Journal of Pharmacy and Pharmacology最新文献_第2页

Correction to: FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption. 更正：葛根素抑制破骨细胞生成和骨吸收的关键靶点 FoxO1

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae052

引用次数: 0

Immunotherapy in Alzheimer's disease: focusing on the efficacy of gantenerumab on amyloid-β clearance and cognitive decline. 阿尔茨海默病的免疫疗法：关注甘特奈鲁单抗对淀粉样蛋白-β清除和认知能力下降的疗效。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae066

Ali Azargoonjahromi

{"title":"Immunotherapy in Alzheimer's disease: focusing on the efficacy of gantenerumab on amyloid-β clearance and cognitive decline.","authors":"Ali Azargoonjahromi","doi":"10.1093/jpp/rgae066","DOIUrl":"10.1093/jpp/rgae066","url":null,"abstract":"Gantenerumab, a human monoclonal antibody (mAb), has been thought of as a potential agent to treat Alzheimer's disease (AD) by specifically targeting regions of the amyloid-β (Aβ) peptide sequence. Aβ protein accumulation in the brain leads to amyloid plaques, causing neuroinflammation, oxidative stress, neuronal damage, and neurotransmitter dysfunction, thereby causing cognitive decline in AD. Gantenerumab involves disrupting Aβ aggregation and promoting the breakdown of larger Aβ aggregates into smaller fragments, which facilitates the action of Aβ-degrading enzymes in the brain, thus slowing down the progression of AD. Moreover, Gantenerumab acts as an opsonin, coating Aβ plaques and enhancing their recognition by immune cells, which, combined with its ability to improve the activity of microglia, makes it an intriguing candidate for promoting Aβ plaque clearance. Indeed, the multifaceted effects of Gantenerumab, including Aβ disaggregation, enhanced immune recognition, and improved microglia activity, may position it as a promising therapeutic approach for AD. Of note, reports suggest that Gantenerumab, albeit its capacity to reduce or eliminate Aβ, has not demonstrated effectiveness in reducing cognitive decline. This review, after providing an overview of immunotherapy approaches that target Aβ in AD, explores the efficacy of Gantenerumab in reducing Aβ levels and cognitive decline.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: 1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson's disease. 更正：基于1H-NMR的代谢组学分析中药促进间充质干细胞归巢对威尔逊氏病小鼠模型肝纤维化的干预作用

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae036

引用次数: 0

In silico evidence of bitopertin's broad interactions within the SLC6 transporter family. 比托哌汀在 SLC6 转运体家族中的广泛相互作用的硅学证据。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae051

Gustavo Almeida de Carvalho, Paul Magogo Tambwe, Lucas Rodrigues Couto Nascimento, Bruna Kelly Pedrosa Campos, Raphaela Almeida Chiareli, Guilhermino Pereira Nunes Junior, Ricardo Menegatti, Renato Santiago Gomez, Mauro Cunha Xavier Pinto

{"title":"In silico evidence of bitopertin's broad interactions within the SLC6 transporter family.","authors":"Gustavo Almeida de Carvalho, Paul Magogo Tambwe, Lucas Rodrigues Couto Nascimento, Bruna Kelly Pedrosa Campos, Raphaela Almeida Chiareli, Guilhermino Pereira Nunes Junior, Ricardo Menegatti, Renato Santiago Gomez, Mauro Cunha Xavier Pinto","doi":"10.1093/jpp/rgae051","DOIUrl":"10.1093/jpp/rgae051","url":null,"abstract":"The Glycine Transporter Type 1 (GlyT1) significantly impacts central nervous system functions, influencing glycinergic and glutamatergic neurotransmission. Bitopertin, the first GlyT1 inhibitor in clinical trials, was developed for schizophrenia treatment but showed limited efficacy. Despite this, bitopertin's repositioning could advance treating various pathologies. This study aims to understand bitopertin's mechanism of action using computational methods, exploring off-target effects, and providing a comprehensive pharmacological profile. Similarity Ensemble Approach (SEA) and SwissTargetPrediction initially predicted targets, followed by molecular modeling on SWISS-MODEL and GalaxyWeb servers. Binding sites were identified using PrankWeb, and molecular docking was performed with DockThor and GOLD software. Molecular dynamics analyses were conducted on the Visual Dynamics platform. Reverse screening on SEA and SwissTargetPrediction identified GlyT1 (SLC6A9), GlyT2 (SLC6A5), PROT (SLC6A7), and DAT (SLC6A3) as potential bitopertin targets. Homology modeling on SwissModel generated high-resolution models, optimized further on GalaxyWeb. PrankWeb identified similar binding sites in GlyT1, GlyT2, PROT, and DAT, indicating potential interaction. Docking studies suggested bitopertin's interaction with GlyT1 and proximity to GlyT2 and PROT. Molecular dynamics confirmed docking results, highlighting bitopertin's target stability beyond GlyT1. The study concludes that bitopertin potentially interacts with multiple SLC6 family targets, indicating a broader pharmacological property.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative pharmacokinetics of five primary constituents in Huai-hua powder: a study on normal rats and rats with ulcerative colitis. 怀化粉中五种主要成分的药代动力学比较：对正常大鼠和溃疡性结肠炎大鼠的研究。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae062

Yiwei Shi, Guoyue Zhong, Huilian Huang, Nazhi Li, Jinxiang Zeng, Jixiao Zhu, Jinbin Yuan, Jian Liang

{"title":"Comparative pharmacokinetics of five primary constituents in Huai-hua powder: a study on normal rats and rats with ulcerative colitis.","authors":"Yiwei Shi, Guoyue Zhong, Huilian Huang, Nazhi Li, Jinxiang Zeng, Jixiao Zhu, Jinbin Yuan, Jian Liang","doi":"10.1093/jpp/rgae062","DOIUrl":"10.1093/jpp/rgae062","url":null,"abstract":"Objectives: The goal of this research was to develop a fast, reliable, and sensitive method to simultaneously quantify five key components of Huai-hua Powder (HHP) in rat plasma with genistein served as the internal standard. Furthermore, the established method was used to perform a comparative evaluation of the pharmacokinetic properties of HHP in normal rats and rats with ulcerative colitis (UC).Methods: Chromatographic separation was conducted using an ACQUITY HSS T3 column held at a constant temperature of 35°C, with acetonitrile and a 0.1% formic acid solution in water employed as the mobile phases. Multiple-reaction monitoring facilitated MS operation in positive-negative-ion-switching mode. The method's validation demonstrated exceptional linearity (with a correlation coefficient of r ≥ 0.9970), and the validation tests, encompassing precision within and between days, accuracy, recovery, matrix effect, and stability; all met the predefined acceptable criteria.Key findings: The results revealed significant variations in the pharmacokinetic characteristics of the five components between normal and UC rats, suggesting altered drug metabolism rates and extents in the latter group.Conclusions: These findings offer crucial scientific insights into the potential clinical application of HHP, particularly in the context of treating UC.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas. 在体内和硅学中阐明薰衣草乙醇提取物镇痛作用的可能潜力和机制。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae072

Muhammad Muzammil Nazir, Sana Inam, Muhammad Umar Ijaz, Nimrah Zafar, Derya Karatas Yeni, Farkhanda Asad, Iqra Farzeen, Asma Ashraf

{"title":"In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas.","authors":"Muhammad Muzammil Nazir, Sana Inam, Muhammad Umar Ijaz, Nimrah Zafar, Derya Karatas Yeni, Farkhanda Asad, Iqra Farzeen, Asma Ashraf","doi":"10.1093/jpp/rgae072","DOIUrl":"10.1093/jpp/rgae072","url":null,"abstract":"Objectives: Our research focused on plant's ethanolic extract Lavandula stoechas flower part to investigate the potential analgesic effects and possible pathways involvements.Methods: Four experimental tests were performed on Swiss albino mice with five animals in each group at different doses (50, 100, and 200mg/kg); formalin test, tail-flick test, acetic acid-induced writhing, and hot-plate test. The opioidergic, noradrenergic, cholinergic, and K channel blockers in the analgesic actions were also carried out for the potential route involvement.Key finding: The percentage inhibition for abdominal writhing's and formalin activity showed a dose-dependent manner for early and late phases reducing abdominal writhing's and time period of licking, respectively. Tail immersion and hot-plate test demonstrated a substantial and dose-dependent increase in the latency time and time period of paw liking and jumping response respectively. GC-MS showed the abundantly present compounds were octadecatrienoic acid (34.35%), n-hexadecanoic acid (12.98%). In silico analyses have revealed three compounds that had good interactions with 6y3c receptor proteins, demonstrating strong binding affinities and satisfying docking parameters.Conclusions: Overall, these studies showed that ethanolic extract of L. stoechas is an important medicinal plant, with both central and peripheral antinociceptive and analgesic activities supporting its traditional use for therapeutic purposes.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of efficacy of chrysin in diabetes-associated cardiac complications in chick embryo and murine model. 在小鸡胚胎和小鼠模型中评估金丝桃素对糖尿病相关心脏并发症的疗效。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae088

Joyani Das, Suparna Roy Sarkar, Ankita Das, Ananya Barui, Papiya Mitra Mazumder

{"title":"Assessment of efficacy of chrysin in diabetes-associated cardiac complications in chick embryo and murine model.","authors":"Joyani Das, Suparna Roy Sarkar, Ankita Das, Ananya Barui, Papiya Mitra Mazumder","doi":"10.1093/jpp/rgae088","DOIUrl":"10.1093/jpp/rgae088","url":null,"abstract":"Objectives: Patients with type 2 diabetes or prolonged diabetic condition are webbed into cardiac complications. This study aimed to ascertain the utility of chick embryo as an alternative to the mammalian model for type 2 diabetes-induced cardiac complications and chrysin as a protective agent.Methods: Diabetes was activated in ovo model (chick embryo) using glucose along with β-hydroxybutyric acid. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Alamar, and Kenacid blue assay were used to compare with chrysin-administered group. Blood glucose level, total cholesterol, triglyceride, and high-density lipoprotein were considered as endpoints. Diabetes was induced in Wistar albino rats by administering a high-fat diet and a subdued dose of streptozotocin (35 mg/kg, b.w). Percentage of glycated hemoglobin, creatinine kinase-MB, tumor necrosis factor-α, and C-reactive protein were evaluated and compared with chrysin administered group.Key findings: Chrysin treatment improved elevated blood glucose levels and dyslipidemia in a diabetic group of whole embryos. Condensed cellular growth and protein content as well as enhanced cytotoxicity in ovo were shielded by chrysin. Chrysin reduced cardiac and inflammatory markers in diabetic rats and provided cellular protection to damage the heart of diabetic rats.Conclusion: The protective action of chrysin in ovo model induced a secondary complication associated with diabetes, evidenced that the ovo model is an effective alternative in curtailing higher animal use in scientific research.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer's disease rat models. 丹参酮 IIA 和四甲基吡嗪纳米乳剂对阿尔茨海默病大鼠模型认知障碍和神经元损伤的治疗作用

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae069

Liang Fang, Hongyan Cheng, Weidong Chen, Can Peng, Yuanxu Liu, Caiyun Zhang

引用次数: 0

Correction to: Investigation of polysaccharide from Radix Aconiti Lateralis Preparata (Fuzi) cardio protective effect on doxorubicin-induced chronic cardiotoxicity. 更正：附子多糖对多柔比星诱导的慢性心脏毒性的心脏保护作用研究。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae029

引用次数: 0

Exploration of the potential mechanism of aqueous extract of Artemisia capillaris for the treatment of non-alcoholic fatty liver disease based on network pharmacology and experimental verification. 基于网络药理学和实验验证的茵陈蒿水提取物治疗非酒精性脂肪肝的潜在机制探讨

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-08-26 DOI: 10.1093/jpp/rgae061

Meng Liang, Siyu Dong, Yi Guo, Yuyi Zhang, Xiao Xiao, Jun Ma, Xiaowen Jiang, Wenhui Yu

{"title":"Exploration of the potential mechanism of aqueous extract of Artemisia capillaris for the treatment of non-alcoholic fatty liver disease based on network pharmacology and experimental verification.","authors":"Meng Liang, Siyu Dong, Yi Guo, Yuyi Zhang, Xiao Xiao, Jun Ma, Xiaowen Jiang, Wenhui Yu","doi":"10.1093/jpp/rgae061","DOIUrl":"https://doi.org/10.1093/jpp/rgae061","url":null,"abstract":"Objectives: Non-alcoholic fatty liver disease (NAFLD) is a nutritional and metabolic disease with a high prevalence today. Artemisia capillaris has anti-inflammatory, antioxidant, and other effects. However, the mechanism of A. capillaris in treating NAFLD is still poorly understood.Methods: This study explored the mechanism of A. capillaris in the treatment of NAFLD through network pharmacology and molecular docking, and verified the results through in vivo experiments using a high-fat diet-induced mouse model and in vitro experiments using an oleic acid-induced HepG2 cell model.Key findings: Aqueous extract of A. capillaris (AEAC) can reduce blood lipids, reduce liver lipid accumulation and liver inflammation in NAFLD mice, and improve NAFLD. Network pharmacology analysis revealed that 51 drug ingredients in A. capillaris correspond to 370 targets that act on NAFLD. GEO data mining obtained 93 liver differentially expressed genes related to NAFLD. In the UHPLC-MS detection results, 36 components were characterized and molecular docked with JNK. Verified in vitro and in vivo, the results show that JNK and the phosphorylation levels of IL-6, IL-1β, c-Jun, c-Fos, and CCL2 are key targets and pathways.Conclusions: This study confirmed that AEAC reduces lipid accumulation and inflammation in the liver of NAFLD mice by inhibiting the JNK/AP-1 pathway.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0