Journal of Pharmacy and Pharmacology最新文献_第3页

Compare Phellodendri Chinensis Cortex before and after salt-water processing to ameliorate diabetic nephropathy via metabolomics and microbiome analysis. 通过代谢组学和微生物组学分析比较黄柏皮盐水处理前后对糖尿病肾病的改善作用。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-04 DOI: 10.1093/jpp/rgaf033

Huangyao Zhu, Shufan Jin, Siqi Fan, Wanqiu Liu, Yizhu Wang, Jingwen Ha, Yuxuan Lu, Zheling Li, Ma Mi, Jie Zhang, Wenyuan Liu, Lamu Yixi, Feng Feng, Jian Xu

{"title":"Compare Phellodendri Chinensis Cortex before and after salt-water processing to ameliorate diabetic nephropathy via metabolomics and microbiome analysis.","authors":"Huangyao Zhu, Shufan Jin, Siqi Fan, Wanqiu Liu, Yizhu Wang, Jingwen Ha, Yuxuan Lu, Zheling Li, Ma Mi, Jie Zhang, Wenyuan Liu, Lamu Yixi, Feng Feng, Jian Xu","doi":"10.1093/jpp/rgaf033","DOIUrl":"https://doi.org/10.1093/jpp/rgaf033","url":null,"abstract":"Objectives: The study aims to investigate the therapeutic effects and the underlying mechanisms of Phellodendri Chinensis Cortex (PC) and its salt-water processed form (SPC) on diabetic nephropathy (DN).Methods: Histopathological examination, biochemical evaluation immunohistochemistry/immunofluorescence assay were used to compare the effects of PC and SPC on DN. Intestinal microbiota was sequenced by 16S rDNA, serum differential metabolites were identified by UPLC-Q/TOF-MS to elucidate the mechanism.Results: PC and SPC could improve renal function, reduce blood glucose, proteinuria, inflammation, and oxidative stress, and restoring gut microbiota homeostasis in DN rats, with SPC showing superior efficacy. PC influenced 8 metabolites, primarily in glycerolipid metabolism and pentose and glucuronate interconversions, whereas SPC affected 30 metabolites, predominantly in pathways closely associated with glucose and lipid metabolism, including pentose and glucuronate interconversions, ether lipid metabolism and glycerophospholipid metabolism. Correlation analysis identified specific gut microbiota, such as Enterobacteriaceae, Muribaculaceae, and Lachnospiraceae, as highly correlated with the metabolic effects induced by PC and SPC.Conclusion: The study provides evidence that PC and SPC have a beneficial effect on DN, with SPC exhibiting enhanced therapeutic potential. Furthermore, SPC could better restore gut microbiota diversity and structure, and improved glucose and lipid metabolism.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol and microRNAs: shared cellular targets and new insights for developing anti-seizure modalities. 大麻二酚和microrna：共享细胞靶点和开发抗癫痫模式的新见解。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-06-04 DOI: 10.1093/jpp/rgaf039

Arya Afrooghe, Elham Ahmadi, Maryam Shayan, Mohammad Amin Dabbagh Ohadi, Amir Hossein Behnoush, Ahmad Reza Dehpour

{"title":"Cannabidiol and microRNAs: shared cellular targets and new insights for developing anti-seizure modalities.","authors":"Arya Afrooghe, Elham Ahmadi, Maryam Shayan, Mohammad Amin Dabbagh Ohadi, Amir Hossein Behnoush, Ahmad Reza Dehpour","doi":"10.1093/jpp/rgaf039","DOIUrl":"https://doi.org/10.1093/jpp/rgaf039","url":null,"abstract":"Cannabidiol (CBD) and 9-tetrahydrocannabinol (THC) are the two main components of cannabis that provide its therapeutic benefits. CBD has been extensively studied for its role in reducing seizures, among its many other uses. While the exact mechanisms by which CBD works to relieve seizures have not yet been fully determined, it is evident that CBD effectively diminishes seizure activity and is now being used as an approved treatment for severe forms of non-responsive epilepsy. As essential components of several biological processes, microRNAs (miRNAs) are crucial for achieving optimal cellular functioning. During the past few years, there has been an increasing interest in elucidating the functional significance of microRNAs in epilepsy. Yet, there is still considerable ambiguity regarding the precise mechanisms by which miRNAs are involved in seizure disorders and also their direct interaction with CBD. Herein, we seek to present an overview of the varying mechanisms by which CBD offers therapeutic benefits concerning seizures. Accordingly, we highlighted the shared molecular targets between microRNAs and CBD in alleviating seizure symptoms to shed light on the ways in which new therapeutic and diagnostic modalities could be shaped in the future.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications. 全面回顾科学报道的植物化学物质，以管理慢性糖尿病并发症的异常性疼痛。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-31 DOI: 10.1093/jpp/rgaf012

Piyali Devroy, Dorothy Das, Asis Bala, Ashis Kumar Mukherjee

{"title":"A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications.","authors":"Piyali Devroy, Dorothy Das, Asis Bala, Ashis Kumar Mukherjee","doi":"10.1093/jpp/rgaf012","DOIUrl":"https://doi.org/10.1093/jpp/rgaf012","url":null,"abstract":"Background: The global prevalence of diabetes mellitus and its associated complications is increasing, impacting both developed and developing nations. One common complication is neuropathy and neuropathic pain, which often manifests as symptoms such as allodynia-a condition where patients experience pain from non-painful stimuli.Objective: This review seeks to explore scientifically validated medicinal plants and phytochemicals, presenting the findings in an organized format based on published literature.Methodology: Data were searched in pubmed literature and only the scientifically reported phytochemicals were considered to include in this review.Key findings: The U.S. Food and Drug Administration (FDA) has not approved many medications targeting the root causes of neuropathy. Instead, various strategies are employed to manage the symptoms of allodynia. Research on plant-based ethno-pharmaceuticals aims to address the symptoms without affecting the disease's progression, which involves the gradual loss of nerve fibres from the extremities. This article delves into allodynia's different forms, implications, and underlying signalling mechanisms.Conclusion: The hope is that further research on phytochemicals could lead to the development of therapies for managing various forms of allodynia in diabetic patients.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action. 评估菠萝蛋白酶在糖尿病管理中的作用：对研究证据和作用机制的系统回顾。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-29 DOI: 10.1093/jpp/rgaf021

Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi, Ahmed Hussein Zwamel

{"title":"Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action.","authors":"Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi, Ahmed Hussein Zwamel","doi":"10.1093/jpp/rgaf021","DOIUrl":"https://doi.org/10.1093/jpp/rgaf021","url":null,"abstract":"Background: The use of complementary and alternative medicine is becoming increasingly important in the prevention and management of complications related to diabetes.Methods: A comprehensive literature search was conducted across major databases (EMBASE, Scopus, PubMed, Google Scholar, Web of Science, Cochrane Library) up to December 2024. The search focused on studies examining the effect of bromelain on glycemic control, lipid profiles, and related mediators in diabetes.Key findings: Bromelain supplementation demonstrated positive effects on key metabolic markers. Bromelain may stimulate AMPK in muscle cells, enhancing glucose uptake and utilization, potentially lowering blood glucose levels, and benefiting individuals with diabetes. Although direct evidence of bromelain's impact on incretin levels is limited, its ability to modulate gastrointestinal function and improve nutrient absorption could indirectly influence incretin secretion. Moreover, Peptides or smaller amino acids resulting from bromelain's proteolytic activity enter the bloodstream and potentially enhance nutrient absorption, which plays an important role in evaluating the therapeutic potential of bromelain in diabetes management.Conclusion: Bromelain supplementation is effective in improving glycemic and lipid indices in diabetes. However, further research is needed to clarify the underlying mechanisms, including bromelain's potential interaction with the incretin system and its role in modulating insulin resistance through various pathways.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragaria orientalis attenuates hepatic fibrosis through modulation of FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling in rats. 黄芪通过调节大鼠FXR/CYP7A1、ERK/p38 MAPK和TLR4/MyD88/NF-κB信号通路减轻肝纤维化。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-29 DOI: 10.1093/jpp/rgaf022

Chu-Ling Zhang, Hai-Yan Yang, Jia-Le Yi, Meng-Ke Song, Zhao-Da Yu, Jia-Yu Huang, Li-Tao Yi, Min Li, Ji-Xiao Zhu

{"title":"Fragaria orientalis attenuates hepatic fibrosis through modulation of FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling in rats.","authors":"Chu-Ling Zhang, Hai-Yan Yang, Jia-Le Yi, Meng-Ke Song, Zhao-Da Yu, Jia-Yu Huang, Li-Tao Yi, Min Li, Ji-Xiao Zhu","doi":"10.1093/jpp/rgaf022","DOIUrl":"https://doi.org/10.1093/jpp/rgaf022","url":null,"abstract":"Objectives: Fragaria orientalis Losinsk is widely used in Tibetan medicine to remove and eliminate yellow water, a symptom of visceral abscesses including hepatitis, suggesting that Fragaria orientalis may exert potential therapeutic benefits for liver conditions. This study aimed to elucidate the hepatoprotective mechanisms of Fragaria orientalis extract against hepatic fibrosis in rats, focusing on the FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB signaling pathways.Methods: Chemical profiling was measured by UPLC-Q-TOF/MS, followed by HPLC fingerprint. Hepatic fibrosis was induced in rats treated with 40% CCl4. Subsequently, the anti-fibrotic effects of Fragaria orientalis involved in different signaling pathways were examined.Results: Administration of Fragaria orientalis extract reduced serum levels of ALT, AST, ALP, TNF-α, IL-1β, and IL-6, as well as hepatic MDA, while increasing GSH-Px and SOD in liver homogenates. UPLC analysis identified key constituents, including quercetin-3-O-glucuronide and ellagic acid, contributing to its hepatoprotective profile. The extract modulated the FXR/CYP7A1, ERK/p38 MAPK, and TLR4/MyD88/NF-κB pathways, supporting its role in attenuating liver fibrosis.Conclusion: In conclusion, these findings suggest that Fragaria orientalis possesses hepatoprotective effects against hepatic fibrosis, likely through modulating oxidative stress, inflammation, and bile acid regulation pathways.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcuma longa L. extract and residue prevent Alzheimer's disease in mice by regulating microglia and TLR4/NF-κB signaling pathway. 姜黄提取物和残渣通过调节小胶质细胞和TLR4/NF-κB信号通路预防小鼠阿尔茨海默病。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-27 DOI: 10.1093/jpp/rgaf034

Zhihui Xu, Jianlin Li, Xiaotong Liu, Liaoyuan Liu, Weixiong Lin, Dongmei Sun, Yu Zeng

{"title":"Curcuma longa L. extract and residue prevent Alzheimer's disease in mice by regulating microglia and TLR4/NF-κB signaling pathway.","authors":"Zhihui Xu, Jianlin Li, Xiaotong Liu, Liaoyuan Liu, Weixiong Lin, Dongmei Sun, Yu Zeng","doi":"10.1093/jpp/rgaf034","DOIUrl":"https://doi.org/10.1093/jpp/rgaf034","url":null,"abstract":"Background: Curcuma longa L. (CL) is renowned for its various health benefits and has shown potential in alleviating Alzheimer's disease (AD). The post-aqueous extraction residues (CLR) may retain valuable nutritional components. The research aimed to explore their chemical composition and neuroprotective mechanism against Aβ1-42-induced AD mice.Methods: We employed UPLC-Q-Exactive/MS to characterize the chemical constituents of CL and CLR. An HPLC method was developed to quantify three predominant curcuminoids. To investigate their neuroprotective effects against Aβ1-42-induced AD mice, we assessed cognitive function using the Morris water maze and evaluated neuronal damage through histopathological examination. Molecular mechanisms were explored using immunofluorescence, ELISA, and qRT-PCR assays.Results: The study unveiled 47 and 36 compounds in CL and CLR, respectively, and eight significant differential components. HPLC analysis revealed that CLR contained substantial curcuminoids. In Aβ1-42-induced AD mice, CL and CLR improved spatial learning and memory ability, ameliorated pathological alterations in the hippocampal region, and regulated overactivated microglia. Moreover, CL and CLR inhibited the TLR4/NF-κB inﬂammatory pathway.Conclusion: CL and CLR exhibit the anti-AD effect by regulating microglia and suppressing the TLR4/NF-κB signaling pathway, which provides a scientific basis for future nutraceutical and pharmaceutical development.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of chemical and blood transition components of Xipayi Maizibizi Oral Liquid and its excitatory purine regulation-mechanism study in treating overactive bladder. 喜帕依麦子滋口服液化学成分、血运成分分析及治疗膀胱过动症的兴奋性嘌呤调节机制研究。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-27 DOI: 10.1093/jpp/rgaf011

Menglu Wang, Yang Yang, Jiamei Xie, Yuhang Du, Yige Zhao, Yongcheng An, Ziyi Shan, Changhao He, Wanxin Fu, Yan Huang, Huilin Zhang, Baosheng Zhao

{"title":"Analysis of chemical and blood transition components of Xipayi Maizibizi Oral Liquid and its excitatory purine regulation-mechanism study in treating overactive bladder.","authors":"Menglu Wang, Yang Yang, Jiamei Xie, Yuhang Du, Yige Zhao, Yongcheng An, Ziyi Shan, Changhao He, Wanxin Fu, Yan Huang, Huilin Zhang, Baosheng Zhao","doi":"10.1093/jpp/rgaf011","DOIUrl":"https://doi.org/10.1093/jpp/rgaf011","url":null,"abstract":"Objective: To explore the chemical components and blood transition components of Xipayi Maizibizi Oral Liquid (XP) as well as the efficacy and mechanism of XP in the treatment of overactive bladder (OAB).Methods: The chemical components and blood transition components were analysed. Rats were undergone bladder outlet obstruction surgery and divided into five groups. The study observed the general conditions, urodynamic argument and the bladder histopathological changes. The expression levels of ATP and P2X3 were evaluated.Results: One hundred and eighty-six chemical components were identified in XP, including 26 phenolic acids, 37 flavonoids, 7 quinones, 11 lignans and coumarins, 8 tannins, 9 alkaloids, 37 terpenoids, 32 steroids, and 19 other components. One hundred and twenty-eight components of XP were found in the blood, including 23 phenolic acids, 22 flavonoids, 3 quinones, 8 lignans and coumarins, 7 tannins, 7 alkaloids, 21 terpenoids, 20 steroids, and 17 other components. XP demonstrated effective treatment of OAB and downregulated the expression of ATP and P2X3.Conclusion: The characterization of the chemical composition and blood transition components of XP provided a foundation for further pharmacodynamic material basis and quality control of XP. XP could enhance the pathological status of rats with OAB by regulating ATP/P2X3.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach. 全谱大麻油与omega-3鱼油联合用于神经性疼痛管理：一种新的治疗方法。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-26 DOI: 10.1093/jpp/rgaf027

Cristina F Elorriaga, María E Olivera, Hugo Gongora Jara, Carlos H Laino

{"title":"Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach.","authors":"Cristina F Elorriaga, María E Olivera, Hugo Gongora Jara, Carlos H Laino","doi":"10.1093/jpp/rgaf027","DOIUrl":"https://doi.org/10.1093/jpp/rgaf027","url":null,"abstract":"Objectives: Current pharmacological treatments for neuropathic pain have limited efficacy and may cause undesirable side effects. Cannabidiol (CBD)-enriched cannabis oil and omega-3 fatty acids (ω-3) have emerged as potential therapeutic options due to their analgesic and anti-inflammatory properties. This study aimed to assess the antinociceptive effects of combining CBD-enriched cannabis oil and ω-3 in rat models of acute and neuropathic pain.Methods: Using the hot plate test for acute pain and the chronic constriction injury (CCI) model for neuropathic pain, thermal and mechanical hypersensitivity were evaluated. Additionally, walking track analysis and the rotarod test assessed functional recovery of the sciatic nerve. Beyond that, the histological analysis of sciatic nerves exposed the neuropathological findings of the treatments.Key findings: The combined treatment of CBD-enriched cannabis oil and ω-3 effectively prevented thermal and mechanical hypersensitivity, while also improving motor impairment-induced peripheral neuropathy. Finally, combination treatment showed a protective effect against degeneration resulting from CCI.Conclusions: These findings underscore the potential of CBD-enriched cannabis oil and ω-3 as a novel therapeutic approach for neuropathic pain management, offering promising implications for future research and clinical practice.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis. 富5-羟基- l -色氨酸的栀子提取物可降低外阴阴道念珠菌病小鼠模型的感染和炎症。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-24 DOI: 10.1093/jpp/rgaf024

Matteo Puccetti, Alessandro Di Michele, Cinzia Pagano, Elisa Pecorari, Alice Coletti, Leonardo Tensi, Marilena Pariano, Rita Pecorari, Maurizio Ricci, Luana Perioli

{"title":"Griffonia simplicifolia seeds extract rich in 5-hydroxy-L-tryptophan reduces infection and inflammation in a mouse model of vulvovaginal candidiasis.","authors":"Matteo Puccetti, Alessandro Di Michele, Cinzia Pagano, Elisa Pecorari, Alice Coletti, Leonardo Tensi, Marilena Pariano, Rita Pecorari, Maurizio Ricci, Luana Perioli","doi":"10.1093/jpp/rgaf024","DOIUrl":"https://doi.org/10.1093/jpp/rgaf024","url":null,"abstract":"Background: Griffonia simplicifolia seeds extracts, generally prepared by maceration, are most commonly used in food supplements intended for mental well-being promotion due to the high content of 5-hydroxy-L-tryptophan (5-HTP), direct serotonin precursor. As 5-HTP is involved in many different biochemical pathways, other applications of G. simplicifolia seed extracts were investigated. Considering the well-known serotonin immunomodulatory activity, the object of this study was to optimize 5-HTP yield by a new extraction procedure, exploit its immunomodulatory activity in a preclinical model of vulvovaginal candidiasis (VVC) for its responsiveness to immunomodulation, and formulate the extract in a suitable vaginal formulation.Methods: High-power ultrasonic technique (HPU) was used for the first time to obtain an extract from Griffonia seeds (GSE-HPU). The amount of 5-HTP was measured by UHPLC-MS/MS. The extract was assessed in C57BL/6 mice model intravaginally infected with C. albicans.Results: The results showed that the new extraction procedure greatly increased 5-HTP yield (82.8% w/w of the extract weight); formulated in \"tablets for vaginal solution\" properly characterized, the GSE-HPU showed a remarkable protective activity in VVC as reduces inflammation, tissue pathology, and fungal growth.Conclusions: The protective efficacy of GSE-HPU in VVC suggests its potential use in vaginal infections and associated inflammatory pathology.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential applications of nanocomposites in 3D-printed drug delivery systems. 纳米复合材料在3d打印给药系统中的潜在应用。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-23 DOI: 10.1093/jpp/rgaf028

Marwan Algellay, Satyajit D Sarker, Matthew Roberts, Lucy A Bosworth, Touraj Ehtezazi

{"title":"The potential applications of nanocomposites in 3D-printed drug delivery systems.","authors":"Marwan Algellay, Satyajit D Sarker, Matthew Roberts, Lucy A Bosworth, Touraj Ehtezazi","doi":"10.1093/jpp/rgaf028","DOIUrl":"https://doi.org/10.1093/jpp/rgaf028","url":null,"abstract":"Additive manufacturing is a renowned technology for producing three-dimensional objects, based on ceramic, metal, and plastic materials for different applications. This review examines and provides a perspective on using nanomaterials along with biopolymeric matrices for 3D printing (3DP) with potential applications in pharmaceutical dosage forms. Many 3DP methods have been developed for the formulation of drug delivery systems, including stereolithography, fused deposition modelling (FDM), selective laser sintering, and bioprinting through droplet- or extrusion-assisted techniques. Polymeric drug-loaded nanocapsules regulated the drug release profiles from 3D-printed tablets with faster drug release from 50% infill tablets. Also, incorporating nanomaterials/micro-ribbons significantly changed the mechanical and flow properties of polymers used in 3DP. For example, the addition of 1% w/w chitosan micro-ribbons to poly-vinyl alcohol powder improved filament mechanical properties for FDM 3DP in terms of flexibility and stiffness, with enhanced disintegration time of 3D-printed oral films. Berberine nanoparticles were integrated into a biodegradable and biocompatible 3D-printed pill, which facilitated sustained drug release and improved gastrointestinal absorption. Furthermore, nanocrystals enhanced the solubility of 3D-printed oral films. In conclusion, nanocomposites improved 3D-printed drug delivery systems in different aspects such as mechanical strength, solubility, and drug release profiles.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0