Journal of Pharmacy and Pharmacology最新文献

Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action. 评估菠萝蛋白酶在糖尿病管理中的作用：对研究证据和作用机制的系统回顾。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-29 DOI: 10.1093/jpp/rgaf021

Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi, Ahmed Hussein Zwamel

{"title":"Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action.","authors":"Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi, Ahmed Hussein Zwamel","doi":"10.1093/jpp/rgaf021","DOIUrl":"https://doi.org/10.1093/jpp/rgaf021","url":null,"abstract":"Background: The use of complementary and alternative medicine is becoming increasingly important in the prevention and management of complications related to diabetes.Methods: A comprehensive literature search was conducted across major databases (EMBASE, Scopus, PubMed, Google Scholar, Web of Science, Cochrane Library) up to December 2024. The search focused on studies examining the effect of bromelain on glycemic control, lipid profiles, and related mediators in diabetes.Key findings: Bromelain supplementation demonstrated positive effects on key metabolic markers. Bromelain may stimulate AMPK in muscle cells, enhancing glucose uptake and utilization, potentially lowering blood glucose levels, and benefiting individuals with diabetes. Although direct evidence of bromelain's impact on incretin levels is limited, its ability to modulate gastrointestinal function and improve nutrient absorption could indirectly influence incretin secretion. Moreover, Peptides or smaller amino acids resulting from bromelain's proteolytic activity enter the bloodstream and potentially enhance nutrient absorption, which plays an important role in evaluating the therapeutic potential of bromelain in diabetes management.Conclusion: Bromelain supplementation is effective in improving glycemic and lipid indices in diabetes. However, further research is needed to clarify the underlying mechanisms, including bromelain's potential interaction with the incretin system and its role in modulating insulin resistance through various pathways.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragaria orientalis attenuates hepatic fibrosis through modulation of FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling in rats. 黄芪通过调节大鼠FXR/CYP7A1、ERK/p38 MAPK和TLR4/MyD88/NF-κB信号通路减轻肝纤维化。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-29 DOI: 10.1093/jpp/rgaf022

Chu-Ling Zhang, Hai-Yan Yang, Jia-Le Yi, Meng-Ke Song, Zhao-Da Yu, Jia-Yu Huang, Li-Tao Yi, Min Li, Ji-Xiao Zhu

{"title":"Fragaria orientalis attenuates hepatic fibrosis through modulation of FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling in rats.","authors":"Chu-Ling Zhang, Hai-Yan Yang, Jia-Le Yi, Meng-Ke Song, Zhao-Da Yu, Jia-Yu Huang, Li-Tao Yi, Min Li, Ji-Xiao Zhu","doi":"10.1093/jpp/rgaf022","DOIUrl":"https://doi.org/10.1093/jpp/rgaf022","url":null,"abstract":"Objectives: Fragaria orientalis Losinsk is widely used in Tibetan medicine to remove and eliminate yellow water, a symptom of visceral abscesses including hepatitis, suggesting that Fragaria orientalis may exert potential therapeutic benefits for liver conditions. This study aimed to elucidate the hepatoprotective mechanisms of Fragaria orientalis extract against hepatic fibrosis in rats, focusing on the FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling pathways.Methods: Chemical profiling was measured by UPLC-Q-TOF/MS, followed by HPLC fingerprint. Hepatic fibrosis was induced in rats treated with 40% CCl4. Subsequently, the anti-fibrotic effects of Fragaria orientalis involved in different signaling pathways were examined.Results: Administration of Fragaria orientalis extract reduced serum levels of ALT, AST, ALP, TNF-α, IL-1β, and IL-6, as well as hepatic MDA, while increasing GSH-Px and SOD in liver homogenates. UPLC analysis identified key constituents, including quercetin-3-O-glucuronide and ellagic acid, contributing to its hepatoprotective profile. The extract modulated the FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB pathways, supporting its role in attenuating liver fibrosis.Conclusion: In conclusion, these findings suggest that Fragaria orientalis possesses hepatoprotective effects against hepatic fibrosis, likely through modulating oxidative stress, inflammation, and bile acid regulation pathways.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcuma longa L. extract and residue prevent Alzheimer's disease in mice by regulating microglia and TLR4/NF-κB signaling pathway. 姜黄提取物和残渣通过调节小胶质细胞和TLR4/NF-κB信号通路预防小鼠阿尔茨海默病。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-27 DOI: 10.1093/jpp/rgaf034

Zhihui Xu, Jianlin Li, Xiaotong Liu, Liaoyuan Liu, Weixiong Lin, Dongmei Sun, Yu Zeng

{"title":"Curcuma longa L. extract and residue prevent Alzheimer's disease in mice by regulating microglia and TLR4/NF-κB signaling pathway.","authors":"Zhihui Xu, Jianlin Li, Xiaotong Liu, Liaoyuan Liu, Weixiong Lin, Dongmei Sun, Yu Zeng","doi":"10.1093/jpp/rgaf034","DOIUrl":"https://doi.org/10.1093/jpp/rgaf034","url":null,"abstract":"Background: Curcuma longa L. (CL) is renowned for its various health benefits and has shown potential in alleviating Alzheimer's disease (AD). The post-aqueous extraction residues (CLR) may retain valuable nutritional components. The research aimed to explore their chemical composition and neuroprotective mechanism against Aβ1-42-induced AD mice.Methods: We employed UPLC-Q-Exactive/MS to characterize the chemical constituents of CL and CLR. An HPLC method was developed to quantify three predominant curcuminoids. To investigate their neuroprotective effects against Aβ1-42-induced AD mice, we assessed cognitive function using the Morris water maze and evaluated neuronal damage through histopathological examination. Molecular mechanisms were explored using immunofluorescence, ELISA, and qRT-PCR assays.Results: The study unveiled 47 and 36 compounds in CL and CLR, respectively, and eight significant differential components. HPLC analysis revealed that CLR contained substantial curcuminoids. In Aβ1-42-induced AD mice, CL and CLR improved spatial learning and memory ability, ameliorated pathological alterations in the hippocampal region, and regulated overactivated microglia. Moreover, CL and CLR inhibited the TLR4/NF-κB inﬂammatory pathway.Conclusion: CL and CLR exhibit the anti-AD effect by regulating microglia and suppressing the TLR4/NF-κB signaling pathway, which provides a scientific basis for future nutraceutical and pharmaceutical development.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of chemical and blood transition components of Xipayi Maizibizi Oral Liquid and its excitatory purine regulation-mechanism study in treating overactive bladder. 喜帕依麦子滋口服液化学成分、血运成分分析及治疗膀胱过动症的兴奋性嘌呤调节机制研究。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-27 DOI: 10.1093/jpp/rgaf011

Menglu Wang, Yang Yang, Jiamei Xie, Yuhang Du, Yige Zhao, Yongcheng An, Ziyi Shan, Changhao He, Wanxin Fu, Yan Huang, Huilin Zhang, Baosheng Zhao

{"title":"Analysis of chemical and blood transition components of Xipayi Maizibizi Oral Liquid and its excitatory purine regulation-mechanism study in treating overactive bladder.","authors":"Menglu Wang, Yang Yang, Jiamei Xie, Yuhang Du, Yige Zhao, Yongcheng An, Ziyi Shan, Changhao He, Wanxin Fu, Yan Huang, Huilin Zhang, Baosheng Zhao","doi":"10.1093/jpp/rgaf011","DOIUrl":"https://doi.org/10.1093/jpp/rgaf011","url":null,"abstract":"Objective: To explore the chemical components and blood transition components of Xipayi Maizibizi Oral Liquid (XP) as well as the efficacy and mechanism of XP in the treatment of overactive bladder (OAB).Methods: The chemical components and blood transition components were analysed. Rats were undergone bladder outlet obstruction surgery and divided into five groups. The study observed the general conditions, urodynamic argument and the bladder histopathological changes. The expression levels of ATP and P2X3 were evaluated.Results: One hundred and eighty-six chemical components were identified in XP, including 26 phenolic acids, 37 flavonoids, 7 quinones, 11 lignans and coumarins, 8 tannins, 9 alkaloids, 37 terpenoids, 32 steroids, and 19 other components. One hundred and twenty-eight components of XP were found in the blood, including 23 phenolic acids, 22 flavonoids, 3 quinones, 8 lignans and coumarins, 7 tannins, 7 alkaloids, 21 terpenoids, 20 steroids, and 17 other components. XP demonstrated effective treatment of OAB and downregulated the expression of ATP and P2X3.Conclusion: The characterization of the chemical composition and blood transition components of XP provided a foundation for further pharmacodynamic material basis and quality control of XP. XP could enhance the pathological status of rats with OAB by regulating ATP/P2X3.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach. 全谱大麻油与omega-3鱼油联合用于神经性疼痛管理：一种新的治疗方法。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-26 DOI: 10.1093/jpp/rgaf027

Cristina F Elorriaga, María E Olivera, Hugo Gongora Jara, Carlos H Laino

{"title":"Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach.","authors":"Cristina F Elorriaga, María E Olivera, Hugo Gongora Jara, Carlos H Laino","doi":"10.1093/jpp/rgaf027","DOIUrl":"https://doi.org/10.1093/jpp/rgaf027","url":null,"abstract":"Objectives: Current pharmacological treatments for neuropathic pain have limited efficacy and may cause undesirable side effects. Cannabidiol (CBD)-enriched cannabis oil and omega-3 fatty acids (ω-3) have emerged as potential therapeutic options due to their analgesic and anti-inflammatory properties. This study aimed to assess the antinociceptive effects of combining CBD-enriched cannabis oil and ω-3 in rat models of acute and neuropathic pain.Methods: Using the hot plate test for acute pain and the chronic constriction injury (CCI) model for neuropathic pain, thermal and mechanical hypersensitivity were evaluated. Additionally, walking track analysis and the rotarod test assessed functional recovery of the sciatic nerve. Beyond that, the histological analysis of sciatic nerves exposed the neuropathological findings of the treatments.Key findings: The combined treatment of CBD-enriched cannabis oil and ω-3 effectively prevented thermal and mechanical hypersensitivity, while also improving motor impairment-induced peripheral neuropathy. Finally, combination treatment showed a protective effect against degeneration resulting from CCI.Conclusions: These findings underscore the potential of CBD-enriched cannabis oil and ω-3 as a novel therapeutic approach for neuropathic pain management, offering promising implications for future research and clinical practice.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis. 富5-羟基- l -色氨酸的栀子提取物可降低外阴阴道念珠菌病小鼠模型的感染和炎症。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-24 DOI: 10.1093/jpp/rgaf024

Matteo Puccetti, Alessandro Di Michele, Cinzia Pagano, Elisa Pecorari, Alice Coletti, Leonardo Tensi, Marilena Pariano, Rita Pecorari, Maurizio Ricci, Luana Perioli

{"title":"Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis.","authors":"Matteo Puccetti, Alessandro Di Michele, Cinzia Pagano, Elisa Pecorari, Alice Coletti, Leonardo Tensi, Marilena Pariano, Rita Pecorari, Maurizio Ricci, Luana Perioli","doi":"10.1093/jpp/rgaf024","DOIUrl":"https://doi.org/10.1093/jpp/rgaf024","url":null,"abstract":"Background: Griffonia simplicifolia seeds extracts, generally prepared by maceration, are most commonly used in food supplements intended for mental well-being promotion due to the high content of 5-hydroxy-L-tryptophan (5-HTP), direct serotonin precursor. As 5-HTP is involved in many different biochemical pathways, other applications of G. simplicifolia seed extracts were investigated. Considering the well-known serotonin immunomodulatory activity, the object of this study was to optimize 5-HTP yield by a new extraction procedure, exploit its immunomodulatory activity in a preclinical model of vulvovaginal candidiasis (VVC) for its responsiveness to immunomodulation, and formulate the extract in a suitable vaginal formulation.Methods: High-power ultrasonic technique (HPU) was used for the first time to obtain an extract from Griffonia seeds (GSE-HPU). The amount of 5-HTP was measured by UHPLC-MS/MS. The extract was assessed in C57BL/6 mice model intravaginally infected with C. albicans.Results: The results showed that the new extraction procedure greatly increased 5-HTP yield (82.8% w/w of the extract weight); formulated in \"tablets for vaginal solution\" properly characterized, the GSE-HPU showed a remarkable protective activity in VVC as reduces inflammation, tissue pathology, and fungal growth.Conclusions: The protective efficacy of GSE-HPU in VVC suggests its potential use in vaginal infections and associated inflammatory pathology.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential applications of nanocomposites in 3D-printed drug delivery systems. 纳米复合材料在3d打印给药系统中的潜在应用。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-23 DOI: 10.1093/jpp/rgaf028

Marwan Algellay, Satyajit D Sarker, Matthew Roberts, Lucy A Bosworth, Touraj Ehtezazi

{"title":"The potential applications of nanocomposites in 3D-printed drug delivery systems.","authors":"Marwan Algellay, Satyajit D Sarker, Matthew Roberts, Lucy A Bosworth, Touraj Ehtezazi","doi":"10.1093/jpp/rgaf028","DOIUrl":"https://doi.org/10.1093/jpp/rgaf028","url":null,"abstract":"Additive manufacturing is a renowned technology for producing three-dimensional objects, based on ceramic, metal, and plastic materials for different applications. This review examines and provides a perspective on using nanomaterials along with biopolymeric matrices for 3D printing (3DP) with potential applications in pharmaceutical dosage forms. Many 3DP methods have been developed for the formulation of drug delivery systems, including stereolithography, fused deposition modelling (FDM), selective laser sintering, and bioprinting through droplet- or extrusion-assisted techniques. Polymeric drug-loaded nanocapsules regulated the drug release profiles from 3D-printed tablets with faster drug release from 50% infill tablets. Also, incorporating nanomaterials/micro-ribbons significantly changed the mechanical and flow properties of polymers used in 3DP. For example, the addition of 1% w/w chitosan micro-ribbons to poly-vinyl alcohol powder improved filament mechanical properties for FDM 3DP in terms of flexibility and stiffness, with enhanced disintegration time of 3D-printed oral films. Berberine nanoparticles were integrated into a biodegradable and biocompatible 3D-printed pill, which facilitated sustained drug release and improved gastrointestinal absorption. Furthermore, nanocrystals enhanced the solubility of 3D-printed oral films. In conclusion, nanocomposites improved 3D-printed drug delivery systems in different aspects such as mechanical strength, solubility, and drug release profiles.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gegen Qinlian Decoction protects kidney in diabetic rats by improving intestinal barrier and regulating intestinal microbiota. 葛根芩连汤通过改善肠道屏障和调节肠道菌群对糖尿病大鼠肾脏的保护作用。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-20 DOI: 10.1093/jpp/rgaf030

Xinyu Zhang, Qing He, Chenxu Zhang, Zhangxin Ji, Dongmei Yang, Xueyang Wang, Conghui Liu, Chuanqi Zhang, Jingjing Yuan, Na Xu, Jun Chu

{"title":"Gegen Qinlian Decoction protects kidney in diabetic rats by improving intestinal barrier and regulating intestinal microbiota.","authors":"Xinyu Zhang, Qing He, Chenxu Zhang, Zhangxin Ji, Dongmei Yang, Xueyang Wang, Conghui Liu, Chuanqi Zhang, Jingjing Yuan, Na Xu, Jun Chu","doi":"10.1093/jpp/rgaf030","DOIUrl":"https://doi.org/10.1093/jpp/rgaf030","url":null,"abstract":"Objectives: To investigate the renoprotective effects of Gegen Qinlian Decoction (GQD) in Diabetes mellitus (DM) rats via the intestinal barrier and microbiota.Methods: GQD was analyzed by UPLC. STZ-induced DM rat models and antibiotic-induced sterile DM rat models were established, and fecal microbiota transplantation was performed in the latter. Renal function, oxidative stress, serum inflammatory factors, and pathological alterations were assessed. Intestinal cells and tight junction were observed by transmission electron microscopy. Inflammatory factors in the colon and tight junction protein expression were evaluated. The gut microbiota and its abundance were assessed by 16sRNA sequencing.Key findings: Four components were determined in the GQD, including puerarin, baicalin, berberine, and liquiritin. After GQD treatment, Scr and BUN were reduced, renal pathological changes were attenuated, intestinal cell swelling was reduced, intestinal tight junctions were improved, and GQD modulated the intestinal microbiota. Furthermore, a fecal bacterial solution containing GQD reduced renal lesions, improved intestinal tight junctions, and regulated intestinal microbiota in DM rats.Conclusions: GQD regulated the intestinal microbiota of DM rats, reduced intestinal inflammation, and repaired the intestinal barrier, thus reducing the burden on the kidneys, and exerting a protective effect on the kidneys of DM rats.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ending nuclear weapons, before they end us†. 在核武器终结我们之前终结它们。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-19 DOI: 10.1093/jpp/rgaf026

Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski

引用次数: 0

Can Quercetin protect against the pre-disposing factors for Alzheimer's disease via inhibiting NLRP3 inflammasome pathway? 槲皮素能否通过抑制NLRP3炎性体通路来预防阿尔茨海默病的易感因素？

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-14 DOI: 10.1093/jpp/rgaf020

Azza S Awad, Bassant M El-Mokadem, Miar M Sherif, Abeer Bishr

{"title":"Can Quercetin protect against the pre-disposing factors for Alzheimer's disease via inhibiting NLRP3 inflammasome pathway?","authors":"Azza S Awad, Bassant M El-Mokadem, Miar M Sherif, Abeer Bishr","doi":"10.1093/jpp/rgaf020","DOIUrl":"https://doi.org/10.1093/jpp/rgaf020","url":null,"abstract":"Objectives: The brain and its cognitive functions are most liable to stress, where it is known to promote the pathological manifestation of Alzheimer's disease (AD). This study aimed to investigate the effect of a 2-week-period of restraint stress (RS), as well as the protective effect of Quercetin in a dose-dependent manner against the early start of AD via studying the NLRP3 inflammasome pathway.Methods: The rats were divided into four groups: control (Con), induction (Ind), where 6 h/day for 2 weeks of RS was induced, low and high doses of Q (Q1+Ind and Q2+Ind, respectively), which were administered before the induction of RS for the same period. Behavioral tests were performed to assess the cognitive functions.Key findings: The higher dose of Q has shown more inhibition of the NLRP3 inflammasome pathway, oxidative stress, as well as the phosphorylated-tau and amyloid-β (Aβ) protein, which were significantly fired up by the 2 weeks of RS. These results were backed with the improved cellular structure in the histopathological examination and enhanced cognitive functions, where the two doses of Q have shown their protective effect.Conclusions: This proves that Q shielded the brain against the initial pathogenesis of AD, induced by 2 weeks of RS.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0