi Liu","doi":"10.1093/jpp/rgaf019","DOIUrl":"10.1093/jpp/rgaf019","url":null,"abstract":"Objectives: As an aromatic aldehyde, Cinnamaldehyde (CAL) is the representative bioactive component of cinnamon, possessing extensive applications in the fields of pharmaceuticals, chemicals, food, and feed. The objective of the present study is to elucidate the state and trends of CAL research via bibliometric and visualized analysis.Methods: Research on CAL was obtained from the Web of Science Core Collection, and knowledge graphs were created employing CiteSpace software. Bibliometric analysis was conducted on 6205 articles published from 1994 to 2023.Key findings: The findings indicate a steadily growing trend in the quantity of papers published on CAL. The collaborative network visualization analysis has determined that China, the Chinese Academy of Sciences, and Kumar Venkitanarayanan have the highest number of publications among all countries, institutions, and authors, respectively. According to the keyword and cocited reference analysis, the primary research hotspots and frontiers include pharmacological effect, underlying mechanism, chemical structure modification, encapsulation technology, and delivery system, highlighting the cross-disciplinary characteristic of CAL research.Conclusions: This study delineates the research hotspots and trends of CAL. Future research should focus on exploring the pharmacological effects and mechanisms of CAL in more depth, optimizing chemical derivatization methods, and refining stimuli-responsive smart release systems of CAL.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"729-751"},"PeriodicalIF":2.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhein induces apoptosis of AGS and MGC803 cells by regulating the Ras/PI3K/AKT and p38/MAPK signaling pathway. Rhein 通过调节 Ras/PI3K/AKT 和 p38/MAPK 信号通路诱导 AGS 和 MGC803 细胞凋亡。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-09 DOI: 10.1093/jpp/rgae115

Meiqi Wan, Anna Gan, Jun Dai, Fei Lin, Ruixuan Wang, Bo Wu, Tingxu Yan, Ying Jia

{"title":"Rhein induces apoptosis of AGS and MGC803 cells by regulating the Ras/PI3K/AKT and p38/MAPK signaling pathway.","authors":"Meiqi Wan, Anna Gan, Jun Dai, Fei Lin, Ruixuan Wang, Bo Wu, Tingxu Yan, Ying Jia","doi":"10.1093/jpp/rgae115","DOIUrl":"10.1093/jpp/rgae115","url":null,"abstract":"Objectives: Rhein is one of the main bioactive compounds in the Polygonaceae plant, and has been proven to have anti-cancer activity in some reports. But the mechanism of Rhein in the treatment of gastric cancer (GC) is limited reported. In this research, network pharmacology combined with in vitro experiments was used for systematically studying the mechanism of Rhein.Methods: Network pharmacology confirmed the major effect signaling pathway and key targets of Rhein in the treatment of GC. Cell viability assay, colony formation assay, fluorescence probe assay, apoptosis assay, western blot and qRT-PCR verified the mechanism of Rhein in the treatment of GC cells (AGS and MGC803 cells).Key findings: The results showed that Rhein significantly induced the apoptosis process of AGS and MGC803 cells by regulating the Ras/phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT) and the p38/mitogen-activated protein kinase signaling pathways. The AKT activator (SC79) and p38 inhibitor (SB202190) inhibited Rhein-induced apoptosis.Conclusions: All results proved that Rhein could be recognized as a potential natural drug for the treatment of GC.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"783-793"},"PeriodicalIF":2.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing the familiar: Future treatment options against chronic kidney disease. 重新利用熟悉的：慢性肾脏疾病的未来治疗方案。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-09 DOI: 10.1093/jpp/rgaf002

Rohan Bhadange, Anil Bhanudas Gaikwad

{"title":"Repurposing the familiar: Future treatment options against chronic kidney disease.","authors":"Rohan Bhadange, Anil Bhanudas Gaikwad","doi":"10.1093/jpp/rgaf002","DOIUrl":"10.1093/jpp/rgaf002","url":null,"abstract":"Objectives: Chronic kidney disease (CKD) is a serious health issue with rising morbidity and mortality rates. Despite advances in understanding its pathophysiology, effective therapeutic options are limited, necessitating innovative treatment approaches. Also, current frontline treatments that are available against CKD are not uniformly effective and often come with significant side effects. Therefore, identifying new therapeutic targets or improving existing treatments for CKD is crucial. Drug repurposing is a promising strategy in the drug discovery process that involves screening existing approved drugs for new therapeutic applications.Key findings: This review discusses the pharmacological mechanisms and clinical evidence that support the efficacy of these repurposed drugs. Various drugs classes such as inodilators, endothelin-1 type A (ET-1A) receptor antagonists, bisphosphonates, mineralocorticoid receptor (MR) antagonists, DNA demethylating agents, nuclear factor erythroid 2-related factor 2 (NRF2) activators, P2X7 inhibitors, autophagy modulators, hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHI) are discussed that could remarkably contribute against CKD.Summary: The review critically examines the potential for repurposing well-established drugs to slow the progression of CKD and enhance patient outcomes. This review emphasizes the importance of a multidisciplinary approach in advancing the field of drug repurposing, ultimately paving the way for innovative and effective therapies for patients suffering from CKD.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"715-728"},"PeriodicalIF":2.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting together cholinesterases and serotonin reuptake against Alzheimer's disease. 联合靶向胆碱酯酶和血清素再摄取治疗阿尔茨海默病。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-07 DOI: 10.1093/jpp/rgaf041

Thomas Guiselin, Cédric Lecoutey, Christophe Rochais, Patrick Dallemagne

{"title":"Targeting together cholinesterases and serotonin reuptake against Alzheimer's disease.","authors":"Thomas Guiselin, Cédric Lecoutey, Christophe Rochais, Patrick Dallemagne","doi":"10.1093/jpp/rgaf041","DOIUrl":"https://doi.org/10.1093/jpp/rgaf041","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and memory loss, with limited therapeutic options. Traditional treatments primarily focus on acetylcholinesterase inhibitors (AChEIs), which aim to increase acetylcholine levels in the brain, and selective serotonin reuptake inhibitors (SSRIs), which modulate serotonin levels. However, these treatments often provide only modest symptom relief. This review explores the potential benefits of combined targeting of cholinesterases and serotonin reuptake as a novel therapeutic strategy for AD. We discuss the pathophysiological role of acetylcholine and serotonin in AD, highlighting their impact on cognitive function, mood regulation, and neuroplasticity. By targeting both cholinergic and serotonergic systems, this dual approach may offer synergistic effects, improving cognitive function, reducing neuropsychiatric symptoms, and enhancing neuroprotective mechanisms. The review also examines preclinical and clinical studies investigating the efficacy of combination therapies and outlines the challenges and opportunities in their development. Ultimately, this combined targeting approach holds promise for providing more effective and comprehensive treatment options for AD, addressing both cognitive and behavioural symptoms associated with the disease.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury. 更正：异尿酸原可减轻stz诱导的主动脉损伤中的炎症并调节Nrf2/caspase-3信号。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-06 DOI: 10.1093/jpp/rgaf046

引用次数: 0

Thymol suppressed tumor growth in vitro and in vivo through inducing calcium overload in colorectal cancer. 百里香酚通过诱导结直肠癌钙超载抑制肿瘤生长。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-06 DOI: 10.1093/jpp/rgaf040

Hao Lin, Zongjun Chen, Weizhong Yang, Xianwei Wang

{"title":"Thymol suppressed tumor growth in vitro and in vivo through inducing calcium overload in colorectal cancer.","authors":"Hao Lin, Zongjun Chen, Weizhong Yang, Xianwei Wang","doi":"10.1093/jpp/rgaf040","DOIUrl":"https://doi.org/10.1093/jpp/rgaf040","url":null,"abstract":"Background: Thymol, a bioactive phenolic compound, has proven to possess multiple anti-cancer activities, yet the function and underlying mechanism in colorectal cancer (CRC) remain unclear.Objectives: To shed light on the possible therapeutic effects of thymol in CRC based on calcium homeostasis regulation, and seek to explore the molecular pathways of calcium overload in the thymol-induced anti-CRC activity.Methods: The effects of thymol on cell proliferation, viability, apoptosis, anti-inflammatory effects, and calcium overload phenotype were investigated in HCT116 and CT26 cells. In addition, the in vivo therapeutic efficacies of thymol on CT26 xenograft tumor were also researched. Furthermore, molecular mechanisms of thymol-induced calcium overload were detected by Western blot, RT-qPCR, and immunofluorescence assays.Results: We demonstrated that thymol significantly inhibited the proliferation, viability, and induced apoptosis of HCT116 and CT26 cells. And, thymol suppressed the secretion of inflammatory factors. Furthermore, thymol promoted cell damage mediated by increased mitochondrial membrane potential in both two cells. In addition, thymol triggered the energy metabolism inhibition induced by calcium overload in HCT116 and CT26 cells. Besides, in vivo experiments based on CT26 xenograft tumor model also validated the positive anti-CRC activities.Conclusions: Thymol inhibits CRC partially through inducing calcium overload, which provides an innovative solution for developing anti-CRC drugs.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compare Phellodendri Chinensis Cortex before and after salt-water processing to ameliorate diabetic nephropathy via metabolomics and microbiome analysis. 通过代谢组学和微生物组学分析比较黄柏皮盐水处理前后对糖尿病肾病的改善作用。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-04 DOI: 10.1093/jpp/rgaf033

Huangyao Zhu, Shufan Jin, Siqi Fan, Wanqiu Liu, Yizhu Wang, Jingwen Ha, Yuxuan Lu, Zheling Li, Ma Mi, Jie Zhang, Wenyuan Liu, Lamu Yixi, Feng Feng, Jian Xu

{"title":"Compare Phellodendri Chinensis Cortex before and after salt-water processing to ameliorate diabetic nephropathy via metabolomics and microbiome analysis.","authors":"Huangyao Zhu, Shufan Jin, Siqi Fan, Wanqiu Liu, Yizhu Wang, Jingwen Ha, Yuxuan Lu, Zheling Li, Ma Mi, Jie Zhang, Wenyuan Liu, Lamu Yixi, Feng Feng, Jian Xu","doi":"10.1093/jpp/rgaf033","DOIUrl":"https://doi.org/10.1093/jpp/rgaf033","url":null,"abstract":"Objectives: The study aims to investigate the therapeutic effects and the underlying mechanisms of Phellodendri Chinensis Cortex (PC) and its salt-water processed form (SPC) on diabetic nephropathy (DN).Methods: Histopathological examination, biochemical evaluation immunohistochemistry/immunofluorescence assay were used to compare the effects of PC and SPC on DN. Intestinal microbiota was sequenced by 16S rDNA, serum differential metabolites were identified by UPLC-Q/TOF-MS to elucidate the mechanism.Results: PC and SPC could improve renal function, reduce blood glucose, proteinuria, inflammation, and oxidative stress, and restoring gut microbiota homeostasis in DN rats, with SPC showing superior efficacy. PC influenced 8 metabolites, primarily in glycerolipid metabolism and pentose and glucuronate interconversions, whereas SPC affected 30 metabolites, predominantly in pathways closely associated with glucose and lipid metabolism, including pentose and glucuronate interconversions, ether lipid metabolism and glycerophospholipid metabolism. Correlation analysis identified specific gut microbiota, such as Enterobacteriaceae, Muribaculaceae, and Lachnospiraceae, as highly correlated with the metabolic effects induced by PC and SPC.Conclusion: The study provides evidence that PC and SPC have a beneficial effect on DN, with SPC exhibiting enhanced therapeutic potential. Furthermore, SPC could better restore gut microbiota diversity and structure, and improved glucose and lipid metabolism.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol and microRNAs: shared cellular targets and new insights for developing anti-seizure modalities. 大麻二酚和microrna：共享细胞靶点和开发抗癫痫模式的新见解。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-04 DOI: 10.1093/jpp/rgaf039

Arya Afrooghe, Elham Ahmadi, Maryam Shayan, Mohammad Amin Dabbagh Ohadi, Amir Hossein Behnoush, Ahmad Reza Dehpour

{"title":"Cannabidiol and microRNAs: shared cellular targets and new insights for developing anti-seizure modalities.","authors":"Arya Afrooghe, Elham Ahmadi, Maryam Shayan, Mohammad Amin Dabbagh Ohadi, Amir Hossein Behnoush, Ahmad Reza Dehpour","doi":"10.1093/jpp/rgaf039","DOIUrl":"https://doi.org/10.1093/jpp/rgaf039","url":null,"abstract":"Cannabidiol (CBD) and 9-tetrahydrocannabinol (THC) are the two main components of cannabis that provide its therapeutic benefits. CBD has been extensively studied for its role in reducing seizures, among its many other uses. While the exact mechanisms by which CBD works to relieve seizures have not yet been fully determined, it is evident that CBD effectively diminishes seizure activity and is now being used as an approved treatment for severe forms of non-responsive epilepsy. As essential components of several biological processes, microRNAs (miRNAs) are crucial for achieving optimal cellular functioning. During the past few years, there has been an increasing interest in elucidating the functional significance of microRNAs in epilepsy. Yet, there is still considerable ambiguity regarding the precise mechanisms by which miRNAs are involved in seizure disorders and also their direct interaction with CBD. Herein, we seek to present an overview of the varying mechanisms by which CBD offers therapeutic benefits concerning seizures. Accordingly, we highlighted the shared molecular targets between microRNAs and CBD in alleviating seizure symptoms to shed light on the ways in which new therapeutic and diagnostic modalities could be shaped in the future.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications. 全面回顾科学报道的植物化学物质，以管理慢性糖尿病并发症的异常性疼痛。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-31 DOI: 10.1093/jpp/rgaf012

Piyali Devroy, Dorothy Das, Asis Bala, Ashis Kumar Mukherjee

{"title":"A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications.","authors":"Piyali Devroy, Dorothy Das, Asis Bala, Ashis Kumar Mukherjee","doi":"10.1093/jpp/rgaf012","DOIUrl":"https://doi.org/10.1093/jpp/rgaf012","url":null,"abstract":"Background: The global prevalence of diabetes mellitus and its associated complications is increasing, impacting both developed and developing nations. One common complication is neuropathy and neuropathic pain, which often manifests as symptoms such as allodynia-a condition where patients experience pain from non-painful stimuli.Objective: This review seeks to explore scientifically validated medicinal plants and phytochemicals, presenting the findings in an organized format based on published literature.Methodology: Data were searched in pubmed literature and only the scientifically reported phytochemicals were considered to include in this review.Key findings: The U.S. Food and Drug Administration (FDA) has not approved many medications targeting the root causes of neuropathy. Instead, various strategies are employed to manage the symptoms of allodynia. Research on plant-based ethno-pharmaceuticals aims to address the symptoms without affecting the disease's progression, which involves the gradual loss of nerve fibres from the extremities. This article delves into allodynia's different forms, implications, and underlying signalling mechanisms.Conclusion: The hope is that further research on phytochemicals could lead to the development of therapies for managing various forms of allodynia in diabetic patients.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0