Journal of Pharmacy and Pharmacology最新文献_第4页

Mangiferin and norathyriol acting on Alzheimer's disease biomarkers: acetylcholinesterase, β-secretase (BACE-1), and amyloid β-peptide. 芒果苷和去甲酰基三醇作用于阿尔茨海默病生物标志物：乙酰胆碱酯酶、β-分泌酶（BACE-1）和淀粉样β-肽。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-11 DOI: 10.1093/jpp/rgaf055

Tiago Bento de Oliveira, Ana Claudia Beneton Galeriani, José R Rodrigues de Souza, Daniel F Kawano, Maria Teresa Salles Trevisan, Wanda P Almeida

{"title":"Mangiferin and norathyriol acting on Alzheimer's disease biomarkers: acetylcholinesterase, β-secretase (BACE-1), and amyloid β-peptide.","authors":"Tiago Bento de Oliveira, Ana Claudia Beneton Galeriani, José R Rodrigues de Souza, Daniel F Kawano, Maria Teresa Salles Trevisan, Wanda P Almeida","doi":"10.1093/jpp/rgaf055","DOIUrl":"https://doi.org/10.1093/jpp/rgaf055","url":null,"abstract":"Objectives: Mangiferin, a chemical constituent of Mangifera indica, has been the subject of extensive investigation due to its diverse biological activities, as detailed in numerous scientific studies. Its aglycone, norathyriol, has similarly garnered attention from researchers. In furtherance of our ongoing research goals, this article presents an evaluation of these compounds in relation to biomarkers associated with Alzheimer's disease.Methods: The inhibition of acetylcholinesterase (AChE) and β-secretase (BACE-1), as well as the aggregation of the amyloid beta (Aβ)42 peptide, was assessed using Ellman's colourimetric method, fluorescence resonance energy transfer (FRET), and thioflavin-T fluorescence emission, respectively.Key findings: Mangiferin exhibited no inhibitory effect on AChE, whereas norathyriol demonstrated an inhibitory concentration (IC50) of 6.23 μM. Molecular docking revealed that the mangiferin-AChE and mangiferin-BACE-1 complexes did not interact with sites related to enzyme activity. In contrast, norathyriol showed favourable interactions with Asp72 at the peripheral site of AChE and formed significant interactions with BACE-1 through hydrogen bonds, as suggested by molecular docking. The IC50 of norathyriol for BACE-1 inhibition was found to be 9.75 μM. The reduction in Aβ42 aggregation by norathyriol was only 28%.Conclusion: We conclude that norathyriol is a promising prototype for drug development aimed at treating Alzheimer's disease.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achyranthes bidentata Bl. (Huai NiuXi) and Cyathula officinalis Kuan (Chuan NiuXi): ethnopharmacology, phytochemistry, and pharmacology of two frequently used traditional Chinese medicine. 怀牛膝和川牛膝：两种常用中药的民族药理学、植物化学和药理学研究。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-11 DOI: 10.1093/jpp/rgaf059

Ke-Yi Meng, Xin Yu, Tong Wu, Ao Sun, Nan Zhao, Ting-Ting He, Jun-Hong Chai

{"title":"Achyranthes bidentata Bl. (Huai NiuXi) and Cyathula officinalis Kuan (Chuan NiuXi): ethnopharmacology, phytochemistry, and pharmacology of two frequently used traditional Chinese medicine.","authors":"Ke-Yi Meng, Xin Yu, Tong Wu, Ao Sun, Nan Zhao, Ting-Ting He, Jun-Hong Chai","doi":"10.1093/jpp/rgaf059","DOIUrl":"https://doi.org/10.1093/jpp/rgaf059","url":null,"abstract":"Objectives: The roots of Achyranthes bidentata Bl. (ABB) and Cyathula officinalis Kuan (COK) are the main medicinal parts in traditional Chinese applications and are often used as a substitutes for each other in specific prescriptions. This article systematically reviews the research progress of ABB and COK in ethnopharmacology, phytochemistry, and pharmacology. Through comparative analysis, the commonalities and characteristics of the two are clarified. Based on the existing research results of ABB, the aim is to promote research on the pharmacological mechanism of COK and provide a scientific basis for its clinical application.Methods: ABB and COK data were collected from publicly available scientific databases, such as PubMed, CNKI, The Plant List, SpringerLink, and so on.Key findings: ABB and COK can be substituted for each other in traditional medicine. Research in phytochemistry has found that the two have a large number of similar chemical components, and modern pharmacology has also found that ABB and COK can treat the same diseases.Conclusions: ABB and COK have similar pharmacological activities, but there are relatively few pharmacological studies on COK. Based on ABB, it can provide valuable information for the study of COK, which is of great significance for its drug development and clinical research of COK.Highlights: ","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Berberine-loaded mesoporous silica nanomaterials inhibit pancreatic cancer targeting cancer stem cells. 载小檗碱的介孔二氧化硅纳米材料抑制胰腺癌靶向肿瘤干细胞。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-08 DOI: 10.1093/jpp/rgaf058

Xihuang Cao, Songyuan Pang, Yanping Li, Xue Song, Huan Tang, Hong Lv, Fuwen Luo, Yue Pan

{"title":"Berberine-loaded mesoporous silica nanomaterials inhibit pancreatic cancer targeting cancer stem cells.","authors":"Xihuang Cao, Songyuan Pang, Yanping Li, Xue Song, Huan Tang, Hong Lv, Fuwen Luo, Yue Pan","doi":"10.1093/jpp/rgaf058","DOIUrl":"https://doi.org/10.1093/jpp/rgaf058","url":null,"abstract":"Objectives: To investigate the anti-pancreatic ductal adenocarcinoma (PDAC) effect of mesoporous silica nanoparticles loaded with berberine (MSN-BBR) both in vitro and in vivo.Methods: Disulfide-bridged MSN loaded with berberine (BBR) was synthesized and characterized. The study assessed the anti-PDAC effect and the impact on the stemness of pancreatic cancer stem cells (PCSCs) in Panc1 cells and mice. Pathological morphology in the pancreas of mice was evaluated through immunohistochemical and immunofluorescence staining, while protein expressions were analyzed via western blot.Key findings: MSN-BBR glutathione-degraded and released BBR. Moreover, MSN-BBR demonstrated the inhibition of Panc1 cell viability and the stemness ability of PCSC by suppressing the epithelial-mesenchymal transition (EMT) pathway. Consistent with these cellular outcomes, MSN-BBR also impeded the growth of pancreatic tumors by specifically targeting PCSC.Conclusions: MSN-BBR exhibited degradation and BBR release ability. Notably, MSN-BBR exhibited enhanced efficacy in combating PDAC by selectively focusing on PCSC compared to BBR.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Niosomes for enhanced oral delivery of pioglitazone: in vitro characterization and in vivo evaluation. 增强吡格列酮口服给药的Niosomes：体外表征和体内评价。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf015

Aya R Elbasuony, Abdelaziz E Abdelaziz, Eman A Mazyed, Gamal M El Maghraby

{"title":"Niosomes for enhanced oral delivery of pioglitazone: in vitro characterization and in vivo evaluation.","authors":"Aya R Elbasuony, Abdelaziz E Abdelaziz, Eman A Mazyed, Gamal M El Maghraby","doi":"10.1093/jpp/rgaf015","DOIUrl":"10.1093/jpp/rgaf015","url":null,"abstract":"Objectives: The aim was to investigate oleic acid and nigella oil modified niosomes as novel carriers for enhanced pioglitazone (PGZ) oral delivery.Methods: PGZ was encapsulated into niosomes of cholesterol, tween 80, and span 60 before (F1) and after incorporation of nigella oil (F2) or oleic acid (F3) as membrane fluidizers. Niosomes were characterized for morphology, size, zeta potential, PGZ entrapment, and release. Hypoglycemic effect was also assessed.Key findings: Vesicles were spherical recording size values of 286.4, 111.3, and 137.5 nm for F1, F2, and F3 niosomes, respectively. The zeta potential predicted good stability of niosomes. The lipophilic nature of PGZ resulted in more than 99% entrapment into niosomes. PGZ niosomes significantly boosted rate and extent of hypoglycemic activity compared with the unprocessed PGZ. This is clear from the Tmax, which was 3.6, 1.5, 0.87, and 0.62 h for control, F1, F2, and F3, respectively. This was associated with increase in the area above hypoglycemia curve, which was 655.8, 1613.6, 1617.2, and 1764.9 mg h/dl for the same formulations, respectively.Conclusion: Vesicular structure is responsible for enhanced oral bioavailability and drug release is not the limiting factor. Fluidizing material showed potential contribution in enhanced efficacy but requires future verification.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1075-1084"},"PeriodicalIF":3.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential applications of nanocomposites in 3D-printed drug delivery systems. 纳米复合材料在3d打印给药系统中的潜在应用。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf028

Marwan Algellay, Satyajit D Sarker, Matthew Roberts, Lucy A Bosworth, Touraj Ehtezazi

{"title":"The potential applications of nanocomposites in 3D-printed drug delivery systems.","authors":"Marwan Algellay, Satyajit D Sarker, Matthew Roberts, Lucy A Bosworth, Touraj Ehtezazi","doi":"10.1093/jpp/rgaf028","DOIUrl":"10.1093/jpp/rgaf028","url":null,"abstract":"Additive manufacturing is a renowned technology for producing three-dimensional objects, based on ceramic, metal, and plastic materials for different applications. This review examines and provides a perspective on using nanomaterials along with biopolymeric matrices for 3D printing (3DP) with potential applications in pharmaceutical dosage forms. Many 3DP methods have been developed for the formulation of drug delivery systems, including stereolithography, fused deposition modelling (FDM), selective laser sintering, and bioprinting through droplet- or extrusion-assisted techniques. Polymeric drug-loaded nanocapsules regulated the drug release profiles from 3D-printed tablets with faster drug release from 50% infill tablets. Also, incorporating nanomaterials/micro-ribbons significantly changed the mechanical and flow properties of polymers used in 3DP. For example, the addition of 1% w/w chitosan micro-ribbons to poly-vinyl alcohol powder improved filament mechanical properties for FDM 3DP in terms of flexibility and stiffness, with enhanced disintegration time of 3D-printed oral films. Berberine nanoparticles were integrated into a biodegradable and biocompatible 3D-printed pill, which facilitated sustained drug release and improved gastrointestinal absorption. Furthermore, nanocrystals enhanced the solubility of 3D-printed oral films. In conclusion, nanocomposites improved 3D-printed drug delivery systems in different aspects such as mechanical strength, solubility, and drug release profiles.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"986-1001"},"PeriodicalIF":3.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gegen Qinlian Decoction protects kidney in diabetic rats by improving intestinal barrier and regulating intestinal microbiota. 葛根芩连汤通过改善肠道屏障和调节肠道菌群对糖尿病大鼠肾脏的保护作用。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf030

Xinyu Zhang, Qing He, Chenxu Zhang, Zhangxin Ji, Dongmei Yang, Xueyang Wang, Conghui Liu, Chuanqi Zhang, Jingjing Yuan, Na Xu, Jun Chu

{"title":"Gegen Qinlian Decoction protects kidney in diabetic rats by improving intestinal barrier and regulating intestinal microbiota.","authors":"Xinyu Zhang, Qing He, Chenxu Zhang, Zhangxin Ji, Dongmei Yang, Xueyang Wang, Conghui Liu, Chuanqi Zhang, Jingjing Yuan, Na Xu, Jun Chu","doi":"10.1093/jpp/rgaf030","DOIUrl":"10.1093/jpp/rgaf030","url":null,"abstract":"Objectives: To investigate the renoprotective effects of Gegen Qinlian Decoction (GQD) in Diabetes mellitus (DM) rats via the intestinal barrier and microbiota.Methods: GQD was analyzed by UPLC. STZ-induced DM rat models and antibiotic-induced sterile DM rat models were established, and fecal microbiota transplantation was performed in the latter. Renal function, oxidative stress, serum inflammatory factors, and pathological alterations were assessed. Intestinal cells and tight junction were observed by transmission electron microscopy. Inflammatory factors in the colon and tight junction protein expression were evaluated. The gut microbiota and its abundance were assessed by 16sRNA sequencing.Key findings: Four components were determined in the GQD, including puerarin, baicalin, berberine, and liquiritin. After GQD treatment, Scr and BUN were reduced, renal pathological changes were attenuated, intestinal cell swelling was reduced, intestinal tight junctions were improved, and GQD modulated the intestinal microbiota. Furthermore, a fecal bacterial solution containing GQD reduced renal lesions, improved intestinal tight junctions, and regulated intestinal microbiota in DM rats.Conclusions: GQD regulated the intestinal microbiota of DM rats, reduced intestinal inflammation, and repaired the intestinal barrier, thus reducing the burden on the kidneys, and exerting a protective effect on the kidneys of DM rats.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1109-1119"},"PeriodicalIF":3.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ending nuclear weapons, before they end us†. 在核武器终结我们之前终结它们。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf026

Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski

引用次数: 0

Validating the antidiabetic potential of Nakima (Tupistra clarkei Hook.f.), a traditional food from eastern Himalayan region, through network pharmacology and in vivo experimentation. 通过网络药理学和体内实验验证喜马拉雅东部地区传统食物Nakima （Tupistra clarkei Hook.f.）的抗糖尿病潜力。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf014

Sutapa Datta, Soumita Bhattacharjee, Supriyo Ghosh, Amlan Jyoti Ghosh, Tilak Saha, Arnab Sen

{"title":"Validating the antidiabetic potential of Nakima (Tupistra clarkei Hook.f.), a traditional food from eastern Himalayan region, through network pharmacology and in vivo experimentation.","authors":"Sutapa Datta, Soumita Bhattacharjee, Supriyo Ghosh, Amlan Jyoti Ghosh, Tilak Saha, Arnab Sen","doi":"10.1093/jpp/rgaf014","DOIUrl":"10.1093/jpp/rgaf014","url":null,"abstract":"Objective: To explore and understand the antidiabetic activity of Tupistra clarkei Hook.f. inflorescence, providing a scientific explanation to the ethnomedicinal properties.Methods: The constituents of the plant were determined through GC-MS analysis, which were used for target prediction and network pharmacology to understand how the plant regulates hyperglycaemia and other diabetes complications. These properties were validated in vivo along with further assessment of the antioxidant potential of the plant, both in vitro and in vivo.Key findings: The plant showed good phenol-flavonoid content, and antioxidant potential both in vitro and in vivo. GC-MS analysis identified 24 constituents of the plant. In silico analysis showed their ability to target 166 proteins that are associated with pathways in controlling hyperglycaemia and other diabetic consequences, protection of pancreatic tissue, insulin secretion, and insulin resistance. This was reflected in the in vivo experiment where T. clarkei showed ability to reduce FBG, LDL-C, VLDL-C levels, improve the levels of HDL-C, and also facilitate reversal of damage in pancreatic islets.Conclusion: Our study validated the antidiabetic potential Tupistra clarkei inflorescence in the in silico and in vivo assessment, and has proved to have good antioxidant activity and potential against diabetes. However, further clinical trials are essential.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1059-1074"},"PeriodicalIF":3.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Andrographolide attenuates oxidative stress and apoptosis in osteoporosis rats via MEK/ERK and Beclin-1/ATG-5-mediated autophagy pathway. 穿心术内酯通过MEK/ERK和Beclin-1/ atg -5介导的自噬途径减轻骨质疏松大鼠的氧化应激和细胞凋亡。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf052

Yankun Li, Guomin Li, Rui Luo, Bo Li

{"title":"Andrographolide attenuates oxidative stress and apoptosis in osteoporosis rats via MEK/ERK and Beclin-1/ATG-5-mediated autophagy pathway.","authors":"Yankun Li, Guomin Li, Rui Luo, Bo Li","doi":"10.1093/jpp/rgaf052","DOIUrl":"https://doi.org/10.1093/jpp/rgaf052","url":null,"abstract":"Objectives: To explore how andrographolide (AG) activates autophagy and reduces oxidative stress in osteoporosis.Methods: An ovariectomized rat (OVX) model was created in vivo. Osteoblasts were obtained from rat skulls in vitro, and an oxidative stress model was induced by H2O2. Masson staining and micro-CT were utilized to assess pathological damage to bone tissue following treatment with AG, 3-MA, or silencing the ATG-5 gene. The kit detected changes in oxidative stress-related indices, flow cytometry detected apoptosis, alkaline phosphatase and Alizarin Red S staining assessed osteogenic differentiation ability, and Western blot detected changes in osteogenic differentiation-related indices and autophagy-related indices.Key findings: AG therapy clearly reduced pathological damage and inhibited oxidative stress in OVX rats. AG also significantly boosted osteoblast viability, reduced apoptosis, and facilitated osteoblast differentiation. Furthermore, AG treatment substantially elevated the expression of Runx, OPG, BMP-2, as well as autophagy-related proteins MEK, ERK, ATG-5, Beclin-1, and LC3.Conclusions: These findings indicate that AG possesses antioxidant and anti-osteoporosis properties, and that its mechanism may be linked to the MEK/ERK and Beclin-1/ATG-5-mediated autophagy pathways. These results establish the groundwork for the development of AG as an osteoporosis treatment, as well as new directions and therapeutic targets for the intervention of oxidative stress and autophagy-related disorders.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach. 全谱大麻油与omega-3鱼油联合用于神经性疼痛管理：一种新的治疗方法。

IF 3.2 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-08-04 DOI: 10.1093/jpp/rgaf027

Cristina F Elorriaga, María E Olivera, Hugo Gongora Jara, Carlos H Laino

{"title":"Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach.","authors":"Cristina F Elorriaga, María E Olivera, Hugo Gongora Jara, Carlos H Laino","doi":"10.1093/jpp/rgaf027","DOIUrl":"10.1093/jpp/rgaf027","url":null,"abstract":"Objectives: Current pharmacological treatments for neuropathic pain have limited efficacy and may cause undesirable side effects. Cannabidiol (CBD)-enriched cannabis oil and omega-3 fatty acids (ω-3) have emerged as potential therapeutic options due to their analgesic and anti-inflammatory properties. This study aimed to assess the antinociceptive effects of combining CBD-enriched cannabis oil and ω-3 in rat models of acute and neuropathic pain.Methods: Using the hot plate test for acute pain and the chronic constriction injury (CCI) model for neuropathic pain, thermal and mechanical hypersensitivity were evaluated. Additionally, walking track analysis and the rotarod test assessed functional recovery of the sciatic nerve. Beyond that, the histological analysis of sciatic nerves exposed the neuropathological findings of the treatments.Key findings: The combined treatment of CBD-enriched cannabis oil and ω-3 effectively prevented thermal and mechanical hypersensitivity, while also improving motor impairment-induced peripheral neuropathy. Finally, combination treatment showed a protective effect against degeneration resulting from CCI.Conclusions: These findings underscore the potential of CBD-enriched cannabis oil and ω-3 as a novel therapeutic approach for neuropathic pain management, offering promising implications for future research and clinical practice.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1097-1108"},"PeriodicalIF":3.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0