Journal of Pharmacy and Pharmacology最新文献_第2页

Enhancing hair growth through phytochemicals: mechanisms, supporting evidence, and future directions. 通过植物化学物质促进头发生长：机制、支持证据和未来方向。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-07-01 DOI: 10.1093/jpp/rgaf023

Rasaq Onikola, Aminat Mohammed, Ridwan Shittu, Habiba Nazir, Lianyan Wang

{"title":"Enhancing hair growth through phytochemicals: mechanisms, supporting evidence, and future directions.","authors":"Rasaq Onikola, Aminat Mohammed, Ridwan Shittu, Habiba Nazir, Lianyan Wang","doi":"10.1093/jpp/rgaf023","DOIUrl":"10.1093/jpp/rgaf023","url":null,"abstract":"Aims: To explore the mechanisms, formulations, delivery strategies, and therapeutic potential of phytochemicals in promoting hair growth, emphasizing their effects on hair follicle physiology and growth cycles.Methods: Databases including PubMed, Springer, Wiley Online Library, Web of Science, CBM, CNKI, Elsevier, Google Scholar, and other databases were searched using key terms such as \"phytochemicals,\" \"hair growth,\" \"hair follicles,\" \"growth factors,\" and \"natural treatments\" were used to identify experimental and clinical studies on phytochemicals affecting hair growth.Key findings: Key phytochemicals stimulate hair follicles and promote keratinocyte proliferation. Malva verticillata influences the (Wingless/Integrated and β-catenin) Wnt/β-catenin pathway and AKT (protein kinase B) signaling. Elephantopus scaber L. extracts elevate insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF), while Sophora flavescens boosts IGF-1 and keratinocyte growth factor (KGF) by increasing mRNA levels. Similarly, Epigallocatechin-3-gallate activates AKT signaling, caffeine reduces transforming growth factor-β2 (TGF-β2) and raises IGF-1, and Carthamus tinctorius enhances VEGF and KGF while suppressing TGF-β1. Although evidence highlights their potential, challenges remain in improving bioavailability and standardizing formulations.Conclusions: Phytochemicals offer natural, safer alternatives for promoting hair growth with fewer side effects than conventional drugs. Further research is needed to optimize formulations and improve bioavailability.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"897-910"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action. 评估菠萝蛋白酶在糖尿病管理中的作用：对研究证据和作用机制的系统回顾。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-07-01 DOI: 10.1093/jpp/rgaf021

Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi, Ahmed Hussein Zwamel

{"title":"Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action.","authors":"Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi, Ahmed Hussein Zwamel","doi":"10.1093/jpp/rgaf021","DOIUrl":"10.1093/jpp/rgaf021","url":null,"abstract":"Background: The use of complementary and alternative medicine is becoming increasingly important in the prevention and management of complications related to diabetes.Methods: A comprehensive literature search was conducted across major databases (EMBASE, Scopus, PubMed, Google Scholar, Web of Science, Cochrane Library) up to December 2024. The search focused on studies examining the effect of bromelain on glycemic control, lipid profiles, and related mediators in diabetes.Key findings: Bromelain supplementation demonstrated positive effects on key metabolic markers. Bromelain may stimulate AMPK in muscle cells, enhancing glucose uptake and utilization, potentially lowering blood glucose levels, and benefiting individuals with diabetes. Although direct evidence of bromelain's impact on incretin levels is limited, its ability to modulate gastrointestinal function and improve nutrient absorption could indirectly influence incretin secretion. Moreover, Peptides or smaller amino acids resulting from bromelain's proteolytic activity enter the bloodstream and potentially enhance nutrient absorption, which plays an important role in evaluating the therapeutic potential of bromelain in diabetes management.Conclusion: Bromelain supplementation is effective in improving glycemic and lipid indices in diabetes. However, further research is needed to clarify the underlying mechanisms, including bromelain's potential interaction with the incretin system and its role in modulating insulin resistance through various pathways.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"884-896"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragaria orientalis attenuates hepatic fibrosis through modulation of FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling in rats. 黄芪通过调节大鼠FXR/CYP7A1、ERK/p38 MAPK和TLR4/MyD88/NF-κB信号通路减轻肝纤维化。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-07-01 DOI: 10.1093/jpp/rgaf022

Chu-Ling Zhang, Hai-Yan Yang, Jia-Le Yi, Meng-Ke Song, Zhao-Da Yu, Jia-Yu Huang, Li-Tao Yi, Min Li, Ji-Xiao Zhu

{"title":"Fragaria orientalis attenuates hepatic fibrosis through modulation of FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling in rats.","authors":"Chu-Ling Zhang, Hai-Yan Yang, Jia-Le Yi, Meng-Ke Song, Zhao-Da Yu, Jia-Yu Huang, Li-Tao Yi, Min Li, Ji-Xiao Zhu","doi":"10.1093/jpp/rgaf022","DOIUrl":"10.1093/jpp/rgaf022","url":null,"abstract":"Objectives: Fragaria orientalis Losinsk is widely used in Tibetan medicine to remove and eliminate yellow water, a symptom of visceral abscesses including hepatitis, suggesting that Fragaria orientalis may exert potential therapeutic benefits for liver conditions. This study aimed to elucidate the hepatoprotective mechanisms of Fragaria orientalis extract against hepatic fibrosis in rats, focusing on the FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling pathways.Methods: Chemical profiling was measured by UPLC-Q-TOF/MS, followed by HPLC fingerprint. Hepatic fibrosis was induced in rats treated with 40% CCl4. Subsequently, the anti-fibrotic effects of Fragaria orientalis involved in different signaling pathways were examined.Results: Administration of Fragaria orientalis extract reduced serum levels of ALT, AST, ALP, TNF-α, IL-1β, and IL-6, as well as hepatic MDA, while increasing GSH-Px and SOD in liver homogenates. UPLC analysis identified key constituents, including quercetin-3-O-glucuronide and ellagic acid, contributing to its hepatoprotective profile. The extract modulated the FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB pathways, supporting its role in attenuating liver fibrosis.Conclusion: In conclusion, these findings suggest that Fragaria orientalis possesses hepatoprotective effects against hepatic fibrosis, likely through modulating oxidative stress, inflammation, and bile acid regulation pathways.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"922-932"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects. 探索阴道给药的潜力：创新、疗效和治疗前景。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-26 DOI: 10.1093/jpp/rgaf045

Eva Sanchez Armengol, Florina Veider, Gioconda Millotti, Gergely Kali, Andreas Bernkop-Schnürch, Flavia Laffleur

{"title":"Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects.","authors":"Eva Sanchez Armengol, Florina Veider, Gioconda Millotti, Gergely Kali, Andreas Bernkop-Schnürch, Flavia Laffleur","doi":"10.1093/jpp/rgaf045","DOIUrl":"https://doi.org/10.1093/jpp/rgaf045","url":null,"abstract":"Vaginal drug delivery has gained significant interest due to its numerous advantages, such as good blood flow, bypassing the first-pass effect, low systemic side effects, and potential for sustained release of pharmaceuticals. Initially targeting contraception and local effects from antibacterial, antifungal, and antiviral agents, recent advancements have broadened its scope. Notably, microbicide formulations showed promise against sexually transmitted diseases, offering superior protection and effective hormone therapies due to the vagina's large surface area and high permeability. The main agents used in vaginal delivery include contraceptives, prostaglandins, steroids, and antimicrobial substances, administered through tablets, suppositories, ointments, gels, creams, and vaginal rings. However, challenges such as slow dissolution and short residence time necessitate novel delivery systems. Mucoadhesive polymers are particularly valuable for enhancing drug absorption and extending treatment options. Comparative studies indicate that vaginal absorption of drugs like human growth hormone and insulin surpasses other parenteral routes. The development of standardized in vitro and in vivo testing methods remains crucial due to the diverse drug systems. While vaginal drug delivery offers benefits, such as high vascularization, low enzymatic activity, and increased bioavailability, it also faces drawbacks, including limited drug compatibility, sensitivity to vaginal pH, patient compliance issues, and potential local irritation. This review aims to elucidate the pathway, propose standardized methods for specific therapeutic areas, and highlight novel formulations like hydrogels and lipid nanoparticles for treating various diseases.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating reversible inhibitory drug-drug interactions: enzyme kinetics, and in vitro-to-in vivo scaling models. 评估可逆的抑制性药物-药物相互作用：酶动力学和体外-体内缩放模型。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-20 DOI: 10.1093/jpp/rgaf029

Qingchen Zhang, David J Greenblatt, Philip W Melchert, John S Markowitz

{"title":"Evaluating reversible inhibitory drug-drug interactions: enzyme kinetics, and in vitro-to-in vivo scaling models.","authors":"Qingchen Zhang, David J Greenblatt, Philip W Melchert, John S Markowitz","doi":"10.1093/jpp/rgaf029","DOIUrl":"https://doi.org/10.1093/jpp/rgaf029","url":null,"abstract":"Background: Polypharmacy is common in clinical practice, making the consideration of potential drug-drug interactions (DDIs) an important factor in clinical therapeutics. In vitro methods are applied for screening and anticipating possible DDIs, with mathematical models playing a key role in evaluating inhibitor potency and scaling pharmacokinetic parameters from in vitro data. Despite extensive research on this topic, varying assumptions and experimental settings across studies have led to inconsistency among models, with the possible consequence of misapplication of enzyme kinetic models and scaling procedures, and misdirection in DDI evaluation and predictions.Methods: This study reviews and summarizes common enzyme kinetic models used to analyse substrate-enzyme-inhibitor interactions across six different mechanisms of inhibition, and derives the corresponding in vitro to in vivo scaling model for use in connecting to clinical DDI studies.Results: A single operational equation was developed, along with a method for determining the inhibition mechanism and the connection to anticipation of in vivo pharmacokinetics.Conclusion: Analysis based on the equation shows that, for inhibitors with the same inhibition constant (Ki), competitive inhibitors will pose a higher potential for DDIs compared to non-competitive inhibitors, while complete inhibitors will result in a higher potential for DDI than partial inhibitors.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined neuroprotective potential of vitamin E and levodopa/carbidopa in a rat model of rotenone-induced Parkinson's disease: role of AMPK/SIRT1/PGC-1α and HMGB1/RAGE axes. 维生素E和左旋多巴/卡比多巴联合对鱼tenone诱导的帕金森病大鼠模型的神经保护作用：AMPK/SIRT1/PGC-1α和HMGB1/RAGE轴的作用

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-20 DOI: 10.1093/jpp/rgaf044

Alaa S Wahba, Nehal S Wahba, Ghadir A Sayed, Sara K Hamed, Dina M Abo-Elmatty, Noha M Mesbah, Ahmed M Reda

{"title":"Combined neuroprotective potential of vitamin E and levodopa/carbidopa in a rat model of rotenone-induced Parkinson's disease: role of AMPK/SIRT1/PGC-1α and HMGB1/RAGE axes.","authors":"Alaa S Wahba, Nehal S Wahba, Ghadir A Sayed, Sara K Hamed, Dina M Abo-Elmatty, Noha M Mesbah, Ahmed M Reda","doi":"10.1093/jpp/rgaf044","DOIUrl":"https://doi.org/10.1093/jpp/rgaf044","url":null,"abstract":"This study investigated the molecular mechanisms underlying the neuroprotective effects of vitamin E in a rotenone-induced Parkinson's disease (PD) rat model, in comparison to levodopa/carbidopa (LD/CD), and evaluated the benefit of their combined use. PD was induced by rotenone (2.5 mg/kg/day, i.p) for 42 days. On day 14, disease onset was confirmed via behavioral deficits and reduced striatal tyrosine hydroxylase (TH) levels. From day 15 to day 42, Parkinsonian rats received vitamin E (100 IU/kg/day, i.p), LD/CD (20/5 mg/kg/day, i.p), or both. ROT-intoxicated rats exhibited progressive motor dysfunction, striatal neurodegeneration, neuronal loss, reduced TH/dopamine levels, and α-synuclein aggregation. These changes were associated with suppressed AMPK/SIRT1/PGC-1α signaling, impaired mitochondrial biogenesis and function, defective mitophagy, heightened oxidative stress, and upregulation of the pro-inflammatory HMGB1/RAGE pathway. Treatment with either vitamin E or LD/CD significantly ameliorated behavioral, histopathological, and molecular abnormalities. Notably, the combination therapy elicited the most robust neuroprotective effects, exceeding the efficacy of monotherapies. Our data affords the molecular basis for managing PD by vitamin E add-on therapy with LD/CD, a strategy that could potentially reduce the need for higher LD/CD doses to overcome wearing-off and may even imply a dose reduction, thereby minimizing the risks of high-dose LD/CD monotherapy.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naochuxue formula attenuates early brain injury following subarachnoid hemorrhage by inhibiting neuronal apoptosis via network pharmacology and in vivo experiments. 网络药理学和体内实验表明脑初血方通过抑制神经细胞凋亡减轻蛛网膜下腔出血后早期脑损伤。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-17 DOI: 10.1093/jpp/rgaf035

Huiying Yan, Limei Fang, Chang Qi, Mingquan Li, Qile Song, Haipeng Sun, Bo Liu, Lina Feng

{"title":"Naochuxue formula attenuates early brain injury following subarachnoid hemorrhage by inhibiting neuronal apoptosis via network pharmacology and in vivo experiments.","authors":"Huiying Yan, Limei Fang, Chang Qi, Mingquan Li, Qile Song, Haipeng Sun, Bo Liu, Lina Feng","doi":"10.1093/jpp/rgaf035","DOIUrl":"https://doi.org/10.1093/jpp/rgaf035","url":null,"abstract":"Objectives: Investigate Naochuxue formula's mechanism in the treatment of subarachnoid hemorrhage.Methods: Analyzed Naochuxue formula's active components via nontargeted metabolomics, and predicted the core targets using network pharmacology. Sprague‒Dawley rats were randomly divided into six groups: sham, model, Naochuxue formula low, medium and high dose groups, and edaravone. Neurological deficits were assessed using the modified Garcia score and tissue damage was assessed by measuring the brain water content. Blood‒brain barrier permeability was assessed using the Evans blue procedure and pathological changes in the lesion site were observed through HE staining and Nissl staining. TUNEL staining and Caspase-3 immunofluorescence were used to observe the apoptosis of neurons in the hippocampus. The distribution and expression of p-PI3K and p-AKT were determined using immunohistochemistry. The expression of the apoptosis-related genes Caspase-3, Bcl-2, and Bax was determined using RT‒PCR.Key findings: Compared with the model group, rats in the high-dose Naochuxue formula group exhibited significant improvements in neurological defects, brain histopathology, blood‒brain barrier permeability and brain edema on Day 3 posttreatment, downregulated Bax and Caspase-3 expression, and significantly upregulated p-PI3K, p-AKT, and Bcl-2 expression (all P < 0.05).Conclusions: High-dose formula for 3 days activated PI3K/AKT signaling pathway, inhibitd neuronal apoptosis, and exerted neuroprotective effects.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanoparticle/silk fibroin-based nanofiber enhances skin regeneration. 金纳米粒子/丝素纳米纤维增强皮肤再生。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-16 DOI: 10.1093/jpp/rgaf025

Ozan Ozcan, Elif Tufan, Aleyna Muhan, Esin Ak, Göksel Şener, Tugba Tunali-Akbay

{"title":"Gold nanoparticle/silk fibroin-based nanofiber enhances skin regeneration.","authors":"Ozan Ozcan, Elif Tufan, Aleyna Muhan, Esin Ak, Göksel Şener, Tugba Tunali-Akbay","doi":"10.1093/jpp/rgaf025","DOIUrl":"https://doi.org/10.1093/jpp/rgaf025","url":null,"abstract":"Objectives: The aim of this study was to determine the wound-healing potential of gold nanoparticles and silk fibroin-based nanofiber produced by green chemistry.Methods: The electrospinning method was used to prepare the nanofiber. Twenty rats were exposed to a 7-day treatment period and another 20 rats were exposed to a 21-day treatment period. Rat groups were control, silver, silk fibroin, and silk + gold nanoparticle groups for each period. The effect of the gold nanoparticle/silk fibroin-based nanofiber was examined in skin samples by using biochemical and histological analysis. In biochemical analysis, skin oxidant and antioxidant parameters were determined.Key findings: Parameters indicating skin damage returned to their previous levels 7 and 21 days after the wound formation using gold nanoparticle/silk fibroin-based nanofiber. Gold nanoparticle/silk fibroin-based nanofiber initiated hair follicle formation at the wound site and accelerated the re-epithelialization process.Conclusions: It was found that the nanofiber prepared by adding gold nanoparticles to silk fibroin had better wound-healing properties than silk fibroin nanofibers without gold nanoparticles.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk stratification of AUC upward deviation in patients with low serum creatinine levels treated with vancomycin: a multicenter retrospective study. 万古霉素治疗低血清肌酐水平患者AUC向上偏移的风险分层：一项多中心回顾性研究

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-16 DOI: 10.1093/jpp/rgaf038

Tomoyuki Ishigo, Ayako Suzuki, Yuta Ibe, Satoshi Fujii, Masahide Fukudo, Hiroaki Yoshida, Hiroaki Tanaka, Hisato Fujihara, Fumihiro Yamaguchi, Fumiya Ebihara, Takumi Maruyama, Yukihiro Hamada, Masaru Samura, Fumio Nagumo, Toshiaki Komatsu, Atsushi Tomizawa, Akitoshi Takuma, Hiroaki Chiba, Yoshifumi Nishi, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto

{"title":"Risk stratification of AUC upward deviation in patients with low serum creatinine levels treated with vancomycin: a multicenter retrospective study.","authors":"Tomoyuki Ishigo, Ayako Suzuki, Yuta Ibe, Satoshi Fujii, Masahide Fukudo, Hiroaki Yoshida, Hiroaki Tanaka, Hisato Fujihara, Fumihiro Yamaguchi, Fumiya Ebihara, Takumi Maruyama, Yukihiro Hamada, Masaru Samura, Fumio Nagumo, Toshiaki Komatsu, Atsushi Tomizawa, Akitoshi Takuma, Hiroaki Chiba, Yoshifumi Nishi, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto","doi":"10.1093/jpp/rgaf038","DOIUrl":"https://doi.org/10.1093/jpp/rgaf038","url":null,"abstract":"Introduction: In patients with diminished muscle mass, serum creatinine (SCr) levels may be misleadingly low, potentially leading to overestimations of kidney function and unexpectedly high blood levels of vancomycin. This study aimed to identify factors contributing to this discrepancy and develop a flowchart for stratifying the risk of excessive vancomycin exposure, measured as an upward deviation in the area under the concentration-time curve (AUC) in patients with low SCr levels.Methods: We analyzed data from patients who received vancomycin and had an SCr value <0.6 mg/dL. The discrepancy between the AUC24-48 h initial dosing and AUC24-48 h TDM was calculated; a ratio (AUC24-48 h TDM/AUC24-48 h initial dosing) higher than 1.2 defined an upward deviation in the AUC. A decision tree model was constructed using classification and regression tree algorithms.Results: Among the 95 patients (median age [interquartile range], 69 [58, 80] years; 68% female), the upward AUC deviation was 40% (38/95). Three factors (creatinine clearance: 115 ml/min, age: 69 years, and blood urea nitrogen/SCr: 17) were selected for the decision flowchart and included in four subgroups.Conclusion: We developed a flowchart to identify patients with low SCr levels whose AUC at therapeutic drug monitoring deviated upward by >20% from the predicted AUC.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Novel oral fast-disintegrating drug delivery devices with predefined inner structure fabricated by Three-Dimensional Printing. 修正：用三维打印技术制造具有预定内部结构的新型口服快速崩解给药装置。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-13 DOI: 10.1093/jpp/rgaf047

引用次数: 0