Journal of Renal Injury Prevention最新文献

{"title":"Prevalence of renal pathological disorders in kidney transplant recipients: an observational study in the north of Iran","authors":"E. Ramezanzadeh, A. Monfared, M. Khosravi, Reyhane Ghanbari, Tina Yazdanipour, Ehsan Kazemnezhad Leyli","doi":"10.34172/jrip.2023.32139","DOIUrl":"https://doi.org/10.34172/jrip.2023.32139","url":null,"abstract":"Introduction: There are possible adverse effects and pathological disorders that can occur after kidney transplantation. The prevalence of these outcomes in kidney transplant patients is different worldwide. Objectives: In this study, we decided to take a general look at the prevalence of pathological disorders in kidney transplant patients undergoing biopsy. Patients and Methods: This cross-sectional study was conducted on 206 kidney transplant recipients who underwent biopsy of transplanted kidney at Razi medical education center in Rasht city between 2008 and 2019. Information was collected from medical records and interviewing patients. The data were analyzed using SPSS software version 26. They were summarized as the mean (SD) or as median (IQR). The frequency distribution (percentage) was conducted to describe the qualitative variables. Results: Out of 206 patients, 143 (69.4%) were male and the mean age at transplantation was 46.7±13.6 years. About 42.72% were non-relative donors, 47.57% were brain dead donors and 9.71% were family donors. The most common pathological disorder was nephrotoxic caused by calcineurin inhibitors (CNIs) (41.75%) and the most common type of graft rejection was antibody-dependent graft rejection (46.12%). In terms of transplant outcome, 35.92% of the patients suffered transplant rejection and 23.3% of them died. The results of this study did not show a significant relationship between the administration of immunosuppressive drugs and the pathological disorders. Conclusion: The present study showed that the most common pathological disorder in kidney transplant patients was CNIs nephrotoxicity, and the most common type of transplant rejection was antibody-dependent transplant rejection.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46495847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of hemodynamic indices of dialysis patients in continuous renal replacement therapy and intermittent renal replacement therapy methods with ultrasonic cardiac output monitor in intensive care unit","authors":"A. Najafi, Ayda Vakili Ardabili, Z. Aghsaeifard, H. Sharifnia","doi":"10.34172/jrip.2023.32114","DOIUrl":"https://doi.org/10.34172/jrip.2023.32114","url":null,"abstract":"Introduction: Acute kidney injury (AKI) is a common complication in the intensive care unit (ICU) and is independently associated with end-stage renal disease and higher mortality in the ICU. There are different methods to supporting kidney function in critically ill patients. The renal replacement therapy (RRT) can be conducted continuously, intermittently, or in combination. Objectives: The purpose of our study is to investigate the hemodynamic indices of dialysis patients in the ICU by two methods high flow continuous renal replacement therapy (CRRT) and intermittently renal replacement therapy (IRRT) of ultrasonic cardiac output monitor (USCOM). Patients and Methods: In this study conducted at Sina hospital, patients requiring dialysis hospitalized to the ICU were studied. Around 48 patients benefited from rapid CRRT or IRRT in the opinion of a specialist. Basic patient information was recorded. To check hemodynamic parameters during dialysis, USCOM was carried out to check corrected flow time value (FTc) parameters, systemic vascular resistance (SVR) and cardiac output. Results were compared between the IRRT and CRRT groups. Results: This study was conducted on 48 patients who were candidates for dialysis. Patients were divided into high flow CRRT and IRRT groups based on clinical indications. In CRRT group, 19 patients (79.2%) and in the IRRT group, 20 patients (83.3%) were male (P=0.712). Their mean age was 68.70 ± 8.25 years in the CRRT group and 68.58 ± 7.19 years in the IRRT group. All patients had cardiac output monitored using USCOM or ultrasound. The mean Sequential Organ Failure Assessment (SOFA) score in the CRRT group was 7 and in the IRRT group was 6, with no significant difference among them. FTc value variable or modified flow time in the carotid artery, cardiac output, cardiac index, SVR variable and mean arterial pressure in in the two groups at four evaluated times (before dialysis, 15 minutes later, one hour later and end of dialysis) from the study the difference were not statistically significant. Conclusion: Although previos studies have recommended CRRT, our study showed significant difference may not be existed between IRRT and CRRT.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41869571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 outcomes in kidney transplant recipients receiving a combination of sofosbuvir-daclatasvir treatment; a single-center study","authors":"F. Yaghoubi, F. Tavakoli, Davood Dalil, M. Akhavan, Samira Abbasloo","doi":"10.34172/jrip.2023.32130","DOIUrl":"https://doi.org/10.34172/jrip.2023.32130","url":null,"abstract":"Introduction: In the coronavirus disease 2019 (COVID-19) era, kidney transplantation recipients (KTRs) are at high risk due to using immunosuppressive drugs. Considering the lack of definitive cure for COVID-19, repurposing existing pharmaceuticals is a way to find an immediate medication. Objectives: This study aimed to evaluate the COVID-19 outcomes in KTRs, receiving combination of sofosbuvir and daclatasvir (SOF-DAC) treatment. Patients and Methods: This research was an observational study of 12 adult kidney transplant recipients with COVID-19, admitted to Shariati hospital, Tehran, Iran (October to December 2020). All the patients received a once-daily combination pill of SOF-DAC at a dose of 400/60 mg for 10 days. Results: Around October to December 2020, 12 adult KTR patients were recruited; four patients (33.3%) died and eight patients survived (66.7%). Acute kidney injury (AKI) secondary to COVID-19 was seen in 11 patients of the study population (91.7%), including four dead cases. Two of the three patients who underwent dialysis due to kidney complications, died. The laboratory results showed that the mean level of each parameter white blood cells (WBC), international normalized ratio (INR), C-reactive protein (CRP), ferritin, D-dimer on the last day of hospital stay was significantly different between two groups of survived and dead patients at a 95% confidence level (P<0.05). Conclusion: Sofosbuvir combined with DAC for treatment of KTRs with COVID-19 infection reduced the mortality rate. Further, this medication was safe. Patients tolerated it well, and no serious adverse effects were observed. Larger studies are needed to validate these results.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45935416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential biomarkers of chronic kidney disease progression among kidney-derived proteins; a review","authors":"S. P. Kademani, Prabhudas Nelaturi, Vishnu Bhat, Sathya Sagar, R. Sambandam","doi":"10.34172/jrip.2023.32040","DOIUrl":"https://doi.org/10.34172/jrip.2023.32040","url":null,"abstract":"The incidence and mortality rate of kidney disease and its progression to end-stage disease have predominantly increased worldwide. Other morbid conditions, such as diabetes and hypertension, are major risk factors for kidney disease. Detection of kidney disease is difficult due to its heterogeneity and complex pathophysiology. Kidney injury and advanced stages of the disease are currently assessed by traditional biomarkers such as serum creatinine, albuminuria, proteinuria and estimated glomerular filtration rate. Numerous biomarkers derived from the kidney involved in endothelial dysfunction, inflammatory processes and tubular cell damage are potential targets for disease progression management. The review summarized potential biomarkers of chronic kidney disease (CKD) to improve patient care in various clinical practices with an increased focus on loss of kidney function.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49328990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients","authors":"M. Arabi, H. Samimagham, Azadeh Moradkhani, Fatemeh Khajavi Mayvan, Sara Binaei, Ali Salimi Asl, Mitra Kazemi Jahromi","doi":"10.34172/jrip.2022.32126","DOIUrl":"https://doi.org/10.34172/jrip.2022.32126","url":null,"abstract":"Introduction: Vitamin D deficiency is a common clinical finding in the general population and hospitalized patients, including patients in the intensive care unit (ICU). Acute kidney injury (AKI) occurs in more than 50% in ICU admitted patients. Objectives: There are few studies regarding AKI in COVID-19 patients, therefore we investigated the relationship between vitamin D3 deficiency and the occurrence of AKI in COVID-19 patients. Patients and Methods: This cross-sectional study was conducted on 69 COVID-19 patients who were hospitalized in the ward for 12 months. Their serum vitamin D3 levels were measured in the first 24 hours of hospitalization in the ward. Patients were divided into three groups based on the serum levels of vitamin D3: >50 ng/mL as normal, 20-50 ng/mL as insufficient and <20 ng/mL as deficiency status. The patients were studied until the occurrence of acute renal injury or the occurrence of death. Results: Out of 69 hospitalized patients in the ward with COVID-19, there were 39 patients in group vitamin D3<20 ng/mL, 21 patients in group vitamin D3 of 20-50ng/mL and 9 patients in group of vitamin D3>50 ng/mL. The frequencies of AKI in groups of vitamin D3<20 ng/mL, 20-50 ng/mL, and >50 ng/mL were 46%, 28%, and 23%, respectively. A significant relationship was observed between AKI and our study groups (P=0.011). Furthermore, there was a significant association between our study groups and mortality (P=0.014), ICU admission (P=0.041) and hospital length of stay (P=0.017). In another division in patients with different levels of vitamin D3 in the presence or absence of AKI, there were significant associations between patients with vitamin D3<20 ng/mL and the presence of AKI and also with mortality (P=0.042), ICU admission (P=0.024) and additionally with hospital length of stay (P=0.027). Conclusion: Our study showed significant association between vitamin D deficiency and AKI in ICU-admitted COVID-19 patients. Moreover, there were relationships between vitamin D deficiency and mortality, ICU admission and hospital length of stay. These results suggest the correction of vitamin D deficiency may be beneficial to reduce AKI in patient with COVID-19.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47562409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus infection after COVID-19 in a kidney transplant patient, a case report","authors":"M. Alizadeh, A. Elsagh, Mana Mohamadi Afrakoti, Z. Khavari","doi":"10.34172/jrip.2023.32042","DOIUrl":"https://doi.org/10.34172/jrip.2023.32042","url":null,"abstract":"COVID-19, with its complications and co-infections is the most important pandemic, which has placed great strain on even the most developed health care systems, especially on the kidney transplant patients. We present a case of cytomegalovirus (CMV) reactivation after remission of COVID-19 in a kidney transplant patient, admitted to the emergency department. Fever, dyspnea, weakness and tachypnea are the most common symptoms of COVID-19, which can mislead physicians to make inappropriate decisions. We concluded that CMV can potentially increase the mortality risk of kidney transplant recipients (KTRs).","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48153921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute antibody-mediated rejection of kidney allograft; mind the fibrin thrombi","authors":"Dorsa Jahangiri, M. Ardalan, M. Mubarak, S. Alimohammadi, H. Jahantigh, Sanam Saeifar","doi":"10.34172/jrip.2022.32094","DOIUrl":"https://doi.org/10.34172/jrip.2022.32094","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44646627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring quality of life among patients with urinary stone disease; A qualitative study","authors":"Malik Ayyad, Omar Ayaad","doi":"10.34172/jrip.2023.32106","DOIUrl":"https://doi.org/10.34172/jrip.2023.32106","url":null,"abstract":"Introduction: Urinary stone disease is considered one of the common causes of emergency hospital admissions. Understanding the patients’ perspectives on their quality of life is essential to evaluating the effectiveness of treatments and technologies. Objectives: This study aims to investigate the quality of life among patients with urinary stone disease. Patients and Methods: A qualitative design was utilized. A purposeful sampling method was used to select the patients. Around 30 participants from patients were selected. The data were collected using semi-structured open-ended interviews with patients. Thematic analysis was utilized to develop the themes. Results: The main themes included pain, other physical symptoms, psychological symptoms, diet, Job-related activities, daily activities and lifestyle, and social and sexual life. The results showed that pain, other physical symptoms, and changes in daily activities and lifestyle were the most reported negative life experiences. In contrast, job-related activities and psychological symptoms were the least reported negative life experience among patients with renal stone disease. The quality of life among patients with first stone former and ureteric stone was affected compared to patients with recurrent and/or renal stones. Conclusion: Our qualitative study provides deep insights into the impact of urinary stone disease on several aspects of quality of life. The findings are expected to aid in the development of patient-centered interventions for individuals suffering from urinary stone disease.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42536771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the gut microbiota in oxalate nephrolithiasis","authors":"N. Sturov, S. Popov, Zakhar A. Ivanov, E. I. Rusanova, Georgy N. Kobylyanu","doi":"10.34172/jrip.2022.32060","DOIUrl":"https://doi.org/10.34172/jrip.2022.32060","url":null,"abstract":"The gut microbiota (GM) is currently considered as a pathogenic factor in a number of diseases. It is known that some gastrointestinal diseases cause a high risk of developing urolithiasis. The study gives modern data demonstrating the influence of the GM, in particular Oxalobacter formigenes, on the formation of oxalate kidney stones. The relationship between the presence of inflammatory bowel diseases and the use of antimicrobial drugs with oxalate homeostasis was demonstrated, methods for correcting the GM in patients with urolithiasis, including the use of probiotics and diet therapy, were analyzed. The studies presented in the article demonstrate that the correction of the GM can be considered as a therapeutic goal and be an actual component of the complex treatment and metaphylaxis of nephrolithiasis.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42286454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between preeclampsia and COVID-19; a narrative review on recent findings","authors":"A. Hassanzadeh Rad, Gelayol Chatrnour, S. Ghazanfar Tehran, Amirhossein Fakhre Yaseri","doi":"10.34172/jrip.2022.32061","DOIUrl":"https://doi.org/10.34172/jrip.2022.32061","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is an infectious disease first diagnosed in December 2019. Regarding previous studies that indicated the potential association between preeclampsia (PE) and COVID-19, it is pertinent to assess these conditions’ clinical manifestations and laboratory findings comprehensively. We performed this narrative review, considering the importance of pregnancy and its maternal and fetal outcomes and the lack of a definite mechanism of COVID-19 in pregnant women with PE. It is noteworthy that both conditions may have overlapped characteristics that may affect the outcomes during pregnancy.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44401233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}