Journal of Pharmacy and Pharmacology最新文献_第10页

Correction to: 1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson's disease. 更正：基于1H-NMR的代谢组学分析中药促进间充质干细胞归巢对威尔逊氏病小鼠模型肝纤维化的干预作用

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae036

引用次数: 0

Comparative pharmacokinetics of five primary constituents in Huai-hua powder: a study on normal rats and rats with ulcerative colitis. 怀化粉中五种主要成分的药代动力学比较：对正常大鼠和溃疡性结肠炎大鼠的研究。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae062

Yiwei Shi, Guoyue Zhong, Huilian Huang, Nazhi Li, Jinxiang Zeng, Jixiao Zhu, Jinbin Yuan, Jian Liang

{"title":"Comparative pharmacokinetics of five primary constituents in Huai-hua powder: a study on normal rats and rats with ulcerative colitis.","authors":"Yiwei Shi, Guoyue Zhong, Huilian Huang, Nazhi Li, Jinxiang Zeng, Jixiao Zhu, Jinbin Yuan, Jian Liang","doi":"10.1093/jpp/rgae062","DOIUrl":"10.1093/jpp/rgae062","url":null,"abstract":"Objectives: The goal of this research was to develop a fast, reliable, and sensitive method to simultaneously quantify five key components of Huai-hua Powder (HHP) in rat plasma with genistein served as the internal standard. Furthermore, the established method was used to perform a comparative evaluation of the pharmacokinetic properties of HHP in normal rats and rats with ulcerative colitis (UC).Methods: Chromatographic separation was conducted using an ACQUITY HSS T3 column held at a constant temperature of 35°C, with acetonitrile and a 0.1% formic acid solution in water employed as the mobile phases. Multiple-reaction monitoring facilitated MS operation in positive-negative-ion-switching mode. The method's validation demonstrated exceptional linearity (with a correlation coefficient of r ≥ 0.9970), and the validation tests, encompassing precision within and between days, accuracy, recovery, matrix effect, and stability; all met the predefined acceptable criteria.Key findings: The results revealed significant variations in the pharmacokinetic characteristics of the five components between normal and UC rats, suggesting altered drug metabolism rates and extents in the latter group.Conclusions: These findings offer crucial scientific insights into the potential clinical application of HHP, particularly in the context of treating UC.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1160-1168"},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico evidence of bitopertin's broad interactions within the SLC6 transporter family. 比托哌汀在 SLC6 转运体家族中的广泛相互作用的硅学证据。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae051

Gustavo Almeida de Carvalho, Paul Magogo Tambwe, Lucas Rodrigues Couto Nascimento, Bruna Kelly Pedrosa Campos, Raphaela Almeida Chiareli, Guilhermino Pereira Nunes Junior, Ricardo Menegatti, Renato Santiago Gomez, Mauro Cunha Xavier Pinto

{"title":"In silico evidence of bitopertin's broad interactions within the SLC6 transporter family.","authors":"Gustavo Almeida de Carvalho, Paul Magogo Tambwe, Lucas Rodrigues Couto Nascimento, Bruna Kelly Pedrosa Campos, Raphaela Almeida Chiareli, Guilhermino Pereira Nunes Junior, Ricardo Menegatti, Renato Santiago Gomez, Mauro Cunha Xavier Pinto","doi":"10.1093/jpp/rgae051","DOIUrl":"10.1093/jpp/rgae051","url":null,"abstract":"The Glycine Transporter Type 1 (GlyT1) significantly impacts central nervous system functions, influencing glycinergic and glutamatergic neurotransmission. Bitopertin, the first GlyT1 inhibitor in clinical trials, was developed for schizophrenia treatment but showed limited efficacy. Despite this, bitopertin's repositioning could advance treating various pathologies. This study aims to understand bitopertin's mechanism of action using computational methods, exploring off-target effects, and providing a comprehensive pharmacological profile. Similarity Ensemble Approach (SEA) and SwissTargetPrediction initially predicted targets, followed by molecular modeling on SWISS-MODEL and GalaxyWeb servers. Binding sites were identified using PrankWeb, and molecular docking was performed with DockThor and GOLD software. Molecular dynamics analyses were conducted on the Visual Dynamics platform. Reverse screening on SEA and SwissTargetPrediction identified GlyT1 (SLC6A9), GlyT2 (SLC6A5), PROT (SLC6A7), and DAT (SLC6A3) as potential bitopertin targets. Homology modeling on SwissModel generated high-resolution models, optimized further on GalaxyWeb. PrankWeb identified similar binding sites in GlyT1, GlyT2, PROT, and DAT, indicating potential interaction. Docking studies suggested bitopertin's interaction with GlyT1 and proximity to GlyT2 and PROT. Molecular dynamics confirmed docking results, highlighting bitopertin's target stability beyond GlyT1. The study concludes that bitopertin potentially interacts with multiple SLC6 family targets, indicating a broader pharmacological property.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1199-1211"},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas. 在体内和硅学中阐明薰衣草乙醇提取物镇痛作用的可能潜力和机制。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae072

Muhammad Muzammil Nazir, Sana Inam, Muhammad Umar Ijaz, Nimrah Zafar, Derya Karatas Yeni, Farkhanda Asad, Iqra Farzeen, Asma Ashraf

{"title":"In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas.","authors":"Muhammad Muzammil Nazir, Sana Inam, Muhammad Umar Ijaz, Nimrah Zafar, Derya Karatas Yeni, Farkhanda Asad, Iqra Farzeen, Asma Ashraf","doi":"10.1093/jpp/rgae072","DOIUrl":"10.1093/jpp/rgae072","url":null,"abstract":"Objectives: Our research focused on plant's ethanolic extract Lavandula stoechas flower part to investigate the potential analgesic effects and possible pathways involvements.Methods: Four experimental tests were performed on Swiss albino mice with five animals in each group at different doses (50, 100, and 200mg/kg); formalin test, tail-flick test, acetic acid-induced writhing, and hot-plate test. The opioidergic, noradrenergic, cholinergic, and K channel blockers in the analgesic actions were also carried out for the potential route involvement.Key finding: The percentage inhibition for abdominal writhing's and formalin activity showed a dose-dependent manner for early and late phases reducing abdominal writhing's and time period of licking, respectively. Tail immersion and hot-plate test demonstrated a substantial and dose-dependent increase in the latency time and time period of paw liking and jumping response respectively. GC-MS showed the abundantly present compounds were octadecatrienoic acid (34.35%), n-hexadecanoic acid (12.98%). In silico analyses have revealed three compounds that had good interactions with 6y3c receptor proteins, demonstrating strong binding affinities and satisfying docking parameters.Conclusions: Overall, these studies showed that ethanolic extract of L. stoechas is an important medicinal plant, with both central and peripheral antinociceptive and analgesic activities supporting its traditional use for therapeutic purposes.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1178-1198"},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of efficacy of chrysin in diabetes-associated cardiac complications in chick embryo and murine model. 在小鸡胚胎和小鼠模型中评估金丝桃素对糖尿病相关心脏并发症的疗效。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae088

Joyani Das, Suparna Roy Sarkar, Ankita Das, Ananya Barui, Papiya Mitra Mazumder

{"title":"Assessment of efficacy of chrysin in diabetes-associated cardiac complications in chick embryo and murine model.","authors":"Joyani Das, Suparna Roy Sarkar, Ankita Das, Ananya Barui, Papiya Mitra Mazumder","doi":"10.1093/jpp/rgae088","DOIUrl":"10.1093/jpp/rgae088","url":null,"abstract":"Objectives: Patients with type 2 diabetes or prolonged diabetic condition are webbed into cardiac complications. This study aimed to ascertain the utility of chick embryo as an alternative to the mammalian model for type 2 diabetes-induced cardiac complications and chrysin as a protective agent.Methods: Diabetes was activated in ovo model (chick embryo) using glucose along with β-hydroxybutyric acid. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Alamar, and Kenacid blue assay were used to compare with chrysin-administered group. Blood glucose level, total cholesterol, triglyceride, and high-density lipoprotein were considered as endpoints. Diabetes was induced in Wistar albino rats by administering a high-fat diet and a subdued dose of streptozotocin (35 mg/kg, b.w). Percentage of glycated hemoglobin, creatinine kinase-MB, tumor necrosis factor-α, and C-reactive protein were evaluated and compared with chrysin administered group.Key findings: Chrysin treatment improved elevated blood glucose levels and dyslipidemia in a diabetic group of whole embryos. Condensed cellular growth and protein content as well as enhanced cytotoxicity in ovo were shielded by chrysin. Chrysin reduced cardiac and inflammatory markers in diabetic rats and provided cellular protection to damage the heart of diabetic rats.Conclusion: The protective action of chrysin in ovo model induced a secondary complication associated with diabetes, evidenced that the ovo model is an effective alternative in curtailing higher animal use in scientific research.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"1225-1235"},"PeriodicalIF":2.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer's disease rat models. 丹参酮 IIA 和四甲基吡嗪纳米乳剂对阿尔茨海默病大鼠模型认知障碍和神经元损伤的治疗作用

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae069

Liang Fang, Hongyan Cheng, Weidong Chen, Can Peng, Yuanxu Liu, Caiyun Zhang

引用次数: 0

Correction to: Investigation of polysaccharide from Radix Aconiti Lateralis Preparata (Fuzi) cardio protective effect on doxorubicin-induced chronic cardiotoxicity. 更正：附子多糖对多柔比星诱导的慢性心脏毒性的心脏保护作用研究。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI: 10.1093/jpp/rgae029

引用次数: 0

Mesenchymal stem cell-derived exosomal microRNA-367-3p mitigates lower limb ischemia/reperfusion injury in mouse skeletal muscle via EZH2 targeting. 间充质干细胞衍生的外泌体microRNA-367-3p通过EZH2靶向缓解小鼠骨骼肌下肢缺血再灌注损伤

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-08-13 DOI: 10.1093/jpp/rgae086

Huanhuan Sun, Jueqiong Wang, Wei Bi, Feng Zhang, Kai Zhang, Xitao Tian, Xiang Gao, Yanrong Zhang

{"title":"Mesenchymal stem cell-derived exosomal microRNA-367-3p mitigates lower limb ischemia/reperfusion injury in mouse skeletal muscle via EZH2 targeting.","authors":"Huanhuan Sun, Jueqiong Wang, Wei Bi, Feng Zhang, Kai Zhang, Xitao Tian, Xiang Gao, Yanrong Zhang","doi":"10.1093/jpp/rgae086","DOIUrl":"https://doi.org/10.1093/jpp/rgae086","url":null,"abstract":"Objective: This study aimed to investigate the protective effect of bone marrow mesenchymal stem cell-derived exosomes (BMSCs-exo) against lower limb ischemia/reperfusion (I/R) injury-induced pyroptosis in skeletal muscle.Methods: A mouse model of lower limb I/R injury was utilized to assess the impact of BMSCs-exo, particularly when loaded with microRNA-367-3p (miR-367-3p), on pyroptosis. Histological examination, wet weight/dry weight ratio measurements, and luciferase assays were employed to elucidate the mechanisms involved.Key findings: BMSCs-exo effectively suppressed pyroptosis in injured skeletal muscle tissue. Loading BMSCs-exo with miR-367-3p enhanced this protective effect by downregulating key pyroptosis-related proteins. Luciferase assays identified enhancer of zeste homolog 2 (EZH2) as a direct target of miR-367-3p in BMSCs-exo.Conclusions: BMSCs-exo loaded with miR-367-3p safeguarded mouse skeletal muscle against pyroptosis-induced I/R injury by targeting EZH2. These findings offer valuable insights into potential therapeutic strategies for lower limb I/R injuries, emphasizing the therapeutic potential of BMSCs-exo in mitigating tissue damage caused by pyroptosis.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current treatments for oropharyngeal squamous cell carcinoma and the move towards molecular therapy. 口咽鳞状细胞癌的现有治疗方法以及分子疗法的发展。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-08-13 DOI: 10.1093/jpp/rgae107

Mitra Elmi, Joshua H Dass, Crispin R Dass

引用次数: 0

Research progress on ethnobotany, phytochemistry, pharmacological action, and applications of Engelhardia roxburghiana Wall: a review. 关于 Engelhardia roxburghiana Wall 的民族植物学、植物化学、药理作用和应用的研究进展：综述。

IF 2.8 4区医学

Journal of Pharmacy and Pharmacology Pub Date : 2024-08-02 DOI: 10.1093/jpp/rgae021

Yuxin Li, Wenxin Xia, Tingting Li, Yuanyuan Zhang, Wenjin Zhang, Jiahui Yue, Lulu Wang, Xiangdong Zhu, Xueyan Fu

{"title":"Research progress on ethnobotany, phytochemistry, pharmacological action, and applications of Engelhardia roxburghiana Wall: a review.","authors":"Yuxin Li, Wenxin Xia, Tingting Li, Yuanyuan Zhang, Wenjin Zhang, Jiahui Yue, Lulu Wang, Xiangdong Zhu, Xueyan Fu","doi":"10.1093/jpp/rgae021","DOIUrl":"10.1093/jpp/rgae021","url":null,"abstract":"Objectives: Engelhardia roxburghiana Wall is a plant of the Juglandaceae family, and its leaves is the main part used as a medicine. It is used to relieve heat and pain, gasification, and dampness. The purpose of this review is to provide a systematic review about the botany, traditional uses, phytochemistry, pharmacology, and toxicology of this plant.Key findings: Many compounds have been isolated and identified from the plant, including flavonoids, triterpenoids, steroids, quinones, essential oils, and other types of chemical constituents. Extensive pharmacological activities of the extracts or compounds of E. roxburghiana Wall in vivo and in vitro were mainly confirmed, including anti-cancer, anti-diabetic, anti-inflammatory, and anti-allergic effects.Summary: In this paper, the botany, traditional uses, phytochemistry, and pharmacology of E. roxburghiana Wall were reviewed. In the future, E. roxburghiana Wall needs further study, such as paying more attention to quality control and the utilization on agriculture. In addition, discussing the medicinal components of decoction as well as the toxicity will also contribute to the progress of clinical trial studies.","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":"909-929"},"PeriodicalIF":2.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0